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1.发明授权公开(公告)号：US09012194B2
公开(公告)日：2015-04-21
申请号：US11722356
申请日：2005-12-22
摘要： A method for producing sophorolipids having protein inducer and/or repressor activities having the steps of synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids and non-lactonic sophorolipids and then utilizing the natural mixture as a protein inducing agent, utilizing the natural mixture as a protein repressing agent, and/or utilizing the natural mixture as a combined protein induction/repressor agent. An application of the sophorolipid compound produced according to the method as a microbial media component.
摘要翻译： 一种制备具有蛋白诱导剂和/或阻遏物活性的槐糖脂的方法，其具有以下步骤：通过在发酵培养基中发酵假丝酵母发酵来合成槐糖脂，以形成天然槐糖脂和非内酰槐糖的天然混合物，然后将天然混合物用作 蛋白质诱导剂，利用天然混合物作为蛋白质抑制剂，和/或利用天然混合物作为组合的蛋白质诱导/抑制剂。 根据该方法生产的槐糖脂化合物作为微生物培养基成分的应用。
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2.发明申请公开(公告)号：US20110223239A1
公开(公告)日：2011-09-15
申请号：US13112122
申请日：2011-05-20
申请人： Richard A. Gross , Vishal Shah , Gustavo F. Doncel
发明人： Richard A. Gross , Vishal Shah , Gustavo F. Doncel
IPC分类号： A61K31/7028 , A61K9/127 , A61P15/16 , A61P31/18
CPC分类号： A61K31/704 , A61K36/062 , A61K45/06 , C07H15/24 , C12P19/44 , A61K2300/00
摘要： A method for inactivating spermatozoa, neutralizing or inactivating a virus, and neutralizing or inactivating HIV using sophorolipids having spermicidal and/or antiviral properties produced by synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids compounds and non-lactonic sophorolipids compounds and utilizing the natural mixture as a spermicidal and/or antiviral agent, and/or separating the lactonic sophorolipids from the natural mixture to form a lactonic fraction and mixing all remaining fractions to form a non-lactonic fraction and utilizing the lactonic fraction and/or the non-lactonic fraction as an spermicidal and/or antiviral agent, and sophorolipid compounds for use as spermicidal and/or antiviral agents.
摘要翻译： 一种灭活精子，中和或灭活病毒的方法，以及使用具有杀精和/或抗病毒性质的槐糖脂中和或灭活的方法，其通过在发酵培养基中通过发酵假丝酵母发酵来合成槐糖脂，以形成内酯槐糖脂化合物的天然混合物和 非内酯槐糖脂化合物，并将天然混合物用作杀精和/或抗病毒剂，和/或从天然混合物中分离内酯槐糖脂以形成内酯级分，并混合所有剩余部分以形成非内酯级分并利用 内酯级分和/或非内酯级分作为杀精和/或抗病毒剂，以及用作杀精和/或抗病毒剂的槐糖脂化合物。
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3.发明申请公开(公告)号：US20110217344A1
公开(公告)日：2011-09-08
申请号：US13112144
申请日：2011-05-20
申请人： Richard A. Gross , Vishal Shah , Gustavo F. Doncel
发明人： Richard A. Gross , Vishal Shah , Gustavo F. Doncel
IPC分类号： A61K31/7028 , C07H15/06 , A61K9/00 , A61P31/12 , A61P15/18
CPC分类号： A61K31/704 , A61K36/062 , A61K45/06 , C07H15/24 , C12P19/44 , A61K2300/00
摘要： Sophorolipid compounds having spermicidal and/or antiviral properties prepared by synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids compounds and non-lactonic sophorolipids compounds and utilizing the natural mixture as a spermicidal and/or antiviral agent, and/or separating the lactonic sophorolipids from the natural mixture to form a lactonic fraction and mixing all remaining fractions to form a non-lactonic fraction and utilizing the lactonic fraction and/or the non-lactonic fraction as an spermicidal and/or antiviral agent, and sophorolipid compounds for use as spermicidal and/or antiviral agents.
摘要翻译： 通过在发酵培养基中发酵假丝酵母合成槐糖脂制备具有杀精和/或抗病毒性质的槐糖脂化合物，以形成内酯槐糖脂化合物和非内酯槐糖脂化合物的天然混合物，并将该天然混合物用作杀精和/或抗病毒 试剂和/或从天然混合物中分离内酯槐糖脂以形成内酯级分，并混合所有剩余部分以形成非内酯级分，并利用内酯级分和/或非内酯级分作为杀精和/或抗病毒 药剂和槐糖脂化合物，用作杀精和/或抗病毒剂。
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4.发明申请METHOD FOR NEUTRALIZING FUNGI USING SOPHOROLIPIDS AND ANTIFUNGAL SOPHOROLIPIDS FOR USE THEREIN 有权使用异戊酸和抗真菌SOPHOROLIPER使用真菌中和真菌的方法公开(公告)号：US20090186836A1
公开(公告)日：2009-07-23
申请号：US12360486
申请日：2009-01-27
申请人： Richard A. Gross , Vishal Shah
发明人： Richard A. Gross , Vishal Shah
CPC分类号： C12P7/62 , A61K31/7024 , C12P19/44 , C12P19/62
摘要： 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octa-decenoate, lactonic and open ring 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, methyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, ethyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, hexyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, ethyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate-6″-acetate and ethyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate-6′,6″-diacetate sophorolipids and uses thereof as antifungal agents.
摘要翻译： 17-L - [（2'-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） - 氧基] - 顺式-9-八氢癸酸酯，内酯和开环17-L - [（2'-O- β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） - 氧基] - 顺式-9-十八碳烯酸甲酯，17-L - [（2'-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） - 氧基] 顺式-9-十八烯酸乙酯，17-L - [（2'-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） - 氧基] - 顺式-9-十八碳烯酸乙酯，17-L - [（2'- O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） - 氧基] - 顺式-9-十八碳烯酸乙酯，17-L - [（2'-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） ] - 顺式-9-十八碳烯酸酯-6“ - 乙酸酯和17-L - [（2'-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） - 氧基] - 顺式-9-十八碳烯酸酯-6' ，6“ - 二乙酸槐糖脂及其用作抗真菌剂。
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公开(公告)号：US20120231068A1
公开(公告)日：2012-09-13
申请号：US13412100
申请日：2012-03-05
申请人： Richard A. Gross , Vishal Shah , Gustavo Doncel
发明人： Richard A. Gross , Vishal Shah , Gustavo Doncel
CPC分类号： A61K31/704 , A61K36/062 , A61K45/06 , C07H15/24 , C12P19/44 , A61K2300/00
摘要： A method for neutralizing or inactivating a virus, and neutralizing or inactivating HIV using sophorolipids having antiviral properties produced by synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids compounds and non-lactonic sophorolipids compounds and utilizing the natural mixture as an antiviral agent, and/or separating the lactonic sophorolipids from the natural mixture to form a lactonic fraction and mixing all remaining fractions to form a non-lactonic fraction and utilizing the lactonic fraction and/or the non-lactonic fraction as an antiviral agent, and sophorolipid compounds for use as antiviral agents.
摘要翻译： 一种用于中和或灭活病毒的方法，并且使用具有抗病毒性质的槐糖脂中和或灭活HIV的方法，其通过在发酵培养基中通过发酵假丝酵母发酵来合成槐糖脂以形成内酯槐糖脂化合物和非内酯槐糖脂化合物的天然混合物并利用 天然混合物作为抗病毒剂，和/或从天然混合物中分离内酯槐糖脂以形成内酯级分，并将所有剩余部分混合以形成非内酯级分，并将内酯级分和/或非内酯级分用作 抗病毒剂和用作抗病毒剂的槐糖脂化合物。
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6.发明授权公开(公告)号：US08796228B2
公开(公告)日：2014-08-05
申请号：US12360486
申请日：2009-01-27
申请人： Richard A. Gross , Vishal Shah
发明人： Richard A. Gross , Vishal Shah
IPC分类号： A61K31/70
CPC分类号： C12P7/62 , A61K31/7024 , C12P19/44 , C12P19/62
摘要： 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octa-decenoate, lactonic and open ring 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, methyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, ethyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, hexyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, ethyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate-6″-acetate and ethyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate-6′,6″-diacetate sophorolipids and uses thereof as antifungal agents.
摘要翻译： 17-L - [（2'-O-和bgr-D-吡喃葡萄糖基 - ＆bgr-D-吡喃葡萄糖基） - 氧基] - 顺式-9-八氢癸酸酯，内酯和开环17-L - [（2'- O-吡喃葡萄糖基-D-吡喃葡萄糖基） - 氧基] - 顺式-9-十八碳烯酸甲酯，17-L - [（2'-O-和b-D-吡喃葡萄糖基 - D-吡喃葡萄糖基） - 氧基] - 顺式-9-十八碳烯酸乙酯，17-L - [（2'-O-和bgr-D-吡喃葡萄糖基 - -L - [（2'-O-和bgr-D-吡喃葡萄糖基 - ＆bgr-D-吡喃葡萄糖基） - 氧基] - 顺式-9-十八碳烯酸乙酯，17-L - [（2'-O- - 吡喃葡萄糖基-β-吡喃葡萄糖基） - 氧基] - 顺式-9-十八碳烯酸酯-6“ - 乙酸酯和17-L - [（2'-O-和bgr-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基 ） - 氧基] - 顺-9-十八碳烯酸酯-6'，6“ - 二乙酸槐糖脂及其用作抗真菌剂。
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7.发明授权Production of an α-carboxyl-ω-hydroxy fatty acid using a genetically modified Candida strain 有权使用遗传修饰的假丝酵母菌株生产α-羧基-ω-羟基脂肪酸公开(公告)号：US08158391B2
公开(公告)日：2012-04-17
申请号：US12436729
申请日：2009-05-06
申请人： Richard A. Gross , Wenhua Lu , Jon Ness , Jeremy Minshull
发明人： Richard A. Gross , Wenhua Lu , Jon Ness , Jeremy Minshull
CPC分类号： C12P7/6427 , C12N9/0006 , C12P7/42 , C12P7/44 , C12P7/6409
摘要： A substantially pure Candida host cell for the production of a α-carboxyl-ω-hydroxy fatty acid having a carbon chain length in the range from C6 to C22, a α,ω-dicarboxylic fatty acid having a carbon chain length in the range from C6 to C22, or mixtures thereof, is provided. The Candida host cell is characterized by a first genetic modification class and a second genetic modification class. The first genetic modification class comprises one or more genetic modifications that disrupt the peroxisomal β-oxidation pathway. The second genetic modification class comprises one or more genetic modifications that collectively or individually disrupt at least one gene selected from the group consisting of a CYP52A type cytochrome P450, a fatty alcohol oxidase, and an alcohol dehydrogenase.
摘要翻译： 用于生产碳链长度在C6至C22范围内的α-羧基-ω-羟基脂肪酸的基本上纯的假丝酵母宿主细胞，具有碳链长度范围的α，ω-二羧酸脂肪酸 C6至C22，或其混合物。 念珠菌宿主细胞的特征在于第一遗传修饰类和第二遗传修饰类。 第一种遗传修饰类包括一种或多种破坏过氧化物酶体和氧化途径的遗传修饰。 第二遗传修饰类包括共同或单独破坏选自CYP52A型细胞色素P450，脂肪醇氧化酶和醇脱氢酶中的至少一种基因的一种或多种遗传修饰。
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8.发明授权Method for preparing long-chain hydroxyacids, diacids and oligomers and polymers thereof 有权制备长链羟基酸，二酸和低聚物及其聚合物的方法公开(公告)号：US08143034B2
公开(公告)日：2012-03-27
申请号：US12195996
申请日：2008-08-21
申请人： Richard A. Gross , Wenhua Lu , Yixin Yang
发明人： Richard A. Gross , Wenhua Lu , Yixin Yang
CPC分类号： C12P7/6436 , C12P7/6409
摘要： A method and process for the preparation of ricinoleic acid analogs and oligomers and polymers containing such ricinoleic acid analogs.
摘要翻译： 用于制备蓖麻油酸类似物和含有这种蓖麻油酸类似物的低聚物和聚合物的方法和方法。
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9.发明授权公开(公告)号：US08021350B2
公开(公告)日：2011-09-20
申请号：US12320613
申请日：2009-01-29
申请人： Anthony Calabro , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , Keiji Kamohara , Michael K. Banbury
发明人： Anthony Calabro , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , Keiji Kamohara , Michael K. Banbury
CPC分类号： C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译： 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成大分子网络。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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公开(公告)号：US07968522B2
公开(公告)日：2011-06-28
申请号：US11691191
申请日：2007-03-26
申请人： Richard A. Gross
发明人： Richard A. Gross
IPC分类号： A61K31/7016 , A61K31/7028 , C07H15/10
CPC分类号： A61K31/7016 , A61K31/739 , C12P19/44 , C12P19/62 , A61K2300/00
摘要： A method and composition for the prophylaxis or treatment of humans or animals for septic shock and sepsis using a mixture of sophorolipids.
摘要翻译： 用于使用槐糖脂混合物预防或治疗脓毒性休克和败血症的人或动物的方法和组合物。
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