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    INTRALUMINAL SCAFFOLD WITH CONFORMING AXIAL STRUT
    2.
    发明申请
    INTRALUMINAL SCAFFOLD WITH CONFORMING AXIAL STRUT 审中-公开
    具有符合轴向条纹的内镜片

    公开(公告)号：US20120046731A1

    公开(公告)日：2012-02-23

    申请号：US13087344

    申请日：2011-04-14

    申请人： Randolf von Oepen ,  Kevin J. Ehrenreich ,  Travis R. Yribarren

    发明人： Randolf von Oepen ,  Kevin J. Ehrenreich ,  Travis R. Yribarren

    IPC分类号： A61F2/82

    CPC分类号： A61F2/915 ,  A61F2/2475 ,  A61F2/88 ,  A61F2/958 ,  A61F2002/825 ,  A61F2002/8483 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0076 ,  A61F2230/0078

    摘要： Devices and methods for treating veins and venous conditions, such as chronic cerebrospinal venous insufficiency, are provided. In one aspect, the disclosed subject matter provides an intraluminal scaffold having a generally tubular body with a lumen defined therethrough, the tubular body having a compressed condition for delivery and an expanded condition for implant within a vessel having a distended portion, at least a length of the tubular body configured to form an enlarged portion in the expanded condition to engage a wall of the distended portion of the vessel. Methods for fabricating and using the scaffold, methods for remodeling a vein, and methods of deploying a medical device in a vessel without negatively impacting the function of a valve of the vessel, are also provided.

    摘要翻译： 提供了用于治疗静脉和静脉疾病如慢性脑脊髓静脉功能不全的装置和方法。 在一个方面，所公开的主题提供了一种管腔内支架，其具有通过其限定的内腔的大体管状体，该管状体具有用于输送的压缩状态和用于植入物的膨胀状态，该容器具有扩张部分，至少长度 所述管体被构造成在膨胀状态下形成扩大部分以接合容器的扩张部分的壁。 还提供了制造和使用支架的方法，用于重建静脉的方法，以及在容器中部署医疗装置的方法，而不会不利地影响容器的阀的功能。

    Expandable Member Formed Of A Fibrous Matrix For Intraluminal Drug Delivery
    4.
    发明申请
    Expandable Member Formed Of A Fibrous Matrix For Intraluminal Drug Delivery 有权
    用于腔内药物递送的纤维基质形成的可膨胀构件

    公开(公告)号：US20100081992A1

    公开(公告)日：2010-04-01

    申请号：US12238627

    申请日：2008-09-26

    申请人： Kevin J. Ehrenreich ,  Richard R. Newhauser ,  Randolf von Oepen ,  John Stankus

    发明人： Kevin J. Ehrenreich ,  Richard R. Newhauser ,  Randolf von Oepen ,  John Stankus

    IPC分类号： A61M25/10

    CPC分类号： A61M25/104 ,  A61L29/16 ,  A61L2300/606 ,  A61M25/10 ,  A61M25/1029 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1075 ,  D01D5/0076

    摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements with a therapeutic agent incorporated therein. The therapeutic agent can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the therapeutic agent. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is delivered to the desired treatment site.

    摘要翻译： 一种管腔内导管装置，其具有由其中结合有治疗剂的纤维元件基质形成的可扩张构件。 治疗剂可以以同轴构型涂覆在纤维元件上。 纤维元件还可以具有包含围绕治疗剂的保护性物质的第二涂层。 纤维元素的基质可以通过静电纺丝形成。 将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件具有分散在其中的治疗剂，并且将导管装置推进到期望的治​​疗部位。 一旦在所需的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并将治疗剂递送到所需的治疗部位。

    APPARATUS AND METHOD FOR FORMATION OF FOIL-SHAPED STENT STRUTS
    8.
    发明申请
    APPARATUS AND METHOD FOR FORMATION OF FOIL-SHAPED STENT STRUTS 审中-公开
    用于形成椎体形状的椎弓根的装置和方法

    公开(公告)号：US20130005218A1

    公开(公告)日：2013-01-03

    申请号：US13173353

    申请日：2011-06-30

    申请人： Randolf von Oepen ,  Kevin J. Ehrenreich

    发明人： Randolf von Oepen ,  Kevin J. Ehrenreich

    IPC分类号： B24C1/00

    CPC分类号： B24C1/083 ,  A61F2/915 ,  A61F2002/068 ,  A61F2002/91566 ,  A61F2230/0004

    摘要： A device and method is disclosed for reducing turbulent blood flow over stent struts of an intravascular stent implanted in, for example, a coronary artery. An abrasive slurry is passed over the struts of an intravascular stent in order to remove a portion of the stent struts to form an airfoil shape. When the stent having airfoil-shaped struts is implanted in an artery, the flow of blood over the airfoil shape will reduce the likelihood of turbulent blood flow and thereby will reduce the likelihood of turbulent blood flow and thereby reduce the likelihood of a buildup in plaque or injury to the vessel wall.

    摘要翻译： 公开了一种用于减少植入在例如冠状动脉中的血管内支架的支架支柱上的湍流血流的装置和方法。 研磨浆料通过血管内支架的支柱，以便去除支架支架的一部分以形成翼型形状。 当具有翼型支柱的支架植入动脉时，血液在翼型上的流动将降低湍流血流的可能性，从而降低湍流血流的可能性，从而降低斑块积聚的可能性 或损伤血管壁。

    INTRALUMINAL SCAFFOLD HAVING AN ENLARGED PORTION
    9.
    发明申请
    INTRALUMINAL SCAFFOLD HAVING AN ENLARGED PORTION 审中-公开
    具有放大部分的INTRALUMINAL SCAFFOLD

    公开(公告)号：US20120046729A1

    公开(公告)日：2012-02-23

    申请号：US13087341

    申请日：2011-04-14

    申请人： Randolf von Oepen ,  Kevin J. Ehrenreich ,  Travis R. Yribarren

    发明人： Randolf von Oepen ,  Kevin J. Ehrenreich ,  Travis R. Yribarren

    IPC分类号： A61F2/82

    CPC分类号： A61F2/915 ,  A61F2/2475 ,  A61F2/88 ,  A61F2/958 ,  A61F2002/825 ,  A61F2002/8483 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0076 ,  A61F2230/0078

    摘要： Devices and methods for treating veins and venous conditions, such as chronic cerebrospinal venous insufficiency, are provided. In one aspect, the disclosed subject matter provides an intraluminal scaffold having a generally tubular body with a lumen defined therethrough, the tubular body having a compressed condition for delivery and an expanded condition for implant within a vessel having a distended portion, at least a length of the tubular body configured to form an enlarged portion in the expanded condition to engage a wall of the distended portion of the vessel. Methods for fabricating and using the scaffold, methods for remodeling a vein, and methods of deploying a medical device in a vessel without negatively impacting the function of a valve of the vessel, are also provided.

    摘要翻译： 提供了用于治疗静脉和静脉疾病如慢性脑脊髓静脉功能不全的装置和方法。 在一个方面，所公开的主题提供了一种管腔内支架，其具有通过其限定的内腔的大体管状体，该管状体具有用于输送的压缩状态和用于植入物的膨胀状态，该容器具有扩张部分，至少长度 所述管体被构造成在膨胀状态下形成扩大部分以接合容器的扩张部分的壁。 还提供了制造和使用支架的方法，用于重建静脉的方法，以及在容器中部署医疗装置的方法，而不会不利地影响容器的阀的功能。

    Expandable Member Formed Of A Fibrous Matrix Having Hydrogel Polymer For Intraluminal Drug Delivery
    10.
    发明申请
    Expandable Member Formed Of A Fibrous Matrix Having Hydrogel Polymer For Intraluminal Drug Delivery 有权
    具有用于腔内药物递送的水凝胶聚合物的纤维基质的可膨胀构件

    公开(公告)号：US20100076377A1

    公开(公告)日：2010-03-25

    申请号：US12238026

    申请日：2008-09-25

    申请人： Kevin J. Ehrenreich ,  Richard R. Newhauser ,  Randolf von Oepen ,  John Stankus

    发明人： Kevin J. Ehrenreich ,  Richard R. Newhauser ,  Randolf von Oepen ,  John Stankus

    IPC分类号： A61M29/00 ,  A61M31/00

    CPC分类号： A61M25/1029 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/606 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1088

    摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent incorporated therein. The hydrogel polymer can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the hydrogel polymer having a therapeutic agent therein. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is released from the hydrogel polymer and delivered to the desired treatment site.

    摘要翻译： 一种管腔内导管装置，其具有由纤维元件基质形成的可膨胀构件，所述可扩张构件包括其中结合有治疗剂的水凝胶聚合物。 水凝胶聚合物可以以同轴构型涂覆在纤维元件上。 纤维元件还可以具有包含围绕水凝胶聚合物的保护性物质的第二涂层，其中具有治疗剂。 纤维元素的基质可以通过静电纺丝形成。 将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件包括其中分散有治疗剂的水凝胶聚合物，并将导管装置推进到 所需治疗部位。 一旦在期望的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并且将治疗剂从水凝胶聚合物释放并递送到所需的治疗部位。