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    Process for fixing inorganic species in an organic matrix
    2.
    发明授权
    Process for fixing inorganic species in an organic matrix 失效
    有机基质固定无机物种的过程

    公开(公告)号：US5064877A

    公开(公告)日：1991-11-12

    申请号：US380523

    申请日：1989-07-17

    申请人： Rudiger Nass ,  Helmut Schmidt

    发明人： Rudiger Nass ,  Helmut Schmidt

    IPC分类号： C08F2/46 ,  C08F2/44 ,  C08F2/48 ,  C08F230/04

    CPC分类号： C08F2/44 ,  C08F230/04

    摘要： A process is described for fixing an inorganic species in an organic matr which comprises bringing a compound of the formula MR.sub.n in which M is selected from sub-group metals, lanthanides, actinides, Al, Sn, B and Si, and the radicals R can be replaced by a complexing agent, into contact with a complexing agent, the complexing agent containing a functional group which is capable of participating in a polymerization or polycondensation reaction. After complexing, hydrolysis and condensation are preferably first carried out, followed by polymerization or polycondensation.

    摘要翻译： 描述了将无机物质固定在有机基质中的方法，其包括使其中M选自亚族金属，镧系元素，锕系元素，Al，Sn，B和Si的式MRn化合物，以及基团R 可以被络合剂代替，与络合剂接触，该络合剂含有能够参与聚合或缩聚反应的官能团。 络合后，优选首先进行水解和缩合，然后进行聚合或缩聚。

    Process for producing weakly agglomerated nanoscalar particles
    4.
    发明授权
    Process for producing weakly agglomerated nanoscalar particles 失效
    生产弱聚集的纳米级颗粒的方法

    公开(公告)号：US5935275A

    公开(公告)日：1999-08-10

    申请号：US945411

    申请日：1997-10-29

    申请人： Detlef Burgard ,  Rudiger Nass ,  Helmut Schmidt

    发明人： Detlef Burgard ,  Rudiger Nass ,  Helmut Schmidt

    IPC分类号： C01B13/32 ,  B01J2/00 ,  B01J19/00 ,  C01F7/02 ,  C01G1/02 ,  C01G23/053 ,  C01G25/02 ,  C04B35/626 ,  B05D7/00 ,  B01D9/00

    CPC分类号： B82Y30/00 ,  B01J2/00 ,  C01G1/02 ,  C01G23/053 ,  C01G25/02 ,  C04B35/626 ,  C01P2004/64 ,  Y10T428/2991

    摘要： A description is given of a process for producing weakly agglomerated, densified and/or crystallized nanosize particles which is characterized in that either(a) a suspension containing amorphous or partially crystalline nanosize particles is produced in a conventional manner from precursors for the nanosize particles, where the nanosize particles are produced in a solvent which has no solvent capability, or only a low solvent capability, for the particles and in the presence of at least one surface-blocking substance, or(b) an already formed powder comprising amorphous or partially crystalline nanosize particles is suspended in the solvent specified under (a) in the presence of the surface-blocking substance or substances specified under (a), or(c) a sol containing amorphous or partially crystalline nanosize particles is suspended in the solvent specified under (a) in the presence of the surface-blocking substance or substances specified under (a); andthe suspension thus produced is subjected to conditions which lead to a densification and/or crystallization of the nanosize particles.

    摘要翻译： PCT No.PCT / EP96 / 01756 Sec。 371日期1997年10月29日第 102（e）1997年10月29日PCT PCT 1996年4月26日PCT公布。 第WO96 / 34829号公报 日本1996年11月7日描述了一种生产弱聚集，致密化和/或结晶的纳米尺寸颗粒的方法，其特征在于（a）含有无定形或部分结晶的纳米尺寸颗粒的悬浮液以常规方式从前体制备 对于纳米尺寸颗粒，其中纳米尺寸颗粒在对于颗粒和至少一种表面阻挡物质存在下不具有溶剂能力或仅具有低溶剂能力的溶剂中制备，或（b）已经形成的纳米尺寸颗粒 包含无定形或部分结晶的纳米尺寸颗粒的粉末悬浮在（a）中指定的溶剂中，在表面阻挡物质或（a）或（c）所指定的物质的存在下，含有无定形或部分结晶的纳米尺寸颗粒的溶胶被悬浮 在（a）中规定的溶剂中，在表面阻挡物质或（a）规定的物质的存在下; 并且由此产生的悬浮液经受导致纳米尺寸颗粒的致密化和/或结晶的条件。

    Process for producing tin sintered bodies and coatings
    5.
    发明授权
    Process for producing tin sintered bodies and coatings 失效
    生产锡烧结体和涂层的方法

    公开(公告)号：US5750193A

    公开(公告)日：1998-05-12

    申请号：US632502

    申请日：1996-05-06

    申请人： Rudiger Nass ,  Mesut Aslan ,  Sener Albayrak ,  Helmut Schmidt ,  Ertugrul Arpac

    发明人： Rudiger Nass ,  Mesut Aslan ,  Sener Albayrak ,  Helmut Schmidt ,  Ertugrul Arpac

    IPC分类号： C04B41/85 ,  C04B35/58 ,  C04B35/64 ,  B05D7/00

    CPC分类号： C04B35/58014 ,  C04B35/632 ,  C04B35/6325 ,  C04B41/009 ,  C04B41/5068 ,  C04B41/87

    摘要： TiN sintered bodies and coatings are produced by dispersing nanocrystalline TiN powder in water and/or a polar organic solvent as dispersing agent in the presence of at least one low molecular organic compound having at least one functional group which can react or interact with groups on the surface of the powder particles, removing the dispersing agent and sintering the surface-modified TiN which has been processed into green bodies or coatings before or after the removal of the dispersing agent.

    摘要翻译： PCT No.PCT / EP94 / 03335 Sec。 371日期：1996年5月6日 102（e）日期1996年5月6日PCT 1994年10月10日PCT PCT。 公开号WO95 / 10491 日期1995年04月20日TiN烧结体和涂层通过在至少一种具有至少一个能够反应的官能团的低分子有机化合物存在下，将纳米晶体TiN粉末分散在水和/或极性有机溶剂中作为分散剂来制备， 与粉末颗粒表面上的基团相互作用，除去分散剂，并在除去分散剂之前或之后烧结已经加工成生坯或涂层的表面改性TiN。

    Nanoscale particles having an iron oxide-containing core enveloped by at least two shells
    8.
    发明授权
    Nanoscale particles having an iron oxide-containing core enveloped by at least two shells 失效
    具有包含至少两个壳的含氧化铁芯的纳米级颗粒

    公开(公告)号：US06979466B2

    公开(公告)日：2005-12-27

    申请号：US10391356

    申请日：2003-03-17

    申请人： Christoph Lesniak ,  Thomas Schiestel ,  Helmut Schmidt ,  Andreas Jordan

    发明人： Christoph Lesniak ,  Thomas Schiestel ,  Helmut Schmidt ,  Andreas Jordan

    IPC分类号： A61K9/16 ,  A61K41/00 ,  A61P35/00 ,  A61K9/51

    CPC分类号： A61K41/0052

    摘要： The invention relates to nanoscale particles suited especially for use in tumor therapy by hyperthermia. Said particles comprise a (preferably superparamagnetic) iron oxide-containing core and at least two shells surrounding said core. The (innermost) shell adjoining the core is an envelope which comprises groups capable of forming cationic groups and is broken down by human or animal tissue at such a slow rate as to allow for association of the core surrounded by said envelope with the surface of cells and/or for absorption of said core into the inside of cells. The outer shell(s) consist(s) of species having neutral and/or anionic groups which allow the nanoscale particles to appear to the outside as having a neutral or negative charge and which are broken down by human or animal tissue more rapidly than the innermost shell—and in so doing uncover the shells underneath—but still sufficiently slowly so as to ensure that the nanoscale particles are adequately distributed in a tissue infiltrated with same particles in a particular point.

    摘要翻译： 本发明涉及特别适用于通过高热治疗肿瘤治疗的纳米级颗粒。 所述颗粒包含（优选超顺磁性）含氧化铁的芯和围绕所述芯的至少两个壳。 与核心相邻的（最内侧）壳是包含能够形成阳离子基团并且以如此慢的速率被人或动物组织分解以允许由所述包膜包围的核与细胞表面缔合的基团 和/或用于将所述核吸收到细胞内部。 外壳由具有中性和/或阴离子基团的物质组成，其允许纳米级颗粒以外面的形式出现在外部，具有中性或负电荷，并且比人或动物组织更快地分解 最内层的壳体，并且在其中露出壳下面，但是仍然足够缓慢，以便确保纳米级颗粒在特定的点上适当地分布在渗透有相同颗粒的组织中。

    Particles having a magnetic core and outer glass layer for separating biological material
    9.
    发明授权
    Particles having a magnetic core and outer glass layer for separating biological material 失效
    具有用于分离生物材料的磁芯和外部玻璃层的颗粒

    公开(公告)号：US06255477B1

    公开(公告)日：2001-07-03

    申请号：US08952969

    申请日：1998-03-11

    申请人： Jörg Kleiber ,  Thomas Walter ,  Herbert Harttig ,  Christoph Lesniak ,  Martin Mennig ,  Michael Riedling ,  Helmut Schmidt

    发明人： Jörg Kleiber ,  Thomas Walter ,  Herbert Harttig ,  Christoph Lesniak ,  Martin Mennig ,  Michael Riedling ,  Helmut Schmidt

    IPC分类号： C12N1500

    CPC分类号： C03C3/111 ,  B03C1/01 ,  B82Y25/00 ,  C03C3/078 ,  C03C3/083 ,  C03C3/085 ,  C03C3/087 ,  C03C3/089 ,  C03C3/091 ,  C03C3/102 ,  C03C3/105 ,  C03C3/108 ,  C07H21/00 ,  C12N15/1013 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6834 ,  H01F1/0063 ,  H01F1/112 ,  H01F1/36 ,  Y10S428/90 ,  Y10S435/814 ,  Y10T428/2996

    摘要： Magnetic glass particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 &mgr;m and any pores of the glass surface have a diameter of less than 10 nm. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3. In using the magnetic glass particles to separate a biological material, the particles are contacted with a fluid containing the biological material such that the biological material binds to the glass surface, and the bound biological material is separated from the fluid such as by using a magnetic field. Before applying a magnetic field, the magnetic particles may sediment when contacted with the biological material.

    摘要翻译： 制备磁性玻璃颗粒，其包含涂覆有具有基本无孔玻璃表面的玻璃层的磁芯。 颗粒用于分离生物材料如核酸。 制备颗粒的优选方法是通过用由醇和金属醇盐形成的溶胶形成磁芯的混合物，喷雾干燥混合物以用一层凝胶溶胶涂覆芯，并加热涂覆的芯以获得 磁性玻璃颗粒。 优选地，颗粒的平均粒度小于100μm，并且玻璃表面的任何孔具有小于10nm的直径。 磁芯可以是包含固定在云母芯上的云母芯和磁铁矿颗粒的复合材料，并且玻璃层可以含有氧化硼。 磁芯材料包括磁铁矿（Fe3O4）和Fe2O3。 在使用磁性玻璃颗粒分离生物材料时，颗粒与包含生物材料的流体接触，使得生物材料结合到玻璃表面，并且结合的生物材料与流体分离，例如通过使用磁性 领域。 在施加磁场之前，当与生物材料接触时，磁性颗粒可能沉淀。