-
公开(公告)号：US09625475B2
公开(公告)日：2017-04-18
申请号：US12727723
申请日：2010-03-19
申请人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号： A61K31/55 , C07D487/00 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00 , G01N33/68 , C07D471/18 , C07D487/10 , G01N33/50
CPC分类号： G01N33/6896 , C07D471/18 , C07D487/10 , G01N33/5058 , G01N2800/2814 , G01N2800/30
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
-
公开(公告)号：US08383657B2
公开(公告)日：2013-02-26
申请号：US12338849
申请日：2008-12-18
IPC分类号： A61K31/427 , C07D277/04 , C07D277/12
CPC分类号： C07D277/18 , C07D401/02 , C07D417/02 , C07D417/14
摘要： The invention relates to novel thiazolylidine urea and amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
摘要翻译： 本发明涉及作为神经元烟碱性受体的PAM的新型噻唑烷脲和酰胺衍生物，包含其的组合物，制备这些化合物的方法，以及使用这些化合物和组合物的方法。
-
公开(公告)号：US20090221648A1
公开(公告)日：2009-09-03
申请号：US12338865
申请日：2008-12-18
申请人： Lynne E. Rueter , Gerald B. Fox , Kaitlin E. Browman , James P. Sullivan , Jorge D. Brioni , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Kathleen H. Mortell , Murali Gopalakrishnan
发明人： Lynne E. Rueter , Gerald B. Fox , Kaitlin E. Browman , James P. Sullivan , Jorge D. Brioni , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Kathleen H. Mortell , Murali Gopalakrishnan
IPC分类号： A61K31/465 , A61P25/00
CPC分类号： A61K45/06 , A61K31/465 , A61K2300/00
摘要： The present invention relates to compositions for treatment of cognitive deficits. Such compositions can have a nicotinic acetylcholine receptor ligand, of either α4β2 subtype or α7 nicotinic acetylcholine subtype, and a histamine-3 receptor ligand, a method of using the same, and a related article of manufacture. Combinations of such active agents with psychostimulants or monoamine reuptake inhibitors also is contemplated.
摘要翻译： 本发明涉及用于治疗认知缺陷的组合物。 这样的组合物可以具有α4β2亚型或α7烟碱型乙酰胆碱亚型的烟碱型乙酰胆碱受体配体和组胺3受体配体，使用该配体的方法和相关的制造方法。 也考虑了这些活性剂与精神兴奋剂或单胺再摄取抑制剂的组合。
-
公开(公告)号：US20100249105A1
公开(公告)日：2010-09-30
申请号：US12727723
申请日：2010-03-19
申请人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号： A61K31/55 , A61P25/28 , A61P25/16 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/02 , C07D487/04 , A61K31/439 , C07D471/00
CPC分类号： G01N33/6896 , C07D471/18 , C07D487/10 , G01N33/5058 , G01N2800/2814 , G01N2800/30
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
-
公开(公告)号：US20100087471A1
公开(公告)日：2010-04-08
申请号：US12568085
申请日：2009-09-28
申请人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号： A61K31/439 , C12Q1/02 , C07D471/08
CPC分类号： G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译： 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
-
公开(公告)号：US09063126B2
公开(公告)日：2015-06-23
申请号：US12568085
申请日：2009-09-28
申请人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号： A61K31/439 , C07D471/08 , G01N33/50 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/68
CPC分类号： G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译： 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
-
公开(公告)号：US20090163470A1
公开(公告)日：2009-06-25
申请号：US12338849
申请日：2008-12-18
IPC分类号： A61K31/427 , C07D277/18 , A61K31/426 , A61K31/5377 , A61K31/497 , C12Q1/02 , C07D417/14 , C07D417/02 , A61K31/454 , C07D401/02
CPC分类号： C07D277/18 , C07D401/02 , C07D417/02 , C07D417/14
摘要： The invention relates to novel thiazolylidine urea and amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
摘要翻译： 本发明涉及作为神经元烟碱性受体的PAM的新型噻唑烷脲和酰胺衍生物，包含其的组合物，制备这些化合物的方法，以及使用这些化合物和组合物的方法。
-
公开(公告)号：US20100216748A1
公开(公告)日：2010-08-26
申请号：US12775735
申请日：2010-05-07
申请人： Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
发明人： Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
IPC分类号： A61K31/655 , C07D207/34 , A61K31/402 , A61P25/28 , A61P29/00 , A61P25/34 , A61P17/02 , A61P19/02 , A61P37/06 , A61P1/04 , A61P25/24 , A61P25/18 , C07D405/10 , A61K31/4025 , C07D409/10 , C07D401/10 , A61K31/4439 , C07D413/10 , A61K31/5377 , C07D403/12 , A61K31/454 , C12Q1/02
CPC分类号： C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
摘要： The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及一系列取代的吡咯衍生物，包含其的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
-
公开(公告)号：US07741364B2
公开(公告)日：2010-06-22
申请号：US11769395
申请日：2007-06-27
申请人： Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
发明人： Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
IPC分类号： A01N43/36
CPC分类号： C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
摘要： The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及一系列取代的吡咯衍生物，包含其的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。
-
公开(公告)号：US08609713B2
公开(公告)日：2013-12-17
申请号：US12775735
申请日：2010-05-07
申请人： Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
发明人： Ramin Faghih , Gregory A. Gfesser , Christopher L. Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl J. Gubbins , Rachid El Kouhen , Jinhe Li
IPC分类号： A61K31/40 , C07D207/30
CPC分类号： C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
摘要： The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及一系列取代的吡咯衍生物，包含其的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。
-
-
-
-
-
-
-
-
-
搜索结果
39 条记录 (耗时 0.031 秒)
