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![Novel 2-Phenyl-Imidazo[4,5-B]Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase for the Treatment of Dementia and Neurodegenerative Disorders](/abs-image/US/2008/10/16/US20080255106A1/abs.jpg.150x150.jpg)
1.发明申请Novel 2-Phenyl-Imidazo[4,5-B]Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase for the Treatment of Dementia and Neurodegenerative Disorders 审中-公开新型2-苯基 - 咪唑并[4,5-B]吡啶衍生物作为糖原合酶激酶抑制剂治疗痴呆和神经退行性疾病公开(公告)号：US20080255106A1
公开(公告)日：2008-10-16
申请号：US12088897
申请日：2006-10-02
申请人： Per I. Arvidsson , Erwan Arzel , Jeremy Burrows , Helena Gyback , Tobias Rein , Didier Rotticci , Peter Soderman
发明人： Per I. Arvidsson , Erwan Arzel , Jeremy Burrows , Helena Gyback , Tobias Rein , Didier Rotticci , Peter Soderman
IPC分类号： A61K31/437 , A61P25/00 , C07D471/04 , A61K31/541 , A61K31/496 , A61P3/10 , A61K31/5377
CPC分类号： C07D471/04
摘要： Compounds of formula I wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, as a base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, processes for their preparation and new intermediates used therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 5，R 4， R 6和R 7如说明书中所定义，作为其盐或其盐的碱或其药学上可接受的盐，溶剂化物或溶剂合物，其方法为 制剂和其中使用的新中间体，含有所述化合物的药物制剂和所述化合物在治疗中的用途。
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![Novel Imidazo [4,5-b] Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase 3 for Use in the Treatment of Dementia and Neurodegenerative Disorders](/abs-image/US/2008/10/16/US20080255085A1/abs.jpg.150x150.jpg)
2.发明申请Novel Imidazo [4,5-b] Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase 3 for Use in the Treatment of Dementia and Neurodegenerative Disorders 审中-公开新型咪唑并[4,5-b]吡啶衍生物作为糖原合成酶激酶3抑制剂用于治疗痴呆和神经退行性疾病公开(公告)号：US20080255085A1
公开(公告)日：2008-10-16
申请号：US12089002
申请日：2006-10-02
申请人： Per I Arvidsson , Erwan Arzel , Jeremy Burrows , Martina Claesson , Colin Ray , Tobias Rein , Didier Rotticci , Peter Soderman
发明人： Per I Arvidsson , Erwan Arzel , Jeremy Burrows , Martina Claesson , Colin Ray , Tobias Rein , Didier Rotticci , Peter Soderman
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/496 , A61P25/16 , A61P25/28 , A61K31/437 , A61K31/551
CPC分类号： C07D471/04
摘要： Compounds of formula I wherein X is or Y; and wherein A, Y, R1, R2, R3, R4 and R5 are as defined in the specification as a base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, processes for their preparation, new intermediates used therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译： 其中X为或Y的式I化合物; 并且其中A，Y，R 1，R 2，R 3，R 4和R 4， 5的定义如本说明书中作为其盐或其药学上可接受的盐，溶剂化物或其盐的溶剂化物，其制备方法，其中使用的新中间体，含有所述化合物的药物制剂以及所述化合物的用途 治疗。
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3.发明申请Pyrimidine Derivatives and Their Use in Therapy as well as the Use of Pyrimidine Derivatives in the Manufacture of a Medicament for Prevention and/or Treatment of Alzheimer's Disease 审中-公开嘧啶衍生物及其在治疗中的应用以及嘧啶衍生物在制造预防和/或治疗阿尔茨海默病药物中的应用公开(公告)号：US20090105252A1
公开(公告)日：2009-04-23
申请号：US12089008
申请日：2006-10-02
申请人： Lars Andersson , Erwan Arzel , Stefan Berg , Jeremy Burrows , Sven Hellberg , Fernando Huerta , Torben Pedersen , Tobias Rein , Didier Rotticci , Karin Staaf , Dominika Turek
发明人： Lars Andersson , Erwan Arzel , Stefan Berg , Jeremy Burrows , Sven Hellberg , Fernando Huerta , Torben Pedersen , Tobias Rein , Didier Rotticci , Karin Staaf , Dominika Turek
IPC分类号： A61K31/5377 , C07D403/02 , A61K31/506 , C07D413/14 , A61P25/28 , C07D403/14 , A61K31/496
CPC分类号： C07D405/14 , A61K31/506 , C07D401/14 , C07D403/04 , C07D409/14
摘要： Compounds of formula I wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification as a base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, processes for their preparation, new intermediates used therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9如说明书中所定义的式I化合物或其盐，溶剂化物或其盐的溶剂合物，其制备方法，新的 其中使用的中间体，含有所述化合物的药物制剂和所述化合物在治疗中的用途。
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公开(公告)号：US20080188503A1
公开(公告)日：2008-08-07
申请号：US11769113
申请日：2007-06-27
申请人： Jeremy Burrows , Fernando Huerta , Tobias Rein , Didier Rotticci , Karin Staaf , Dominika Turek
发明人： Jeremy Burrows , Fernando Huerta , Tobias Rein , Didier Rotticci , Karin Staaf , Dominika Turek
IPC分类号： A61K31/506 , C07D401/04 , A61P25/28
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14
摘要： The present invention relates to a compound of formula (I): as a free base or a pharmaceutically acceptable salt thereof. The present invention also relates to pharmaceutical formulations containing said compound and to the use of said compound in therapy. The present invention further relates to a process for the preparation of the compound of formula (I).
摘要翻译： 本发明涉及式（I）的化合物：作为游离碱或其药学上可接受的盐。 本发明还涉及含有所述化合物的药物制剂和所述化合物在治疗中的用途。 本发明还涉及制备式（I）化合物的方法。
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公开(公告)号：US20080188502A1
公开(公告)日：2008-08-07
申请号：US11769102
申请日：2007-06-27
申请人： Jeremy Burrows , Fernando Huerta , Fredrik Lake , Torben Pedersen , Didier Rotticci , Tobias Rein , Karin Staaf , Ulrika Yngve
发明人： Jeremy Burrows , Fernando Huerta , Fredrik Lake , Torben Pedersen , Didier Rotticci , Tobias Rein , Karin Staaf , Ulrika Yngve
IPC分类号： A61K31/506 , C07D401/04 , A61P25/28
CPC分类号： C07D401/14 , C07D405/14
摘要： The present invention relates to a compound of formula (I): as a free base or a pharmaceutically acceptable salt thereof. The present invention also relates to pharmaceutical formulations containing said compound and to the use of said compound in therapy. The present invention further relates to a process for the preparation of compound of formula (I) and to new intermediates used therein.
摘要翻译： 本发明涉及式（I）的化合物：作为游离碱或其药学上可接受的盐。 本发明还涉及含有所述化合物的药物制剂和所述化合物在治疗中的用途。 本发明还涉及制备式（I）化合物及其中使用的新中间体的方法。
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6.发明申请公开(公告)号：US20110028489A1
公开(公告)日：2011-02-03
申请号：US12856879
申请日：2010-08-16
申请人： Lars Andersson , Stefan Berg , Jeremy Burrows , Sven Hellberg , Fernando Huerta , Tobias Rein
发明人： Lars Andersson , Stefan Berg , Jeremy Burrows , Sven Hellberg , Fernando Huerta , Tobias Rein
IPC分类号： A61K31/497 , C07D233/22 , C07D401/14 , C07D241/04 , C07D403/14 , A61K31/4164 , A61K31/506 , A61K31/4965 , A61P19/00
CPC分类号： C07D403/04 , A61K31/506 , C07D401/14
摘要： The present invention relates to a new use of pyrimidine derivatives of formula I, as a free base or a pharmaceutically acceptable salt thereof in the manufacture of a medicament in the treatment and/or prophylaxis of Alzheimer's Disease:
摘要翻译： 本发明涉及式I的嘧啶衍生物作为游离碱或其药学上可接受的盐在制备用于治疗和/或预防阿尔茨海默病中的药物中的新用途：
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7.发明申请Use of Pyrimidine Derivatives in the Manufacture of a Medicament for Prevention and/or Treatment of Alzheimer's Disease 审中-公开嘧啶衍生物在制造预防和/或治疗阿尔茨海默病药物中的应用公开(公告)号：US20080214560A1
公开(公告)日：2008-09-04
申请号：US12088899
申请日：2006-10-02
申请人： Lars Andersson , Stefan Berg , Jeremy Burrows , Sven Hellberg , Fernando Huerta , Tobias Rein
发明人： Lars Andersson , Stefan Berg , Jeremy Burrows , Sven Hellberg , Fernando Huerta , Tobias Rein
IPC分类号： A61K31/497 , A61K31/506 , C07D239/28
CPC分类号： C07D403/04 , A61K31/506 , C07D401/14
摘要： Pyrimidine derivatives of formula I, wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification, as a base or a pharmaceutically acceptable salt thereof in the manufacture of pharmaceutical compositions and in the treatment or prophylaxis of Alzheimer's Disease.
摘要翻译： 式I的嘧啶衍生物，其中R 1，R 2，R 3，R 4，R 4， > 5，R 6，R 7，R 8和R 9如上所定义。 本说明书作为其药物组合物的制备中的碱或其药学上可接受的盐，并且用于治疗或预防阿尔茨海默氏病。
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![Imidazo[4,5-B]Pyridine-7-Carboxamides 704](/abs-image/US/2010/09/16/US20100234593A1/abs.jpg.150x150.jpg)
公开(公告)号：US20100234593A1
公开(公告)日：2010-09-16
申请号：US12593432
申请日：2008-03-28
申请人： Per Arvidsson , Jeremy Burrows , Peter Soderman , Ulrika Yngve
发明人： Per Arvidsson , Jeremy Burrows , Peter Soderman , Ulrika Yngve
IPC分类号： C07D413/14 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to new compounds of formula (I) as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.
摘要翻译： 本发明涉及作为其盐的游离碱或其药学上可接受的盐，溶剂合物或溶剂化物的新的式（I）化合物，其制备方法和其中使用的新中间体，含有所述治疗活性化合物的药物制剂和 所述活性化合物在治疗中的用途。
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9.发明申请Novel 2-Amino-Imidazole-4-One Compounds and Their Use in the Manufacture of a Medicament to Be Used in the Treatment of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration and Dementia 审中-公开新型2-氨基咪唑-4-酮化合物及其在制造用于治疗认知功能障碍，阿尔茨海默病，神经退行性和痴呆症药物中的应用公开(公告)号：US20090233930A9
公开(公告)日：2009-09-17
申请号：US12094276
申请日：2006-11-20
申请人： Stefan Berg , Jeremy Burrows , Gianni Chessari , Miles Stuart Congreve , Johan Hedstrom , Sven Hellberg , Katharina Hogdin , Jacob Kihlstrom , Karin Kolmodin , Johan Lindstrom , Christopher Murray , Sahil Patel
发明人： Stefan Berg , Jeremy Burrows , Gianni Chessari , Miles Stuart Congreve , Johan Hedstrom , Sven Hellberg , Katharina Hogdin , Jacob Kihlstrom , Karin Kolmodin , Johan Lindstrom , Christopher Murray , Sahil Patel
IPC分类号： A61K31/5377 , C07D401/10 , A61K31/4725 , C07D339/08 , A61P25/28 , C07F7/08 , C12N9/99 , C07D413/12
CPC分类号： C07D233/88 , C07C25/22 , C07C25/24 , C07C39/373 , C07C43/1747 , C07C43/23 , C07C47/575 , C07C49/792 , C07C49/813 , C07C49/83 , C07C49/84 , C07D209/08 , C07D217/06 , C07D233/86 , C07D265/36 , C07D307/79 , C07D339/08 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/04 , C07F7/1804
摘要： This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译： 本发明涉及具有以下结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。 这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。
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10.发明申请Sulphonylpiperidine derivatives containing an aryl or heteroaryl group for use as matrix metalloproteinase inhibitors 审中-公开含有用作基质金属蛋白酶抑制剂的芳基或杂芳基的磺酰基哌啶衍生物公开(公告)号：US20060173041A1
公开(公告)日：2006-08-03
申请号：US10520861
申请日：2003-07-09
IPC分类号： A61K31/445 , A61K31/454 , C07D401/02
CPC分类号： C07D401/12 , C07D211/96 , C07D401/14 , C07D409/12 , C07D413/12 , C07D495/04
摘要： A compound of formula (1), wherein B is an ortho substituted monocyclic aryl or heteroaryl group or a bicyclic aryl or heteroaryl group; useful in the inhibition of one or more metalloproteinases, and in particular TACE.
摘要翻译： 式（1）的化合物，其中B是邻位取代的单环芳基或杂芳基或双环芳基或杂芳基; 可用于抑制一种或多种金属蛋白酶，特别是TACE。
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