公开(公告)号：US11360098B2

公开(公告)日：2022-06-14

申请号：US15277879

申请日：2016-09-27

申请人： QUEST DIAGNOSTICS INVESTMENTS LLC

发明人： Diana Tran ,  Darren Weber ,  Nigel Clarke

IPC分类号： G01N31/00 ,  G01N33/53 ,  G01N33/68

摘要： Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. In another aspect, provided herein are methods for determining the ratio of amyloid beta 42 (Aβ42) to amyloid beta 40 (Aβ40). In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.

公开(公告)号：US20170089917A1

公开(公告)日：2017-03-30

申请号：US15277879

申请日：2016-09-27

申请人： QUEST DIAGNOSTICS INVESTMENTS LLC

发明人： Diana Tran ,  Darren Weber ,  Nigel Clarke

IPC分类号： G01N33/68

CPC分类号： G01N33/6848 ,  G01N33/6827 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/52

摘要： Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. In another aspect, provided herein are methods for determining the ratio of amyloid beta 42 (Aβ42) to amyloid beta 40 (Aβ40). In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.

公开(公告)号：US20220349897A1

公开(公告)日：2022-11-03

申请号：US17839262

申请日：2022-06-13

申请人： QUEST DIAGNOSTICS INVESTMENTS LLC

发明人： Diana Tran ,  Darren Weber ,  Nigel Clarke

IPC分类号： G01N33/68

摘要： Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. In another aspect, provided herein are methods for determining the ratio of amyloid beta 42 (Aβ42) to amyloid beta 40 (Aβ40). In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.

公开(公告)号：US20160349221A1

公开(公告)日：2016-12-01

申请号：US15167866

申请日：2016-05-27

申请人： QUEST DIAGNOSTICS INVESTMENTS LLC

发明人： Scott Goldman ,  Mildred Goldman ,  Leslie Edinboro ,  Diana Tran ,  Julia Addiss ,  Darren Weber ,  Porus Mistry ,  Nigel Clarke

IPC分类号： G01N30/72 ,  G01N33/49 ,  G01N33/493 ,  H01J49/00 ,  H01J49/14

CPC分类号： G01N33/49 ,  G01N1/4055 ,  G01N33/493 ,  G01N2030/8822 ,  H01J49/00

摘要： Mass spectrometric methods are described for determining the amount of analyte in a sample collected by a microsampling device. Provided herein are methods directed to quantitating the amount of an analyte in a sample by extracting an analyte from a sample collected by a microsampling device, purifying the sample by liquid chromatography, ionizing the analyte to generate one or more ions detectable by mass spectrometry; and determining the amount of the one or more ions by mass spectrometry. The amount of analyte in the sample is related to the amount of analyte in the patient.

摘要翻译： 描述了用于确定由微量采样装置收集的样品中的分析物的量的质谱方法。 本文提供的方法是通过从微量取样装置收集的样品提取分析物，通过液相色谱纯化样品，离子化分析物以产生可通过质谱法检测的一种或多种离子来定量样品中分析物的量; 并通过质谱测定一种或多种离子的量。 样品中分析物的量与患者中分析物的量有关。