公开(公告)号：US07041490B1

公开(公告)日：2006-05-09

申请号：US09201228

申请日：1998-11-30

申请人： Remy Griffais ,  Susan K. Hoiseth ,  Robert John Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah Diane Fletcher

发明人： Remy Griffais ,  Susan K. Hoiseth ,  Robert John Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah Diane Fletcher

IPC分类号： C12N1/21 ,  C12N15/31

CPC分类号： C07K14/295

摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.

摘要翻译： 本发明的主题是编码沙眼衣原体的多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程或毒力中涉及代谢，或由其编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及沙眼衣原体基因组的转录基因产物，例如反义和核酶分子，其可用于控制微生物的生长。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断沙眼衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌特别是沙眼衣原体感染的药物，特别是疫苗组合物。

公开(公告)号：US20090274701A1

公开(公告)日：2009-11-05

申请号：US12491449

申请日：2009-06-25

申请人： REMY GRIFFAIS ,  Susan K. Hoiseth ,  Robert John Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah Diane Fletcher

发明人： REMY GRIFFAIS ,  Susan K. Hoiseth ,  Robert John Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah Diane Fletcher

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C07K14/21 ,  C07K16/12 ,  A61K31/7088 ,  A61K35/74 ,  A61K38/16 ,  A61K39/02 ,  C12P21/06 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C07K14/295 ,  A01K2217/05 ,  A61K39/00

摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia pneumoniae genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia pneumoniae infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia pneumoniae, infections.

摘要翻译： 本发明的主题是编码肺炎衣原体多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程中或在毒力中参与代谢，由此编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及可用于控制微生物生长的肺炎衣原体基因组的转录基因产物，例如反义和核酶分子。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断肺炎衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌，特别是肺炎衣原体感染的药物，特别是疫苗组合物。

公开(公告)号：US06559294B1

公开(公告)日：2003-05-06

申请号：US09198452

申请日：1998-11-23

申请人： Remy Griffais ,  Susan K. Hoiseth ,  Robert John Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah Diane Fletcher

发明人： Remy Griffais ,  Susan K. Hoiseth ,  Robert John Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah Diane Fletcher

IPC分类号： C07H2102

CPC分类号： C07K14/295 ,  A01K2217/05 ,  A61K39/00

摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia pneumoniae genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia pneumoniae infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia pneumoniae, infections.

公开(公告)号：US20110159041A1

公开(公告)日：2011-06-30

申请号：US13036310

申请日：2011-02-28

申请人： Remy Griffais ,  Susan K. Hoiseth ,  Robert J. Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah D. Fletcher

发明人： Remy Griffais ,  Susan K. Hoiseth ,  Robert J. Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah D. Fletcher

IPC分类号： A61K39/118 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C07K14/295 ,  C07K16/12 ,  A61K38/16 ,  C12N9/10 ,  C07H21/00 ,  C12P21/00 ,  C12Q1/68 ,  G01N33/53 ,  A61P31/04 ,  A61P37/04

CPC分类号： C07K14/295

摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.

摘要翻译： 本发明的主题是编码沙眼衣原体的多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程或毒力中涉及代谢，或由其编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及沙眼衣原体基因组的转录基因产物，例如反义和核酶分子，其可用于控制微生物的生长。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断沙眼衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌特别是沙眼衣原体感染的药物，特别是疫苗组合物。

公开(公告)号：US08143024B2

公开(公告)日：2012-03-27

申请号：US13036310

申请日：2011-02-28

申请人： Rémy Griffais ,  Susan K. Hoiseth ,  Robert J. Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah D. Fletcher

发明人： Rémy Griffais ,  Susan K. Hoiseth ,  Robert J. Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah D. Fletcher

IPC分类号： C12P21/06 ,  C12N15/09 ,  C07H21/04 ,  A61K39/118

CPC分类号： C07K14/295

摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.

摘要翻译： 本发明的主题是编码沙眼衣原体的多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程或毒力中涉及代谢，或由其编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及沙眼衣原体基因组的转录基因产物，例如反义和核酶分子，其可用于控制微生物的生长。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断沙眼衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌特别是沙眼衣原体感染的药物，特别是疫苗组合物。

公开(公告)号：US07910329B2

公开(公告)日：2011-03-22

申请号：US12491474

申请日：2009-06-25

申请人： Rémy Griffais ,  Susan K. Hoiseth ,  Robert J. Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah D. Fletcher

发明人： Rémy Griffais ,  Susan K. Hoiseth ,  Robert J. Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah D. Fletcher

IPC分类号： C12N15/09 ,  C12N1/20 ,  C12P21/04 ,  C07H21/04 ,  A61K39/118

CPC分类号： C07K14/295

摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.

摘要翻译： 本发明的主题是编码沙眼衣原体的多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程或毒力中涉及代谢，或由其编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及沙眼衣原体基因组的转录基因产物，例如反义和核酶分子，其可用于控制微生物的生长。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断沙眼衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌特别是沙眼衣原体感染的药物，特别是疫苗组合物。

公开(公告)号：US07601531B2

公开(公告)日：2009-10-13

申请号：US11366942

申请日：2006-03-02

申请人： Rémy Griffais ,  Susan K. Hoiseth ,  Robert J. Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah D. Fletcher

发明人： Rémy Griffais ,  Susan K. Hoiseth ,  Robert J. Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah D. Fletcher

IPC分类号： C12N1/21 ,  C12N15/31 ,  C07H21/04

CPC分类号： C07K14/295 ,  A01K2217/05 ,  A61K39/00

摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia pneumoniae genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia pneumoniae infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia pneumoniae, infections.

摘要翻译： 本发明的主题是编码肺炎衣原体多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程中或在毒力中参与代谢，由此编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及可用于控制微生物生长的肺炎衣原体基因组的转录基因产物，例如反义和核酶分子。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断肺炎衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌，特别是肺炎衣原体感染的药物，特别是疫苗组合物。

公开(公告)号：US07101963B2

公开(公告)日：2006-09-05

申请号：US10289762

申请日：2002-11-07

申请人： Rémy Griffais ,  Susan K. Hoiseth ,  Robert J. Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah D. Fletcher

发明人： Rémy Griffais ,  Susan K. Hoiseth ,  Robert J. Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah D. Fletcher

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K1/00 ,  C12Q1/68 ,  C12N15/00

CPC分类号： C07K14/295 ,  A01K2217/05 ,  A61K39/00

摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia pneumoniae genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia pneumoniae infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia pneumoniae, infections.

摘要翻译： 本发明的主题是编码肺炎衣原体多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程中或在毒力中参与代谢，由此编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及可用于控制微生物生长的肺炎衣原体基因组的转录基因产物，例如反义和核酶分子。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断肺炎衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌，特别是肺炎衣原体感染的药物，特别是疫苗组合物。

公开(公告)号：US07575913B2

公开(公告)日：2009-08-18

申请号：US11366965

申请日：2006-03-02

申请人： Rémy Griffais ,  Susan K. Hoiseth ,  Robert J. Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah D. Fletcher

发明人： Rémy Griffais ,  Susan K. Hoiseth ,  Robert J. Zagursky ,  Benjamin J. Metcalf ,  Joel A. Peek ,  Banumathi Sankaran ,  Leah D. Fletcher

IPC分类号： C12N1/21 ,  C12N15/31 ,  C07H21/04

CPC分类号： C07K14/295

摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.

摘要翻译： 本发明的主题是编码沙眼衣原体的多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程或毒力中涉及代谢，或由其编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及沙眼衣原体基因组的转录基因产物，例如反义和核酶分子，其可用于控制微生物的生长。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断沙眼衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌特别是沙眼衣原体感染的药物，特别是疫苗组合物。

公开(公告)号：US20070053927A1

公开(公告)日：2007-03-08

申请号：US11366942

申请日：2006-03-02

申请人： Remy Griffais ,  Susan Hoiseth ,  Robert Zagursky ,  Benjamin Metcalf ,  Joel Peek ,  Banumathi Sankaran ,  Leah Fletcher

发明人： Remy Griffais ,  Susan Hoiseth ,  Robert Zagursky ,  Benjamin Metcalf ,  Joel Peek ,  Banumathi Sankaran ,  Leah Fletcher

IPC分类号： A61K39/02 ,  C07H21/04 ,  C12P21/06 ,  C12N1/21 ,  C12N15/74 ,  C07K14/295 ,  C07K16/12

CPC分类号： C07K14/295 ,  A01K2217/05 ,  A61K39/00

摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia pneumoniae genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia pneumoniae infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia pneumoniae, infections.

摘要翻译： 本发明的主题是编码肺炎衣原体多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程中或在毒力中参与代谢，由此编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及可用于控制微生物生长的肺炎衣原体基因组的转录基因产物，例如反义和核酶分子。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断肺炎衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌，特别是肺炎衣原体感染的药物，特别是疫苗组合物。