公开(公告)号：US20070123523A1

公开(公告)日：2007-05-31

申请号：US11620608

申请日：2007-01-05

Applicant: Hong Liu ,  David Tully ,  Phillip Alper ,  Robert Epple ,  Arnab Chatterjee ,  Michael Roberts

Inventor： Hong Liu ,  David Tully ,  Phillip Alper ,  Robert Epple ,  Arnab Chatterjee ,  Michael Roberts

IPC: A61K31/165 ,  A61K31/54 ,  A61K31/497 ,  A61K31/445

CPC classification number: C07D327/04 ,  C07D277/82 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

公开(公告)号：US07384970B2

公开(公告)日：2008-06-10

申请号：US10807613

申请日：2004-03-23

Applicant: Hong Liu ,  Phil Alper ,  Arnab Chatterjee ,  David Tully ,  Badry Bursulaya ,  David Woodmansee ,  Robert Epple ,  Jennifer Leslie Harris ,  Jun Li

Inventor： Hong Liu ,  Phil Alper ,  Arnab Chatterjee ,  David Tully ,  Badry Bursulaya ,  David Woodmansee ,  Robert Epple ,  Jennifer Leslie Harris ,  Jun Li

IPC: A61K31/4045 ,  C07D209/08

CPC classification number: C07D405/12 ,  C07C237/22 ,  C07C237/24 ,  C07C257/18 ,  C07C311/19 ,  C07C311/29 ,  C07C2601/14 ,  C07D207/12 ,  C07D207/24 ,  C07D209/08 ,  C07D209/42 ,  C07D211/60 ,  C07D213/71 ,  C07D231/14 ,  C07D257/04 ,  C07D261/18 ,  C07D271/10 ,  C07D307/20 ,  C07D307/24 ,  C07D307/68 ,  C07D309/08 ,  C07D311/22 ,  C07D333/40 ,  C07D335/02 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

Abstract translation: 本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。

公开(公告)号：US20070275906A1

公开(公告)日：2007-11-29

申请号：US11749430

申请日：2007-05-16

Applicant: David Tully ,  Arnab Chatterjee ,  Agnes Vidal ,  Hank Petrassi ,  Zhiwei Wang ,  Badry Bursulaya ,  Glen Spraggon

Inventor： David Tully ,  Arnab Chatterjee ,  Agnes Vidal ,  Hank Petrassi ,  Zhiwei Wang ,  Badry Bursulaya ,  Glen Spraggon

IPC: A61K38/04 ,  A61K31/454 ,  C07K5/04

CPC classification number: C07D417/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0821 ,  C07K5/0827

Abstract: The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.

Abstract translation: 本发明提供了可用于调节通道活化蛋白酶的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与通道活化蛋白酶（包括但不限于前列腺素PRSS22，TMPRSS11）相关的病症的方法 （例如TMPRSS11B，TMPRSS11E），TMPRSS2，TMPRSS3，TMPRSS4（MTSP-2），matriptase（MTSP-1），CAP2，CAP3，胰蛋白酶，组织蛋白酶A或嗜中性粒细胞弹性蛋白酶。

公开(公告)号：US07109243B2

公开(公告)日：2006-09-19

申请号：US10807612

申请日：2004-03-23

Applicant: Hong Liu ,  David Tully ,  Robert Epple ,  Badry Bursulaya ,  Jennifer Williams ,  Arnab Chatterjee ,  Jennifer Leslie Harris ,  Jun Li

Inventor： Hong Liu ,  David Tully ,  Robert Epple ,  Badry Bursulaya ,  Jennifer Williams ,  Arnab Chatterjee ,  Jennifer Leslie Harris ,  Jun Li

IPC: A01N47/28

CPC classification number: C07D307/68 ,  C07C237/14 ,  C07C237/20 ,  C07C255/57 ,  C07C275/28 ,  C07C275/30 ,  C07C275/42 ,  C07C2601/14 ,  C07D213/56 ,  C07D213/64 ,  C07D237/24 ,  C07D239/52 ,  C07D277/56 ,  C07D333/38

Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

Abstract translation: 本发明提供用于选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶（例如cathespin K）的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。

公开(公告)号：US06906158B2

公开(公告)日：2005-06-14

申请号：US10799360

申请日：2004-03-11

Applicant: David Tully

Inventor： David Tully

IPC: C08F26/00 ,  C08F26/06 ,  C08F124/00 ,  C08F126/06 ,  C08F126/08 ,  C08F134/02 ,  C08F226/06 ,  C08G73/06 ,  G01N20060101

CPC classification number: C08F226/06 ,  C08F2/38 ,  C08F26/06 ,  C08F126/06

Abstract: This invention provides novel methods for synthesis of narrow polydispersity oxazolone-containing polymers via nitroxide-mediated living free radical polymerization, as well as the products and derivatives thereof.

Abstract translation: 本发明提供了通过硝基氧介导的活性自由基聚合合成窄的多分散恶唑酮聚合物的新方法及其产物和衍生物。

公开(公告)号：US20050049244A1

公开(公告)日：2005-03-03

申请号：US10868459

申请日：2004-06-10

Applicant: Hong Liu ,  David Tully ,  Phillip Alper ,  Robert Epple ,  Arnab Chatterjee ,  Michael Roberts

Inventor： Hong Liu ,  David Tully ,  Phillip Alper ,  Robert Epple ,  Arnab Chatterjee ,  Michael Roberts

IPC: A61K20060101 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/47 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/537 ,  A61K31/54 ,  C07D277/82 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07D327/04 ,  C07D277/82 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

公开(公告)号：US20080242671A1

公开(公告)日：2008-10-02

申请号：US12055154

申请日：2008-03-25

Applicant: Hong Liu ,  Phillip Alper ,  Arnab Chatterjee ,  David Tully ,  Badry Bursulaya ,  David Woodmansee ,  Robert Epple ,  Jennifer Leslie Harris ,  Jun Li

Inventor： Hong Liu ,  Phillip Alper ,  Arnab Chatterjee ,  David Tully ,  Badry Bursulaya ,  David Woodmansee ,  Robert Epple ,  Jennifer Leslie Harris ,  Jun Li

IPC: A61K31/501 ,  A61K31/165 ,  C07C233/63 ,  A61K31/454 ,  C07D401/12 ,  C07D209/04 ,  A61K31/404 ,  C07D401/14

CPC classification number: C07D405/12 ,  C07C237/22 ,  C07C237/24 ,  C07C257/18 ,  C07C311/19 ,  C07C311/29 ,  C07C2601/14 ,  C07D207/12 ,  C07D207/24 ,  C07D209/08 ,  C07D209/42 ,  C07D211/60 ,  C07D213/71 ,  C07D231/14 ,  C07D257/04 ,  C07D261/18 ,  C07D271/10 ,  C07D307/20 ,  C07D307/24 ,  C07D307/68 ,  C07D309/08 ,  C07D311/22 ,  C07D333/40 ,  C07D335/02 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

公开(公告)号：US20070276002A1

公开(公告)日：2007-11-29

申请号：US11749001

申请日：2007-05-15

Applicant: David Tully ,  Arnab Chatterjee ,  Hank Michael Petrassi ,  Badry Bursulaya ,  Glen Spraggon

Inventor： David Tully ,  Arnab Chatterjee ,  Hank Michael Petrassi ,  Badry Bursulaya ,  Glen Spraggon

IPC: A61K31/454 ,  A61K31/4439 ,  A61K31/4178 ,  A61K31/4025 ,  A61K31/401 ,  C07D403/02

CPC classification number: C07K5/0806 ,  A61K38/00 ,  C07K5/06165

Abstract: The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.

Abstract translation: 本发明提供了可用于调节通道活化蛋白酶的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与通道活化蛋白酶相关的病症的方法，包括但不限于前列腺素PRSS22，TMPRSS11（ 例如TMPRSS11B，TMPRSS11E），TMPRSS2，TMPRSS3，TMPRSS4（MTSP-2），matriptase（MTSP-1），CAP2，CAP3，胰蛋白酶，组织蛋白酶A或嗜中性粒细胞弹性蛋白酶。

公开(公告)号：US20070232606A1

公开(公告)日：2007-10-04

申请号：US11568459

申请日：2005-04-29

Applicant: Hong Liu ,  David Tully ,  Arnab Chatterjee ,  Phillip Alper ,  David Woodmansee ,  Daniel Mutnick

Inventor： Hong Liu ,  David Tully ,  Arnab Chatterjee ,  Phillip Alper ,  David Woodmansee ,  Daniel Mutnick

IPC: A61K31/535 ,  C07D413/00

CPC classification number: C07D263/56 ,  C07D211/66 ,  C07D273/02 ,  C07D277/64 ,  C07D295/185 ,  C07D307/30

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.

Abstract translation: 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与组织蛋白酶S活性相关的疾病或病症的方法。

公开(公告)号：US5966770A

公开(公告)日：1999-10-19

申请号：US78988

申请日：1998-05-14

Applicant: Kevin T. Byrne ,  David Tully

Inventor： Kevin T. Byrne ,  David Tully

IPC: B24D15/02 ,  B26D7/08 ,  A47L13/08 ,  A47L13/04

CPC classification number: B26D7/088 ,  B24D15/02

Abstract: A slicer blade cleaning tool including a handle having a grasping area at a first end of a length and breadth to be easily held by the fingers and palm of one hand, and also having a downwardly extending prolongation and attached scraper at an opposite end, with the prolongation and scraper being constructed of a heavy plastic able to withstand forces downwardly and upwardly applied to the prolongation and to the scraper as the scraper is held against a rotating slicing blade in cleaning cheese and/or meat residue remaining after a slicing or cutting action is completed.

Abstract translation: 一种切片机刀片清洁工具，其包括具有在一长度和宽度的第一端处的抓握区域的手柄，以便容易地由一只手的手指和手掌握住，并且在相对端具有向下延伸的延长部分和附着的刮刀， 延长部分和刮刀由能够承受向下和向上施加到伸长部分上的力的重塑料和刮刀构成，因为在切片或切割动作之后残留的清洁干酪和/或肉残留物中刮刀被保持在旋转的切片刀片上 完成了。