摘要:
The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnI) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
摘要:
Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of CHF in plasma. A panel consisting of cardiac pathology (cTnI, BNP) and vascular inflammation (IL-6, TNFα, IL-17a) biomarkers provided a sensitivity of 94% for association with CHF.
摘要:
Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of CHF in plasma. A panel consisting of cardiac pathology (cTnI, BNP) and vascular inflammation (IL-6, TNFα, IL-17a) biomarkers provided a sensitivity of 94% for association with CHF.
摘要:
Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
摘要:
The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles, e.g., protein molecules, or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
摘要:
The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
摘要:
The invention provides a Virtual Local Area Network (VLAN) over a DLSw interconnection so that VLAN identification is preserved as a packet is forwarded from a source VLAN over the TCP/IP link of the DLSw interconnection to a corresponding destination VLAN. A packet assigned to a VLAN is received by a first router. The first router uses a universal parser to determine the VLAN assignment of the packet. The parser is universal as it responds to the type of packet and type of VLAN (Ethernet, IEEE 802.5, etc.). The parser then writes VLAN information into a data structure in the router memory. The parsed data written into the data structure may include the following: the VLAN identification; a user priority identification; a CFI tag field; etc. The information fields in the data structure are assigned to the particular packet as it is processed by the router. Finally, as an outgoing encapsulated packet is built by the router, the fields of the data structure are read by the processes building the packet and written into fields of the encapsulating header. An encapsulated packet is then built by the first router for transmission over a TCP/IP connection with an encapsulating SSP header. A second router receives the encapsulated packet. The second router then builds a VLAN packet in response to the VLAN identification read from the encapsulating header and transmits the packet onto a destination VLAN corresponding to the source VLAN.
摘要:
The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.
摘要:
A method and system for validating a Command Line Interface (CLI) configlet on an image is provided. The method includes creating a parse graph using a plurality of self-describing data constructs, identifying a plurality of parse chain data constructs in the parse graph, deriving at least one CLI/configlet from the image file based on the plurality of self-describing data constructs; and comparing the at least one CLI/configlet derived from the image file with a plurality of CLIs/configlets.
摘要:
A method, a system, a computer readable medium, and an apparatus for providing information related to a configuration file to a user are provided. The user provides the configuration file to the system of the invention. The system conducts a search for the information related to the configuration file. The information is sought in at least one source, and the information that is found in the source is provided back to the user.