公开(公告)号：US5331966A

公开(公告)日：1994-07-26

申请号：US168725

申请日：1993-12-16

申请人： Tom D. Bennett ,  William J. Combs ,  Kallok, Michael J. ,  Brian B. Lee ,  Rahul Mehra ,  George J. Klein

发明人： Tom D. Bennett ,  William J. Combs ,  Kallok, Michael J. ,  Brian B. Lee ,  Rahul Mehra ,  George J. Klein

IPC分类号： A61N1/365 ,  A61B5/0402 ,  A61N1/362 ,  A61N1/375 ,  A61B5/0428

CPC分类号： A61N1/3686 ,  A61N1/36185 ,  A61N1/3622 ,  A61N1/0504 ,  A61N1/3756 ,  Y10S128/903

摘要： A method and apparatus for providing an enhanced capability of detecting and gathering electrical cardiac signals via an array of relatively closely spaced subcutaneous electrodes (located on the body of an implanted device) which may be employed with suitable switching circuits, signal processors, and memory to process the electrical cardiac signals between any selected pair or pairs of the electrode array in order to provide a leadless, orientation insensitive means for receiving the electrical signal from the heart. This far-field EGM may be used to provide storage and analysis of arrhythmic events and to provide control signals for the delivery of various therapies including pacing, cardioversion and defibrillation therapies as well as the delivery of antiarrhythmic drugs, and, in the pacing context, to effect capture detection and automatic stimulation threshold adaption, recording of PMT episodes, measurement of refractory periods in order to set timing windows for antitachy pacing therapies, and as a control signal for use in adjusting pacing rate to physiologic demand.

摘要翻译： 一种用于提供通过相对紧密间隔的皮下电极（位于植入装置的主体上）的阵列来检测和收集电心电信号的增强能力的方法和装置，其可以与合适的开关电路，信号处理器和存储器一起使用 处理任何所选择的一对或一对电极阵列之间的电心脏信号，以便提供用于从心脏接收电信号的无引导方向不敏感的装置。 这种远场EGM可用于提供心律失常事件的存储和分析，并提供用于递送各种疗法的控制信号，包括起搏，心脏复律和除颤疗法以及递送抗心律失常药物，并且在起搏背景下， 以实现捕获检测和自动刺激阈值适应，记录PMT发作，测量不良期以设置反向起搏治疗的时间窗口，以及用作调整生理需求起搏速率的控制信号。

公开(公告)号：US06599242B1

公开(公告)日：2003-07-29

申请号：US09619296

申请日：2000-07-19

申请人： Vincent E. Splett ,  Brian B. Lee ,  William J. Combs

发明人： Vincent E. Splett ,  Brian B. Lee ,  William J. Combs

IPC分类号： A61B500

CPC分类号： A61B5/0006 ,  A61B5/0031 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/7203 ,  A61B5/7232

摘要： An improved turning point system and method for performing data compression is disclosed. The system improves the conventional turning point compression method by selecting a predetermined number of the “best” turning points in the sample window including data samples X0 and XN. From this sample-window, ones of the data samples X1 through X(N−1) will be identified as turning points using a selected one of a disclosed set of turning point detection methods. In one embodiment, a turning point is identified by determining that the slopes in the lines interconnecting adjacent data points have different polarities. In an alternative embodiment, a data sample XM is considered a turning point if the slope of the line between the data samples XM and X(M+1) has a different polarity as compared to the slope of the last waveform segment that was encountered that did not have a slope of zero. According to one mechanism, amplitude thresholding is used to detect whether an identified turning point is likely the result of noise such that the turning point status of the data sample should be disregarded. After data samples are identified as turning points, ones of the identified turning points are identified as the “best” turning points to be selected for retention. The best turning points may be identified by determining which waveform segment included within a sample window has the largest change of amplitude. An alternative embodiment detects which of the turning points has the greatest signal amplitude compared to a reference value. Yet another embodiment selects as the best turning point that point having an amplitude that differs the most from the amplitude of the first data sample in the sample window. Still other embodiments retain the turning point having an amplitude which is more positive, or alternatively, more negative, than the other data samples. According to one aspect of the invention, the compression ratio varies based on the frequency of the input waveform. In another embodiment, position data is retained to indicate the relative position of retained data samples as compared to the position of other retained data samples. This position data may be calculated at a frequency that is less than the frequency of the sampled data.

公开(公告)号：US5987352A

公开(公告)日：1999-11-16

申请号：US33678

申请日：1998-03-03

申请人： George J. Klein ,  Dwight H. Warkentin ,  Kenneth M. Riff ,  Brian B. Lee ,  James K. Carney ,  Gregg Turi ,  Anthony J. Varrichio

发明人： George J. Klein ,  Dwight H. Warkentin ,  Kenneth M. Riff ,  Brian B. Lee ,  James K. Carney ,  Gregg Turi ,  Anthony J. Varrichio

IPC分类号： A61B5/0492 ,  A61B5/0404 ,  A61B5/0408 ,  A61B5/0478 ,  A61N1/375 ,  A61B5/0402

CPC分类号： A61N1/375

摘要： A minimally invasive implant, means for insertion, and description of how to most efficiently use it are described n several embodiments. This implant preferably has a segmented looping memory for storing triggered physiologic events. Preferred events for setting autotriggers to record physiologic signals occurring during events include arrhythmias and syncopal events. Preferably the device can function without a microprocessor. An outside device or other patient activated manual trigger is included. Auto triggers and manually set triggers may be of different sizes. The preferred physiologic events are ECG signals. Electrode spacing can be critical. Additional sensors may be provided to the device. Preferred communications with the device is through telemetry such as is used for pacemakers and other implanted devices.

摘要翻译： 在几个实施例中描述了微创植入物，用于插入的手段和如何最有效地使用它的描述。 该植入物优选地具有用于存储触发的生理事件的分段循环存储器。 设置自动跟踪器记录事件中发生的生理信号的首选事件包括心律失常和晕厥事件。 优选地，该装置可以在没有微处理器的情况下工作。 包括外部设备或其他患者激活的手动触发器。 自动触发器和手动设置触发器可能具有不同的大小。 优选的生理事件是ECG信号。 电极间距可能很重要。 可以向设备提供附加的传感器。 与设备的首选通信是通过诸如用于起搏器和其他植入设备的遥测。

公开(公告)号：US07912537B2

公开(公告)日：2011-03-22

申请号：US11380435

申请日：2006-04-27

申请人： Brian B. Lee ,  Eric J. Panken ,  Can Cinbis ,  Gerard J. Hill ,  John J. Grevious

发明人： Brian B. Lee ,  Eric J. Panken ,  Can Cinbis ,  Gerard J. Hill ,  John J. Grevious

IPC分类号： A61N1/06

CPC分类号： A61N1/37288 ,  A61N1/3611 ,  A61N1/36135 ,  A61N1/36585 ,  Y10S128/903

摘要： A physiological monitoring or therapy delivery system includes autonomous, wirelessly linked, implantable devices located at different areas to sense physiologic signals and deliver therapy. At least one of the implantable devices can trigger synchronized action (e.g. data capture or therapy delivery) by other implantable devices via a telemetry link.

摘要翻译： 生理监测或治疗递送系统包括位于不同区域的自主的，无线连接的可植入装置，以感测生理信号并递送治疗。 可植入装置中的至少一个可以经由遥测链路触发其它可植入装置的同步动作（例如数据捕获或治疗传递）。

公开(公告)号：US20110004265A1

公开(公告)日：2011-01-06

申请号：US12825798

申请日：2010-06-29

申请人： William K. Wenger ,  Paul G. Krause ,  William J. Plombon ,  Steven N. Lu ,  Sean B. McAdams ,  Brian B. Lee ,  Lee Stylos ,  Judy B. Salzer ,  G. Jordan Montgomery

发明人： William K. Wenger ,  Paul G. Krause ,  William J. Plombon ,  Steven N. Lu ,  Sean B. McAdams ,  Brian B. Lee ,  Lee Stylos ,  Judy B. Salzer ,  G. Jordan Montgomery

IPC分类号： A61N1/00

CPC分类号： A61N1/08 ,  A61B50/30 ,  A61B2050/0065 ,  A61N1/372 ,  A61N1/375 ,  A61N2001/37294

摘要： A system, comprising a sterilizable package; an implantable medical device placed inside the sterilizable package; and an electrical interface electrically coupled to the implantable medical device and extending from inside the sterilizable package to outside the sterilizable package. In various embodiments, the interface may include package contacts electrically coupled to electrode terminals on the implantable medical device, patient terminals and conductors extending between the package contacts and the patient terminals.

摘要翻译： 一种包括可灭菌包装的系统; 可植入医疗器械放置在可灭菌包装内; 以及电接口，其电耦合到所述可植入医疗装置并且从所述可灭菌包装内部延伸到所述可灭菌包装之外。 在各种实施例中，接口可以包括电耦合到可植入医疗装置上的电极端子的封装接点，在封装触点和患者端子之间延伸的患者端子和导体。

公开(公告)号：US06496715B1

公开(公告)日：2002-12-17

申请号：US09718689

申请日：2000-11-22

申请人： Brian B. Lee ,  Michael R. Kane ,  Eric J. Panken ,  James D. Reinke

发明人： Brian B. Lee ,  Michael R. Kane ,  Eric J. Panken ,  James D. Reinke

IPC分类号： A61B504

CPC分类号： A61N1/375

摘要： A system and method for determining the optimal positioning of an implantable system for sensing physiologic signals within a body. According to a one embodiment of the system, electrodes are positioned on an external surface of a body, and an ECG monitoring device is used to measure cardiac signals between various pairs of the electrodes. One or more of the electrodes may be re-positioned until an electrode pair position and orientation is located that provides a maximum signal reading. This position and orientation may then be used as the position and orientation in which to implant a corresponding device.

摘要翻译： 一种用于确定用于感测身体内的生理信号的可植入系统的最佳定位的系统和方法。 根据系统的一个实施例，电极定位在身体的外表面上，并且使用ECG监测装置来测量各对电极之间的心脏信号。 一个或多个电极可以被重新定位，直到位于提供最大信号读数的电极对位置和取向。 然后可以将该位置和取向用作植入相应装置的位置和取向。

公开(公告)号：US6163723A

公开(公告)日：2000-12-19

申请号：US177540

申请日：1998-10-22

申请人： Jonathan P. Roberts ,  Glenn M. Roline ,  Brian B. Lee

发明人： Jonathan P. Roberts ,  Glenn M. Roline ,  Brian B. Lee

IPC分类号： A61N1/365

CPC分类号： A61N1/36585

摘要： An implantable dual transducer apparatus for use with an implantable medical device and control method are disclosed. The dual transducer assembly includes two physiologic sensors coupled to the medical device via a pair of lead conductors. Switching circuitry is controlled by the medical device to selectively activate and deactivate the two physiologic sensors by application of a supply voltage of an appropriate polarity. Each sensor of the dual transducer assembly is connected to the pair of lead conductors through a respective power switch. In response to the polarity of the supply voltage applied to the lead conductors, the power switches activate or deactivate their respective sensor in an alternating manner. Selective activation of one of the sensor while concurrently deactivating the other sensor of the dual transducer assembly provides for reduced power consumption and reliable communication of sensor data and other information transmitted over the pair of lead conductors. The power switches may be constructed using diodes, including discrete or substrate diodes, or transistors, such as n-channel and p-channel transistors. A wide variety of physiologic sensors may be incorporated into the dual transducer assembly.

摘要翻译： 公开了一种用于可植入医疗装置和控制方法的可植入双传感器装置。 双传感器组件包括经由一对引线导体耦合到医疗装置的两个生理传感器。 切换电路由医疗设备控制，以通过施加适当极性的电源电压来选择性地激活和去激活两个生理传感器。 双传感器组件的每个传感器通过相应的电源开关连接到一对引线导体。 响应于施加到引线导体的电源电压的极性，功率开关以交替方式激活或去激活它们各自的传感器。 在同时禁用双重传感器组件的另一个传感器的同时，选择性地激活传感器之一，可以降低传感器数据和通过一对引线导体传输的其他信息的功耗和可靠的通信。 功率开关可以使用二极管构成，包括分立或衬底二极管，或晶体管，例如n沟道和p沟道晶体管。 可以将多种生理传感器并入双重换能器组件中。

公开(公告)号：US20120283705A1

公开(公告)日：2012-11-08

申请号：US13101613

申请日：2011-05-05

申请人： Brian B. Lee ,  Sara M. Hoeppner

发明人： Brian B. Lee ,  Sara M. Hoeppner

IPC分类号： A61B17/00

CPC分类号： A61N1/372 ,  A61B17/28 ,  A61B17/30 ,  A61B2017/00738 ,  A61B2017/305 ,  A61N1/37205 ,  A61N1/3756

摘要： A percutaneous delivery tool may be used to implant a medical device, for example, within a subcutaneous space. The percutaneous delivery tool may include a handle, first and second attachment members, and first and second connecting members connecting the attachment members to the handle. In some examples, the first and second attachment members are configured to receive the medical device such that the medical device is positioned between the attachment members. In some additional examples, the first and second connecting members are angled with respect to the handle, the first connecting member is angled with respect to the first attachment member, and the second connecting member is angled with respect to the second attachment member.

摘要翻译： 可以使用经皮递送工具来植入医疗装置，例如在皮下空间内。 经皮递送工具可以包括手柄，第一和第二附接构件以及将附接构件连接到手柄的第一和第二连接构件。 在一些示例中，第一和第二附接构件构造成接收医疗装置，使得医疗装置位于附接构件之间。 在一些附加示例中，第一和第二连接构件相对于手柄成一定角度，第一连接构件相对于第一附接构件成角度，并且第二连接构件相对于第二附接构件成角度。

公开(公告)号：US20080188764A1

公开(公告)日：2008-08-07

申请号：US11554275

申请日：2006-10-30

申请人： Brian B. Lee ,  Eric J. Panken

发明人： Brian B. Lee ,  Eric J. Panken

IPC分类号： A61B5/04

CPC分类号： A61B5/046 ,  A61B5/02405 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/395

摘要： A method and apparatus for detecting atrial arrhythmias include acquiring a cardiac signal comprising R-waves. Differences between pairs of consecutive R-R intervals occurring during a first time interval are computed from the cardiac signal. An atrial arrhythmia is detected subsequent to the first time interval in response to the computed differences. Storage of the cardiac signal is triggered in response to the atrial arrhythmia detection.

摘要翻译： 用于检测心房心律失常的方法和装置包括获取包括R波的心脏信号。 从心脏信号计算在第一时间间隔期间发生的连续R-R间隔对之间的差异。 响应于所计算的差异，在第一时间间隔之后检测心房心律失常。 响应于心房心律失常检测触发心脏信号的存储。

公开(公告)号：US07035684B2

公开(公告)日：2006-04-25

申请号：US10376062

申请日：2003-02-26

申请人： Brian B. Lee

发明人： Brian B. Lee

IPC分类号： A61B5/04

CPC分类号： A61N1/36514 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/0452 ,  A61B5/7232 ,  A61N1/05 ,  A61N1/3702

摘要： A minimally invasive, implantable monitor and associated method for chronically monitoring a patient's hemodynamic function based on signals sensed by one or more acoustical sensors. The monitor may be implanted subcutaneously or submuscularly in relation to the heart to allow acoustic signals generated by heart or blood motion to be received by a passive or active acoustical sensor. Circuitry for filtering and amplifying and digitizing acoustical data is included, and sampled data may be continuously or intermittently written to a looping memory buffer. ECG electrodes and associated circuitry may be included to simultaneously record ECG data. Upon a manual or automatic trigger event acoustical and ECG data may be stored in long-term memory for future uploading to an external device. The external device may present acoustical data visually and acoustically with associated ECG data to allow interpretation of both electrical and mechanical heart function.

摘要翻译： 基于由一个或多个声学传感器感测到的信号的用于长期监测患者血液动力学功能的微创可植入监测器和相关方法。 监测器可以相对于心脏皮下或肌肉下植入，以允许由心脏或血液运动产生的声信号由被动或主动声学传感器接收。 包括用于滤波和放大和数字化声学数据的电路，并且采样数据可以被连续地或间歇地写入循环存储器缓冲器。 可以包括ECG电极和相关联的电路以同时记录ECG数据。 在手动或自动触发事件中，声学和ECG数据可以存储在长期存储器中，以便将来上传到外部设备。 外部设备可以使用相关的ECG数据在视觉和声学上呈现声学数据，以允许解释电和机械心脏功能。