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公开(公告)号：US20090069327A1
公开(公告)日：2009-03-12
申请号：US12162313
申请日：2007-02-06
申请人： Qiang Ding , Pingda Ren , Qiong Zhang , Xia Wang , Taebo Sim , Pamela A. Albaugh , Nathanael S. Gray
发明人： Qiang Ding , Pingda Ren , Qiong Zhang , Xia Wang , Taebo Sim , Pamela A. Albaugh , Nathanael S. Gray
IPC分类号： A61K31/5377 , C07D403/14 , C07D413/14 , A61K31/444 , A61P43/00 , C07D239/42 , A61K31/497
CPC分类号： C07D239/42 , C07D401/04 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Bmx, b-RAF, c-RAF, c-SRC, KDR, CSK, FGFR3, JAK2, Lck, Met, PKCα, SAPK2α, Tie2, TrkB and P70S6K kinases.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，Bcr-Abl异常活化的疾病或病症 ，Bmx，b-RAF，c-RAF，c-SRC，KDR，CSK，FGFR3，JAK2，Lck，Met，PKCalpha，SAPK2alpha，Tie2，TrkB和P70S6K激酶。
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公开(公告)号：US07745437B2
公开(公告)日：2010-06-29
申请号：US11628881
申请日：2005-06-09
申请人： Pingda Ren , Xia Wang , Guobao Zhang , Qiang Ding , Shuli You , Qiong Zhang , Greg Chopiuk , Pamela A. Albaugh , Taebo Sim , Nathanael Schiander Gray
发明人： Pingda Ren , Xia Wang , Guobao Zhang , Qiang Ding , Shuli You , Qiong Zhang , Greg Chopiuk , Pamela A. Albaugh , Taebo Sim , Nathanael Schiander Gray
IPC分类号： C07D403/04 , A61K31/4178
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, PDGF-R, trkB, c-SRC, BMX, FGFR3, b-RAF, ΣΓK, Tιε2, Λχκ, θNK2α2, MKK4, c-RAF, MKK6, SAPK2α and SAPK2β kinases.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症 ，PDGF-R，trkB，c-SRC，BMX，FGFR3，b-RAF，＆amp; Ggr; K，Tι＆egr; 2，Λχ＆kgr;; thetas;NK2α2，MKK4，c-RAF，MKK6，SAPK2α和SAPK2＆ 激酶。
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公开(公告)号：US20090105250A1
公开(公告)日：2009-04-23
申请号：US11814912
申请日：2006-01-19
申请人： Taebo Sim , Nathanael Schiander Gray , Hyun Soo Lee , Yi Liu , Pingda Ren , Shuli You , Qiong Zhang , Qiang Ding , Xia Wang , Songchun Jiang , Pamela A. Albaugh
发明人： Taebo Sim , Nathanael Schiander Gray , Hyun Soo Lee , Yi Liu , Pingda Ren , Shuli You , Qiong Zhang , Qiang Ding , Xia Wang , Songchun Jiang , Pamela A. Albaugh
IPC分类号： A61K31/427 , C07D277/56 , C07D417/14 , C07D417/12 , A61K31/454 , A61K31/506 , A61K31/5377 , A61K31/426
CPC分类号： C07D277/56 , C07D417/12 , C07D417/14
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, FGFR3, PDGFRβ and b-Raf kinases.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，Bcr-Abl异常活化的疾病或病症 ，FGFR3，PDGFRbeta和b-Raf激酶。
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公开(公告)号：US20070225286A1
公开(公告)日：2007-09-27
申请号：US11628881
申请日：2005-06-09
申请人： Pingda Ren , Xia Wang , Guobao Zhang , Qiang Ding , Shull You , Qiong Zhang , Greg Chopiuk , Pamela Albaugh , Taebo Sim , Nathanael Gray
发明人： Pingda Ren , Xia Wang , Guobao Zhang , Qiang Ding , Shull You , Qiong Zhang , Greg Chopiuk , Pamela Albaugh , Taebo Sim , Nathanael Gray
IPC分类号： A61K31/496 , A61K31/497 , A61K31/5355 , C07D401/04 , C07D403/04
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, PDGF-R, trkB, c-SRC, BMX, FGFR3, b-RAF, ΣΓK, Ttε2, Λχκ, ΘNK2α2, MKK4, c-RAF, MKK6, SAPK2α and SAPK2β kinases.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症 ，PDGF-R，trkB，c-SRC，BMX，FGFR3，b-RAF，SigmaGammaK，Ttepsilon2，Lambdachikappa，ThetaNK2alpha2，MKK4，c-RAF，MKK6，SAPK2α和SAPK2β激酶。
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公开(公告)号：US07642255B2
公开(公告)日：2010-01-05
申请号：US12099708
申请日：2008-04-08
申请人： Taebo Sim , Hyun Soo Lee , Pingda Ren , Qiang Ding , Yi Liu , Bing Li , Lintong Li , Xia Wang , Tetsuo Uno , Guobao Zhang , Nathanael Schiander Gray , Shuli You
发明人： Taebo Sim , Hyun Soo Lee , Pingda Ren , Qiang Ding , Yi Liu , Bing Li , Lintong Li , Xia Wang , Tetsuo Uno , Guobao Zhang , Nathanael Schiander Gray , Shuli You
IPC分类号： C07D413/14 , C07D471/04 , C07D487/04 , A61K31/535 , A61K31/497 , A61K31/519 , C07D251/12 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症 ，Bmx，c-Raf，Csk，Fes，FGFR，Flt3，Ikk，IR，JNK，Lck，Mkk，PKC，PKD，Rsk，SAPK，Syk，Trk，BTK，Src，EGFR，IGF，Mek，Ros和Tie2 激酶。
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公开(公告)号：US20080221098A1
公开(公告)日：2008-09-11
申请号：US12099708
申请日：2008-04-08
申请人： Taebo Sim , Hyun Soo Lee , Pingda Ren , Qiang Ding , Yi Liu , Bing Li , Lintong Li , Xia Wang , Tetsuo Uno , Guobao Zhang , Nathanael Schiander Gray , Shuli You
发明人： Taebo Sim , Hyun Soo Lee , Pingda Ren , Qiang Ding , Yi Liu , Bing Li , Lintong Li , Xia Wang , Tetsuo Uno , Guobao Zhang , Nathanael Schiander Gray , Shuli You
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/519 , A61K31/496
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症 ，Bmx，c-Raf，Csk，Fes，FGFR，Flt3，Ikk，IR，JNK，Lck，Mkk，PKC，PKD，Rsk，SAPK，Syk，Trk，BTK，Src，EGFR，IGF，Mek，Ros和Tie2 激酶。
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公开(公告)号：US07371750B2
公开(公告)日：2008-05-13
申请号：US10909227
申请日：2004-07-29
申请人： Taebo Sim , Hyun Soo Lee , Pingda Ren , Qiang Ding , Guobao Zhang , Yi Liu , Xia Wang , Tetsuo Uno , Bing Li , Lintong Li , Nathanael Schiander Gray , Shuli You
发明人： Taebo Sim , Hyun Soo Lee , Pingda Ren , Qiang Ding , Guobao Zhang , Yi Liu , Xia Wang , Tetsuo Uno , Bing Li , Lintong Li , Nathanael Schiander Gray , Shuli You
IPC分类号： A61K31/5355 , A61K31/53 , A61K31/497 , A61K31/513 , C07D413/12 , C07D253/065 , C07D487/04 , C07D413/14 , A61P35/00 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症 ，Bmx，c-Raf，Csk，Fes，FGFR，Flt3，Ikk，IR，JNK，Lck，Mkk，PKC，PKD，Rsk，SAPK，Syk，Trk，BTK，Src，EGFR，IGF，Mek，Ros和Tie2 激酶。
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公开(公告)号：US20050222177A1
公开(公告)日：2005-10-06
申请号：US10909227
申请日：2004-07-29
申请人： Taebo Sim , Hyun Lee , Pingda Ren , Qiang Ding , Yi Liu , Bing Li , Lintong Li , Xia Wang , Tetsuo Uno , Guobao Zhang , Nathanael Gray , Shuli You
发明人： Taebo Sim , Hyun Lee , Pingda Ren , Qiang Ding , Yi Liu , Bing Li , Lintong Li , Xia Wang , Tetsuo Uno , Guobao Zhang , Nathanael Gray , Shuli You
IPC分类号： A61K20060101 , A61K31/5025 , A61K31/519 , C07D471/04 , C07D487/02 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症 ，Bmx，c-Raf，Csk，Fes，FGFR，Flt3，Ikk，IR，JNK，Lck，Mkk，PKC，PKD，Rsk，SAPK，Syk，Trk，BTK，Src，EGFR，IGF，Mek，Ros和Tie2 激酶。
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公开(公告)号：US20100029605A1
公开(公告)日：2010-02-04
申请号：US12444129
申请日：2007-09-24
申请人： Pamela Albaugh , Gregory S. Chopiuk , Qiang Ding , Shenlin Huang , Zuosheng Liu , Shifeng Pan , Pingda Ren , Xia Wang , Xing Wang , yongping Xie , Chengzhi Zhang , Qiong Zhang , Guobao Zhang , Daniel Poon , Paul Renhowe , Martin Sendzik
发明人： Pamela Albaugh , Gregory S. Chopiuk , Qiang Ding , Shenlin Huang , Zuosheng Liu , Shifeng Pan , Pingda Ren , Xia Wang , Xing Wang , yongping Xie , Chengzhi Zhang , Qiong Zhang , Guobao Zhang , Daniel Poon , Paul Renhowe , Martin Sendzik
IPC分类号： A61K31/506 , C07D413/14 , C07D403/14 , C07D403/04 , A61K31/5377 , A61K31/519
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，ARG，BCR异常活化的疾病或病症 -Abl，BRK，EphB，Fms，Fyn，KDR，c-Kit，LCK，PDGF-R，b-Raf，c-Raf，SAPK2，Src，Tie2和TrkB激酶。
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公开(公告)号：US08202876B2
公开(公告)日：2012-06-19
申请号：US12444129
申请日：2007-09-24
申请人： Pamela Albaugh , Gregory B. Chopiuk , Qiang Ding , Shenlin Huang , Zuosheng Liu , Shifeng Pan , Pingda Ren , Xia Wang , Xing Wang , Yongping Xie , Chengzhi Zhang , Qiong Zhang , Guobao Zhang , Daniel Poon , Paul Renhowe , Martin Sendzik
发明人： Pamela Albaugh , Gregory B. Chopiuk , Qiang Ding , Shenlin Huang , Zuosheng Liu , Shifeng Pan , Pingda Ren , Xia Wang , Xing Wang , Yongping Xie , Chengzhi Zhang , Qiong Zhang , Guobao Zhang , Daniel Poon , Paul Renhowe , Martin Sendzik
IPC分类号： C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D231/00 , C07D403/02 , A01N43/56 , A61K31/415
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，ARG，BCR异常活化的疾病或病症 -Abl，BRK，EphB，Fms，Fyn，KDR，c-Kit，LCK，PDGF-R，b-Raf，c-Raf，SAPK2，Src，Tie2和TrkB激酶。
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