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公开(公告)号：US12147888B2
公开(公告)日：2024-11-19
申请号：US17500429
申请日：2021-10-13
Inventor： Changhyun Kim , Houk Jang , Henry Julian Hinton , Hyeonjin Shin , Minhyun Lee , Donhee Ham
IPC: G06N3/045 , G06F18/214 , G06T7/11
Abstract: Disclosed is a neural computer including an image sensor capable of controlling a photocurrent. The neural computer according to an embodiment includes a preprocessor configured to receive an image and generate a feature map for the received image; a flattening unit configured to transform the feature map generated by the preprocessor into tabular data to provide data output; and an image classifier configured to classify images received through the preprocessor by using the data output by the flattening unit as an input value. The preprocessor includes an optical signal processor configured to receive the image and generate the feature map.
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2.发明公开公开(公告)号：US20230184739A1
公开(公告)日：2023-06-15
申请号：US17891964
申请日：2022-08-19
Applicant: President and Fellows of Harvard College
Inventor： Donhee Ham , Wenxuan Wu , Jeffrey T. Abbott , Henry Julian Hinton , Hongkun Park
IPC: G01N33/487 , B01L3/00
CPC classification number: G01N33/48728 , B01L3/50853 , B01L2300/0829 , B01L2300/0645 , B01L2300/0636
Abstract: Disclosed herein are semiconductor devices to provide a CMOS-compatible, wafer-scale, multi-well platform that can be used for biomedical or other applications, and methods to operate the same. In some embodiments, circuitry is provided underneath a multiple-well array to electrically interface with electrodes in the wells. To interface with electrodes in a large array, circuitry may be fabricated on a single silicon (Si) wafer having a dimension that is at least the same or larger than that of the multiple-well array. According to one aspect of the present disclosure, standard CMOS fabrication process such as those known to be used in a standard semiconductor foundry may be used without expensive customization for complex fabrication procedures. This may help the production cost to be lowered in some cases.
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公开(公告)号：US11374171B2
公开(公告)日：2022-06-28
申请号：US16823865
申请日：2020-03-19
Inventor： Minhyun Lee , Dovran Amanov , Renjing Xu , Houk Jang , Haeryong Kim , Hyeonjin Shin , Yeonchoo Cho , Donhee Ham
Abstract: Provided are memristors and neuromorphic devices including the memristors. A memristor includes a lower electrode and an upper electrode that are apart from each other and first and second two-dimensional material layers that are arranged between the lower electrode and the upper electrode and stacked without a chemical bond therebetween.
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公开(公告)号：US20250067705A1
公开(公告)日：2025-02-27
申请号：US18294759
申请日：2022-06-13
Applicant: President and Fellows of Harvard College
Inventor： Donhee Ham , Young-Ha Hwang , Henry Julian Hinton , Han Sae Jung , Woo-Bin Jung
IPC: G01N27/416
Abstract: An electrochemical apparatus includes an array of pixels disposed on a chip, stimulator circuitry disposed on the chip and configured to provide electrical input signals to cause stimulation of the pixels of the array, and sensor circuitry disposed on the chip and configured to read electrical output signals from the pixels of the array. The stimulator circuitry is configured to provide the input signals to cause stimulation of the pixels individually, and the sensor circuitry is configured to selectively read the output signals from the pixels while the pixels are being stimulated. The sensor circuitry is configured to measure an open-circuit voltage at each of the pixels and a current flow at each of the pixels while the pixels are being stimulated by the stimulator circuitry. The open-circuit voltage may be measured while the current flow is being measured.
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公开(公告)号：US20240325731A1
公开(公告)日：2024-10-03
申请号：US18501690
申请日：2023-11-03
Applicant: President and Fellows of Harvard College
Inventor： Hongkun Park , Donhee Ham , Jeffrey T. Abbott , Ling Qin , Marsela Jorgolli , Tianyang Ye
CPC classification number: A61N1/0531 , A61N1/05 , A61N1/0536 , A61N1/06 , B82Y5/00 , H01L23/48 , H01L23/49 , H01L29/0676 , H01L2924/0002 , H01L2924/10253 , H01L2924/14
Abstract: The present invention generally relates to nanowires. In one aspect, the present invention is generally directed to systems and methods of individually addressing nanowires on a surface, e.g., that are substantially upstanding or vertically-oriented with respect to the surface. In some cases, one or more nanowires may be individually addressed using various integrated circuit (“IC”) technologies, such as CMOS. For example, the nanowires may form an array on top of an active CMOs integrated circuit.
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Patent Agency Ranking
公开(公告)号：US20240219370A1
公开(公告)日：2024-07-04
申请号：US18365172
申请日：2023-08-03
Applicant: President and Fellows of Harvard College
Inventor： Donhee Ham , Jeffrey T. Abbott , Hongkun Park , Wenxuan Wu
CPC classification number: G01N33/48728 , A61B5/053 , A61B5/24 , A61N1/18 , C12M35/02 , C12N13/00 , G01N27/00 , A61B2562/0285 , B82Y15/00
Abstract: Methods and systems for stimulating and monitoring electrogenic cells are described. Some systems for stimulating electrogenic cells are based on the injection of electric currents into the cells via electrodes connected to the cells. Such stimulators may comprise an impedance element having an input terminal and an output terminal coupled to an electrode, and a voltage follower coupled between the input terminal and the output terminal of the impedance element, the voltage follower being configured to maintain a substantially constant voltage between the input terminal and the output terminal of the impedance element. The impedance element may comprise one or more switched capacitors at least in some embodiments. In some embodiments, the voltage follower may be implemented using a source follower.
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公开(公告)号：US11985910B2
公开(公告)日：2024-05-14
申请号：US17836435
申请日：2022-06-09
Inventor： Minhyun Lee , Dovran Amanov , Renjing Xu , Houk Jang , Haeryong Kim , Hyeonjin Shin , Yeonchoo Cho , Donhee Ham
CPC classification number: H10N70/826 , H10B63/80 , H10N70/24 , H10N70/8416
Abstract: Provided are memristors and neuromorphic devices including the memristors. A memristor includes a lower electrode and an upper electrode that are apart from each other and first and second two-dimensional material layers that are arranged between the lower electrode and the upper electrode and stacked without a chemical bond therebetween.
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公开(公告)号：US20230056865A1
公开(公告)日：2023-02-23
申请号：US17869940
申请日：2022-07-21
Inventor： Seijoon Kim , Renjing Xu , Hongkun Park , Donhee Ham , SANG JOON KIM
IPC: G06N3/06
Abstract: A method and apparatus with artificial network generation and/or implementation corresponding to a natural neural network are disclosed. The method includes performing an adjusting, based on a firing time difference between an action potential (AP) of a first biological neuron and a post-synaptic potential (PSP) of a second biological neuron, of a first conductance value of a first memory corresponding to the first and second biological neurons, adjusting the firing time difference based on the PSP of the second biological neuron, and performing another adjusting, by controlling another firing time difference between the AP of the first biological neuron and the PSP of the second biological neuron to be the adjusted firing time difference, of a second conductance value of the first memory corresponding to the first and second biological neurons.
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公开(公告)号：US12174140B2
公开(公告)日：2024-12-24
申请号：US16760723
申请日：2018-10-30
Applicant: President and Fellows of Harvard College
Inventor： Donhee Ham , Hongkun Park , Keith Krenek , Tianyang Ye , Jeffrey T. Abbott , Wenxuan Wu
IPC: G01N27/327 , C12M1/34 , C12N13/00 , G01N27/416
Abstract: Methods and systems for monitoring the activity of electrogenic networks are described. One representative system includes an array of electrode coupled to an analyzer having a stimulator and a receiver. The electrode is placed in contact with an electrogenic cell. The electrodes can be shaped as nanowires, tubes, cavities and/or cones. The analyzer may be configured to operate in a voltage stimulation mode, in which the cells are stimulated via voltages and monitored via current, or in a current stimulation mode, in which the cells are stimulated via currents and monitored via voltages. The analyzers may be arranged as single-stage amplifiers, and may include a feedback loop shared between the stimulation signal path and the sensing signal path. The feedback loop may be arranged to provide overlapping stimulation and sensing of the electrogenic network's cells.
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公开(公告)号：US11774396B2
公开(公告)日：2023-10-03
申请号：US17940174
申请日：2022-09-08
Applicant: President and Fellows of Harvard College
Inventor： Hongkun Park , Jeffrey T. Abbott , Wenxuan Wu , Tianyang Ye , Han Sae Jung , Donhee Ham
IPC: G01N27/327 , B01J19/08 , C12Q1/02 , G01N33/483
CPC classification number: G01N27/3277 , B01J19/087 , C12Q1/02 , G01N33/4836
Abstract: Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.
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