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    Systems and methods for improving electrochemical analyte sensors
    1.
    发明授权
    Systems and methods for improving electrochemical analyte sensors 有权
    改进电化学分析物传感器的系统和方法

    公开(公告)号：US07081195B2

    公开(公告)日：2006-07-25

    申请号：US11007635

    申请日：2004-12-07

    申请人： Peter Simpson ,  James Brauker ,  Victoria Carr-Brendel ,  Paul Goode ,  Mark Tapsak

    发明人： Peter Simpson ,  James Brauker ,  Victoria Carr-Brendel ,  Paul Goode ,  Mark Tapsak

    IPC分类号： G01N27/327

    CPC分类号： A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  C12Q1/006 ,  G01N27/3274

    摘要： An analyte-measuring device, particularly an electrochemical sensor, is provided for measuring current values at multiple bias potential settings to assess the quality of the analyte measurement, identify interference in the signal, and calculate substantially interference-free analyte concentration measurements. The device and method are suitable for calculating substantially interference-free analyte concentration measurements when glucose is the analyte and acetaminophen is an interfering species.

    摘要翻译： 提供分析物测量装置，特别是电化学传感器，用于在多个偏置电位设置下测量电流值，以评估分析物测量的质量，识别信号中的干扰，并计算基本上无干扰的分析物浓度测量。 当葡萄糖是分析物和对乙酰氨基酚是干扰物质时，该装置和方法适合于计算基本无干扰的分析物浓度测定。

    Oxygen enhancing membrane systems for implantable devices
    4.
    发明申请
    Oxygen enhancing membrane systems for implantable devices 有权
    用于可植入装置的氧增强膜系统

    公开(公告)号：US20060200019A1

    公开(公告)日：2006-09-07

    申请号：US11410392

    申请日：2006-04-25

    申请人： James Petisce ,  Mark Tapsak ,  Peter Simpson ,  Victoria Carr-Brendel ,  James Brauker

    发明人： James Petisce ,  Mark Tapsak ,  Peter Simpson ,  Victoria Carr-Brendel ,  James Brauker

    IPC分类号： A61B5/05 ,  C12Q1/00 ,  G01N33/487

    CPC分类号： A61B5/1473 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/14735 ,  A61B5/14865

    摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

    摘要翻译： 本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。 优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。 高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。 优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。

    Electrochemical sensors including electrode systems with increased oxygen generation
    6.
    发明申请
    Electrochemical sensors including electrode systems with increased oxygen generation 有权
    电化学传感器包括增加氧气产生的电极系统

    公开(公告)号：US20050051440A1

    公开(公告)日：2005-03-10

    申请号：US10897377

    申请日：2004-07-21

    申请人： Peter Simpson ,  Paul Goode ,  Mark Tapsak ,  Victoria Carr-Brendel

    发明人： Peter Simpson ,  Paul Goode ,  Mark Tapsak ,  Victoria Carr-Brendel

    IPC分类号： A61B5/00 ,  C12Q1/00 ,  G01N33/487 ,  C12M1/00 ,  G01N1/00

    CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/14546 ,  C12Q1/003 ,  G01N27/3272

    摘要： The present invention relates generally to systems and methods for increasing oxygen generation in electrochemical sensors in order to overcome the oxygen limitations. The preferred embodiments employ electrode systems with at least two electrodes in relatively close proximity to each other; wherein at least one electrode is configured to generate oxygen and at least one other electrode is configured to sense an analyte or a product of a reaction indicative of the concentration of analyte. The oxygen generated by the oxygen-generating electrode is available to the catalyst within a membrane system and/or the counter electrode, thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions.

    摘要翻译： 本发明一般涉及用于增加电化学传感器中的氧气产生的系统和方法，以克服氧限制。 优选实施例采用电极系统，其中至少两个电极彼此相对靠近; 其中至少一个电极被配置为产生氧，并且至少一个其它电极被配置为感测分析物或指示分析物浓度的反应的产物。 由氧发生电极产生的氧气可用于膜系统和/或对电极内的催化剂，从而使得优选实施方案的电化学传感器能够在缺血状态下起作用。

    Porous membranes for use with implantable devices
    8.
    发明申请
    Porous membranes for use with implantable devices 有权
    多孔膜用于可植入装置

    公开(公告)号：US20050112169A1

    公开(公告)日：2005-05-26

    申请号：US10647065

    申请日：2003-08-22

    申请人： James Brauker ,  Victoria Carr-Brendel ,  Mark Tapsak

    发明人： James Brauker ,  Victoria Carr-Brendel ,  Mark Tapsak

    IPC分类号： A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61K45/00

    CPC分类号： A61L31/146 ,  A61L31/10 ,  A61L31/14

    摘要： A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo.

    摘要翻译： 用于植入软组织中的膜包括支撑组织向内生长的第一结构域，破坏通常在异物反应中发现的收缩力，促进血管分布，并妨碍阻隔细胞层的形成，以及抵抗细胞附着的第二结构域是 对细胞和细胞过程不可渗透，并允许分析物通过。 该膜允许体内长期的分析物输送，并且适用于可植入分析物传感器，细胞移植装置，药物递送装置和/或电信号传递或测量装置的生物界面。 膜结构，包括腔体尺寸，深度和互连性，在体内提供膜的长期稳定的功能。