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    Process for the manufacturing of iodinated contrast agents
    6.
    发明授权
    Process for the manufacturing of iodinated contrast agents 失效
    碘化造影剂的制造方法

    公开(公告)号：US5728877A

    公开(公告)日：1998-03-17

    申请号：US685034

    申请日：1996-07-23

    申请人： Pier Lucio Anelli ,  Marino Brocchetta ,  Ornella Gazzotti ,  Fulvio Uggeri

    发明人： Pier Lucio Anelli ,  Marino Brocchetta ,  Ornella Gazzotti ,  Fulvio Uggeri

    IPC分类号： C07C231/12 ,  C07C235/48 ,  C07C237/46 ,  C07C233/65

    CPC分类号： C07C231/12

    摘要： A process for the preparation of compounds of general formula (I) ##STR1## characterized in that the corresponding derivatives of general formula (II) ##STR2## are reacted with the compounds of general formula (III) ##STR3## wherein Z is halogen atom or a reactive residue of a sulfonic acid or a --N.sup.+ (R.sub.9).sub.3 cation wherein R.sub.9 is a (C.sub.1 -C.sub.6) alkyl group and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 R.sub.6 R.sub.7 and R.sub.8 are as herein defined.

    摘要翻译： 制备通式（I）化合物（I）的方法，其特征在于通式（II）的相应衍生物与式（III）的化合物反应：IMAGE （III）其中Z是卤素原子或磺酸或-N +（R9）3阳离子的反应性残基，其中R9是（C1-C6）烷基，R1，R2，R3，R4，R5 R6 R7和 R8如本文所定义。

    Benzyloxy derivatives of DTPA for MRI
    9.
    发明授权
    Benzyloxy derivatives of DTPA for MRI 失效
    用于MRI的DTPA的苄氧基衍生物

    公开(公告)号：US6099824A

    公开(公告)日：2000-08-08

    申请号：US904646

    申请日：1997-08-01

    申请人： Pier Lucio Anelli ,  Andrea Beltrami ,  Fulvio Uggeri ,  Mario Virtuani

    发明人： Pier Lucio Anelli ,  Andrea Beltrami ,  Fulvio Uggeri ,  Mario Virtuani

    IPC分类号： A61K49/06 ,  C07C229/16 ,  C07C229/22 ,  C07C229/76 ,  A61B5/055

    CPC分类号： C07C229/76 ,  A61K49/06 ,  C07C229/16 ,  C07C229/22 ,  Y10S514/836

    摘要： Compounds which can chelate paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI), the compounds having formula (I) ##STR1## wherein R is a --(CH.sub.2).sub.m --O--R.sub.2 group or hydrogen,R.sub.2 is a (C.sub.6 -C.sub.10) aryl, or an alkyl(C.sub.1 -C.sub.5)-aryl(C.sub.6 -C.sub.10) group, substituted or not by a group L corresponding to a OH group or a OR.sub.3 group, wherein R.sub.3 is a linear or branched (C.sub.1 -C.sub.5) alkyl group; or L is NH.sub.2, halogen, COOH or CONR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are independently hydrogen, or a linear or branched (C.sub.1 -C.sub.5) alkyl which can be substituted by 1-6 hydroxy groups and/or 1-6 alkoxy groups,R.sub.1 can have the same meanings as R, independently from it, except for hydrogen,Z is independently OH or OR.sub.6, or NR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are as previously defined, and R.sub.6 is a (C.sub.1 -C.sub.10) alkyl, linear or branched, which can be substituted by 1-6 hydroxyl and/or alkoxyl groups,m is between 1 and 5.

    摘要翻译： 可以螯合顺磁性双金属和三价金属离子的化合物，它们与所述金属离子的螯合物以及它们在磁共振成像（MRI）中作为造影剂的用途，具有式（I）的化合物其中R是 - （CH 2）m O-R 2 基团或氢，R2是（C6-C10）芳基或（C1-C5） - 芳基（C6-C10）烷基，被对应于OH基团或OR3基团的基团L取代或不被取代，其中R3 是直链或支链（C1-C5）烷基; 或L是NH 2，卤素，COOH或CONR 4 R 5，其中R 4和R 5独立地是氢，或可被1-6个羟基和/或1-6个烷氧基取代的直链或支链（C1-C5）烷基，R1可以 具有与R独立的含义，除氢外，Z独立地为OH或OR 6，或NR 4 R 5，其中R 4和R 5如前所定义，R 6为直链或支链的（C1-C10）烷基，其可以是 被1-6个羟基和/或烷氧基取代，m在1和5之间。