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1.发明授权Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof 有权具有狭义地均匀垂直和非随机组织的孔隙率和孔密度的细胞支持基质及其制备方法公开(公告)号：US08921109B2
公开(公告)日：2014-12-30
申请号：US11523833
申请日：2006-09-19
IPC分类号： C12N5/00 , A61L27/38 , A61L27/24 , A61L27/56 , C12N5/077 , C12N5/07 , A61F2/30 , A61F2/08 , A61F2/38
CPC分类号： C12N5/0068 , A61F2/08 , A61F2/30756 , A61F2/3872 , A61F2002/30062 , A61F2210/0004 , A61F2310/00365 , A61L27/24 , A61L27/3817 , A61L27/3843 , A61L27/56 , A61L2400/18 , A61L2430/06 , A61L2430/10 , C12N5/0655 , C12N2533/54 , C12N2535/00
摘要： A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro.
摘要翻译： 具有狭义地均匀垂直和非随机组织的孔隙率和孔密度的细胞支持基质及其制备方法。 适用于制备细胞或非细胞植入物的基质，用于生长和从头形成关节透明样软骨。 一种凝胶基质复合体系，其包含基于胶原的基质，其具有能够在体内和体外从软骨细胞产生透明样软骨的狭义孔隙度。
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2.发明授权Double-structured tissue implant and a method for preparation and use thereof 有权双重结构的组织植入物及其制备和使用方法公开(公告)号：US08685107B2
公开(公告)日：2014-04-01
申请号：US11894124
申请日：2007-08-20
IPC分类号： A61F2/02
CPC分类号： A61L27/48 , A61F2002/0086 , A61F2210/0076 , A61F2310/00371 , A61F2310/00982 , A61L27/24 , A61L27/3817 , A61L27/54 , A61L27/56 , A61L2400/18 , A61L2430/34 , C08L89/06
摘要： A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.
摘要翻译： 双组织组织植入物及其制备和使用方法，用于植入组织缺陷。 双重结构的组织植入物包括主要支架和由可溶性胶原溶液组合的辅助支架，所述可溶性胶原溶液与产生并定位在主要支架内的非离子表面活性剂组合。 独立的二次支架植入物或单位。 制备双结构植入物或独立的第二支架的方法，其包括冻干和脱水热处理。
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3.发明授权Method for use of a double-structured tissue implant for treatment of tissue defects 有权使用双组织植入物治疗组织缺陷的方法公开(公告)号：US08070827B2
公开(公告)日：2011-12-06
申请号：US11982268
申请日：2007-10-31
申请人： Sonya Shortkroff , Laurence J. B. Tarrant , Eric J. Roos , Robert Lane Smith , Hans Peter Ingemar Claesson
发明人： Sonya Shortkroff , Laurence J. B. Tarrant , Eric J. Roos , Robert Lane Smith , Hans Peter Ingemar Claesson
IPC分类号： A61F2/02
CPC分类号： A61L27/48 , A61L27/38 , A61L27/54 , A61L27/56 , A61L2300/254 , A61L2300/258 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/428 , A61L2300/43 , A61L2300/802
摘要： A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit.
摘要翻译： 用于双组织植入物或用于治疗组织缺陷的独立植入物的二次支架的方法。 双重结构的组织植入物包括主要支架和由可溶性胶原溶液组合的辅助支架，所述可溶性胶原溶液与产生并定位在主要支架内的非离子表面活性剂组合。 独立的二次支架植入物或单位。
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4.发明授权Method for preparing and implanting a cartilage construct to treat cartilage lesions 有权用于制备和植入软骨构造物以治疗软骨损伤的方法公开(公告)号：US07537780B2
公开(公告)日：2009-05-26
申请号：US10626459
申请日：2003-07-22
申请人： Shuichi Mizuno , Akihiko Kusanagi , Laurence J. B. Tarrant , Toshimasa Tokuno , Robert Lane Smith
发明人： Shuichi Mizuno , Akihiko Kusanagi , Laurence J. B. Tarrant , Toshimasa Tokuno , Robert Lane Smith
CPC分类号： A61L27/24 , A61F2/28 , A61F2310/00365 , A61K35/12 , A61L27/3633 , A61L27/38 , A61L27/3817 , A61L27/3843 , A61L27/3852 , A61L27/3895 , A61L27/56 , A61L2430/06 , C12N5/0655
摘要： Neo-cartilage constructs for growth and surface coating for the de novo formation of a superficial cartilage layer. A method for generation of the neo-cartilage and the neo-cartilage construct. A method for repair and restoration of the injured, damaged, diseased or aged cartilage into its full functionality and for treatment of injured or diseased cartilage by implanting the neo-cartilage construct between two layers of biologically acceptable sealants.
摘要翻译： 用于生长和表面涂层的新软骨构建体用于从头形成的软骨层。 用于产生新软骨和新软骨构建体的方法。 通过将新软骨构建体植入两层生物可接受的密封剂之间，将损伤的，损伤的，患病的或老化的软骨修复和恢复成其全部功能并用于治疗受损或患病的软骨的方法。
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公开(公告)号：US08906686B2
公开(公告)日：2014-12-09
申请号：US11413419
申请日：2006-04-28
申请人： Shuichi Mizuno , Akihiko Kusanagi , Laurence J. B. Tarrant , Toshimasa Tokuno , Robert Lane Smith
发明人： Shuichi Mizuno , Akihiko Kusanagi , Laurence J. B. Tarrant , Toshimasa Tokuno , Robert Lane Smith
IPC分类号： A61L27/24 , A61L27/38 , A61L27/56 , A61K35/32 , C12N5/077 , A61K9/00 , A61L27/36 , A61K35/12
CPC分类号： A61L27/3895 , A61F2/28 , A61F2310/00365 , A61K9/0024 , A61K35/12 , A61K35/32 , A61L27/24 , A61L27/3633 , A61L27/38 , A61L27/3817 , A61L27/3843 , A61L27/3852 , A61L27/54 , A61L27/56 , A61L2300/64 , A61L2430/06 , C12N5/0655 , C12N2521/00 , C12N2533/54
摘要： Neo-cartilage constructs suitable for implantation into a joint cartilage lesion in situ and a method for repair and restoration of function of injured, traumatized, aged or diseased cartilage. The construct comprises at least chondrocytes incorporated into a support matrix processed according to the algorithm comprising variable hydrostatic or atmospheric pressure or non-pressure conditions, variable rate of perfusion, variable medium composition, variable temperature, variable cell density and variable time to which the chondrocytes are subjected.
摘要翻译： 适用于植入关节软骨病变的新软骨构造和修复和恢复损伤，受损，老化或患病软骨功能的方法。 该构建体至少包含软骨细胞，该软骨细胞结合到根据包括可变静水压力或大气压或非压力条件，可变灌注速率，可变介质组成，可变温度，可变细胞密度和可变时间的算法处理的支持基质中，软骨细胞 受到影响
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6.发明授权公开(公告)号：US08070810B2
公开(公告)日：2011-12-06
申请号：US11653024
申请日：2007-01-12
IPC分类号： A61F2/08
CPC分类号： A61L27/386 , A61B17/00491 , A61B17/1146 , A61B2017/1132 , A61F2/08 , A61L2430/10 , Y10S623/908
摘要： A method and a means for repair and reconstruction of ruptured ligaments and tendons by in vivo or ex vivo repair and reconstruction surgical procedures. The method comprises providing a biodegradable sleeve placed around the frayed edges of an injured ligament or tendon for protecting the ligament or tendon injury with a protective shield. A composition comprising a biodegradable tissue adhesive applied on top of, around and/or between the frayed edges of the injured ligament.
摘要翻译： 一种通过体内或体外修复和重建外科手术修复和重建破裂韧带和肌腱的方法和手段。 该方法包括提供放置在损伤的韧带或腱的磨损边缘周围的可生物降解的套管，以用保护性护罩保护韧带或腱损伤。 一种组合物，其包含施加在损伤的韧带的磨损边缘之间，周围和/或之间的可生物降解的组织粘合剂。
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公开(公告)号：US07157428B2
公开(公告)日：2007-01-02
申请号：US10998230
申请日：2004-11-26
CPC分类号： A61K38/39 , A61L24/0031 , A61L24/102 , A61L27/26 , A61L27/34 , A61L27/48 , A61L27/52 , A61L2430/06 , C08L89/06
摘要： A method for repair of meniscal injuries comprising induction of meniscal regeneration by introducing a strongly adhesive collagen-polyethylene glycol (PEG) hydrogel to a site of injury.
摘要翻译： 一种修复半月板损伤的方法，包括通过将强粘合性胶原 - 聚乙二醇（PEG）水凝胶引入损伤部位诱导半月板再生。
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公开(公告)号：US07560432B2
公开(公告)日：2009-07-14
申请号：US11285928
申请日：2005-11-23
摘要： A method for in situ repair of meniscal injuries comprising induction of meniscal repair and regeneration by introducing an adhesive collagen-polyethylene glycol (PEG) hydrogel to a site of injury alone, supplemented with a synovial tissue or in conjunction with a support matrix.
摘要翻译： 一种用于半月板损伤的原位修复的方法，其包括通过将粘合性胶原 - 聚乙二醇（PEG）水凝胶引入单独的损伤部位，补充有滑膜组织或与支持基质结合来诱导半月板修复和再生。
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公开(公告)号：US07468192B2
公开(公告)日：2008-12-23
申请号：US10625822
申请日：2003-07-22
申请人： Shuichi Mizuno , Akihiko Kusanagi , Laurence J. B. Tarrant , Toshimasa Tokuno , Robert Lane Smith
发明人： Shuichi Mizuno , Akihiko Kusanagi , Laurence J. B. Tarrant , Toshimasa Tokuno , Robert Lane Smith
CPC分类号： A61L27/3852 , A61F2/28 , A61F2310/00365 , A61K35/12 , A61L27/24 , A61L27/3633 , A61L27/38 , A61L27/3817 , A61L27/3843 , A61L27/3895 , A61L27/56 , A61L2430/06 , C12N5/0655
摘要： A method for treatment of injured, damaged, diseased or aged articular cartilage using neo-cartilage constructs implanted into a joint cartilage lesion in situ. The implantation of the construct initiates and achieves incorporation of neo-cartilage into a native surrounding cartilage including a formation of a new superficial cartilage layer overgrowing and sealing the lesion in the joint cartilage.
摘要翻译： 使用植入关节软骨损伤中的新软骨构建物治疗损伤的，损伤的，患病的或老化的关节软骨的方法。 该构建体的植入开始并实现新软骨并入本体周围软骨中，包括形成在关节软骨中过度生长和密封损伤的新的浅表软骨层。
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10.发明授权Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof 有权用于治疗关节软骨，骨或软骨缺损和损伤的无细胞基质植入物及其使用方法公开(公告)号：US07217294B2
公开(公告)日：2007-05-15
申请号：US10882581
申请日：2004-06-30
IPC分类号： A61F2/30
CPC分类号： A61F2/30756 , A61F2002/30535 , A61F2250/0058 , A61L27/24 , A61L27/34 , A61L27/3633 , A61L27/3654 , A61L27/52 , A61L27/58 , A61L2430/06
摘要： An acellular matrix implant for treatment of defects and injuries of articular cartilage, bone or osteochondral bone and a method for treatment of injured, damaged, diseased or aged articular cartilage or bone, using the acellular matrix implant implanted into a joint cartilage lesion in situ and a bone-inducing composition implanted into an osteochondral or bone defect. A method for repair and restoration of the injured, damaged, diseased or aged cartilage or bone into its full functionality by implanting the acellular matrix implant between two layers of biologically acceptable sealants and/or the bone-inducing composition into the osteochondral bone or skeletal bone defect. A method for fabrication of the acellular matrix implant of the invention. A method for preparation of bone-inducing composition.
摘要翻译： 一种用于治疗关节软骨，骨或软骨软骨缺损和损伤的无细胞基质植入物，以及使用植入关节软骨病变中的无细胞基质植入物治疗损伤的，损伤的，患病的或老化的关节软骨或骨的方法，以及 植入骨软骨或骨缺损的骨诱导组合物。 通过将无细胞基质植入物植入两层生物学上可接受的密封剂和/或骨诱导组合物进入骨软骨骨或骨骼骨中来修复和恢复损伤的，损伤的，患病的或老化的软骨或骨骼成为其全部功能的方法 缺陷。 本发明的无细胞基质植入物的制造方法。 骨诱导组合物的制备方法。
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