公开(公告)号：US20150283244A1

公开(公告)日：2015-10-08

申请号：US14387178

申请日：2013-03-12

申请人： Karen H. Ohlfest ,  Regents of the University of Minnesota

发明人： Chun Wang ,  Wenshou Wang ,  John R. Ohlfest

IPC分类号： A61K47/34 ,  C08G65/332 ,  A61K39/00 ,  C08G63/664 ,  A61K31/192 ,  A61K38/38

CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/5153 ,  A61K31/192 ,  A61K31/437 ,  A61K38/385 ,  A61K39/0005 ,  C08G63/664 ,  C08G65/3322

摘要： The invention provides semi-solid systems for delivering biologically active materials that include a polymer comprising 1) one or more units of formula Ia, IIa, or IIIa: (formula Ia, IIa, IIIa) and 2) one or more units comprising polycaprolactone; wherein R and Ra have any of the values defined in the application.

摘要翻译： 本发明提供用于递送生物活性材料的半固体系统，其包括聚合物，其包含1）一种或多种式Ia，IIa或IIIa单元：（式Ia，IIa，IIIa）和2）一种或多种包含聚己内酯的单元; 其中R和R a具有在本申请中定义的任何值。

公开(公告)号：US20210290300A1

公开(公告)日：2021-09-23

申请号：US17204150

申请日：2021-03-17

申请人： Boston Scientific Scimed, Inc. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Bruce R. Forsyth ,  Chun Wang ,  Samuel Hanson

IPC分类号： A61B18/14 ,  A61L27/36

摘要： In some aspects, the present disclosure pertains to methods of treating a tissue volume comprising (a) administering an implantable composition comprising a releasable membrane-active agent to a target site such that the membrane-active agent is locally released to the tissue volume and (b) performing irreversible, reversible and/or thermal treatment by application of a pulsed electric field to the tissue volume. In other aspects, the present disclosure pertains to embolic compositions that comprise releasable membrane-active agents.

公开(公告)号：US10226534B2

公开(公告)日：2019-03-12

申请号：US15021573

申请日：2014-09-12

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Wenshou Wang ,  Chun Wang

IPC分类号： A61K47/34 ,  A61K9/06 ,  A61K38/38 ,  C08G65/331 ,  A61K9/51 ,  C08G63/664 ,  C08G81/00 ,  C08L71/02 ,  A61K9/00

摘要： The invention provides semi-solid systems for delivering biologically active materials that include a polymer comprising 1) one or more polycaprolactone (PCL) units and 2) at least one or more polyethylene glycol (PEG) units; wherein at least one of said polycaprolactone units is conjugated to a PEG forming an acetal group.

公开(公告)号：US12121288B2

公开(公告)日：2024-10-22

申请号：US17204150

申请日：2021-03-17

申请人： Boston Scientific Scimed, Inc. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Bruce R. Forsyth ,  Chun Wang ,  Samuel Hanson

IPC分类号： A61B18/14 ,  A61B18/00 ,  A61L27/36

CPC分类号： A61B18/1477 ,  A61B18/1485 ,  A61L27/3641 ,  A61B2018/00154 ,  A61B2018/00333 ,  A61B2018/00345 ,  A61B2018/00452 ,  A61B2018/00494 ,  A61B2018/00511 ,  A61B2018/00529 ,  A61B2018/00541 ,  A61B2018/00547 ,  A61B2018/00559 ,  A61B2018/00613 ,  A61L2400/06

摘要： In some aspects, the present disclosure pertains to methods of treating a tissue volume comprising (a) administering an implantable composition comprising a releasable membrane-active agent to a target site such that the membrane-active agent is locally released to the tissue volume and (b) performing irreversible, reversible and/or thermal treatment by application of a pulsed electric field to the tissue volume. In other aspects, the present disclosure pertains to embolic compositions that comprise releasable membrane-active agents.

公开(公告)号：US20240216579A1

公开(公告)日：2024-07-04

申请号：US18558837

申请日：2022-05-13

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Joshua Honghan Hou ,  Peter Bedard ,  Chun Wang ,  Ching Yuan ,  Sung Lee ,  Aaron Bae

IPC分类号： A61L27/36 ,  A61F2/14 ,  A61L27/34 ,  A61L27/38 ,  A61L27/54

CPC分类号： A61L27/3604 ,  A61F2/142 ,  A61F2/148 ,  A61L27/34 ,  A61L27/3641 ,  A61L27/3808 ,  A61L27/3839 ,  A61L27/54 ,  A61L2300/404 ,  A61L2400/06 ,  A61L2400/10 ,  A61L2400/12 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2430/16

摘要： A graft injector assembly includes a coating disposed on an interior surface of an injector body to form a lumen. The lumen is structured to store a graft comprising corneal tissue and to allow the graft to exit distally from the injector body, preferably with minimal or no damage to the corneal tissue. The corneal tissue may include a Descemet membrane and endothelial cells, which may be used in Descemet Membrane Endothelial Keratoplasty (DMEK). In one example, the assembly includes an organosilane coating disposed on a glass injector body.

公开(公告)号：US11382929B2

公开(公告)日：2022-07-12

申请号：US16913046

申请日：2020-06-26

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Chun Wang ,  Samuel Hanson

IPC分类号： A61K31/785 ,  A61K31/704 ,  A61P35/00 ,  A61K31/727

摘要： Disclosed herein are compositions comprising a membranolytic polymer or a salt thereof and a chemotherapeutic agent or a salt thereof and compositions comprising a membranolytic polymer or a salt thereof and a shielding polymer or a salt thereof. Also disclosed are methods and uses for treating diseases such as cancer with these compositions.

公开(公告)号：US10179173B2

公开(公告)日：2019-01-15

申请号：US14387178

申请日：2013-03-12

申请人： Regents of the University of Minnesota

发明人： Chun Wang ,  Wenshou Wang ,  John R. Ohlfest

IPC分类号： A61K47/34 ,  C08G63/664 ,  A61K9/51 ,  A61K9/00 ,  A61K9/14 ,  A61K31/192 ,  A61K31/437 ,  A61K38/38 ,  A61K39/00 ,  C08G65/332

摘要： The invention provides semi-solid systems for delivering biologically active materials that include a polymer comprising 1) one or more units of formula Ia, IIa, or IIIa: (formula Ia, IIa, IIIa) and 2) one or more units comprising polycaprolactone; wherein R and Ra have any of the values defined in the application.