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    Plasma concentrator device
    2.
    发明授权
    Plasma concentrator device 有权
    等离子体浓缩装置

    公开(公告)号：US07553413B2

    公开(公告)日：2009-06-30

    申请号：US11342982

    申请日：2006-01-30

    申请人： Randel Dorian ,  Michael D. Leach ,  Richard Wood Storrs

    发明人： Randel Dorian ,  Michael D. Leach ,  Richard Wood Storrs

    IPC分类号： B01D15/02 ,  B01D24/00 ,  B01D29/00

    CPC分类号： A61M1/3679 ,  A61M1/0204 ,  A61M1/3693 ,  A61M2202/0415 ,  Y10T436/25375 ,  Y10T436/255

    摘要： A plasma concentrator of this invention having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator has agitator blades extending outwardly from the lower end. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. The concentrator has a top with an upper opening through which the upper end of the actuator stem extends, and a lower opening in which the filter is positioned. The concentrator chamber can have a cylindrical inner wall, and the agitator blades can have an outer edge in close proximity to the inner wall with the space between the outer edge and the inner wall being less than the diameter of the gel beads. The filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. The method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. The plasma is introduced into a concentration chamber containing a plurality of dehydrated concentrator gel beads and an agitator. Then water is removed from the plasma while stirring the beads to reduce plasma polarization and breaking up clumps of beads that form during the agitation. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.

    摘要翻译： 本发明的等离子体浓缩器具有浓缩器室，浓缩器凝胶珠，过滤器和搅拌器。 搅拌器具有从下端向外延伸的搅拌器叶片。 搅拌器端部定位在聚光器室中并被支撑以围绕其中心轴线旋转并且用于沿其中心轴线往复运动。 集中器具有顶部，其具有上部开口，致动器杆的上端延伸穿过该上部开口，以及下部开口，过滤器定位在该开口中。 浓缩器室可以具有圆柱形内壁，并且搅拌器叶片可以具有紧邻内壁的外边缘，外边缘和内壁之间的空间小于凝胶珠的直径。 选择过滤器以在环境重力条件下阻止等离子体的有效流动，并允许等离子体和等离子体浓缩物在分离重力的离心力下流过其中。 该方法通过除去水而不使血浆中的纤维蛋白原显着变性来浓缩血浆。 将等离子体引入含有多个脱水浓缩器凝胶珠和搅拌器的浓缩室中。 然后在搅拌珠子的同时从等离子体中除去水，以减少等离子极化并破坏在搅拌过程中形成的珠粒团块。 然后可以将离心力施加到浓缩的等离子体中，其量足以将大部分等离子体浓缩物与珠粒分离。

    Plasma Concentrator Device
    3.
    发明申请
    Plasma Concentrator Device 有权
    等离子集中器

    公开(公告)号：US20090236297A1

    公开(公告)日：2009-09-24

    申请号：US12476838

    申请日：2009-06-02

    申请人： Randel Dorian ,  Michael D. Leach ,  Richard Wood Storrs

    发明人： Randel Dorian ,  Michael D. Leach ,  Richard Wood Storrs

    IPC分类号： B01D33/27

    CPC分类号： A61M1/3679 ,  A61M1/0204 ,  A61M1/3693 ,  A61M2202/0415 ,  Y10T436/25375 ,  Y10T436/255

    摘要： A plasma concentrator having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. A filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. A method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.

    摘要翻译： 具有浓缩器室，浓缩器凝胶珠，过滤器和搅拌器的等离子体浓缩器。 搅拌器端部定位在聚光器室中并被支撑以围绕其中心轴线旋转并且用于沿其中心轴线往复运动。 选择过滤器以阻止等离子体在环境重力条件下的有效流动，并允许等离子体和等离子体浓缩物在分离重力的离心力下流过其中。 方法通过除去水而不使血浆中的纤维蛋白原显着变性来浓缩血浆。 然后可以将离心力施加到浓缩的等离子体中，其量足以将大部分等离子体浓缩物与珠粒分离。

    Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone
    4.
    发明授权
    Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone 有权
    骨移植组合物，其包含骨材料和包含变性脱矿质骨的载体

    公开(公告)号：US07670384B2

    公开(公告)日：2010-03-02

    申请号：US11407409

    申请日：2006-04-19

    申请人： Mukesh Kumar ,  Ned M. Hamman ,  Michael D. Leach ,  John Manocchio ,  Paul D'Antonio ,  Daryl L. Carter

    发明人： Mukesh Kumar ,  Ned M. Hamman ,  Michael D. Leach ,  John Manocchio ,  Paul D'Antonio ,  Daryl L. Carter

    IPC分类号： A61F2/28 ,  A61K35/32

    CPC分类号： A61L27/365 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/3691 ,  A61L2430/02 ,  A61M5/204 ,  A61M5/3129

    摘要： Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is formed into a shape suitable for administration to the bone. Methods are provided for making formed compositions for application to a bone surface of a human or animal subject comprise mixing a demineralized bone and water; heating the mixture to form a carrier; mixing the carrier with bone to form a moldable composition; and molding the moldable composition to produce a formed composition. Several apparatuses are provided in which to hydrate the formed bone composition. Methods of hydrating a formed bone composition are also provided.

    摘要翻译： 用于施用于人或动物受试者的骨表面的成形组合物，包括：骨材料; 以及包含变性软化骨的载体，其中所述组合物形成适于施用于骨的形状。 提供用于制备用于施用于人或动物对象的骨表面的成形组合物的方法包括混合脱矿质骨和水; 加热混合物形成载体; 将载体与骨混合以形成可成型组合物; 并模塑可模制组合物以产生形成的组合物。 提供了几种用于水合形成的骨组合物的装置。 还提供了水合形成的骨组合物的方法。

    Method and Apparatus to Create Autologous Clotting Serum
    6.
    发明申请
    Method and Apparatus to Create Autologous Clotting Serum 有权
    创建自体凝血血清的方法和装置

    公开(公告)号：US20130045523A1

    公开(公告)日：2013-02-21

    申请号：US13209982

    申请日：2011-08-15

    申请人： Michael D. Leach ,  Jennifer E. Woodell-May ,  Hillary Overholser ,  Joel C. Higgins ,  Jason Chavarria ,  Ned M. Hamman

    发明人： Michael D. Leach ,  Jennifer E. Woodell-May ,  Hillary Overholser ,  Joel C. Higgins ,  Jason Chavarria ,  Ned M. Hamman

    IPC分类号： C12N9/74 ,  C12M1/00

    CPC分类号： B01F15/026 ,  A61K35/16 ,  B01F1/0027 ,  B01F3/04446 ,  B01F13/0023 ,  B01F13/0052 ,  B01F15/00512 ,  B01F15/0227 ,  B01F15/0237 ,  B01F15/0266

    摘要： A clotting serum production device including a main chamber, an inlet housing, and an outlet port. The main chamber is defined by a first end wall, a second end wall opposite to the first end wall, and a side wall extending between the first end wall and the second end wall. The inlet housing extends from the first end wall. The inlet housing includes a first inlet port, a second inlet port, and a first conduit extending between the first inlet port and a second conduit. The second conduit extends between the second inlet port and the main chamber. The inlet housing is configured to provide one-way fluid flow from the first inlet port to the second inlet port and to provide one-way fluid flow from the second inlet port to the main chamber. An outlet port is in fluid communication with the main chamber and provides fluid communication with an exterior of the clotting serum production device.

    摘要翻译： 一种凝血清洗生产装置，包括主室，入口壳体和出口。 主室由第一端壁，与第一端壁相对的第二端壁和在第一端壁和第二端壁之间延伸的侧壁限定。 入口壳体从第一端壁延伸。 入口壳体包括第一入口端口，第二入口端口和在第一入口端口和第二管道之间延伸的第一管道。 第二导管在第二入口和主室之间延伸。 入口壳体构造成提供从第一入口到第二入口的单向流体流，并且提供从第二入口到主室的单向流体流。 出口与主室流体连通并提供与凝血血清生产装置的外部的流体连通。

    Buoy suspension fractionation system
    7.
    发明授权
    Buoy suspension fractionation system 有权
    浮标分离系统

    公开(公告)号：US08328024B2

    公开(公告)日：2012-12-11

    申请号：US13198038

    申请日：2011-08-04

    申请人： Michael D. Leach ,  Randel Dorian ,  Jacy C. Hoeppner

    发明人： Michael D. Leach ,  Randel Dorian ,  Jacy C. Hoeppner

    IPC分类号： B01D21/26 ,  B01D45/12 ,  B04B5/02 ,  B04B7/00

    CPC分类号： B01D21/262 ,  A61M1/029 ,  A61M1/3693 ,  A61M2202/0427 ,  B01L3/50215 ,  B01L2200/026

    摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.

    摘要翻译： 使用离心分离悬浮液如血液的分离器包括分离容器和浮标。 浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。 引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。 浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。

    Method and apparatus for preparing platelet rich plasma and concentrates thereof
    9.
    发明授权
    Method and apparatus for preparing platelet rich plasma and concentrates thereof 有权
    制备富血小板血浆及其浓缩物的方法和装置

    公开(公告)号：US07987995B2

    公开(公告)日：2011-08-02

    申请号：US12772497

    申请日：2010-05-03

    申请人： Randel Dorian ,  Michael D. Leach

    发明人： Randel Dorian ,  Michael D. Leach

    IPC分类号： B01D15/02 ,  B01D21/26 ,  B01D33/00 ,  B04B3/00 ,  B04B7/08

    CPC分类号： B01D63/02 ,  A61M1/0281 ,  A61M1/3482 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0427 ,  B01D2313/44 ,  B01D2313/58 ,  B01F11/0005 ,  B01F13/0052 ,  B04B5/0442 ,  B04B2005/0478

    摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.

    摘要翻译： 本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。 离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。 浓缩器组件包括用于制备PRP浓缩物的去水模块。 离心鼓分离器具有红细胞捕集器。 除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。 中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板的活化和PRP中存在的任何痕量红细胞的破坏 。

    Buoy Suspension Fractionation System
    10.
    发明申请
    Buoy Suspension Fractionation System 有权
    浮标分离系统

    公开(公告)号：US20110021334A1

    公开(公告)日：2011-01-27

    申请号：US12897401

    申请日：2010-10-04

    申请人： Michael D. Leach ,  Randel Dorian ,  Jacy C. Hoeppner

    发明人： Michael D. Leach ,  Randel Dorian ,  Jacy C. Hoeppner

    IPC分类号： B01D21/26

    CPC分类号： B01D21/262 ,  A61M1/029 ,  A61M1/3693 ,  B01D21/26 ,  B01L3/50215 ,  B01L2200/026 ,  B01L2400/0409 ,  G01N33/491

    摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.

    摘要翻译： 使用离心分离悬浮液如血液的分离器包括分离容器和浮标。 浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。 引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。 浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。