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    Light generating device to intravascular use
    1.
    发明授权
    Light generating device to intravascular use 有权
    发光装置用于血管内使用

    公开(公告)号：US07252677B2

    公开(公告)日：2007-08-07

    申请号：US10799357

    申请日：2004-03-12

    申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer Kristine Matson ,  Steven Ross Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer Kristine Matson ,  Steven Ross Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    IPC分类号： A61N5/06

    CPC分类号： A61N5/0601 ,  A61B2018/2261 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0652 ,  A61N2005/1003

    摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.

    摘要翻译： 用于照射血管组织部分的光产生装置，以进行光动力疗法。 在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。 可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。 光纤可选地将来自光源的光引导到漫射元件。 光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。 线性光源元件特别适用于处理容器中组织的细长部分。 旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

    Photodynamic therapy apparatus and method for vascular tissue treatment
    2.
    发明授权
    Photodynamic therapy apparatus and method for vascular tissue treatment 有权
    光动力治疗仪和血管组织治疗方法

    公开(公告)号：US07730894B2

    公开(公告)日：2010-06-08

    申请号：US11773555

    申请日：2007-07-05

    申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer Kristine Matson ,  Steven Ross Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer Kristine Matson ,  Steven Ross Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    IPC分类号： A61B19/00

    CPC分类号： A61N5/0601 ,  A61B2018/2261 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0652 ,  A61N2005/1003

    摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.

    摘要翻译： 用于照射血管组织部分的光产生装置，以进行光动力疗法。 在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。 可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。 光纤可选地将来自光源的光引导到漫射元件。 光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。 线性光源元件特别适用于处理容器中组织的细长部分。 旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

    MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES AND METHODS FOR MANUFACTURING SAME
    6.
    发明申请
    MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES AND METHODS FOR MANUFACTURING SAME 审中-公开
    采用柔性光结构的医疗设备及其制造方法

    公开(公告)号：US20110077464A1

    公开(公告)日：2011-03-31

    申请号：US12890480

    申请日：2010-09-24

    申请人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    发明人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    IPC分类号： A61B1/06

    CPC分类号： A61N5/062 ,  A61N2005/0652

    摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

    摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

    Medical apparatus employing flexible light structures
    7.
    发明授权
    Medical apparatus employing flexible light structures 有权
    采用柔性灯光结构的医疗器械

    公开(公告)号：US08685071B2

    公开(公告)日：2014-04-01

    申请号：US13401747

    申请日：2012-02-21

    申请人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    发明人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    IPC分类号： A61N5/06

    CPC分类号： A61N5/062 ,  A61N2005/0652

    摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

    摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

    MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES
    8.
    发明申请
    MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES 有权
    使用灵活的轻型结构的医疗设备

    公开(公告)号：US20120149986A1

    公开(公告)日：2012-06-14

    申请号：US13401747

    申请日：2012-02-21

    申请人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichtlenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick YEO ,  Hugh Narciso

    发明人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichtlenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick YEO ,  Hugh Narciso

    IPC分类号： A61B1/06

    CPC分类号： A61N5/062 ,  A61N2005/0652

    摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

    摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

    Light delivery system
    9.
    发明授权
    Light delivery system 有权
    发光系统

    公开(公告)号：US08685005B2

    公开(公告)日：2014-04-01

    申请号：US12445061

    申请日：2007-10-11

    申请人： Jonathan S. Dahm ,  William Louis Barnard ,  James C. Chen ,  David B. Shine

    发明人： Jonathan S. Dahm ,  William Louis Barnard ,  James C. Chen ,  David B. Shine

    IPC分类号： A61B18/18 ,  A61N5/06 ,  A61B19/00 ,  A61N1/30

    CPC分类号： A61N5/062 ,  A61B18/24 ,  A61N5/0601 ,  A61N2005/0652

    摘要： A light delivery system to provide light treatment to a patient includes a catheter assembly having a plurality of light sources that transmit light towards a target site within a patient. In one embodiment, the light delivery system has a plurality of light sources mounted to a flexible transparent base that extends at least partially through a distal tip of the catheter assembly. The light sources can be wire bonded or mounted in a flip chip arrangement onto the base. In one embodiment to produce the distal tip, an array of light energy sources can be held by an array of holders of a fixture device. A vacuum is applied to secure each light energy source in a corresponding holder. While the vacuum is applied, the energy sources are electrically connected by wire bonding. The vacuum can be reduced or stopped thereby permitting removal of the light energy sources from the fixture device.

    摘要翻译： 向患者提供光治疗的光递送系统包括具有多个光源的导管组件，所述多个光源向患者内的目标部位透射光。 在一个实施例中，光输送系统具有安装到柔性透明基底的多个光源，其至少部分延伸穿过导管组件的远端。 光源可以引线键合或以倒装芯片布置安装在基座上。 在产生远端的一个实施例中，光能源阵列可以由固定装置的支架阵列保持。 施加真空以将每个光能源固定在相应的支架中。 当施加真空时，能量源通过引线接合电连接。 可以减少或停止真空，从而允许从固定装置移除光能源。