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1.发明申请公开(公告)号：US20070087403A1
公开(公告)日：2007-04-19
申请号：US10577084
申请日：2004-11-05
申请人： Gwénaëlle Bestel-Corre , Cedric Boisart , Michel Chateau , Benjamin Gonzalez , Philippe Soucaille , Rainer Figge , Olivier Zink
发明人： Gwénaëlle Bestel-Corre , Cedric Boisart , Michel Chateau , Benjamin Gonzalez , Philippe Soucaille , Rainer Figge , Olivier Zink
IPC分类号： C12P33/00 , C12P19/62 , C12P13/04 , C12P17/00 , C12P7/64 , C12P7/40 , C12N15/74 , C12N1/21 , C12N1/18
CPC分类号： C12N9/0036 , C12N9/92 , C12P7/18 , C12P13/005 , C12P13/04 , C12P33/16
摘要： The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Said strains are characterised in that one or more NADPH-oxidising activities are limited.
摘要翻译： 本发明涉及用于生物转化产生具有NADPH消耗生物合成途径的分子的优化的微生物菌株。 本发明的菌株可用于NADPH消费的生物转化方法中。 所述菌株的特征在于一个或多个NADPH氧化活性受到限制。
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公开(公告)号：US08795990B2
公开(公告)日：2014-08-05
申请号：US11579907
申请日：2005-05-12
CPC分类号： C12N9/1029
摘要： The present invention relates to the use of recombinant homoserine transsuccinylase enzymes with altered feedback sensitivity (MetA*) and possibly recombinant S-adenosyl methionine synthetase enzymes with reduced activity (MetK*) for the production of methionine, its precursors or derivatives thereof.
摘要翻译： 本发明涉及具有改变的反馈敏感性（MetA *）的重组高丝氨酸跨琥珀酰酶和可能具有降低的活性（MetK *）的重组S-腺苷甲硫氨酸合成酶用于产生甲硫氨酸，其前体或衍生物的用途。
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公开(公告)号：US08748136B2
公开(公告)日：2014-06-10
申请号：US12370422
申请日：2009-02-12
CPC分类号： C12P13/12
摘要： The present invention relates to a method for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulphur. The microorganism and/or the culture medium and/or the process parameters were modified in a way that the accumulation of the by-product N-acyl-methionine (NAM) is reduced. The isolation of methionine or its derivatives from the fermentation medium is also claimed.
摘要翻译： 本发明涉及通过在包含碳源和硫源的适当培养基中培养微生物来生产甲硫氨酸或其衍生物的方法。 微生物和/或培养基和/或工艺参数以副产物N-酰基 - 甲硫氨酸（NAM）的积累减少的方式进行修饰。 也要求从发酵培养基中分离甲硫氨酸或其衍生物。
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4.发明授权Optimised micro-organism strains for NADPH-consuming biosynthetic pathways 有权用于NADPH消耗生物合成途径的优化微生物菌株公开(公告)号：US08088620B2
公开(公告)日：2012-01-03
申请号：US10577084
申请日：2004-11-05
申请人： Gwénaëlle Bestel-Corre , Cédric Boisart , Michel Chateau , Benjamin Gonzalez , Philippe Soucaille , Rainer Figge , Olivier Zink
发明人： Gwénaëlle Bestel-Corre , Cédric Boisart , Michel Chateau , Benjamin Gonzalez , Philippe Soucaille , Rainer Figge , Olivier Zink
CPC分类号： C12N9/0036 , C12N9/92 , C12P7/18 , C12P13/005 , C12P13/04 , C12P33/16
摘要： The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Said strains are characterized in that one or more NADPH-oxidizing activities are limited.
摘要翻译： 本发明涉及用于生物转化产生具有NADPH消耗生物合成途径的分子的优化的微生物菌株。 本发明的菌株可用于NADPH消费生物转化方法。 所述菌株的特征在于限制了一种或多种NADPH氧化活性。
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公开(公告)号：US09121043B2
公开(公告)日：2015-09-01
申请号：US13704578
申请日：2011-06-15
申请人： Wanda Dischert , Rainer Figge , Philippe Soucaille
发明人： Wanda Dischert , Rainer Figge , Philippe Soucaille
CPC分类号： C12P7/42 , C12N15/635 , C12N15/70
摘要： The present invention relates to use of inducible promoters in the production of glycolic acid by fermentation. The present invention concerns a method for the production of glycolic acid in a fermentative process comprising the following steps: culturing a modified microorganism in an appropriate culture medium comprising a source of carbon, modulating in said microorganism the expression of a target gene with an external stimulus, and recovering glycolic acid from the culture medium, wherein in said modified microorganism, the expression of at least one gene involved in glycolic acid production is under the control of a heterologous inducible promoter whose activity is modulated with said external stimulus. The invention also concerned the modified microorganism used in the method of glycolic acid production.
摘要翻译： 本发明涉及通过发酵在诱导型促进剂生产乙醇酸中的用途。 本发明涉及在发酵方法中生产乙醇酸的方法，包括以下步骤：在包含碳源的适当培养基中培养经修饰的微生物，在所述微生物中调节靶基因与外部刺激物的表达 并从培养基中回收乙醇酸，其中在所述修饰的微生物中，参与乙醇酸生产的至少一个基因的表达在异源诱导型启动子的控制下，其活性用所述外部刺激调节。 本发明还涉及用于乙醇酸生产方法中的改性微生物。
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公开(公告)号：US20100047879A1
公开(公告)日：2010-02-25
申请号：US12370422
申请日：2009-02-12
IPC分类号： C12P13/12
CPC分类号： C12P13/12
摘要： The present invention relates to a method for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulphur. The microorganism and/or the culture medium and/or the process parameters were modified in a way that the accumulation of the by-product N-acyl-methionine (NAM) is reduced. The isolation of methionine or its derivatives from the fermentation medium is also claimed.
摘要翻译： 本发明涉及通过在包含碳源和硫源的适当培养基中培养微生物来生产甲硫氨酸或其衍生物的方法。 微生物和/或培养基和/或工艺参数以副产物N-酰基 - 甲硫氨酸（NAM）的积累减少的方式进行修饰。 也要求从发酵培养基中分离甲硫氨酸或其衍生物。
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公开(公告)号：US20090029424A1
公开(公告)日：2009-01-29
申请号：US11579907
申请日：2005-05-12
CPC分类号： C12N9/1029
摘要： The present invention relates to the use of recombinant homoserine transsuccinylase enzymes with altered feedback sensitivity (MetA*) and possibly recombinant S-adenosyl methionine synthetase enzymes with reduced activity (MetK*) for the production of methionine, its precursors or derivatives thereof.
摘要翻译： 本发明涉及具有改变的反馈敏感性（MetA *）的重组高丝氨酸跨琥珀酰酶和可能具有降低的活性（MetK *）的重组S-腺苷甲硫氨酸合成酶用于产生甲硫氨酸，其前体或衍生物的用途。
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公开(公告)号：US20130089903A1
公开(公告)日：2013-04-11
申请号：US13704578
申请日：2011-06-15
申请人： Wanda Dischert , Rainer Figge , Philippe Soucaille
发明人： Wanda Dischert , Rainer Figge , Philippe Soucaille
CPC分类号： C12P7/42 , C12N15/635 , C12N15/70
摘要： The present invention relates to use of inducible promoters in the production of glycolic acid by fermentation. The present invention concerns a method for the production of glycolic acid in a fermentative process comprising the following steps: culturing a modified microorganism in an appropriate culture medium comprising a source of carbon, modulating in said microorganism the expression of a target gene with an external stimulus, and recovering glycolic acid from the culture medium, wherein in said modified microorganism, the expression of at least one gene involved in glycolic acid production is under the control of a heterologous inducible promoter whose activity is modulated with said external stimulus. The invention also concerned the modified microorganism used in the method of glycolic acid production.
摘要翻译： 本发明涉及通过发酵在诱导型促进剂生产乙醇酸中的用途。 本发明涉及在发酵方法中生产乙醇酸的方法，包括以下步骤：在包含碳源的适当培养基中培养经修饰的微生物，在所述微生物中调节靶基因与外部刺激物的表达 并从培养基中回收乙醇酸，其中在所述修饰的微生物中，参与乙醇酸生产的至少一个基因的表达在异源诱导型启动子的控制下，其活性用所述外部刺激调节。 本发明还涉及用于乙醇酸生产方法中的改性微生物。
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9.发明申请公开(公告)号：US20080286840A1
公开(公告)日：2008-11-20
申请号：US11883903
申请日：2006-02-07
摘要： A microorganism in which enzymes are expressed that have one or several of the following activities cystathionine-γ-synthases and/or phosphohomoserine sulfhydrylase and/or acylhomoserine sulfhydrylases and that have at the same time low γ-elimination activity is disclosed and also relates to recombinant enzymes that have one or several of the following activities cystathionine-γ-synthase and/or phosphohomoserine and/or acylhomoserine sulfhydrylase, have at the same time low γ-eliminase activity and are used for the fermentative production of amino acids, in particular, methionine.
摘要翻译： 公开了具有一个或几个以下活性的酶的微生物，其具有胱硫醚-γ-合酶和/或磷酸高丝氨酸巯基酯酶和/或酰基高丝氨酸巯基化酶，并且同时具有低的γ-消除活性，并且还涉及重组 具有一个或几个以下活性的胱氨酸-γ-合酶和/或磷酸高丝氨酸和/或酰基高丝氨酸巯基酸酶的酶同时具有低的γ-消除酶活性，并且用于发酵生产氨基酸，特别是甲硫氨酸 。
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10.发明申请Process for the Preparation of a Aspartate and Derived Amino Acids Like Lysine, Threonine, Isoleucine, Methionine, or Homoserine Employing Microorganism with Enhanced Isocitrate Lyase and/or Malate Synthase Expression 审中-公开用赖氨酸，苏氨酸，异亮氨酸，甲硫氨酸或高丝氨酸制备天冬氨酸和衍生的氨基酸的方法，其使用具有增强的异柠檬酸裂解酶和/或苹果酸合酶表达的微生物公开(公告)号：US20080233617A1
公开(公告)日：2008-09-25
申请号：US11997732
申请日：2006-08-11
IPC分类号： C12P13/20
摘要： The present invention relates to increasing the product of aspartate or aspartate-derived metabolites by boosting the activity of the glyoxylate shunt. This is accomplished by increasing the activity of glyoxylate shunt specific enzymes and decreasing the activity of reactions consuming glyoxylate and its precursors.
摘要翻译： 本发明涉及通过提高乙醛酸分流的活性来增加天冬氨酸或天冬氨酸衍生的代谢产物的产物。 这通过增加乙醛酸分流特异性酶的活性并降低消耗乙醛酸及其前体的反应的活性来实现。
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