利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

54 条记录 (耗时 0.026 秒)

    Cardiac drug delivery system
    3.
    发明授权
    Cardiac drug delivery system 有权
    心脏药物输送系统

    公开(公告)号：US07104988B2

    公开(公告)日：2006-09-12

    申请号：US10101301

    申请日：2002-03-19

    申请人： Peter A. Altman ,  John D. Altman

    发明人： Peter A. Altman ,  John D. Altman

    IPC分类号： A61N1/05

    CPC分类号： A61B18/1492 ,  A61B2017/00247 ,  A61B2018/00011 ,  A61B2018/00273 ,  A61B2018/00351 ,  A61B2018/00392 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/1425 ,  A61B2018/1435 ,  A61B2218/002 ,  A61K9/127 ,  A61K9/1676 ,  A61K9/50 ,  A61M25/0084 ,  A61M2025/0089 ,  A61N1/0575 ,  B82Y5/00

    摘要： A system is disclosed, for administering a therapeutic agent locally and to a depth within cardiac tissue. An elongate, flexible catheter contains a flexible electric conductor and supports at its distal end an implantable electrode incorporating a penetrating element, typically a fixation helix or a linear needle that penetrates cardiac tissue as the electrode is implanted. A therapeutic agent is delivered through the electrode, to the cardiac tissue surrounding the penetrating element. The electrode can act as a sensor, to monitor an electrical condition of the surrounding cardiac tissue, and to control delivery of the agent responsive to the sensed electrical condition. Several embodiments feature a distal reservoir adjacent the electrode for effecting transient deliveries of the therapeutic agent in minute quantities. Other embodiments are disclosed for providing sustained deliveries of the agents.

    摘要翻译： 公开了一种用于在局部施用治疗剂并且在心脏组织内施用深度的系统。 细长的柔性导管包含柔性电导体并且在其远端处支撑可植入电极，该可植入电极结合穿透元件，通常为植入电极时穿透心脏组织的固定螺旋线或线性针。 治疗剂通过电极传递到穿透元件周围的心脏组织。 电极可以用作传感器，以监测周围心脏组织的电气状况，并且响应于感测到的电气状况来控制药剂的递送。 几个实施例的特征在于与电极相邻的远端储存器，用于以微量的量实现治疗剂的瞬时输送。 公开了用于提供药剂的持续递送的其它实施方案。

    Drug delivery catheter and steering guide catheter combination
    4.
    发明授权
    Drug delivery catheter and steering guide catheter combination 有权
    药物输送导管和导向导管组合

    公开(公告)号：US07048711B2

    公开(公告)日：2006-05-23

    申请号：US10353233

    申请日：2003-01-27

    申请人： Daniel C. Rosenman ,  Peter A. Altman ,  Brian K. Hakim ,  Daniel J. Kayser ,  Robert E. Maston ,  Douglas McEtchin

    发明人： Daniel C. Rosenman ,  Peter A. Altman ,  Brian K. Hakim ,  Daniel J. Kayser ,  Robert E. Maston ,  Douglas McEtchin

    IPC分类号： A61M37/00

    CPC分类号： A61M25/0084 ,  A61M25/0014 ,  A61M25/0045 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/0097 ,  A61M25/0136 ,  A61M25/0138 ,  A61M25/0147 ,  A61M25/04 ,  A61M2025/0081 ,  A61M2025/0089 ,  A61M2025/0175 ,  A61M2202/0468

    摘要： A system and method for delivering a drug to a target site within a patient's body. The system and method include a steerable guide catheter and a drug delivery catheter. The steerable guide catheter has a first extension tube and a second extension tube that are joined together and form a shoulder. The delivery catheter has a distal docking segment and a proximal docking segment. The guide catheter is inserted into the patient's body, then the delivery catheter is inserted into the guide catheter. The distal docking segment engages the first extension tube, the proximal docking segment engages the second extension tube, and the shoulder limits the distance the delivery catheter can be inserted into the guide catheter. Also, once the delivery catheter is inserted it can be rotated to attach the helical tip to the target site. The guide catheter also includes a steering mechanism as well as a friction mechanism which controls the tension on the steering mechanism. The delivery catheter also includes two luer fittings, each having its own lumen.

    摘要翻译： 一种用于将药物递送到患者体内的目标部位的系统和方法。 该系统和方法包括可导向的导管和药物输送导管。 可引导导管具有连接在一起形成肩部的第一延伸管和第二延伸管。 输送导管具有远端对接部分和近端对接部分。 将引导导管插入患者体内，然后将输送导管插入引导导管。 远端对接部分接合第一延伸管，近端对接部分接合第二延伸管，并且肩部限制输送导管插入导向导管的距离。 另外，一旦输送导管被插入，就可旋转，将螺旋尖端附着到目标部位。 引导导管还包括转向机构以及控制转向机构上的张力的摩擦机构。 输送导管还包括两个鲁尔接头，每个具有自己的内腔。

    Implantable device for penetrating and delivering agents to cardiac tissue
    6.
    再颁专利
    Implantable device for penetrating and delivering agents to cardiac tissue 有权
    用于穿透和递送药物到心脏组织的可植入装置

    公开(公告)号：USRE37463E1

    公开(公告)日：2001-12-11

    申请号：US09146120

    申请日：1998-09-01

    申请人： Peter A. Altman

    发明人： Peter A. Altman

    IPC分类号： A61N105

    CPC分类号： A61N1/056 ,  A61F2/00 ,  A61N1/0573

    摘要： An implantable devices for the effective elimination of an arrhythmogenic site from the myocardium is presented. By inserting small biocompatible conductors and/or insulators into the heart tissue at the arrhythmogenic site, it is possible to effectively eliminate a portion of the tissue from the electric field and current paths within the heart. The device would act as an alternative to the standard techniques for the removal of tissue from the effective contribution to the hearts electrical action which require the destruction of tissue via energy transfer (RF, microwave, cryogenic, etc.). This device is a significant improvement in the state of the art in that it does not require tissue necrosis. In one preferred embodiment the device is a non conductive helix that is permanently implanted into the heart wall around the arrhythmogenic site. In variations on the embodiment, the structure is wholly or partially conductive, the structure is used as an implantable substrate for anti arrhythmic, inflammatory, or angiogenic pharmacological agents, and the structure is deliverable by a catheter with a disengaging stylet. In other preferred embodiments that may incorporate the same variations, the device is a straight or curved stake, or a group of such stakes that are inserted simultaneously.

    摘要翻译： 提出了一种用于从心肌有效消除致心律失常部位的可植入装置。 通过将小的生物相容性导体和/或绝缘体插入致心律失常部位的心脏组织中，可以从心脏内的电场和电流路径有效地消除组织的一部分。 该装置将用作用于从对通过能量转移（RF，微波，低温等）破坏组织的对心脏电作用的有效贡献中去除组织的标准技术的替代。 该装置是现有技术的显着改进，因为其不需要组织坏死。在一个优选实施例中，该装置是永久地植入心律失常部位周围心脏壁的非导电螺旋。 在实施方案的变型中，结构全部或部分导电，该结构用作抗心律不齐，炎性或血管生成药理学的可植入底物，并且该结构可通过具有分离探针的导管递送。 在可以包含相同变化的其它优选实施例中，该装置是同时插入的直的或弯曲的桩或一组这样的桩。

    Method and apparatus for delivering defibrillation therapy through a sensing electrode
    7.
    发明授权
    Method and apparatus for delivering defibrillation therapy through a sensing electrode 失效
    通过感测电极进行除颤治疗的方法和装置

    公开(公告)号：US5545183A

    公开(公告)日：1996-08-13

    申请号：US351864

    申请日：1994-12-07

    申请人： Peter A. Altman

    发明人： Peter A. Altman

    IPC分类号： A61N1/04 ,  A61N1/05 ,  A61N1/39

    CPC分类号： A61N1/3962 ,  A61N1/056 ,  A61N1/0563

    摘要： A pulse generator circuit and method for using a defibrillation lead positioned close to the right ventricular apex to optimize energy delivery and sensing. This method includes operating a defibrillator-pacemaker system in a true bipolar sensing mode as long as high voltage therapy is not required. When required, the defibrillator-pacemaker system delivers a first high voltage therapy via an RV defibrillation electrode, and, using true bipolar sensing, determines whether the first high voltage therapy was successful. If the first high voltage therapy is deemed to be successful, then true bipolar sensing is resumed. Otherwise, the defibrillator-pacemaker system causes a ring electrode to be electrically connected to the RV defibrillation electrode, delivers a second high voltage therapy, and, using integrated bipolar sensing determines whether the second high voltage therapy was successful. In this way, because no new circuit elements are added within the lead, the lead size and complexity are not increased.

    摘要翻译： 脉冲发生器电路和方法，用于使用靠近右心室顶点定位的除颤引线来优化能量输送和感测。 只要不需要高压治疗，该方法包括以真正的双极感测模式操作除颤器起搏器系统。 当需要时，除颤器起搏器系统通过RV除颤电极进行第一次高压治疗，并且使用真正的双极性感测来确定第一次高压治疗是否成功。 如果第一次高电压治疗被认为是成功的，则恢复真正的双极性感测。 否则，除颤起搏器系统使得环形电极与RV除颤电极电连接，进行第二高电压治疗，并且使用集成的双极性检测来确定第二高电压治疗是否成功。 这样，由于在引线内没有添加新的电路元件，因此引线尺寸和复杂度不会增加。

    Method of Preparing Autologous Cells and Method of Use for Therapy
    8.
    发明申请
    Method of Preparing Autologous Cells and Method of Use for Therapy 有权
    自体细胞的制备方法和治疗方法

    公开(公告)号：US20100278783A1

    公开(公告)日：2010-11-04

    申请号：US12434537

    申请日：2009-05-01

    申请人： Didier Rouy ,  Peter A. Altman ,  Benjamin Koziner

    发明人： Didier Rouy ,  Peter A. Altman ,  Benjamin Koziner

    IPC分类号： A61K45/00 ,  C12N5/0775 ,  A61P37/06

    CPC分类号： C12N5/0663 ,  A61K9/0019 ,  A61K35/00 ,  A61K35/10 ,  A61K35/28 ,  A61K2035/124 ,  C12N2500/84 ,  C12N2502/11 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： A method for expanding mesenchymal cells derived from autologous bone marrow in autologous culture medium which can be used in a clinical setting, and a business method for performing such expansions in the future as a service for patients. A method for expanding mesenchymal cells derived from autologous bone marrow in autologous culture medium including a diagnostic kit for the autologous cell therapy to determine whether a patient will respond to the autologous cell therapy for treatment of a disease, in which said kit comprising a system for detecting gene and protein expression comprising at least two isolated DNA molecules wherein each isolated DNA molecule detects expression of a gene that is differentially expressed in the tissue of the patient that is intended to be the source of the autologous cell therapy.

    摘要翻译： 用于扩展可用于临床环境的自体培养基中自体骨髓衍生的间充质细胞的方法，以及将来作为患者服务进行这种扩展的商业方法。 一种在自体培养基中扩增源于自体骨髓的间充质细胞的方法，包括用于自体细胞治疗的诊断试剂盒，以确定患者是否将对自体细胞疗法响应治疗疾病，其中所述试剂盒包含用于 检测包含至少两个分离的DNA分子的基因和蛋白质表达，其中每个分离的DNA分子检测在旨在成为自体细胞治疗来源的患者组织中差异表达的基因的表达。

    Bio-interventional therapeutic treatments for cardiovascular diseases
    9.
    发明授权
    Bio-interventional therapeutic treatments for cardiovascular diseases 有权
    生物介入治疗心血管疾病

    公开(公告)号：US07736346B2

    公开(公告)日：2010-06-15

    申请号：US11253177

    申请日：2005-10-18

    申请人： Aaron Miller ,  Loren Bentley ,  Daniel C. Rosenman ,  Peter A. Altman

    发明人： Aaron Miller ,  Loren Bentley ,  Daniel C. Rosenman ,  Peter A. Altman

    IPC分类号： A61M5/00

    CPC分类号： A61B17/3478 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61M25/0084

    摘要： Catheter-based systems are disclosed for geometrically and temporally controlled deliveries of fluid agents to the heart. Each system includes an elongate catheter shaft, a tissue penetration element at the shaft distal end, and a handle at the shaft proximal end for manipulating the penetrating element. The penetrating element and a proximate conductive coil provide bipolar sensing electrodes. One version of the system includes a fluid lumen through the penetrating element and a contrast fluid lumen open at the catheter shaft distal end. In other versions, the penetrating element contains two fluid lumens. These systems facilitate tissue mapping and therapeutic agent delivery protocols in which several agents can be simultaneously delivered at a depth within heart tissue, prevented from intermingling until they reach the tissue. Treatment and contrast agents can be delivered simultaneously or temporally spaced, directed to the same region or to different regions separated by intervening tissue.

    摘要翻译： 公开了基于导管的系统，用于几何和时间上控制向心脏传递流体剂。 每个系统包括细长的导管轴，在轴远端处的组织穿透元件，以及在轴近端的用于操纵穿透元件的手柄。 穿透元件和邻近的导电线圈提供双极感测电极。 系统的一个版本包括通过穿透元件的流体腔和在导管轴远端开口的造影液腔。 在其他版本中，穿透元件包含两个流体流明。 这些系统促进组织图和治疗剂递送方案，其中可以在心脏组织内的深度同时递送多种试剂，防止混合直到它们到达组织。 治疗和造影剂可以同时或时间间隔地递送，指向相同的区域或由介入组织分开的不同区域。

    Pulmonary vein arrhythmia diagnostic device and method for use
    10.
    发明授权
    Pulmonary vein arrhythmia diagnostic device and method for use 有权
    肺静脉心律失常诊断装置及使用方法

    公开(公告)号：US07351237B2

    公开(公告)日：2008-04-01

    申请号：US11196795

    申请日：2005-08-02

    申请人： Peter A. Altman

    发明人： Peter A. Altman

    IPC分类号： A61M31/00

    CPC分类号： A61F2/82 ,  A61B5/046 ,  A61F2002/821 ,  A61F2250/0067 ,  A61L31/022 ,  A61L31/16 ,  A61L2300/40 ,  A61M25/10 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1086

    摘要： Devices and methods for testing a pulmonary vein to determine whether or not ablation would be effective in terminating atrial fibrillation. The devices and methods include a catheter having an expandable balloon attached to the distal end of the catheter. The balloon has pores on the distal end of the balloon for administering a fluid into the target pulmonary vein. The fluid inhibits the electrical impulses generated by the target pulmonary vein. Once the electrical impulses of the target pulmonary vein have been inhibited it can be determined whether or not the atrial fibrillation continues to occur. If the atrial fibrillation has been eliminated, then ablation or other therapy is appropriate. Thus, the devices and methods limit unnecessary treatment of a pulmonary vein.

    摘要翻译： 用于测试肺静脉以确定消融是否有效终止心房颤动的装置和方法。 装置和方法包括具有附接到导管的远端的可扩张气囊的导管。 气囊在气囊的远端具有孔，用于将流体施用到目标肺静脉中。 流体抑制由目标肺静脉产生的电脉冲。 一旦目标肺静脉的电脉冲被抑制，可以确定心房颤动是否继续发生。 如果心房颤动已被消除，则消融或其他治疗是适当的。 因此，装置和方法限制了肺静脉的不必要的治疗。