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公开(公告)号：US06194598B1
公开(公告)日：2001-02-27
申请号：US09477902
申请日：2000-01-05
IPC分类号： C07F902
CPC分类号： C07H15/203 , C07H19/04 , C07H19/06 , C07H19/16 , C07H21/00 , Y02P20/582
摘要： Nucleotide compositions containing aminooxy moieties are provided. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligonucleotide is modified to include an aminooxy moiety.
摘要翻译： 提供含有氨氧基部分的核苷酸组合物。 根据优选实施方案，提供寡核苷酸和寡核苷酸类似物，其与所选择的RNA或DNA序列特异性杂交，其中寡核苷酸的至少一个核苷部分被修饰为包括氨氧基部分。
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公开(公告)号：US6127533A
公开(公告)日：2000-10-03
申请号：US16520
申请日：1998-01-30
IPC分类号： A01N43/04 , A61K31/7072 , A61K31/7076 , A61P43/00 , C07H15/203 , C07H19/04 , C07H19/048 , C07H19/06 , C07H19/16 , C07H21/00 , C07H21/02
CPC分类号： C07H15/203 , C07H19/04 , C07H19/06 , C07H19/16 , C07H21/00 , Y02P20/582
摘要： Nucleotide compositions containing aminooxy moieties are provided. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligonucleotide is modified to include an aminooxy moiety.
摘要翻译： 提供含有氨氧基部分的核苷酸组合物。 根据优选实施方案，提供寡核苷酸和寡核苷酸类似物，其与所选择的RNA或DNA序列特异性杂交，其中寡核苷酸的至少一个核苷部分被修饰为包括氨氧基部分。
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公开(公告)号：US06660466B1
公开(公告)日：2003-12-09
申请号：US09128036
申请日：1998-08-03
IPC分类号： C12Q100
CPC分类号： C07D295/13 , A61K31/495 , A61K31/496 , C07D261/08 , C07D277/82 , C07D295/15 , C40B40/00 , Y02A50/473 , A61K2300/00
摘要： Compositions comprising novel di-nitrogen heterocycle compounds containing at least one N-meta-substituted alkaryl group are prepared. The compounds of the present invention are useful as antibacterial and as other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents.
摘要翻译： 制备包含含有至少一个N-间位取代的烷芳基的新型二氮杂环化合物的组合物。 本发明的化合物可用作抗细菌剂和其他药剂以及用于制备其它药剂的中间体。 此外，本发明的化合物可用作研究试剂。
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公开(公告)号：US06531584B1
公开(公告)日：2003-03-11
申请号：US09389283
申请日：1999-09-02
IPC分类号： C07H2104
CPC分类号： C07H21/04 , A61K31/7125 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C12N9/0069 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12Q1/68 , C12Y113/11012
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
摘要翻译： 提供组合物和方法用于治疗和诊断适于调节所选蛋白质生产的疾病。 根据优选实施方案，提供寡核苷酸和寡核苷酸类似物，其与所选择的RNA或DNA序列特异性杂交，其中核苷单元的2'-脱氧呋喃糖基部分中的至少一个被修饰。 提供了治疗各种病毒和其他致病因素引起的疾病。
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公开(公告)号：US5859221A
公开(公告)日：1999-01-12
申请号：US468037
申请日：1995-06-06
IPC分类号： A61K38/00 , A61K47/48 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/00 , C12N9/02 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/113 , A61K47/48007 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C12N15/1131 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N9/0069 , C12Q1/68 , C12Y113/11012 , A61K38/00 , A61K48/00 , C12N2310/3125 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
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公开(公告)号：US06610663B2
公开(公告)日：2003-08-26
申请号：US09974326
申请日：2001-10-10
申请人： Phillip Dan Cook , Thomas Bruice , Charles John Guinosso , Andrew Mamoru Kawasaki , Richard Griffey
发明人： Phillip Dan Cook , Thomas Bruice , Charles John Guinosso , Andrew Mamoru Kawasaki , Richard Griffey
IPC分类号： A61K4800
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C07K14/005 , C12N9/0069 , C12N15/1137 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3511 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2740/16322 , C12Q1/68 , C12Q1/6813 , C12Y113/11012
摘要： Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
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公开(公告)号：US5872232A
公开(公告)日：1999-02-16
申请号：US471973
申请日：1995-06-06
IPC分类号： A61K38/00 , A61K47/48 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/00 , C12N9/02 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号： A61K47/48007 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C07K14/005 , C12N15/113 , C12N15/1131 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N9/0069 , C12Q1/68 , C12Q1/6813 , C12Y113/11012 , A61K38/00 , C12N2310/3125 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3511 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2740/16322
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
摘要翻译： 提供组合物和方法用于治疗和诊断适于调节所选蛋白质生产的疾病。 根据优选实施方案，提供寡核苷酸和寡核苷酸类似物，其与所选择的RNA或DNA序列特异性杂交，其中核苷单元的2'-脱氧呋喃糖基部分中的至少一个被修饰。 提供了治疗各种病毒和其他致病因素引起的疾病。
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公开(公告)号：US20090198047A1
公开(公告)日：2009-08-06
申请号：US11764087
申请日：2007-06-15
IPC分类号： C07H21/02
CPC分类号： C07H21/04 , A61K31/7125 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C12N9/0069 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12Q1/68 , C12Y113/11012
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
摘要翻译： 提供组合物和方法用于治疗和诊断适于调节所选蛋白质生产的疾病。 根据优选实施方案，提供寡核苷酸和寡核苷酸类似物，其与所选择的RNA或DNA序列特异性杂交，其中核苷单元的2'-脱氧呋喃糖基部分中的至少一个被修饰。 提供了治疗各种病毒和其他致病因素引起的疾病。
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公开(公告)号：US07138517B2
公开(公告)日：2006-11-21
申请号：US09996263
申请日：2001-11-28
CPC分类号： C12N15/1138 , A61K38/00 , A61K47/51 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C12N9/0069 , C12N15/113 , C12N15/1131 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N15/1137 , C12N2310/3125 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q2525/125 , C12Y113/11012 , C12Q2521/319 , C12Q2525/101
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
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公开(公告)号：US06358931B1
公开(公告)日：2002-03-19
申请号：US08295744
申请日：1994-08-30
申请人： Phillip Dan Cook , Thomas Bruice , Charles John Guinosso , Andrew Mamoru Kawasaki , Richard Griffey
发明人： Phillip Dan Cook , Thomas Bruice , Charles John Guinosso , Andrew Mamoru Kawasaki , Richard Griffey
IPC分类号： C07H2107
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C07K14/005 , C12N9/0069 , C12N15/1137 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3511 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2740/16322 , C12Q1/68 , C12Q1/6813 , C12Y113/11012
摘要： Compositions and methods for modulating the activity of RNA are disclosed, In accordance with preferred embodiments, antisense compositions are prepared targeting reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
摘要翻译： 公开了调节RNA活性的组合物和方法。根据优选实施方案，制备靶向反应部分的反义组合物。 反应性部分优选包含通过具有或不具有插入插入部分的接头与靶向寡核苷酸缀合的一个或两个咪唑官能团。 还公开了治疗学，诊断和研究方法，合成核苷和可以被制成寡核苷酸的核苷片段也是公开的。
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