公开(公告)号：US08431461B1

公开(公告)日：2013-04-30

申请号：US13329035

申请日：2011-12-16

申请人： Qinghua Zhong ,  Yoshie Kimura ,  Tae Won Kim ,  Qian Fu ,  Gladys Lo ,  Ganesh Upadhyaya ,  Yoko Yamaguchi

发明人： Qinghua Zhong ,  Yoshie Kimura ,  Tae Won Kim ,  Qian Fu ,  Gladys Lo ,  Ganesh Upadhyaya ,  Yoko Yamaguchi

IPC分类号： H01L21/336

CPC分类号： H01L29/66477 ,  H01L29/665 ,  H01L29/6653 ,  H01L29/78

摘要： A method for forming devices with silicon gates over a substrate is provided. Silicon nitride spacers are formed on sides of the silicon gates. An ion implant is provided using the silicon nitride spacers as masks to form ion implant regions. A nonconformal layer is selectively deposited over the spacers and gates that selectively deposits a thicker layer on tops of the gates and spacers and between spacers than on sidewalls of the silicon nitride spacers. Sidewalls of the nonconformal layer are etched away on sidewalls of the silicon nitride spacers. The silicon nitride spacers are trimmed.

摘要翻译： 提供了一种用于在衬底上形成具有硅栅极的器件的方法。 氮化硅间隔物形成在硅栅极的侧面上。 使用氮化硅间隔物作为掩模提供离子注入以形成离子注入区域。 非限制性层被选择性地沉积在间隔物和浇口上，所述间隔物和浇口选择性地在栅极和间隔物的顶部和间隔物之间​​沉积较厚的层，而不是在氮化硅间隔物的侧壁上沉积。 在氮化硅间隔物的侧壁上蚀刻掉非共形层的侧壁。 修整氮化硅间隔物。

公开(公告)号：US09079874B2

公开(公告)日：2015-07-14

申请号：US12746795

申请日：2008-12-12

申请人： Kazuhisa Sugimoto ,  Hiromi Nishiura ,  Yoko Yamaguchi ,  Keiichi Hirata ,  Yoshiki Kubota

发明人： Kazuhisa Sugimoto ,  Hiromi Nishiura ,  Yoko Yamaguchi ,  Keiichi Hirata ,  Yoshiki Kubota

IPC分类号： A61K31/385 ,  C07D339/04 ,  A61K9/00 ,  A61K9/20 ,  A61K9/51 ,  B82Y5/00 ,  A61K9/14

CPC分类号： C07D339/04 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/14 ,  A61K9/2018 ,  A61K9/5115 ,  B82Y5/00

摘要： Provision of a stable α-lipoic acid. A method for producing α-lipoic acid nanoparticles, the method comprising the steps of: preparing an aqueous dispersion liquid containing α-lipoic acid and a nonionic surfactant; adding a divalent metal salt into the aqueous dispersion liquid, wherein the divalent metal salt is a divalent metal halide, a divalent metal acetate or a divalent metal gluconate; and adding an alkali metal carbonate or an alkali metal phosphate into the aqueous dispersion liquid which has been added with the divalent metal salt, thereby forming α-lipoic acid nanoparticles.

摘要翻译： 提供稳定的α-硫辛酸。 一种α-硫辛酸纳米粒子的制造方法，该方法包括以下步骤：制备含有α-硫辛酸和非离子表面活性剂的水性分散液; 在水分散液中加入二价金属盐，其中二价金属盐是二价金属卤化物，二价金属乙酸盐或二价金属葡萄糖酸盐; 并在加入二价金属盐的水分散液中加入碱金属碳酸盐或碱金属磷酸盐，从而形成α-硫辛酸纳米粒子。

公开(公告)号：US07361607B2

公开(公告)日：2008-04-22

申请号：US11562929

申请日：2006-11-22

申请人： Yoko Yamaguchi ,  Chris Lee

发明人： Yoko Yamaguchi ,  Chris Lee

IPC分类号： H01L21/302

CPC分类号： H01L21/3065 ,  H01L21/02057 ,  H01L21/0271 ,  H01L21/31116 ,  H01L21/31122 ,  H01L21/31138 ,  H01L21/32137 ,  H01L21/32139

摘要： A method for etching a multi-layer resist defined over a substrate in a plasma etch chamber is provided. The method initiates with introducing the substrate having a pattern defined on a first layer of the multi-layer resist into the etch chamber. SO2 gas flows into the etch chamber and a plasma is struck in the etch chamber while flowing the SO2 gas. The multi-layer resist is then etched.

摘要翻译： 提供了一种在等离子体蚀刻室中蚀刻限定在衬底上的多层抗蚀剂的方法。 该方法通过将具有限定在多层抗蚀剂的第一层上的图案的基板引入蚀刻室来启动。 SO 2气体流入蚀刻室，并且在SO 2气体流动的同时在蚀刻室中撞击等离子体。 然后蚀刻多层抗蚀剂。

公开(公告)号：US06316458B1

公开(公告)日：2001-11-13

申请号：US09557318

申请日：2000-04-25

申请人： Jerry L. Nadler ,  Thomas W. Balon ,  Yoko Yamaguchi

发明人： Jerry L. Nadler ,  Thomas W. Balon ,  Yoko Yamaguchi

IPC分类号： A01N4390

CPC分类号： A61K31/522

摘要： A category of hydroxyalkyl-substituted xanthines are useful in treating patients suffering from disorders associated with impaired glucose metabolism or impaired insulin function. Use of these compounds, for example, restores insulin responsiveness in otherwise insulin-resistant Type 2 diabetic patients, thus reducing elevated blood glucose levels. The subject compounds also act to restore certain defects of lipid metabolism and to enhance the effects of insulin in general. Insulin-enhancing compositions and methods of treating disorders of glucose metabolism are provided.

摘要翻译： 一类羟烷基取代的黄嘌呤可用于治疗患有与葡萄糖代谢受损或胰岛素功能受损相关的疾病的患者。 例如，使用这些化合物可恢复胰岛素抵抗2型糖尿病患者的胰岛素反应性，从而降低血糖水平升高。 主题化合物还起到恢复脂质代谢的某些缺陷并增强胰岛素的作用的作用。 提供胰岛素增强组合物和治疗葡萄糖代谢紊乱的方法。

公开(公告)号：US5067160A

公开(公告)日：1991-11-19

申请号：US328547

申请日：1989-03-24

申请人： Satoshi Omata ,  Hiroshi Shimizu ,  Yoko Yamaguchi

发明人： Satoshi Omata ,  Hiroshi Shimizu ,  Yoko Yamaguchi

IPC分类号： G06T7/00 ,  G06T7/20

CPC分类号： G06T7/20

摘要： The apparatus recognizes a motion of an object which is moving and is hidden in an image signal, and discriminates the object from the background within the signal. The apparatus has an image forming unit comprising non-linear oscillators, which forms an image of the motion of the object in accordance with an adjacent-mutual-interference-rule, on the basis of the image signal. A memory unit, comprising non-linear oscillators, stores conceptualized meanings of several motions. A retrieval unit retrieves a conceptualized meaning close to the motion image of the object. An altering unit alters the rule, on the basis of the conceptualized meaning. The image forming unit, memory unit, retrieval unit and altering unit form a holonic-loop. Successive alterations of the rules by the altering unit within the holonic loop change an ambiguous image formed in the image forming unit into a distinct image.

公开(公告)号：US20100330014A1

公开(公告)日：2010-12-30

申请号：US12865494

申请日：2009-01-29

申请人： Mina Musashi ,  Keiichi Hirata ,  Yoko Yamaguchi

发明人： Mina Musashi ,  Keiichi Hirata ,  Yoko Yamaguchi

IPC分类号： A61K8/34 ,  A61K31/05 ,  A61K31/07

CPC分类号： A61K8/671 ,  A61K8/0295 ,  A61K8/347 ,  A61K2800/52 ,  A61Q19/00 ,  A61Q19/02

摘要： An object of the present invention is to provide a composition for external application on the skin containing hydroquinone as an active ingredient, which has an excellent skin-whitening activity and reduced side effects. The composition for external application on the skin of the present invention as a means for achieving the object is characterized by containing hydroquinone or a derivative thereof compounded with a lyotropic liquid crystal.

摘要翻译： 本发明的目的在于提供一种外用的含有氢醌作为活性成分的皮肤外用组合物，其具有优异的美白活性和副作用。 本发明的外用皮肤外用组合物作为实现目的的手段的特征在于含有与溶致液晶混合的氢醌或其衍生物。

公开(公告)号：US20090075860A1

公开(公告)日：2009-03-19

申请号：US11912964

申请日：2006-04-28

申请人： Yoko Yamaguchi ,  Rie Igarashi

发明人： Yoko Yamaguchi ,  Rie Igarashi

IPC分类号： A61K38/02 ,  A61K47/44 ,  A61K47/34 ,  A61K47/06 ,  A61K31/711

CPC分类号： A61K31/23 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/1274 ,  A61K31/203 ,  A61K47/12 ,  A61K47/44

摘要： An object of the present invention is to provide a transdermal absorption enhancer by which various active ingredients are transdermally absorbed. In accordance with a transdermal absorption enhancer of the present invention which effective ingredient is lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, transdermal absorption of a macromolecular substance and a water-soluble substance was able to be improved.

摘要翻译： 本发明的目的是提供一种经皮吸收增强剂，通过其可以透皮吸收各种活性成分。 根据本发明的透皮吸收增强剂，其有效成分是已经用作外用药物制剂和化妆品的基础材料的溶致液晶，能够对大分子物质和水溶性物质进行经皮吸收 要改进

公开(公告)号：US20080274193A1

公开(公告)日：2008-11-06

申请号：US10586775

申请日：2005-01-21

申请人： Yoko Yamaguchi ,  Rie Igarashi

发明人： Yoko Yamaguchi ,  Rie Igarashi

IPC分类号： A61K31/203 ,  C07C57/03 ,  A61K9/14 ,  A61P3/10

CPC分类号： A61K31/203

摘要： The present invention aims to provide a novel agent for treating and/or preventing diabetes which agent can not only control a blood sugar level but also fundamentally treat a patient with type I diabetes suffering from destruction of β cells and a patient with type II diabetes suffering from dysfunction in insulin secretion. The present invention provides an agent for treating and/or preventing diabetes, the agent containing retinoic acid as an active ingredient. Retinoic acid incorporated as an active ingredient may be all-trans retinoic acid, an isomer thereof, a derivative thereof, a salt thereof or a prodrug thereof. Retinoic acid may be incorporated singly. Alternatively, composite particles of retinoic acid and an appropriate inorganic or organic substance are prepared, and the retinoic acid composite particles may be incorporated.

摘要翻译： 本发明的目的在于提供一种用于治疗和/或预防糖尿病的新型药剂，其不仅可以控制血糖水平，而且可以从根本上治疗患有β细胞破坏的I型糖尿病患者和患有II型糖尿病的患者 从胰岛素分泌功能障碍。 本发明提供了用于治疗和/或预防糖尿病的药剂，其含有视黄酸作为活性成分。 作为活性成分掺入的视黄酸可以是全反式视黄酸，其异构体，其衍生物，其盐或其前药。 维甲酸可以单独加入。 或者，制备视黄酸和合适的无机或有机物质的复合颗粒，并且可以加入视黄酸复合颗粒。

公开(公告)号：US20080038927A1

公开(公告)日：2008-02-14

申请号：US11562929

申请日：2006-11-22

申请人： Yoko Yamaguchi ,  Chris Lee

发明人： Yoko Yamaguchi ,  Chris Lee

IPC分类号： H01L21/461 ,  H01L21/302

CPC分类号： H01L21/3065 ,  H01L21/02057 ,  H01L21/0271 ,  H01L21/31116 ,  H01L21/31122 ,  H01L21/31138 ,  H01L21/32137 ,  H01L21/32139

摘要： A method for etching a multi-layer resist defined over a substrate in a plasma etch chamber is provided. The method initiates with introducing the substrate having a pattern defined on a first layer of the multi-layer resist into the etch chamber. SO2 gas flows into the etch chamber and a plasma is struck in the etch chamber while flowing the SO2 gas. The multi-layer resist is then etched.

摘要翻译： 提供了一种在等离子体蚀刻室中蚀刻限定在衬底上的多层抗蚀剂的方法。 该方法通过将具有限定在多层抗蚀剂的第一层上的图案的基板引入蚀刻室来启动。 SO 2气体流入蚀刻室，并且在SO 2气体流动的同时在蚀刻室中撞击等离子体。 然后蚀刻多层抗蚀剂。

公开(公告)号：US20070014863A1

公开(公告)日：2007-01-18

申请号：US10595412

申请日：2003-10-15

申请人： Yoko Yamaguchi ,  Rie Igarashi ,  Yutaka Mizushima ,  Mitsuko Takenaga

发明人： Yoko Yamaguchi ,  Rie Igarashi ,  Yutaka Mizushima ,  Mitsuko Takenaga

IPC分类号： A61K9/14 ,  A61K31/203

CPC分类号： A61K9/5115 ,  A61K9/1075 ,  A61K9/5089 ,  A61K9/5192 ,  A61K31/203 ,  A61K47/02

摘要： Nanoparticles containing retinoic acid have reduced irritancy of retinoic acid and are suitable for subcutaneous or intravenous administration, as well as for use in sustained-release preparation. The high skin permeability of the nanoparticles makes them suitable for use in pharmaceutical or non-pharmaceutical external preparations or cosmetics intended for skin application. The present invention provides a method for adjusting the particle size of such nanoparticles and nanoparticles produced by such a method. Specifically, the method involves dispersing retinoic acid dissolved in a lower alcohol in an aqueous alkali solution; adding a nonionic surfactant to the dispersion to form a mixed micelle; adding to the micelle a halide or acetate of divalent metal along with a carbonate or phosphate of alkali metal so that the molar ratio of the former to the latter is 1:0 to 1:1.0, thereby depositing a coating of inorganic salt of polyvalent metal on the surface of the micelle; and adjusting the average particle size of the resulting nanoparticles to 5 to 300 nm. The inorganic salt of polyvalent metal may be calcium carbonate, zinc carbonate, or calcium phosphate.

摘要翻译： 含视黄酸的纳米粒子具有降低视黄酸的刺激性，适用于皮下或静脉内给药以及用于持续释放制剂。 纳米颗粒的高皮肤渗透性使得它们适用于用于皮肤应用的药物或非药物外用制剂或化妆品。 本发明提供了一种调节由这种方法生产的纳米颗粒和纳米粒子的粒径的方法。 具体地说，该方法包括将溶解在低级醇中的视黄酸分散在碱性水溶液中; 向分散体中加入非离子表面活性剂以形成混合胶束; 向胶束中加入二价金属的卤化物或乙酸酯以及碱金属的碳酸盐或磷酸盐，使得前者与后者的摩尔比为1:0至1:1.0，由此沉积多价金属的无机盐的涂层 在胶束的表面上; 并将所得纳米粒子的平均粒径调整为5〜300nm。 多价金属的无机盐可以是碳酸钙，碳酸锌或磷酸钙。