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公开(公告)号：US20160296723A1
公开(公告)日：2016-10-13
申请号：US15093264
申请日：2016-04-07
CPC分类号： A61M25/0074 , A61B17/00491 , A61B17/12113 , A61B17/12181 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B2017/00402 , A61B2017/00411 , A61B2017/00495 , A61M25/0026 , A61M25/0068 , A61M2025/0024 , A61M2025/0073
摘要： Dual-lumen catheters for actively mixing two or more fluid components such that they react to form a more viscous pre-polymer formulation at or near the distal tip of the catheter are describe herein. The mixing dynamics within the dual-lumen catheter may be varied depending on the relative viscosity of each individual fluid component, as well as the viscosity of the resulting pre-polymer formulation.
摘要翻译： 本文描述了用于主动混合两种或更多种流体组分以使得它们在导管的远侧末端处或其附近形成更粘稠的预聚物制剂的双腔导管。 双腔导管内的混合动力学可以根据每个单独流体组分的相对粘度以及所得预聚物制剂的粘度而变化。
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公开(公告)号：US20160051264A1
公开(公告)日：2016-02-25
申请号：US14728393
申请日：2015-06-02
申请人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
发明人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
CPC分类号： A61B17/12181 , A61B17/12113 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/07 , A61F2002/065 , A61F2002/077 , A61F2210/0085 , A61J1/2093 , A61L24/0036 , A61L24/0089 , A61L24/046 , A61L31/06 , A61L31/128 , A61L31/146 , A61L2300/60 , A61L2400/06 , A61M37/00 , C08L67/04 , C08L83/04
摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
摘要翻译： 公开了与原位形成聚合物泡沫相关的用于治疗动脉瘤或填充液体的空间的系统，方法和试剂盒。 这些系统包括可插入的医疗装置和具有快速成形外皮的熔岩状材料的原位成形泡沫体，以及由一部分，两部分或多部分制剂形成的较慢的硬化内部。 当用于治疗动脉瘤时，将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。
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公开(公告)号：US09623143B2
公开(公告)日：2017-04-18
申请号：US14215988
申请日：2014-03-17
申请人： Gregory T. Zugates , Adam Rago , Toby Freyman , Upma Sharma , Rany Busold , John Caulkins , Parisa Zamiri , Jennifer Mortensen , Meghan McGill , Daniel K. Bonner
发明人： Gregory T. Zugates , Adam Rago , Toby Freyman , Upma Sharma , Rany Busold , John Caulkins , Parisa Zamiri , Jennifer Mortensen , Meghan McGill , Daniel K. Bonner
CPC分类号： A61L24/0015 , A61L24/0036 , A61L24/046 , A61L27/14 , A61L27/56 , A61L31/04 , A61L31/146 , A61L2300/418 , A61L2400/04 , A61L2430/22 , C08L75/04
摘要： The present invention relates generally to systems and methods and systems for generating polymer foams within body cavities to locate and/or control bleeding. The present invention further relates to methods and systems for generating polymer foams within non-compressible wounds to control or stop bleeding. The present invention further relates to the use of foams and gels for medical and cosmetic purposes.
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公开(公告)号：US20140316367A1
公开(公告)日：2014-10-23
申请号：US14215988
申请日：2014-03-17
申请人： Gregory T. Zugates , Adam Rago , Toby Freyman , Upma Sharma , Rany Busold , John Caulkins , Parisa Zamiri , Jennifer Mortensen , Meghan McGill , Daniel K. Bonner
发明人： Gregory T. Zugates , Adam Rago , Toby Freyman , Upma Sharma , Rany Busold , John Caulkins , Parisa Zamiri , Jennifer Mortensen , Meghan McGill , Daniel K. Bonner
CPC分类号： A61L24/0015 , A61L24/0036 , A61L24/046 , A61L27/14 , A61L27/56 , A61L31/04 , A61L31/146 , A61L2300/418 , A61L2400/04 , A61L2430/22 , C08L75/04
摘要： The present invention relates generally to systems and methods and systems for generating polymer foams within body cavities to locate and/or control bleeding. The present invention further relates to methods and systems for generating polymer foams within non-compressible wounds to control or stop bleeding. The present invention further relates to the use of foams and gels for medical and cosmetic purposes.
摘要翻译： 本发明一般涉及用于在体腔内产生聚合物泡沫以定位和/或控制出血的系统和方法和系统。 本发明还涉及用于在不可压缩伤口内产生聚合物泡沫以控制或止血的方法和系统。 本发明还涉及泡沫和凝胶用于医疗和化妆用途的用途。
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公开(公告)号：US20130110066A1
公开(公告)日：2013-05-02
申请号：US13536557
申请日：2012-06-28
申请人： Upma Sharma , Irina Gitlin , Parisa Zamiri , Toby Freyman , Rany Busold , Lee Core , Janet Chie Komatsu , Jennifer Mortensen
发明人： Upma Sharma , Irina Gitlin , Parisa Zamiri , Toby Freyman , Rany Busold , Lee Core , Janet Chie Komatsu , Jennifer Mortensen
CPC分类号： A61L24/0015 , A61L24/0036 , A61L24/046 , A61L27/14 , A61L27/56 , A61L31/04 , A61L31/146 , A61L2300/418 , A61L2400/04 , A61L2430/22 , C08L75/04
摘要： Medical implants and methods useful in treating postpartum hemorrhage are disclosed. The implants, in some embodiments, comprise polyurethane foams having advantageous mechanical and other properties selected to promote hemostasis when brought in contact with an inner wall of a uterus. Methods of making and deploying such implants are also disclosed.
摘要翻译： 公开了用于治疗产后出血的医疗植入物和方法。 在一些实施方案中，植入物包含具有有利的机械和其他性质的聚氨酯泡沫，当与子宫的内壁接触时，其被选择用于促进止血。 还公开了制造和部署这种植入物的方法。
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公开(公告)号：US20160256170A1
公开(公告)日：2016-09-08
申请号：US14212930
申请日：2014-03-14
申请人： Rany Busold , John Marini , Upma Sharma , Adam Rago , Jennifer Mortensen , Joseph Lomakin , Gregory T. Zugates , Janet Komatsu
发明人： Rany Busold , John Marini , Upma Sharma , Adam Rago , Jennifer Mortensen , Joseph Lomakin , Gregory T. Zugates , Janet Komatsu
CPC分类号： A61B17/12118 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B2017/1205 , A61B2217/005 , A61F2/07 , A61F2/95 , A61F2002/077 , A61M25/0067 , A61M25/007 , A61M25/0074 , A61M25/10 , A61M25/1006 , A61M2025/0004 , A61M2025/0078 , A61M2025/0175
摘要： Systems and method for treating aneurysms are provided which utilize formulations that form polymer foams in situ. The formulations generally have a buoyancy greater than or less than blood, and either float to the top of the aneurysm and foam from the top down or sink to the bottom and foam from the bottom up.
摘要翻译： 提供了用于治疗动脉瘤的系统和方法，其利用原位形成聚合物泡沫的制剂。 制剂通常具有大于或小于血液的浮力，并且浮动到动脉瘤的顶部并且从顶部向下或从底部向下沉入泡沫，并且从下向上浮起泡沫。
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公开(公告)号：US08993831B2
公开(公告)日：2015-03-31
申请号：US13536557
申请日：2012-06-28
申请人： Upma Sharma , Irina Gitlin , Parisa Zamiri , Toby Freyman , Rany Busold , Lee Core , Janet Chie Komatsu , Jennifer Mortensen
发明人： Upma Sharma , Irina Gitlin , Parisa Zamiri , Toby Freyman , Rany Busold , Lee Core , Janet Chie Komatsu , Jennifer Mortensen
IPC分类号： A61F13/53 , A61K47/34 , A61P7/04 , A61K9/00 , A61L24/00 , A61L24/04 , A61L27/14 , A61L27/56 , A61L31/04 , A61L31/14
CPC分类号： A61L24/0015 , A61L24/0036 , A61L24/046 , A61L27/14 , A61L27/56 , A61L31/04 , A61L31/146 , A61L2300/418 , A61L2400/04 , A61L2430/22 , C08L75/04
摘要： Medical implants and methods useful in treating postpartum hemorrhage are disclosed. The implants, in some embodiments, comprise polyurethane foams having advantageous mechanical and other properties selected to promote hemostasis when brought in contact with an inner wall of a uterus. Methods of making and deploying such implants are also disclosed.
摘要翻译： 公开了用于治疗产后出血的医疗植入物和方法。 在一些实施方案中，植入物包含具有有利的机械和其它性质的聚氨酯泡沫，当与子宫的内壁接触时，其被选择用于促进止血。 还公开了制造和部署这种植入物的方法。
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公开(公告)号：US20130317418A1
公开(公告)日：2013-11-28
申请号：US13815910
申请日：2013-03-15
申请人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
发明人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
IPC分类号： A61M37/00
CPC分类号： A61B17/12181 , A61B17/12113 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/07 , A61F2002/065 , A61F2002/077 , A61F2210/0085 , A61J1/2093 , A61L24/0036 , A61L24/0089 , A61L24/046 , A61L31/06 , A61L31/128 , A61L31/146 , A61L2300/60 , A61L2400/06 , A61M37/00 , C08L67/04 , C08L83/04
摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
摘要翻译： 公开了与原位形成聚合物泡沫相关的用于治疗动脉瘤或填充液体的空间的系统，方法和试剂盒。 这些系统包括可插入的医疗装置和具有快速成形外皮的熔岩状材料的原位成形泡沫体，以及由一部分，两部分或多部分制剂形成的较慢的硬化内部。 当用于治疗动脉瘤时，将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。
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9.发明申请公开(公告)号：US20160271293A1
公开(公告)日：2016-09-22
申请号：US14660790
申请日：2015-03-17
申请人： Gregory T. ZUGATES , Adam Rago , Toby Freyman , Upma Sharma , Rany Busold , John Caulkins , Parisa Zamiri , Jennifer Mortensen , David King
发明人： Gregory T. ZUGATES , Adam Rago , Toby Freyman , Upma Sharma , Rany Busold , John Caulkins , Parisa Zamiri , Jennifer Mortensen , David King
CPC分类号： A61B17/0057 , A61B17/12181 , A61B17/12186 , A61B17/12195 , A61B2017/00654 , A61L26/0014 , A61L26/008 , A61L2400/04
摘要： Systems and methods for the treatment of pelvic and junctional hemorrhage are provided, which utilize in situ forming polymer gels and foams to apply pressure to sites of hemorrhage due to penetrating or blunt injury, among other things.
摘要翻译： 提供了用于治疗盆腔和连接出血的系统和方法，其利用原位形成聚合物凝胶和泡沫来施加压力到由于穿透性或钝性损伤引起的出血部位等。
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公开(公告)号：US20160081830A1
公开(公告)日：2016-03-24
申请号：US14953542
申请日：2015-11-30
申请人： Nareak Douk , Rany Busold , Lee Core , Kicherl Ho , My Le , Timothy Walter Robinson , Sarah Kostanski , Benedict Shia , Jerry Brightbill
发明人： Nareak Douk , Rany Busold , Lee Core , Kicherl Ho , My Le , Timothy Walter Robinson , Sarah Kostanski , Benedict Shia , Jerry Brightbill
CPC分类号： A61F2/966 , A61F2/86 , A61F2/90 , A61F2002/826 , A61F2002/9505 , A61F2002/9522 , A61F2002/9665 , A61F2230/0054
摘要： Delivery systems for a polymeric tubular implant, kits that include such delivery systems, and methods of treating patients by implanting tubular implants using the delivery systems. The delivery systems include an inner shaft, an expandable member slidably disposed about the inner shaft and configured to receive the tubular implant, and a tubular outer shaft disposed about the inner shaft.
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