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公开(公告)号：US20050136546A1
公开(公告)日：2005-06-23
申请号：US11010806
申请日：2004-12-13
CPC分类号： B01L3/5085 , B01L2200/026 , B01L2300/0681 , B01L2300/0829 , B01L2400/0409 , Y10T436/111666
摘要： A microtiter plate for processing samples, having a liquid component or a liquid and a solid component or a liquid and a gel component, comprising: a single piece body which has an array of cavities, each cavity having an open upper end, a closed bottom end, and a bottom inner surface and comprises a first chamber for receiving a predetermined volume of a sample to be processed, a second chamber and a passage which fluidically connects the first and second chambers with each other, and a region in the lower part of passage adjacent to the bottom end of the cavity, the region so configured and dimensioned that it allows passage of liquid from one of said chambers to the other only when a centrifugal force is applied to the microtiter plate, but does not allow passage of any solid or gel component the size of which is larger than the width of the region.
摘要翻译： 一种用于处理具有液体组分或液体以及固体组分或液体和凝胶组分的样品的微量滴定板，包括：单体体，其具有空腔阵列，每个空腔具有敞开的上端，封闭的底部 端部和底部内表面，并且包括用于接收预定体积的待处理样品的第一室，第二室和将第一室和第二室彼此流体连接的通道，以及下部的区域 通过与腔的底端相邻的通道，这样构造和尺寸确定为仅当离心力施加到微量滴定板时允许液体从所述腔中的一个通到另一腔，但不允许任何固体通过 或凝胶成分，其大小大于该区域的宽度。
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公开(公告)号：US09267933B2
公开(公告)日：2016-02-23
申请号：US14002269
申请日：2012-03-02
申请人： Christof Fattinger , Patrick Iaiza , Tom Kissling , Dieter Voegelin , Thomas Zumstein , Claudia Mcginnis
发明人： Christof Fattinger , Patrick Iaiza , Tom Kissling , Dieter Voegelin , Thomas Zumstein , Claudia Mcginnis
CPC分类号： G01N33/5014 , B01L3/06 , B01L3/50853 , B01L3/5088 , B01L2300/042 , B01L2300/047 , B01L2300/0829 , C12M23/12 , C12M25/01
摘要： A hanging droplet plate (1) comprises a predetermined number of droplet compartments (10) each being capable of receiving a droplet of a liquid. The respective droplet compartment (10) comprises a circumferential microfluidic wetting barrier (102) which is arranged to surround a respective cavity (100) and which prevents a droplet from spreading beyond the microfluidic wetting barrier (102). The respective compartment (10) comprises a closed bottom (101) and at least one additional circumferential microfluidic wetting barrier (104), each additional circumferential microfluidic wetting barrier (104) which is arranged to surround a preceding circumferential microfluidic wetting barrier (102). A wettable area (103) is arranged between two adjacently arranged microfluidic wetting barriers (102, 104).
摘要翻译： 悬挂的液滴板（1）包括预定数量的液滴隔室（10），每个液滴隔室（10）能够接收液滴。 相应的液滴隔室（10）包括周向微流体润湿屏障（102），其被布置成围绕相应的空腔（100）并且防止液滴扩散到微流体润湿屏障（102）之外。 相应的隔室（10）包括封闭的底部（101）和至少一个附加的周向微流体润湿屏障（104），每个附加的周向微流体润湿屏障（104）被布置成围绕先前的周向微流体润湿屏障（102）。 可湿性区域（103）布置在两个相邻布置的微流体润湿屏障（102,104）之间。
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公开(公告)号：US20100086440A1
公开(公告)日：2010-04-08
申请号：US12587085
申请日：2009-09-30
CPC分类号： G01N35/028 , G01N35/0099 , G01N2035/00435 , G01N2035/0425
摘要： In some embodiments of the present disclosure, a robotic storage system for storing microplates carrying a plurality of sample tubes is provided and may comprise a freezer room having a plurality of freezing units and a first robot being capable of removing a microplate from and moving a microplate into a freezing unit. The first robot may be further capable of transferring the microplate to a processing station, where the microplates are stored in the freezing units such that a plurality of microplates are arranged one above the other in a microplate recipient. The robotic storage system may also include at least one processing room and means for thermally separating the processing room from the freezer room. Each processing room may include a processing station having at least one tube transfer module as well as a second robot for moving the microplates between the microplate recipients and the at least one tube transfer module. The first robot may be designed such that it is only capable of removing a microplate recipient from and moving it into a said freezing unit as well as of transferring it from a freezing unit to a processing station or vice versa.
摘要翻译： 在本公开的一些实施例中，提供了一种用于存储携带多个样品管的微板的机器人存储系统，并且可以包括具有多个冷冻单元的冷冻室，以及能够从微板移除微孔板并移动微孔板的第一机器人 进入冷冻单位。 第一机器人可以进一步能够将微板转移到处理站，其中微孔板被存储在冷冻单元中，使得多个微孔板在微孔板接收器中彼此上下排列。 机器人存储系统还可以包括至少一个处理室和用于将处理室与冷冻室热分离的装置。 每个处理室可以包括具有至少一个管传送模块的处理站以及用于在微板接收器和至少一个管传送模块之间移动微孔板的第二机器人。 第一机器人可以设计成使得其仅能够移除微孔板接收器并将其移动到所述冷冻单元中，以及将其从冷冻单元传送到处理站，反之亦然。
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公开(公告)号：US09201084B2
公开(公告)日：2015-12-01
申请号：US12587085
申请日：2009-09-30
CPC分类号： G01N35/028 , G01N35/0099 , G01N2035/00435 , G01N2035/0425
摘要： A robotic microplate storage system includes a freezer room having freezing units and a first robot for moving and removing microplates into and out of the freezing unit. The first robot can also transfer microplates to a processing station, where the microplates are stored in a microplate recipient within the freezing unit. The storage system may also include at least one processing room which is thermally separated from the freezer room. Each processing room may include a processing station having a tube transfer module and a second robot for moving the microplates between the microplate recipients and the tube transfer module. The first robot may be designed such that it is only capable of removing a microplate recipient from and moving it into a freezing unit as well as transferring it from a freezing unit to a processing station or vice versa.
摘要翻译： 机器人微板存储系统包括具有冷冻单元的冷冻室和用于移动和移出微孔板进入和离开冷冻单元的第一机器人。 第一机器人还可以将微孔板转移到加工站，其中微孔板存储在冷冻单元内的微板接收器中。 存储系统还可以包括与冷冻室热分离的至少一个处理室。 每个处理室可以包括具有管转移模块和第二机器人的处理站，用于在微板接收器和管传送模块之间移动微板。 第一机器人可以设计成使得其仅能够移除微孔板接收器并将其移动到冷冻单元中，并且将其从冷冻单元传送到处理站，反之亦然。
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公开(公告)号：US20140106395A1
公开(公告)日：2014-04-17
申请号：US14002269
申请日：2012-03-02
申请人： Christof Fattinger , Patrick Iaiza , Tom Kissling , Dieter Voegelin , Thomas Zumstein , Claudia Mcginnis
发明人： Christof Fattinger , Patrick Iaiza , Tom Kissling , Dieter Voegelin , Thomas Zumstein , Claudia Mcginnis
IPC分类号： G01N33/50
CPC分类号： G01N33/5014 , B01L3/06 , B01L3/50853 , B01L3/5088 , B01L2300/042 , B01L2300/047 , B01L2300/0829 , C12M23/12 , C12M25/01
摘要： A hanging droplet plate (1) comprises a predetermined number of droplet compartments (10) each being capable of receiving a droplet of a liquid. The respective droplet compartment (10) comprises a circumferential microfluidic wetting barrier (102) which is arranged to surround a respective cavity (100) and which prevents a droplet from spreading beyond the microfluidic wetting barrier (102). The respective compartment (10) comprises a closed bottom (101) and at least one additional circumferential microfluidic wetting barrier (104), each additional circumferential microfluidic wetting barrier (104) which is arranged to surround a preceding circumferential microfluidic wetting barrier (102). A wettable area (103) is arranged between two adjacently arranged microfluidic wetting barriers (102, 104).
摘要翻译： 悬挂的液滴板（1）包括预定数量的液滴隔室（10），每个液滴隔室（10）能够接收液滴。 相应的液滴隔室（10）包括周向微流体润湿屏障（102），其被布置成围绕相应的空腔（100）并且防止液滴扩散到微流体润湿屏障（102）之外。 相应的隔室（10）包括封闭的底部（101）和至少一个附加的周向微流体润湿屏障（104），每个附加的周向微流体润湿屏障（104）被布置成围绕先前的周向微流体润湿屏障（102）。 可湿性区域（103）布置在两个相邻布置的微流体润湿屏障（102,104）之间。
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6.发明申请Unit and Device for the Preparation of Cells and/or Particles in a Liquid and Method for Microscopic Analysis 审中-公开用于制备液体中的细胞和/或颗粒的单元和装置和用于显微镜分析的方法公开(公告)号：US20120276575A1
公开(公告)日：2012-11-01
申请号：US13518278
申请日：2010-12-20
CPC分类号： B01L3/5025 , B01L2200/0647 , B01L2300/069 , B01L2300/0822 , B01L2300/0829 , B01L2400/0409 , B01L2400/0688 , G01N1/2813
摘要： A unit (10) for the preparation of cells contained in a liquid comprises a storage chamber (20) configured to store the liquid containing the cells and to release the stored liquid via an exit opening (22) upon the application of a predetermined external force, in particular a centrifugal force. A passage (30) adjacently arranged to the exit opening (22) has a cross-section larger than that of the exit opening (22). The wall at the transition from the exit opening (22) to the passage (30) forms an edge (32). The unit further comprises an observation member (50) for receiving the released liquid and an absorbing means (40) arranged adjacent to the observation member (50) between the passage (30) and the observation member (50). The absorbing means (40) has an aperture (42) allowing the released liquid to travel onto the observation member (50), and removes the liquid so as to leave the cells on the observation member (50) for observation.
摘要翻译： 用于制备包含在液体中的细胞的单元（10）包括储存室（20），其被配置为储存含有细胞的液体，并且在施加预定的外力时通过出口（22）释放所储存的液体 ，特别是离心力。 相邻地布置在出口开口（22）上的通道（30）的横截面大于出口开口（22）的横截面。 从出口（22）到通道（30）的过渡处的壁形成边缘（32）。 该单元还包括用于接收释放液体的观察构件（50）和在通道（30）和观察构件（50）之间邻近观察构件（50）布置的吸收装置（40）。 吸收装置（40）具有允许释放的液体行进到观察构件（50）上的孔（42），并且除去液体以使细胞留在观察构件（50）上观察。
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公开(公告)号：US20100031685A1
公开(公告)日：2010-02-11
申请号：US12462219
申请日：2009-07-31
CPC分类号： F25D23/025 , F25D11/04 , F25D13/02 , F25D25/04
摘要： Embodiments of the present invention include a convection barrier for a freezer which may comprise a plurality of individual flaps arranged one above the other in a manner such as to be capable of forming a closed curtain of individual flaps, with each individual flap extending over a predetermined width corresponding at least to the width of the interior of the freezer and being pivotable between a closed position and an open position so as to allow access to the interior of the freezer when the flap is in the open position. Embodiments may also include actuation means attached to the individual flaps for allowing an actuator to engage the actuation means of an individual flap so as to pivot the said flap between the closed position and the open position.
摘要翻译： 本发明的实施例包括用于冷冻器的对流屏障，其可以包括多个单独的翼片，所述多个单独的翼片以能够形成单个翼片的闭合帘幕的方式彼此上下布置，每个单独的翼片延伸超过预定的 宽度至少对应于冷冻室内部的宽度，并可在关闭位置和打开位置之间枢转，以便当襟翼处于打开位置时允许进入冷冻室的内部。 实施例还可以包括附接到各个翼片的致动装置，用于允许致动器接合单个翼片的致动装置，以便在闭合位置和打开位置之间枢转所述翼片。
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公开(公告)号：US07438861B2
公开(公告)日：2008-10-21
申请号：US11804279
申请日：2007-05-16
IPC分类号： B01L3/02
CPC分类号： B01L3/021 , B01L2200/147 , B01L2300/1827 , B01L2300/1888 , B01L2400/0487 , G01N35/10 , G01N2035/00425
摘要： A heatable pipette, with a needle has an inner channel defined by an inner wall, arranged to conduct electric current through the inner wall for resistively heating the inner wall. The needle has an outer wall, which is defined between the outer wall and the inner wall and connectable for providing pressure air into the outer channel. By conducting current directly through the inner wall, the inner wall itself operates as resistor. Particularly, if the inner wall is made of an appropriate material, for example of stainless steel, the ohmic resistance of the inner wall is not negligible even if the inner wall is very thin. Therefore, the inner wall can directly be used as resistor for resistance heating of the inner wall even if the needle is manufactured in small dimensions.
摘要翻译： 具有针的可加热移液管具有由内壁限定的内部通道，其布置成将电流传导通过内壁以电阻加热内壁。 该针具有外壁，该外壁限定在外壁和内壁之间，并且可连接用于将压力空气提供到外部通道中。 通过直接通过内壁传导电流，内壁本身作为电阻工作。 特别地，如果内壁由适当的材料制成，例如不锈钢，即使内壁非常薄，内壁的欧姆电阻也不可忽略。 因此，即使在小尺寸制造针的情况下，内壁也可以直接用作内壁的电阻加热用电阻器。
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9.发明申请公开(公告)号：US20120149058A1
公开(公告)日：2012-06-14
申请号：US13254941
申请日：2010-03-19
申请人： Dieter Voegelin
发明人： Dieter Voegelin
CPC分类号： G01N35/1067 , G01N35/028
摘要： An apparatus (2) for the automatic testing of substances for carcinogenicity comprises: a plate support (3) on which at least one micro-well plate (1) can be placed; a movable pipetting unit (4) comprising a predetermined number of pipettes (40); a number of containers (5) containing a liquid culture medium (50), the number of containers (5) corresponding to the number of pipettes (40) of the pipetting unit (4); a dish support (6) on which a corresponding number of dishes (60) can be placed, each having a bottom and an upstanding side wall (601); spinning means (63) for spinning the dishes (60); closing means (62) for placing a lid (600) on each of the dishes; transport means (64,65) for transporting the closed dishes (60) to an intermediate storage (8).
摘要翻译： 一种用于致癌物质自动测试的装置（2）包括：板支撑件（3），可在其上放置至少一个微孔板（1）; 包括预定数量的移液管（40）的移动移液单元（4）; 包含液体培养基（50）的多个容器（5），与移液单元（4）的移液管（40）的数量相对应的容器（5）的数量; 其中可以放置相应数量的餐具（60）的餐具支撑件（6），每个具有底部和直立的侧壁（601）; 用于旋转餐具（60）的纺丝装置（63）; 用于将盖（600）放置在每个盘上的关闭装置（62） 用于将封闭盘（60）运送到中间储存器（8）的输送装置（64,65）。
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公开(公告)号：US09778277B2
公开(公告)日：2017-10-03
申请号：US13254941
申请日：2010-03-19
申请人： Dieter Voegelin , Patrick Iaiza , Thomas Zumstein , Tom Kissling
发明人： Dieter Voegelin , Patrick Iaiza , Thomas Zumstein , Tom Kissling
CPC分类号： G01N35/1067 , G01N35/028
摘要： An apparatus (2) for the automatic testing of substances for carcinogenicity comprises: a plate support (3) on which at least one micro-well plate (1) can be placed; a movable pipetting unit (4) comprising a predetermined number of pipettes (40); a number of containers (5) containing a liquid culture medium (50), the number of containers (5) corresponding to the number of pipettes (40) of the pipetting unit (4); a dish support (6) on which a corresponding number of dishes (60) can be placed, each having a bottom and an upstanding side wall (601); a plurality of spinners (63) for spinning the dishes (60); a plurality of suction cups (62) for placing a lid (600) on each of the dishes; and a plurality of laterally arranged belts (64,65) for transporting the closed dishes (60) to an intermediate storage (8).
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