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公开(公告)号：US08372848B2
公开(公告)日：2013-02-12
申请号：US10593941
申请日：2005-03-23
申请人： Richard A. Houghten , Colette Dooley , Adel Nefzi , Zhiwei Wang , Oliver Civelli , Hiroshi Nagasaki
发明人： Richard A. Houghten , Colette Dooley , Adel Nefzi , Zhiwei Wang , Oliver Civelli , Hiroshi Nagasaki
IPC分类号： A61K31/495 , A61K31/4166 , A61K31/4168 , C07D233/12 , C07D239/10 , C07D239/12
CPC分类号： A61K31/4015 , C07D233/42
摘要： This invention relates generally to N-benzylamino cyclic thioureas, pharmaceutical compositions containing them, and their use as antagonists of melanin-concentrating hormone receptor (MCH receptor).
摘要翻译： 本发明一般涉及N-苄基氨基环硫脲，含有它们的药物组合物及其作为黑色素浓缩激素受体（MCH受体）拮抗剂的用途。
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公开(公告)号：US20080255218A1
公开(公告)日：2008-10-16
申请号：US10593941
申请日：2005-03-23
申请人： Richard A. Houghten , Colette Dooley , Adel Nefzi , Zhiwei Wang , Oliver Civelli , Hiroshi Nagasaki
发明人： Richard A. Houghten , Colette Dooley , Adel Nefzi , Zhiwei Wang , Oliver Civelli , Hiroshi Nagasaki
IPC分类号： A61K31/4164 , A61P3/00 , A61P3/04 , A61P25/24 , C07D233/42 , C07D403/02 , A61K31/4178
CPC分类号： A61K31/4015 , C07D233/42
摘要： This invention relates generally to N-benzylamino cyclic thioureas, pharmaceutical compositions containing them, and their use as antagonists of melanin-concentrating hormone receptor (MCH receptor).
摘要翻译： 本发明一般涉及N-苄基氨基环硫脲，含有它们的药物组合物及其作为黑色素浓缩激素受体（MCH受体）拮抗剂的用途。
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公开(公告)号：US08153725B2
公开(公告)日：2012-04-10
申请号：US12728083
申请日：2010-03-19
IPC分类号： C08F289/00 , C07H21/04 , C07D491/18
CPC分类号： C07D491/18 , C07B2200/11 , C07D491/08 , C07D493/18
摘要： Universal linkers, their facile processes of manufacture and methods of using the same are provided.
摘要翻译： 提供了通用接头，其简便的制造过程及其使用方法。
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公开(公告)号：US20070275906A1
公开(公告)日：2007-11-29
申请号：US11749430
申请日：2007-05-16
申请人： David Tully , Arnab Chatterjee , Agnes Vidal , Hank Petrassi , Zhiwei Wang , Badry Bursulaya , Glen Spraggon
发明人： David Tully , Arnab Chatterjee , Agnes Vidal , Hank Petrassi , Zhiwei Wang , Badry Bursulaya , Glen Spraggon
IPC分类号： A61K38/04 , A61K31/454 , C07K5/04
CPC分类号： C07D417/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.
摘要翻译： 本发明提供了可用于调节通道活化蛋白酶的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与通道活化蛋白酶（包括但不限于前列腺素PRSS22，TMPRSS11）相关的病症的方法 （例如TMPRSS11B，TMPRSS11E），TMPRSS2，TMPRSS3，TMPRSS4（MTSP-2），matriptase（MTSP-1），CAP2，CAP3，胰蛋白酶，组织蛋白酶A或嗜中性粒细胞弹性蛋白酶。
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5.发明授权公开(公告)号：US11178610B2
公开(公告)日：2021-11-16
申请号：US16392509
申请日：2019-04-23
申请人： Haifeng Li , Xiao Lu , Yingmeng Xiang , Chunlei Xu , Di Shi , Zhe Yu , Shiming Xu , Xueming Li , Jiangpeng Dai , Zhiwei Wang
发明人： Haifeng Li , Xiao Lu , Yingmeng Xiang , Chunlei Xu , Di Shi , Zhe Yu , Shiming Xu , Xueming Li , Jiangpeng Dai , Zhiwei Wang
IPC分类号： G05B13/04 , H04W52/02 , G06F1/3287 , G06F1/3209 , H02J3/00 , H02J3/14
摘要： Systems and methods are disclosed for power management by estimating power contingency of a grid at a cloud control center; performing decentralized real-time measurement and making local decisions at one more computer controlled outlets connected to the grid; and aggregating distributed loads to provide emergency frequency support to the grid.
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公开(公告)号：US11119462B2
公开(公告)日：2021-09-14
申请号：US16596093
申请日：2019-10-08
申请人： Renchang Dai , Guangyi Liu , Chen Yuan , Peng Wei , Yongli Zhu , Yi Lu , Zhijun Liao , Zhiwei Wang
发明人： Renchang Dai , Guangyi Liu , Chen Yuan , Peng Wei , Yongli Zhu , Yi Lu , Zhijun Liao , Zhiwei Wang
IPC分类号： G05B99/00 , G05B19/042
摘要： A power system energy management system with dynamic state estimation (DSE) is disclosed wherein system dynamic states are estimated using SCADA measurements, PMU measurements, signals of controllers, digital recorders, protection devices, and smart electronic devices. The DSE is solved first by Unscented Kalman Filter, and if the Unscented Kalman Filter is failed, weighted lease square is used to solve the DSE. If weighted lease square is failed, integration method is used to calculate the dynamic states. In another aspect, Unscented Kalman Filter, weighted lease square, and integration calculation are applied to solve the DSE by nodal parallel computing for each generation system.
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7.发明授权公开(公告)号：US11029344B2
公开(公告)日：2021-06-08
申请号：US16108188
申请日：2018-08-22
申请人： Xiaohu Zhang , Di Shi , Xiao Lu , Zhehan Yi , Qibing Zhang , Zhiwei Wang
发明人： Xiaohu Zhang , Di Shi , Xiao Lu , Zhehan Yi , Qibing Zhang , Zhiwei Wang
摘要： Systems and method are disclosed for monitor long-term voltage stability in a power system by estimating post-contingency operating point(s) considering PV-PQ transitions based on the current operating point; predicting a sensitivity based Thevenin index (STI) for each contingency using the estimated operating condition; and determining a voltage stability assessment (VSA) considering N−1 contingency.
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公开(公告)号：US20210103263A1
公开(公告)日：2021-04-08
申请号：US16596093
申请日：2019-10-08
申请人： Renchang Dai , Guangyi Liu , Chen Yuan , Peng Wei , Yongli Zhu , Yi Lu , Zhijun Liao , Zhiwei Wang
发明人： Renchang Dai , Guangyi Liu , Chen Yuan , Peng Wei , Yongli Zhu , Yi Lu , Zhijun Liao , Zhiwei Wang
IPC分类号： G05B19/042
摘要： A power system energy management system with dynamic state estimation (DSE) is disclosed wherein system dynamic states are estimated using SCADA measurements, PMU measurements, signals of controllers, digital recorders, protection devices, and smart electronic devices. The DSE is solved first by Unscented Kalman Filter, and if the Unscented Kalman Filter is failed, weighted lease square is used to solve the DSE. If weighted lease square is failed, integration method is used to calculate the dynamic states. In another aspect, Unscented Kalman Filter, weighted lease square, and integration calculation are applied to solve the DSE by nodal parallel computing for each generation system.
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9.发明申请公开(公告)号：US20190137550A1
公开(公告)日：2019-05-09
申请号：US16108188
申请日：2018-08-22
申请人： Xiaohu Zhang , Di Shi , Xiao Lu , Zhehan Yi , Qibing Zhang , Zhiwei Wang
发明人： Xiaohu Zhang , Di Shi , Xiao Lu , Zhehan Yi , Qibing Zhang , Zhiwei Wang
摘要： Systems and method are disclosed for monitor long-term voltage stability in a power system by estimating post-contingency operating point(s) considering PV-PQ transitions based on the current operating point; predicting a sensitivity based Thevenin index (STI) for each contingency using the estimated operating condition; and determining a voltage stability assessment (VSA) considering N−1 contingency.
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公开(公告)号：US20180156886A1
公开(公告)日：2018-06-07
申请号：US15787365
申请日：2017-10-18
申请人： Xiao Lu , Xinan Wang , Di Shi , Zhiwei Wang , Jianyu Luo , Chunlei Xu
发明人： Xiao Lu , Xinan Wang , Di Shi , Zhiwei Wang , Jianyu Luo , Chunlei Xu
CPC分类号： G01R35/005 , G01R19/2513 , Y02E60/728 , Y04S10/265
摘要： Data quality of Phasor Measurement Unit (PMU) is receiving increasing attention as it has been identified as one of the limiting factors that affect many wide-area measurement system (WAMS) based applications. In general, existing PMU calibration methods include offline testing and model based approaches. However, in practice, the effectiveness of both is limited due to the very strong assumptions employed. This invention presents a novel framework for online error detection and calibration of PMU measurement using density-based spatial clustering of applications with noise (DBSCAN) based on much relaxed assumptions. With a new problem formulation, the proposed data mining based methodology is applicable across a wide spectrum of practical conditions and one side-product of it is more accurate transmission line parameters for the energy management system (EMS) database and protective relay settings. Case studies are presented to demonstrate the effectiveness of the proposed method.
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