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公开(公告)号：US20150198570A1
公开(公告)日：2015-07-16
申请号：US14594060
申请日：2015-01-09
发明人： Can Ozbal
CPC分类号： G01N33/6848 , G01N1/34 , G01N33/9446 , G01N35/1097 , G01N2001/4088
摘要： Embodiments of the present disclosure present novel systems, devices and methods for an automated biological sample analysis using mass-spectrometry. The time from sample introduction to the reporting of data, in some embodiments, takes a relatively short amount of time (e.g., several minutes). In some embodiments, a biological sample to be analyzed is a blood sample. For many applications, only a single drop of blood may be sufficient. Through the use of a mixture of standards with unique molecular mass, a quantitative analysis of the target analyte can be performed in a single MS run (for example), eliminating the need to create and analyze standard curves. One advantage of such embodiments may be that the system, devices, and methods can eliminate the need for batch creation since the requirement to amortize the time and effort of creating and analyzing standard curves can be eliminated.
摘要翻译： 本公开的实施方案提供了使用质谱法进行自动生物样品分析的新颖系统，装置和方法。 在一些实施例中，从样本介绍到数据报告的时间花费相对较短的时间（例如几分钟）。 在一些实施方案中，待分析的生物样品是血液样品。 对于许多应用，只有一滴血可能就足够了。 通过使用具有独特分子量的标准混合物，可以在单次MS运行（例如）中执行目标分析物的定量分析，从而无需创建和分析标准曲线。 这样的实施例的一个优点可能在于，可以消除系统，设备和方法，因为可以消除创建和分析标准曲线的时间和精力的分摊要求。
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公开(公告)号：US10545155B2
公开(公告)日：2020-01-28
申请号：US16100876
申请日：2018-08-10
发明人： Can Ozbal
摘要： Embodiments of the present disclosure present novel systems, devices and methods for an automated biological sample analysis using mass-spectrometry. The time from sample introduction to the reporting of data, in some embodiments, takes a relatively short amount of time (e.g., several minutes). In some embodiments, a biological sample to be analyzed is a blood sample. For many applications, only a single drop of blood may be sufficient. Through the use of a mixture of standards with unique molecular mass, a quantitative analysis of the target analyte can be performed in a single MS run (for example), eliminating the need to create and analyze standard curves. One advantage of such embodiments may be that the system, devices, and methods can eliminate the need for batch creation since the requirement to amortize the time and effort of creating and analyzing standard curves can be eliminated.
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公开(公告)号：US10101307B2
公开(公告)日：2018-10-16
申请号：US15392546
申请日：2016-12-28
发明人： Can Ozbal
摘要： Systems, apparatus, methods, and kits are provided for automated mass spectrometric analysis of small volumes of liquid samples, such as biological samples. The systems, apparatus, and kits may be used in facilities where high throughput of samples, as well as reliable and repeatable assay results with little training of staff, are needed. Such facilities include hospital emergency wards.
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公开(公告)号：US09557317B2
公开(公告)日：2017-01-31
申请号：US14750693
申请日：2015-06-25
发明人： Can Ozbal
CPC分类号： G01N30/7233 , G01N30/08 , G01N30/6091 , G01N30/6095 , G01N33/491
摘要： Systems, apparatus, methods, and kits are provided for automated mass spectrometric analysis of small volumes of liquid samples, such as biological samples. The systems, apparatus, and kits may be used in facilities where high throughput of samples, as well as reliable and repeatable assay results with little training of staff, are needed. Such facilities include hospital emergency wards.
摘要翻译： 提供了系统，装置，方法和试剂盒，用于对小体积液体样品（如生物样品）进行自动质谱分析。 系统，装置和试剂盒可用于需要高通量样品以及可靠且可重复的测定结果，而且不需要人员培训的设备。 这些设施包括医院急诊室。
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公开(公告)号：US20170108477A1
公开(公告)日：2017-04-20
申请号：US15392546
申请日：2016-12-28
发明人： Can Ozbal
CPC分类号： G01N30/7233 , G01N30/08 , G01N30/6091 , G01N30/6095 , G01N33/491
摘要： Systems, apparatus, methods, and kits are provided for automated mass spectrometric analysis of small volumes of liquid samples, such as biological samples. The systems, apparatus, and kits may be used in facilities where high throughput of samples, as well as reliable and repeatable assay results with little training of staff, are needed. Such facilities include hospital emergency wards.
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公开(公告)号：US20150377842A1
公开(公告)日：2015-12-31
申请号：US14750693
申请日：2015-06-25
发明人： Can Ozbal
CPC分类号： G01N30/7233 , G01N30/08 , G01N30/6091 , G01N30/6095 , G01N33/491
摘要： Systems, apparatus, methods, and kits are provided for automated mass spectrometric analysis of small volumes of liquid samples, such as biological samples. The systems, apparatus, and kits may be used in facilities where high throughput of samples, as well as reliable and repeatable assay results with little training of staff, are needed. Such facilities include hospital emergency wards.
摘要翻译： 提供了系统，装置，方法和试剂盒，用于对小体积液体样品（如生物样品）进行自动质谱分析。 系统，装置和试剂盒可用于需要高通量样品以及可靠且可重复的测定结果，而且不需要人员培训的设备。 这些设施包括医院急诊室。
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7.发明授权公开(公告)号：US11531009B2
公开(公告)日：2022-12-20
申请号：US16474697
申请日：2017-12-28
发明人： Can Ozbal
IPC分类号： G01N30/46 , B01J20/281 , G01N30/60 , G01N30/74 , G01N30/80 , G01N35/00 , G01N30/02 , G01N30/00
摘要： A device for separating one or more molecules of interest in a liquid specimen including a monolithic body defining a fractionation column. The column includes an inlet opening at a proximal end of the fractionation column; an outlet opening at a distal, opposite end of the fractionation column; a solid phase chamber positioned between the inlet opening and the outlet opening; a specimen introduction area adjacent a proximal end of the solid phase chamber; an analyte exit area adjacent a distal end of the solid phase chamber; an inlet chamber adjacent the inlet opening that tapers into the specimen introduction area; and an outlet chamber that extends from the analyte exit area to the outlet opening. A metered amount of solid phase packed within the solid phase chamber between a first porous frit and a second porous frit of the solid phase chamber.
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公开(公告)号：US10067140B2
公开(公告)日：2018-09-04
申请号：US15352066
申请日：2016-11-15
发明人： Can Ozbal
摘要： Embodiments of the present disclosure present novel systems, devices and methods for an automated biological sample analysis using mass-spectrometry. The time from sample introduction to the reporting of data, in some embodiments, takes a relatively short amount of time (e.g., several minutes). In some embodiments, a biological sample to be analyzed is a blood sample. For many applications, only a single drop of blood may be sufficient. Through the use of a mixture of standards with unique molecular mass, a quantitative analysis of the target analyte can be performed in a single MS run (for example), eliminating the need to create and analyze standard curves. One advantage of such embodiments may be that the system, devices, and methods can eliminate the need for batch creation since the requirement to amortize the time and effort of creating and analyzing standard curves can be eliminated.
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公开(公告)号：US20170059580A1
公开(公告)日：2017-03-02
申请号：US15352066
申请日：2016-11-15
发明人： Can Ozbal
CPC分类号： G01N33/6848 , G01N1/34 , G01N33/9446 , G01N35/1097 , G01N2001/4088
摘要： Embodiments of the present disclosure present novel systems, devices and methods for an automated biological sample analysis using mass-spectrometry. The time from sample introduction to the reporting of data, in some embodiments, takes a relatively short amount of time (e.g., several minutes). In some embodiments, a biological sample to be analyzed is a blood sample. For many applications, only a single drop of blood may be sufficient. Through the use of a mixture of standards with unique molecular mass, a quantitative analysis of the target analyte can be performed in a single MS run (for example), eliminating the need to create and analyze standard curves. One advantage of such embodiments may be that the system, devices, and methods can eliminate the need for batch creation since the requirement to amortize the time and effort of creating and analyzing standard curves can be eliminated.
摘要翻译： 本公开的实施方案提供了使用质谱法进行自动生物样品分析的新颖系统，装置和方法。 在一些实施例中，从样本介绍到数据报告的时间花费相对较短的时间（例如几分钟）。 在一些实施方案中，待分析的生物样品是血液样品。 对于许多应用，只有一滴血可能就足够了。 通过使用具有独特分子量的标准混合物，可以在单次MS运行（例如）中执行目标分析物的定量分析，从而无需创建和分析标准曲线。 这样的实施例的一个优点可能在于，可以消除系统，设备和方法，因为可以消除创建和分析标准曲线的时间和精力的分摊要求。
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公开(公告)号：US10545124B2
公开(公告)日：2020-01-28
申请号：US16159309
申请日：2018-10-12
发明人： Can Ozbal
摘要： Systems, apparatus, methods, and kits are provided for automated mass spectrometric analysis of small volumes of liquid samples, such as biological samples. The systems, apparatus, and kits may be used in facilities where high throughput of samples, as well as reliable and repeatable assay results with little training of staff, are needed. Such facilities include hospital emergency wards.
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