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公开(公告)号：US09357951B2
公开(公告)日：2016-06-07
申请号：US12893850
申请日：2010-09-29
IPC分类号： A61B5/1473 , A61B5/1468 , A61B5/1486 , A61B5/145 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/6843 , A61B5/6848 , A61B5/6849 , A61B2560/0443 , A61B2562/0209 , A61B2562/04
摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
摘要翻译： 提供了经配置以连续测量宿主中的分析物浓度的经皮传感器装置。 在一些实施例中，经皮传感器装置100包括构造成用于插入主体皮肤180下方的体内部分160，以及配置成在传感器插入入口之后保留在主体的皮肤180的表面上方的离体部分170 体内部分。 体内部分可以包括构造成用于刺穿主体的皮肤180的组织刺穿元件110和传感器主体120，传感器主体120包括提供足够的柱强度的材料或支撑构件130，以允许传感器主体可以在主机组织中推动而没有 实质屈曲。 离体部分170可以被配置为包括（或可操作地连接）传感器电子单元，并且可以包括安装单元150.这里还描述了传感器主体和组织刺穿元件的各种构造，其可以用于保护 传感器体的膜。
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公开(公告)号：US20110077490A1
公开(公告)日：2011-03-31
申请号：US12893850
申请日：2010-09-29
IPC分类号： A61B5/1473
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/6843 , A61B5/6848 , A61B5/6849 , A61B2560/0443 , A61B2562/0209 , A61B2562/04
摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
摘要翻译： 提供了经配置以连续测量宿主中的分析物浓度的经皮传感器装置。 在一些实施例中，经皮传感器装置100包括构造成用于插入主体皮肤180下方的体内部分160，以及配置成在传感器插入入口之后保留在主体的皮肤180的表面上方的离体部分170 体内部分。 体内部分可以包括构造成用于刺穿主体的皮肤180的组织刺穿元件110和传感器主体120，传感器主体120包括提供足够的柱强度的材料或支撑构件130，以允许传感器主体能够在主机组织中推动而没有 实质屈曲。 离体部分170可以被配置为包括（或可操作地连接）传感器电子单元，并且可以包括安装单元150.这里还描述了传感器主体和组织刺穿元件的各种构造，其可以用于保护 传感器体的膜。
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公开(公告)号：US08828201B2
公开(公告)日：2014-09-09
申请号：US12829296
申请日：2010-07-01
申请人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
发明人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
IPC分类号： G01N33/483 , G01N33/50
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.
摘要翻译： 提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。 例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。 传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成，绝缘层810将导电层820与细长主体分隔开;膜层沉积在 通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。
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公开(公告)号：US20110028816A1
公开(公告)日：2011-02-03
申请号：US12829318
申请日：2010-07-01
申请人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
发明人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
IPC分类号： A61B5/1473
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.
摘要翻译： 提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。 例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。 传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成，绝缘层810将导电层820与细长主体分隔开;膜层沉积在 通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。
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公开(公告)号：US20110028815A1
公开(公告)日：2011-02-03
申请号：US12829306
申请日：2010-07-01
申请人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
发明人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
IPC分类号： A61B5/145
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.
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公开(公告)号：US20110027127A1
公开(公告)日：2011-02-03
申请号：US12829296
申请日：2010-07-01
申请人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
发明人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
IPC分类号： G01N27/00
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.
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公开(公告)号：US09131885B2
公开(公告)日：2015-09-15
申请号：US12829318
申请日：2010-07-01
申请人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
发明人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
IPC分类号： A61B5/05 , A61B5/1473 , A61B5/145 , A61B5/1486 , B05C3/10
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.
摘要翻译： 提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。 例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。 传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成，绝缘层810将导电层820与细长主体分隔开;膜层沉积在 通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。
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公开(公告)号：US09237864B2
公开(公告)日：2016-01-19
申请号：US12829306
申请日：2010-07-01
申请人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
发明人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
IPC分类号： A61B5/00 , A61B5/1473 , A61B5/145 , A61B5/1486 , B05C3/10
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.
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公开(公告)号：US09538946B2
公开(公告)日：2017-01-10
申请号：US12731965
申请日：2010-03-25
IPC分类号： A61B5/00 , A61B5/1486 , A61B5/07 , A61B5/145 , A61B5/1495
CPC分类号： A61B5/1495 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B5/7203 , A61B2560/0456 , A61B2562/247
摘要： A system is provided for monitoring glucose in a host, including a continuous glucose sensor that produces a data stream indicative of a host's glucose concentration and an integrated receiver that receives the data stream from the continuous glucose sensor and calibrates the data stream using a single point glucose monitor that is integral with the integrated receiver. The integrated receiver obtains a glucose value from the single point glucose monitor, calibrates the sensor data stream received from the continuous glucose sensor, and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface.
摘要翻译： 提供一种用于监测主机中的葡萄糖的系统，包括产生指示宿主葡萄糖浓度的数据流的连续葡萄糖传感器和从连续葡萄糖传感器接收数据流并使用单点校准数据流的集成接收器 与集成接收器集成的葡萄糖监测器。 集成接收器从单点葡萄糖监测器获得葡萄糖值，校准从连续葡萄糖传感器接收的传感器数据流，并在用户界面上显示单点葡萄糖测量值和校准的连续葡萄糖传感器值中的一个或两个。
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公开(公告)号：US08882741B2
公开(公告)日：2014-11-11
申请号：US13460219
申请日：2012-04-30
申请人： James H. Brauker , Mark A. Tapsak , Sean T. Saint , Apurv U. Kamath , Paul V. Neale , Peter C. Simpson , Michael Robert Mensinger , Dubravka Markovic
发明人： James H. Brauker , Mark A. Tapsak , Sean T. Saint , Apurv U. Kamath , Paul V. Neale , Peter C. Simpson , Michael Robert Mensinger , Dubravka Markovic
CPC分类号： A61M5/31525 , A61B5/0002 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B2560/0443 , A61M5/1723 , A61M11/00 , A61M15/0001 , A61M2005/1726 , A61M2205/18 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H20/17 , G16H40/63
摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
摘要翻译： 提供了用于集成包括接收器，药物输送装置和任选的单点葡萄糖监测器的连续葡萄糖传感器的系统和方法。 手动集成提供了用户（例如，患者或医生）手动选择数量，类型和/或递送时间的设备之间的物理关联。 设备的半自动化集成包括集成，其中集成组件之间的可操作连接有助于用户（例如患者或医生）在选择，输入，计算或验证葡萄糖值的药物递送量，类型或时间 例如，通过将数据发送到另一个组件，从而减少所需的用户输入量。 设备之间的自动集成包括集成，其中集成组件之间的可操作连接提供对系统的完全控制，而不需要用户交互。
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