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    Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect
    5.
    发明授权
    Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect 有权
    基于具有形状记忆效应的可生物降解或生物相容性聚合物释放活性成分的系统

    公开(公告)号：US08158143B2

    公开(公告)日：2012-04-17

    申请号：US10520782

    申请日：2003-07-10

    申请人： Andreas Lendlein ,  Susi Steuer ,  Annika Tuleweit

    发明人： Andreas Lendlein ,  Susi Steuer ,  Annika Tuleweit

    IPC分类号： A61F13/02

    CPC分类号： A61L27/54 ,  A61F2013/00646 ,  A61K9/0024 ,  A61K47/34 ,  A61L27/18 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/416 ,  A61L2300/43 ,  A61L2300/44 ,  A61L2300/604 ,  A61L2400/16 ,  C08L67/04

    摘要： A drug release system is disclosed comprising a laminate structure comprising at least one layer comprising a matrix made from a shape memory material and at least one drug dispersed in the matrix, and layers from a shape memory material not containing a drug and sandwiching the at least one layer comprising the drug(s) on both surfaces, wherein the shape memory material of the layers not containing a drug, after triggering of the shape memory effect, controls the release rate of the drug(s). Another embodiment comprises at least one drug, a reservoir for receiving the drug(s), and at least one of a coating and a membrane closing the reservoir, wherein one of a material for the reservoir and a material for the coating or membrane is made from a shape memory material and wherein the shape memory material, after triggering the shape memory effect, controls the rate of release of the drug(s).

    摘要翻译： 公开了一种药物释放系统，其包括层压结构，其包括至少一层，其包含由形状记忆材料制成的基质和分散在基质中的至少一种药物，以及来自不含药物的形状记忆材料的层， 一层包含在两个表面上的药物，其中在触发形状记忆效应之后，不含药物的层的形状记忆材料控制药物的释放速率。 另一个实施方案包括至少一种药物，用于接收药物的储存器以及封闭储存器的涂层和膜中的至少一种，其中制备用于储存器的材料和用于涂层或膜的材料之一 来自形状记忆材料，并且其中形状记忆材料在触发形状记忆效应之后控制药物的释放速率。

    Shape memory polymers
    9.
    发明授权
    Shape memory polymers 有权
    形状记忆聚合物

    公开(公告)号：US06720402B2

    公开(公告)日：2004-04-13

    申请号：US10141891

    申请日：2002-05-08

    申请人： Robert S. Langer ,  Andreas Lendlein

    发明人： Robert S. Langer ,  Andreas Lendlein

    IPC分类号： C08G1848

    CPC分类号： G01K5/483 ,  A61B2017/00871 ,  B29C61/003 ,  C08L101/00 ,  Y10S525/903 ,  Y10S977/754

    摘要： Shape memory polymer compositions, articles of manufacture thereof, and methods of preparation and use thereof are described. The shape memory polymer compositions can hold more than one shape in memory. Suitable compositions include at least one hard segment and at least one soft segment. At least one of the hard or soft segments can contain a crosslinkable group, and the segments can be linked by formation of an interpenetrating network or a semi-interpenetrating network, or by physical interactions of the blocks. Objects can be formed into a given shape at a temperature above the Ttrans of the hard segment, and cooled to a temperature below to Ttrans of the soft segment. If the object is subsequently formed into a second shape, the object can return to its original shape by heating the object above the Ttrans of the soft segment and below the Ttrans of the hard segment.

    摘要翻译： 描述形状记忆聚合物组合物，其制备方法及其制备和使用方法。 形状记忆聚合物组合物可以在存储器中保持多于一种形状。 合适的组合物包括至少一个硬链段和至少一个软链段。 硬链段或软链段中的至少一个可以包含可交联基团，并且链段可以通过形成互穿网络或半互穿网络或通过块的物理相互作用而链接。 物体可以在高于硬链段的Ttrans的温度下形成给定的形状，并且被冷却到低于软链段的Ttrans的温度。 如果对象随后形成第二形状，则可以通过将软部分的Ttrans上方的物体加热到硬片段的Ttrans下面，物体可以返回到其原始形状。