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1.发明申请Diagnostic and therapeutic use of F-box proteins for Alzheimer's disease and related neurodegenerative disorders 审中-公开F-box蛋白对阿尔茨海默氏病和相关神经退行性疾病的诊断和治疗应用公开(公告)号：US20070199080A1
公开(公告)日：2007-08-23
申请号：US11703215
申请日：2007-02-07
IPC分类号： A01K67/027 , C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/06 , A61K38/17 , C07K14/705 , C12N5/06
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2821
摘要： The present invention discloses the differential expression of the gene coding for F-box and leucine-rich repeat protein FBL2 in specific brain regions of Alzheimer's disease patients. Based on this finding, the invention provides a method for diagnosing or prognosticating Alzheimer's disease in a subject, or for determining whether a subject is at increased risk of developing Alzheimer's disease. Furthermore, the invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using a gene coding for an F-box and leucine-rich repeat protein, in particular FBL2. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
摘要翻译： 本发明公开了在阿尔茨海默病患者的特定脑区域中编码F盒和富含亮氨酸的重复蛋白FBL2的基因的差异表达。 基于这一发现，本发明提供了一种在受试者中诊断或预测阿尔茨海默病的方法，或用于确定受试者是否处于发展为阿尔茨海默氏病的风险增加的方法。 此外，本发明提供使用编码F盒和富含亮氨酸重复蛋白的基因，特别是FBL2来治疗或预防阿尔茨海默氏病和相关的神经变性疾病的治疗和预防方法。 还公开了筛选神经变性疾病调节剂的方法。
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2.发明申请Diagnostic and therapeutic use of a voltage-gated ion channel scn2a for neurodegenerative diseases 审中-公开诊断和治疗使用电压门控离子通道scn2a用于神经变性疾病公开(公告)号：US20060088827A1
公开(公告)日：2006-04-27
申请号：US10501814
申请日：2003-01-16
IPC分类号： C12Q1/68 , G01N33/567 , G01N33/53 , C07K14/705 , C07K16/28 , A01K67/00
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2267/025 , A01K2267/0312 , A61K38/00 , A61K48/00 , A61K49/0008 , C07K14/705 , G01N33/6872 , G01N33/6896 , G01N2333/705 , G01N2500/10 , G01N2800/28 , G01N2800/2821
摘要： The present invention discloses the differential expression of the gene coding for the voltage-gated ion channel SCN2A in specific brain regions of Alzheimers disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer s disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer s disease and related neurodegenerative disorders using the voltage-gated ion channel gene SCN2A and its corresponding gene products. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
摘要翻译： 本发明公开了在阿尔茨海默病患者的特定脑区域中编码电压门控离子通道SCN2A的基因的差异表达。 基于这一发现，本发明提供了用于诊断或预测受试者中的神经变性疾病，特别是阿尔茨海默氏病，或用于确定受试者是否处于发展该疾病的风险增加的方法。 此外，本发明提供使用电压门控离子通道基因SCN2A及其相应基因产物治疗或预防阿尔茨海默氏病和相关神经变性疾病的治疗和预防方法。 还公开了筛选神经变性疾病调节剂的方法。
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3.发明申请Camp-regulated phosphoprotein for diagnostic and therapeutic use in neurodegenerative diseases 审中-公开营养调节磷蛋白用于诊断和治疗用于神经退行性疾病公开(公告)号：US20060024305A1
公开(公告)日：2006-02-02
申请号：US10509950
申请日：2003-04-01
CPC分类号： C07K14/47 , C07K16/18 , C12Q1/6883 , C12Q2600/158 , G01N33/6896 , G01N2800/28 , G01N2800/2821
摘要： The present invention discloses a novel nucleic acid molecule encoding hTARPP. Further, the present invention discloses the differential expression of hTARPP in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the gene coding for hTARPP. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
摘要翻译： 本发明公开了一种编码hTARPP的新型核酸分子。 此外，本发明公开了在阿尔茨海默病患者的特定脑区中hTARPP的差异表达。 基于这一发现，本发明提供了用于诊断或预测神经变性疾病，特别是阿尔茨海默氏病或用于确定受试者是否处于发展该疾病的风险增加的方法。 此外，本发明提供使用编码hTARPP的基因治疗或预防阿尔茨海默病和相关神经变性疾病的治疗和预防方法。 还公开了筛选神经变性疾病调节剂的方法。
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4.发明申请公开(公告)号：US20060160728A1
公开(公告)日：2006-07-20
申请号：US10512466
申请日：2003-04-25
IPC分类号： A61K38/54 , C12Q1/68 , G01N33/567
CPC分类号： G01N33/6896 , C07K14/4711 , C12Q1/6883 , C12Q2600/158 , G01N2500/00 , G01N2800/28 , G01N2800/2821
摘要： The present invention discloses the differential expression of a gene coding for Ensadin-0138 in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the Ensadin-0138 gene and its corresponding gene products. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
摘要翻译： 本发明公开了在阿尔茨海默病患者的特定脑区域中编码Ensadin-0138的基因的差异表达。 基于这一发现，本发明提供了用于诊断或预测受试者中的神经变性疾病，特别是阿尔茨海默氏病，或用于确定受试者是否处于发展该疾病的风险增加的方法。 此外，本发明提供了使用Ensadin-0138基因及其相应基因产物治疗或预防阿尔茨海默氏病和相关神经变性疾病的治疗和预防方法。 还公开了筛选神经变性疾病调节剂的方法。
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5.发明申请Diagnostic and therapeutic use of an activator protein for vesicle secretion for neurodegenerative diseases 审中-公开用于神经变性疾病的活化蛋白用于囊泡分泌的诊断和治疗用途公开(公告)号：US20050214763A1
公开(公告)日：2005-09-29
申请号：US10504570
申请日：2003-02-14
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N2800/28 , G01N2800/2821
摘要： The present invention discloses the differential expression of the activator protein for vesicle secretion CAPS gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using a gene coding for an activator protein for vesicle secretion, in particular the CAPS gene and its corresponding gene products. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
摘要翻译： 本发明公开了阿尔茨海默病患者特定脑区域中囊泡分泌CAPS基因激活蛋白的差异表达。 基于这一发现，本发明提供了用于诊断或预测受试者中的神经变性疾病，特别是阿尔茨海默氏病，或用于确定受试者是否处于发展该疾病的风险增加的方法。 此外，本发明提供使用编码囊泡分泌的活化蛋白的基因，特别是CAPS基因及其相应的基因产物来治疗或预防阿尔茨海默氏病和相关的神经变性疾病的治疗和预防方法。 还公开了筛选神经变性疾病调节剂的方法。
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6.发明申请Diagnostic and therapeutic use of ma onconeuronal antigents for neurodegenerative diseases 审中-公开诊断和治疗用于神经退行性疾病的马可酮类抗生素公开(公告)号：US20050106569A1
公开(公告)日：2005-05-19
申请号：US10504329
申请日：2003-02-26
CPC分类号： C07K16/32 , A61K38/00 , C12Q1/6883 , C12Q2600/158 , G01N33/6896 , G01N2500/00 , G01N2800/28 , G01N2800/2821
摘要： The present invention discloses the differential expression of the onconeuronal antigen Ma2 gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using a gene coding for an onconeuronal antigen, in particular Ma2 onconeuronal antigen. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
摘要翻译： 本发明公开了阿尔茨海默氏病患者特异性脑区域中抗肿瘤抗原Ma2基因的差异表达。 基于这一发现，本发明提供了用于诊断或预测受试者中的神经变性疾病，特别是阿尔茨海默氏病，或用于确定受试者是否处于发展该疾病的风险增加的方法。 此外，本发明提供了治疗和预防阿尔茨海默氏病和相关神经退行性疾病的治疗和预防方法，该方法使用编码癌基因抗原的基因，特别是Ma2癌基因抗原。 还公开了筛选神经变性疾病调节剂的方法。
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公开(公告)号：US20050176930A1
公开(公告)日：2005-08-11
申请号：US10515477
申请日：2003-05-16
申请人： Johannes Coy , Rainer Hipfel , Birgit Wasser
发明人： Johannes Coy , Rainer Hipfel , Birgit Wasser
IPC分类号： A01K67/027 , A61K35/76 , A61K38/00 , A61K45/00 , A61K48/00 , A61P31/00 , A61P35/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574 , C07K14/82 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to nucleic acids and polypeptides associated with lung cancer. The invention is more specifically related to a nucleic acids and the polypeptides transcribed thereof, the expression of which is significantly altered in association with lung cancer. The invention relates to a series of differentially spliced transcripts of the gene disclosed herein, that are associated with tumors of the respiratory tract. Furthermore the present invention provides a method for early diagnosis, prognosis and monitoring of the disease course and for therapy and vaccination of cell proliferative disorders such as e.g. lung tumors.
摘要翻译： 本发明涉及与肺癌相关的核酸和多肽。 本发明更具体地涉及核酸和转录的多肽，其表达与肺癌相关显着改变。 本发明涉及与本文所公开的基因的一系列差异拼接的转录本，其与呼吸道的肿瘤相关。 此外，本发明提供了一种用于早期诊断，预后和监测疾病进程以及用于治疗和接种细胞增殖性疾病的方法，所述方法包括： 肺肿瘤。
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公开(公告)号：US07883896B2
公开(公告)日：2011-02-08
申请号：US12050002
申请日：2008-03-17
申请人： Johannes Coy , Rainer Hipfel , Birgit Wasser
发明人： Johannes Coy , Rainer Hipfel , Birgit Wasser
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to nucleic acids and polypeptides associated with lung cancer. The invention is more specifically related to a nucleic acids and the polypeptides transcribed thereof, the expression of which is significantly altered in association with lung cancer. The invention relates to a series of differentially spliced transcripts of the gene disclosed herein, that are associated with tumors of the respiratory tract. Furthermore the present invention provides a method for early diagnosis, prognosis and monitoring of the disease course and for therapy and vaccination of cell proliferative disorders such as e.g. lung tumors.
摘要翻译： 本发明涉及与肺癌相关的核酸和多肽。 本发明更具体地涉及核酸和转录的多肽，其表达与肺癌相关显着改变。 本发明涉及与本文所公开的基因的一系列差异拼接的转录本，其与呼吸道的肿瘤相关。 此外，本发明提供了一种用于早期诊断，预后和监测疾病进程以及用于治疗和接种细胞增殖性疾病的方法，所述方法包括： 肺肿瘤。
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9.发明申请公开(公告)号：US20070190529A1
公开(公告)日：2007-08-16
申请号：US10569758
申请日：2004-08-20
申请人： Ruediger Ridder , Anja Reichert , Magnus Von Knebel Doeberitz , Matthias Herkert , Alexander Duwe , Rainer Hipfel , Peter Martin
发明人： Ruediger Ridder , Anja Reichert , Magnus Von Knebel Doeberitz , Matthias Herkert , Alexander Duwe , Rainer Hipfel , Peter Martin
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57484 , G01N33/57411 , Y10T436/25
摘要： The present invention relates to a method for the early diagnosis of neoplastic disorders such as cancers as well as their precursor stages, particularly cancers of the respiratory tract, the urinary system, the reproductive tract, cancer associated with HPV infection or cancer of the anogenital tract, from solubilized body samples. The invention is also directed to test kits usable for this purpose as well as in-vitro diagnostic devices. The development of the kits and in-vitro diagnostic devices for the above purpose is also one aspect of the present invention.
摘要翻译： 本发明涉及一种用于早期诊断肿瘤性疾病如癌症及其前体阶段的方法，特别是呼吸道癌症，泌尿系统，生殖道，与HPV感染有关的癌症或肛门生殖道癌症 ，来自溶解的身体样品。 本发明还涉及可用于该目的的测试试剂盒以及体外诊断装置。 用于上述目的的试剂盒和体外诊断装置的开发也是本发明的一个方面。
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10.发明授权公开(公告)号：US07932047B2
公开(公告)日：2011-04-26
申请号：US10569758
申请日：2004-08-20
申请人： Ruediger Ridder , Anja Reichert , Magnus Von Knebel Doeberitz , Matthias Herkert , Alexander Duwe , Rainer Hipfel , Peter Martin
发明人： Ruediger Ridder , Anja Reichert , Magnus Von Knebel Doeberitz , Matthias Herkert , Alexander Duwe , Rainer Hipfel , Peter Martin
IPC分类号： C12Q1/00 , G01N1/00 , G01N21/00 , G01N21/75 , G01N21/76 , G01N33/00 , G01N33/48 , G01N33/53 , G01N33/566 , G01N33/567 , G01N33/574 , C12P21/08
CPC分类号： G01N33/57484 , G01N33/57411 , Y10T436/25
摘要： The present invention relates to a method for the early diagnosis of neoplastic disorders such as cancers as well as their precursor stages, particularly cancers of the respiratory tract, the urinary system, the reproductive tract, cancer associated with HPV infection or cancer of the anogenital tract, from solubilized body samples. The invention is also directed to test kits usable for this purpose as well as in-vitro diagnostic devices. The development of the kits and in-vitro diagnostic devices for the above purpose is also one aspect of the present invention.
摘要翻译： 本发明涉及一种用于早期诊断肿瘤性疾病如癌症及其前体阶段的方法，特别是呼吸道癌症，泌尿系统，生殖道，与HPV感染有关的癌症或肛门生殖道癌症 ，来自溶解的身体样品。 本发明还涉及可用于该目的的测试试剂盒以及体外诊断装置。 用于上述目的的试剂盒和体外诊断装置的开发也是本发明的一个方面。
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