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公开(公告)号：US20060204536A1
公开(公告)日：2006-09-14
申请号：US11416734
申请日：2006-05-03
IPC分类号： A61F13/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , G01N33/48707
摘要： A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface.
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公开(公告)号：US20050112169A1
公开(公告)日：2005-05-26
申请号：US10647065
申请日：2003-08-22
CPC分类号： A61L31/146 , A61L31/10 , A61L31/14
摘要： A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo.
摘要翻译： 用于植入软组织中的膜包括支撑组织向内生长的第一结构域，破坏通常在异物反应中发现的收缩力，促进血管分布，并妨碍阻隔细胞层的形成，以及抵抗细胞附着的第二结构域是 对细胞和细胞过程不可渗透，并允许分析物通过。 该膜允许体内长期的分析物输送，并且适用于可植入分析物传感器，细胞移植装置，药物递送装置和/或电信号传递或测量装置的生物界面。 膜结构，包括腔体尺寸，深度和互连性，在体内提供膜的长期稳定的功能。
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公开(公告)号：US20050031689A1
公开(公告)日：2005-02-10
申请号：US10842716
申请日：2004-05-10
CPC分类号： A61B5/14865 , A61B5/14532 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , G01N33/48707
摘要： A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface.
摘要翻译： 一种用于可植入装置的生物界面膜，其包括不可再吸收的固体部分，其具有适于在体内支持组织向内生长的多个相互连接的空腔，以及并入生物界面膜中并适于修饰组织反应的生物活性剂。 可以选择生物活性剂以诱导血管形成和/或预防体内阻隔细胞层形成，并且当与其中溶质被输送穿过装置 - 组织界面的可植入装置一起使用时是有利的。
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公开(公告)号：US20060200019A1
公开(公告)日：2006-09-07
申请号：US11410392
申请日：2006-04-25
IPC分类号： A61B5/05 , C12Q1/00 , G01N33/487
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
摘要翻译： 本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。 优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。 高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。 优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。
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公开(公告)号：US20060198864A1
公开(公告)日：2006-09-07
申请号：US11416825
申请日：2006-05-03
IPC分类号： A61F13/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , G01N33/48707
摘要： A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface.
摘要翻译： 一种用于可植入装置的生物界面膜，其包括不可再吸收的固体部分，其具有适于在体内支持组织向内生长的多个相互连接的空腔，以及并入生物界面膜中并适于修饰组织反应的生物活性剂。 可以选择生物活性剂以诱导血管形成和/或预防体内阻隔细胞层形成，并且当与其中溶质被输送穿过装置 - 组织界面的可植入装置一起使用时是有利的。
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公开(公告)号：US07081195B2
公开(公告)日：2006-07-25
申请号：US11007635
申请日：2004-12-07
申请人： Peter Simpson , James Brauker , Victoria Carr-Brendel , Paul Goode , Mark Tapsak
发明人： Peter Simpson , James Brauker , Victoria Carr-Brendel , Paul Goode , Mark Tapsak
IPC分类号： G01N27/327
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/14865 , C12Q1/006 , G01N27/3274
摘要： An analyte-measuring device, particularly an electrochemical sensor, is provided for measuring current values at multiple bias potential settings to assess the quality of the analyte measurement, identify interference in the signal, and calculate substantially interference-free analyte concentration measurements. The device and method are suitable for calculating substantially interference-free analyte concentration measurements when glucose is the analyte and acetaminophen is an interfering species.
摘要翻译： 提供分析物测量装置，特别是电化学传感器，用于在多个偏置电位设置下测量电流值，以评估分析物测量的质量，识别信号中的干扰，并计算基本上无干扰的分析物浓度测量。 当葡萄糖是分析物和对乙酰氨基酚是干扰物质时，该装置和方法适合于计算基本无干扰的分析物浓度测定。
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公开(公告)号：US20050245799A1
公开(公告)日：2005-11-03
申请号：US10838912
申请日：2004-05-03
申请人： James Brauker , Mark Tapsak , Mark Shults , Victoria Carr-Brendel , Jack Fisher , William Seare , Paul Neale
发明人： James Brauker , Mark Tapsak , Mark Shults , Victoria Carr-Brendel , Jack Fisher , William Seare , Paul Neale
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/6882
摘要： Abstract of the DisclosureAn implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
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公开(公告)号：US20050033132A1
公开(公告)日：2005-02-10
申请号：US10846150
申请日：2004-05-14
申请人： Mark Shults , James Brauker , Victoria Carr-Brendel , Mark Tapsak , Dubravka Markovic , Stuart Updike , Rathbun Rhodes
发明人： Mark Shults , James Brauker , Victoria Carr-Brendel , Mark Tapsak , Dubravka Markovic , Stuart Updike , Rathbun Rhodes
CPC分类号： A61L31/10 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , C12Q1/006
摘要： An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.
摘要翻译： 一种可植入分析物测量装置，其包括适于促进血管形成和/或干扰屏障细胞层形成的膜。 膜包括材料，结构和生物活性剂的任何组合，其促进分析物传输以提供可植入分析物测量装置的长期体内性能。
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公开(公告)号：US20050245795A1
公开(公告)日：2005-11-03
申请号：US10838909
申请日：2004-05-03
申请人： Paul Goode , Arnold Holmquist , Mark Tapsak , Mark Shults , Victoria Carr-Brendel , James Brauker , Paul Neale , Jason McClure , Mark Brister , Peter Simpson , Rathbun Rhodes
发明人： Paul Goode , Arnold Holmquist , Mark Tapsak , Mark Shults , Victoria Carr-Brendel , James Brauker , Paul Neale , Jason McClure , Mark Brister , Peter Simpson , Rathbun Rhodes
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： Abstract of the DisclosureAn implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
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公开(公告)号：US20050161346A1
公开(公告)日：2005-07-28
申请号：US11007635
申请日：2004-12-07
申请人： Peter Simpson , James Brauker , Victoria Carr-Brendel , Paul Goode , Mark Tapsak
发明人： Peter Simpson , James Brauker , Victoria Carr-Brendel , Paul Goode , Mark Tapsak
IPC分类号： A61B5/00 , G01N20060101 , G01N27/26
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/14865 , C12Q1/006 , G01N27/3274
摘要： An analyte-measuring device, particularly an electrochemical sensor, is provided for measuring current values at multiple bias potential settings to assess the quality of the analyte measurement, identify interference in the signal, and calculate substantially interference-free analyte concentration measurements. The device and method are suitable for calculating substantially interference-free analyte concentration measurements when glucose is the analyte and acetaminophen is an interfering species.
摘要翻译： 提供分析物测量装置，特别是电化学传感器，用于在多个偏置电位设置下测量电流值，以评估分析物测量的质量，识别信号中的干扰，并计算基本上无干扰的分析物浓度测量。 当葡萄糖是分析物和对乙酰氨基酚是干扰物质时，该装置和方法适合于计算基本无干扰的分析物浓度测定。
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