摘要:
Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
摘要:
Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
摘要:
The compositions and methods of the present invention are based, in part, on our discovery that an effector function mediated by an Fc-containing polypeptide can be altered by modifying one or more amino acid residues within the polypeptide (by, for example, electrostatic optimization). The polypeptides that can be generated according to the methods of the invention are highly variable, and they can include antibodies and fusion proteins that contain an Fc region or a biologically active portion thereof.
摘要:
A lower nozzle for use in a nuclear fuel assembly provided. The lower nozzle is of the type having an axis and comprising a transverse lower tie plate for channelling the coolant through the lower tie plate and a tubular skirt extending axially from the periphery of the lower tie plate, the skirt delimiting an axial housing closed at one end by the lower tie plate and open at the opposite end, a debris filter configured for axial insertion in the housing and snap-fit springs for retaining the debris filter in the housing after insertion. The springs are configured to shift the debris filter axially towards the lower tie plate.
摘要:
A fuel element for a nuclear reactor has fuel rods with nuclear fuel guided through spacers. The spacers are equipped with devices that exert a swirling impulse upon a coolant flowing along the fuel rods. In order to present as little flow resistance as possible for the coolant, these swirl-introducing devices have the form of a vane with a spoonlike or bladelike shape and they extend into the coolant flow. Owing to the shape—here the vane is curved in the longitudinal and in the transverse directions—practically all cross sections of the vane have such a high geometrical moment of inertia that even a vane made of a thin sheet metal is sufficiently rigid. Fuel elements configured according to the invention are particularly suitable for use in boiling water nuclear reactors.
摘要:
In order to obviate the use of supporting rods, an upper end piece of a coolant tube penetrates a fuel assembly head of a nuclear reactor fuel assembly and is supported on the fuel assembly head. A lower end piece of the coolant tube is fastened to and supported by a fuel assembly foot, in particular with rods of partial lengths. A supporting skeleton therefore includes the foot and the coolant tube with spacers. The fuel assembly head and a handle are placed on the skeleton and screwed onto the coolant tube after fuel rods are pushed into meshes of the spacer.
摘要:
In a fuel assembly, lower end pieces of fuel rods, guide tubes and coolant pipes, etc., are inserted and/or screwed into a base plate and secured against lifting by a bolt. In the case of fuel rods, in particular fuel rods which do not extend over the entire length of normal rods, the bolt is screwed onto connecting parts in such a way that a releasable bayonet closure is produced. In the case of coolant pipes of boiling water reactors, there is provided in particular a screw connection which is irreleasably secured against torsion by the bolt.
摘要:
A hydraulic control rod drive for a nuclear reactor, with a a reactor plenum enclosing the drive, comprises first and second hollow bodies together forming a cylinder and a hollow piston. Working fluid is supplied through one of the hollow bodies. The first hollow body is stationary and the second hollow body is disposed coaxially around the first hollow body. The two hollow bodies define an annular gap therebetween so as to allow axial reciprocating movement of the second hollow body, which forms a carrier body for control elements of the control rod. The second hollow body can be lifted, lowered or suspended by feeding working fluid. A portion of the fluid is removed from the inner space via a throttle passage. A positional measurement system determines the relative displacement of the second hollow body by measuring an ultrasonic measurement path. The system includes an ultrasound reflector and an ultrasonic transducer rigidly mounted remote from the ultrasound reflector. Provisions are made for venting the inner space through venting channels which open into the reactor plenum at a security distance from the measurement path so as not to adversely affect the ultrasonic measurement.
摘要:
A nuclear reactor includes a pressure vessel enclosing a plenum, a core in the pressure vessel, a pressure-tight encapsulation in the pressure vessel communicating with the plenum, and control members passing through the encapsulation and having first and second control member segments. The second control member segment has an absorber part to be at least partly inserted into and retracted out of the core for controlling reactivity. The first control member segment has an outer drive part. A control drive is associated with the outer drive part for adjusting the control member along the longitudinal direction thereof. An antieject device for restraining ejection of the control member out of the pressure vessel due to a leak at the encapsulation includes a rod coupling having a disengageable coupling catch interconnecting the first and second control member segments and remaining in engagement during normal control motion of the control member and means for unlocking the coupling catch. After disconnection the second control member segment and the absorber part remain in the core for assuming a position fully inserted into the core.
摘要:
The invention is concerned with a process for the preparation of 1 hydrogen or hydroxy cholesterol derivatives and intermediates therefor. The compounds of the present invention are useful as intermediates in the preparation of 24,25-dihydroxy and 1.alpha., 24,25-trihydroxycholecalciferol.