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公开(公告)号：US20220163494A1
公开(公告)日：2022-05-26
申请号：US17582956
申请日：2022-01-24
摘要： Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.
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公开(公告)号：US20190285654A1
公开(公告)日：2019-09-19
申请号：US16355552
申请日：2019-03-15
摘要： Provided herein are methods for high throughput quantitation of testosterone utilizing at least two different derivatizing agents of different masses. In another aspect, provided herein are methods for determining the amount of testosterone in each of a plurality of human samples with a single mass spectrometric assay by subjecting each of a plurality of human samples to a different derivatizing agent to generate a differently derivatized testosterone in each of the plurality of samples; combining the plurality of samples to form a multiplex sample; and quantifying the amount of testosterone in each sample by mass spectrometry.
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公开(公告)号：US11885780B2
公开(公告)日：2024-01-30
申请号：US17582956
申请日：2022-01-24
CPC分类号： G01N30/8675 , G01N30/7266 , G01N33/74 , G01N2030/009 , G01N2030/027 , G01N2333/635
摘要： Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.
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公开(公告)号：US20190285594A1
公开(公告)日：2019-09-19
申请号：US16355300
申请日：2019-03-15
发明人： Darren Weber , Michael Caufield , Michael McPhaul , Scott Goldman , Nigel Clarke
摘要： Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.
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公开(公告)号：US20230273226A1
公开(公告)日：2023-08-31
申请号：US18143226
申请日：2023-05-04
CPC分类号： G01N33/743 , G01N33/6848 , G01N30/50
摘要： Provided herein are methods for high throughput quantitation of testosterone utilizing at least two different derivatizing agents of different masses. In another aspect, provided herein are methods for determining the amount of testosterone in each of a plurality of human samples with a single mass spectrometric assay by subjecting each of a plurality of human samples to a different derivatizing agent to generate a differently derivatized testosterone in each of the plurality of samples; combining the plurality of samples to form a multiplex sample; and quantifying the amount of testosterone in each sample by mass spectrometry.
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公开(公告)号：US20240110899A1
公开(公告)日：2024-04-04
申请号：US18536566
申请日：2023-12-12
CPC分类号： G01N30/8675 , G01N30/7266 , G01N33/74 , G01N2030/009 , G01N2333/635
摘要： A method for determining the amount of chromogranin A (CgA) in a sample includes: (a) purifying CgA in the sample; (b) adding an internal standard; (c) ionizing CgA and the internal standard to produce one or more CgA ion(s) and one or more internal standard ion(s) detectable by mass spectrometry; (d) determining the amount of the ion(s) from step (c) by mass spectrometry; and (e) correlating the amount of CgA in the sample to the amount of ion(s) measured in step (d).
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公开(公告)号：US20240047186A1
公开(公告)日：2024-02-08
申请号：US18488633
申请日：2023-10-17
发明人： Scott Goldman
CPC分类号： H01J49/0036 , G01N33/92 , H01J49/0027 , H01J49/426 , H01J49/10 , Y10T436/201666 , Y10T436/200833 , Y10T436/20 , G01N2560/00
摘要： The invention relates to the detection of fatty acids. In a particular aspect, the invention relates to methods for detecting very long chain fatty acids and branched chain fatty acids by mass spectrometry.
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公开(公告)号：US11674969B2
公开(公告)日：2023-06-13
申请号：US16355552
申请日：2019-03-15
CPC分类号： G01N33/743 , G01N30/50 , G01N33/6848
摘要： Provided herein are methods for high throughput quantitation of testosterone utilizing at least two different derivatizing agents of different masses. In another aspect, provided herein are methods for determining the amount of testosterone in each of a plurality of human samples with a single mass spectrometric assay by subjecting each of a plurality of human samples to a different derivatizing agent to generate a differently derivatized testosterone in each of the plurality of samples; combining the plurality of samples to form a multiplex sample; and quantifying the amount of testosterone in each sample by mass spectrometry.
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公开(公告)号：US11231401B2
公开(公告)日：2022-01-25
申请号：US16355300
申请日：2019-03-15
摘要： Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.
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10.发明申请METHODS FOR MASS SPECTROMETRIC QUANTITATION OF ANALYTES EXTRACTED FROM A MICROSAMPLING DEVICE 审中-公开从微波装置提取的分析仪的质谱分析方法公开(公告)号：US20160349221A1
公开(公告)日：2016-12-01
申请号：US15167866
申请日：2016-05-27
发明人： Scott Goldman , Mildred Goldman , Leslie Edinboro , Diana Tran , Julia Addiss , Darren Weber , Porus Mistry , Nigel Clarke
IPC分类号： G01N30/72 , G01N33/49 , G01N33/493 , H01J49/00 , H01J49/14
CPC分类号： G01N33/49 , G01N1/4055 , G01N33/493 , G01N2030/8822 , H01J49/00
摘要： Mass spectrometric methods are described for determining the amount of analyte in a sample collected by a microsampling device. Provided herein are methods directed to quantitating the amount of an analyte in a sample by extracting an analyte from a sample collected by a microsampling device, purifying the sample by liquid chromatography, ionizing the analyte to generate one or more ions detectable by mass spectrometry; and determining the amount of the one or more ions by mass spectrometry. The amount of analyte in the sample is related to the amount of analyte in the patient.
摘要翻译： 描述了用于确定由微量采样装置收集的样品中的分析物的量的质谱方法。 本文提供的方法是通过从微量取样装置收集的样品提取分析物，通过液相色谱纯化样品，离子化分析物以产生可通过质谱法检测的一种或多种离子来定量样品中分析物的量; 并通过质谱测定一种或多种离子的量。 样品中分析物的量与患者中分析物的量有关。
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