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17 条记录 (耗时 0.062 秒)

    Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands
    1.
    发明申请
    Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands 审中-公开
    杂芳基稠合吡啶，吡嗪和嘧啶作为CRF1受体配体

    公开(公告)号：US20060199823A1

    公开(公告)日：2006-09-07

    申请号：US11389646

    申请日：2006-03-24

    申请人： Ping Ge ,  Raymond Horvath ,  Lu Zhang ,  Yasuchika Yamaguchi ,  Bernd Kaiser ,  Xuechun Zhang ,  Suoming Zhang ,  He Zhao

    发明人： Ping Ge ,  Raymond Horvath ,  Lu Zhang ,  Yasuchika Yamaguchi ,  Bernd Kaiser ,  Xuechun Zhang ,  Suoming Zhang ,  He Zhao

    IPC分类号： A61K31/498 ,  C07D487/02

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： Substituted heteroaryl fused pyridine, pyrazine, and pyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

    摘要翻译： 提供了作为CRF 1受体的选择性调节剂的取代的杂芳基稠合的吡啶，吡嗪和嘧啶化合物。 这些化合物可用于治疗许多中枢神经系统和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。 还提供了治疗这种疾病以及包装的药物组合物的方法。 本发明的化合物也可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。 给出了在受体定位研究中使用化合物的方法。

    Throttle trigger device for an internal combustion engine of a working tool
    8.
    发明授权
    Throttle trigger device for an internal combustion engine of a working tool 失效
    用于工作工具内燃机的节气门触发装置

    公开(公告)号：US5544544A

    公开(公告)日：1996-08-13

    申请号：US355852

    申请日：1994-12-14

    申请人： Klaus Hoppner ,  Bernd Kaiser

    发明人： Klaus Hoppner ,  Bernd Kaiser

    IPC分类号： F02D9/02 ,  F02D11/02 ,  G01D1/04 ,  G05G5/08

    CPC分类号： F02D11/02 ,  Y10T74/20238 ,  Y10T74/2063

    摘要： A throttle trigger device for an internal combustion engine of a working tool has a throttle trigger connected to the handle of the working tool so as to be pivotable about a pivot axis. A throttle trigger lock is connected to the handle of the working tool so as to be pivotable about a pivot axis. A spring is connected between the throttle trigger and the throttle trigger lock. The throttle trigger, the throttle trigger lock, and the spring form a unitary part. The spring rests at an abutment of the handle at least when under load such that the spring is divided into functionally independent sections, whereby a first section extends between the abutment and the throttle trigger and a second section extends between the abutment and the throttle trigger lock.

    摘要翻译： 用于工作工具的内燃机的节气门触发装置具有连接到作业工具的把手的节流触发器，以便绕枢转轴线枢转。 节气门触发器锁连接到作业工具的把手，以便绕枢转轴线枢转。 节气门触发器和节气门触发器锁之间连接一个弹簧。 油门触发器，油门扳机锁和弹簧形成一体的部件。 弹簧至少在负载下处于手柄的邻接处，使得弹簧被分成功能上独立的部分，由此第一部分在邻接部和节气门触发器之间延伸，并且第二部分在支座和节气门触发锁之间延伸 。