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公开(公告)号：US20140147932A1
公开(公告)日：2014-05-29
申请号：US13660028
申请日：2012-10-25
申请人： Philippe J. Goix , Robert Puskas , John Todd , Richard Livingston , Douglas Held , Sarah Le
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard Livingston , Douglas Held , Sarah Le
IPC分类号： G01N33/577
CPC分类号： G01N33/577 , A61B5/00 , A61B5/0402 , A61B5/412 , A61B5/415 , A61B5/418 , A61B5/7264 , A61B5/7275 , G01N21/6428 , G01N33/582 , G01N33/6863 , G01N33/6869 , G01N33/6872 , G01N33/6887 , G01N33/6896 , G01N33/74 , G01N33/92 , G01N2333/4712 , G01N2333/475 , Y02A90/26 , Y10T436/143333
摘要： The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnI) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
摘要翻译： 本发明公开了使用分子的高灵敏度检测来检测和监测受试者的状况的方法。 本发明提供了一种用于检测或监测受试者状况的方法，包括检测来自受试者的第一样品中的第一标记物并检测第二标志物，其中第一标记物包含生物标志物，例如心肌肌钙蛋白I（cTnI） 或血管内皮生长因子（VEGF），并且其中第一标记物的检测限小于约10pg / ml。 第二标记可以是生物标志物，生理学标记，分子标记或遗传标记。
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公开(公告)号：US08450069B2
公开(公告)日：2013-05-28
申请号：US12795414
申请日：2010-06-07
申请人： Philippe J. Goix , Robert Puskas , John Todd , Richard Livingston , Douglas Held , Sara Le
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard Livingston , Douglas Held , Sara Le
IPC分类号： G01N33/53
CPC分类号： G01N33/6869 , G01N33/6893 , G01N2333/32 , G01N2333/47 , G01N2333/4712 , G01N2333/525 , G01N2333/54 , G01N2333/5412 , G01N2333/58 , G01N2800/32 , G01N2800/325 , G01N2800/60
摘要： Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of CHF in plasma. A panel consisting of cardiac pathology (cTnI, BNP) and vascular inflammation (IL-6, TNFα, IL-17a) biomarkers provided a sensitivity of 94% for association with CHF.
摘要翻译： 心血管疾病，例如充血性心力衰竭，经常在临床症状发作后首先诊断，消除早期干预的可能性。 本发明提供了多标记免疫测定法，包括心脏病理学和血管炎症生物标志物，产生用于血浆中CHF早期检测的更灵敏的测定。 由心脏病理学（cTnI，BNP）和血管炎症（IL-6，TNFα，IL-17a）生物标志物组成的小组提供了与CHF相关的94％的灵敏度。
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公开(公告)号：US20110003707A1
公开(公告)日：2011-01-06
申请号：US12795414
申请日：2010-06-07
申请人： Philippe J. Goix , Robert Puskas , John Todd , Richard Livingston , Douglas Held , Sara Le
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard Livingston , Douglas Held , Sara Le
CPC分类号： G01N33/6869 , G01N33/6893 , G01N2333/32 , G01N2333/47 , G01N2333/4712 , G01N2333/525 , G01N2333/54 , G01N2333/5412 , G01N2333/58 , G01N2800/32 , G01N2800/325 , G01N2800/60
摘要： Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of CHF in plasma. A panel consisting of cardiac pathology (cTnI, BNP) and vascular inflammation (IL-6, TNFα, IL-17a) biomarkers provided a sensitivity of 94% for association with CHF.
摘要翻译： 心血管疾病，例如充血性心力衰竭，经常在临床症状发作后首先诊断，消除早期干预的可能性。 本发明提供了多标记免疫测定法，包括心脏病理学和血管炎症生物标志物，产生用于血浆中CHF早期检测的更灵敏的测定。 由心脏病理学（cTnI，BNP）和血管炎症（IL-6，TNFα，IL-17a）生物标志物组成的小组提供了与CHF相关的94％的灵敏度。
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公开(公告)号：US20090234202A1
公开(公告)日：2009-09-17
申请号：US12398175
申请日：2009-03-04
申请人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Sara Agee
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Sara Agee
CPC分类号： G01N33/577 , A61B5/00 , A61B5/0402 , A61B5/412 , A61B5/415 , A61B5/418 , A61B5/7264 , A61B5/7275 , G01N21/6428 , G01N33/582 , G01N33/6863 , G01N33/6869 , G01N33/6872 , G01N33/6887 , G01N33/6896 , G01N33/74 , G01N33/92 , G01N2333/4712 , G01N2333/475 , Y02A90/26 , Y10T436/143333
摘要： The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnI) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
摘要翻译： 本发明公开了使用分子的高灵敏度检测来检测和监测受试者的状况的方法。 本发明提供了一种用于检测或监测受试者状况的方法，包括检测来自受试者的第一样品中的第一标记物并检测第二标志物，其中第一标记物包含生物标志物，例如心肌肌钙蛋白I（cTnI） 或血管内皮生长因子（VEGF），并且其中第一标记物的检测限小于约10pg / ml。 第二标记可以是生物标志物，生理学标记，分子标记或遗传标记。
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公开(公告)号：US20110111524A1
公开(公告)日：2011-05-12
申请号：US12902182
申请日：2010-10-12
申请人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan Wu
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan Wu
IPC分类号： G01N33/566
CPC分类号： G01N33/68 , G01N21/6428 , G01N21/6486 , G01N33/582 , G01N33/6887 , G01N33/6893 , G01N2333/47 , G01N2800/32 , G01N2800/324 , G01N2800/325 , G01N2800/50
摘要： The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
摘要翻译： 本发明提供了用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。 这些方法，组合物，试剂盒和系统在涉及释放心肌肌钙蛋白的病症中的诊断，预后和测定方法中是有用的。
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公开(公告)号：US20100297672A9
公开(公告)日：2010-11-25
申请号：US12062412
申请日：2008-04-03
申请人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan H.B. Wu
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan H.B. Wu
IPC分类号： G01N33/53 , G01N33/536
CPC分类号： G01N33/68 , G01N21/6428 , G01N21/6486 , G01N33/582 , G01N33/6887 , G01N33/6893 , G01N2333/47 , G01N2800/32 , G01N2800/324 , G01N2800/325 , G01N2800/50
摘要： The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
摘要翻译： 本发明提供了用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。 这些方法，组合物，试剂盒和系统在涉及释放心肌肌钙蛋白的病症中的诊断，预后和测定方法中是有用的。
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公开(公告)号：US07838250B1
公开(公告)日：2010-11-23
申请号：US12062412
申请日：2008-04-03
申请人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan Wu
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan Wu
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , G01N21/6428 , G01N21/6486 , G01N33/582 , G01N33/6887 , G01N33/6893 , G01N2333/47 , G01N2800/32 , G01N2800/324 , G01N2800/325 , G01N2800/50
摘要： The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
摘要翻译： 本发明提供用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。 这些方法，组合物，试剂盒和系统在涉及释放心肌肌钙蛋白的病症中的诊断，预后和测定方法中是有用的。
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公开(公告)号：US08343728B2
公开(公告)日：2013-01-01
申请号：US12902182
申请日：2010-10-12
申请人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan Wu
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan Wu
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , G01N21/6428 , G01N21/6486 , G01N33/582 , G01N33/6887 , G01N33/6893 , G01N2333/47 , G01N2800/32 , G01N2800/324 , G01N2800/325 , G01N2800/50
摘要： The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
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9.发明授权Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties 有权用荧光部分标记的单一蛋白质分子的高灵敏度检测方法公开(公告)号：US07572640B2
公开(公告)日：2009-08-11
申请号：US11784211
申请日：2007-04-04
IPC分类号： G01N21/76
CPC分类号： G01N21/6428 , C07K16/18 , C07K16/22 , C07K16/244 , C07K16/248 , C07K16/2803 , C07K16/2875 , G01N1/28 , G01N15/1459 , G01N27/447 , G01N33/582 , G01N33/68 , G01N35/1095 , G01N2015/1438 , G01N2035/1034 , Y10T436/13
摘要： Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
摘要翻译： 公开了用于分子的高灵敏度检测的方法，试剂盒和组合物。 方法，试剂盒和组合物可用于测定样品中分子的浓度为1飞摩尔，1 attomolar或更低的水平。 方法，试剂盒和组合物还允许在宽范围内测定浓度，例如7-log范围，而不需要样品稀释。
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10.发明申请公开(公告)号：US20080171352A1
公开(公告)日：2008-07-17
申请号：US11830762
申请日：2007-07-30
CPC分类号： G01N21/6428 , C07K16/18 , C07K16/22 , C07K16/244 , C07K16/248 , C07K16/2803 , C07K16/2875 , G01N1/28 , G01N15/1459 , G01N27/447 , G01N33/582 , G01N33/68 , G01N35/1095 , G01N2015/1438 , G01N2035/1034 , Y10T436/13
摘要： Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
摘要翻译： 公开了用于分子的高灵敏度检测的方法，试剂盒和组合物。 方法，试剂盒和组合物可用于测定样品中分子的浓度为1飞摩尔，1 attomolar或更低的水平。 方法，试剂盒和组合物还允许在宽范围内测定浓度，例如7-log范围，而不需要样品稀释。
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