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公开(公告)号：US6046217A
公开(公告)日：2000-04-04
申请号：US151626
申请日：1998-09-11
申请人： Richard Friesen , Rejean Fortin , Daniel Dube , Denis Deschenes
发明人： Richard Friesen , Rejean Fortin , Daniel Dube , Denis Deschenes
IPC分类号： C07D213/61 , C07D213/64 , C07D213/70 , A61K213/22 , C07D31/44
CPC分类号： C07D213/64 , C07D213/61 , C07D213/70
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新化合物以及治疗环加氧酶-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用本发明还包括 用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。
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公开(公告)号：US20050009875A1
公开(公告)日：2005-01-13
申请号：US10916097
申请日：2004-08-11
申请人： Daniel Dube , Rejean Fortin , Richard Friesen , Zhaoyin Wang , Jacques Gauthier
发明人： Daniel Dube , Rejean Fortin , Richard Friesen , Zhaoyin Wang , Jacques Gauthier
IPC分类号： A61K31/44 , A61K31/444 , A61K31/655 , C07D213/04 , C07D213/22 , C07D213/26 , C07D213/34 , C07D213/36 , C07D213/44 , C07D213/54 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用本发明还包括 用于治疗包含式I化合物的COX-2介导的疾病的某些药物组合物。
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公开(公告)号：US5817700A
公开(公告)日：1998-10-06
申请号：US814388
申请日：1997-03-11
申请人： Daniel Dube , Rejean Fortin , Richard Frenette , Richard Friesen , Daniel Guay , Sylvie Prescott
发明人： Daniel Dube , Rejean Fortin , Richard Frenette , Richard Friesen , Daniel Guay , Sylvie Prescott
IPC分类号： C07C311/16 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/44 , C07C321/28 , C07C323/22 , C07C323/62 , C07D333/22 , A61K31/10 , C07C317/10
CPC分类号： C07C311/16 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/44 , C07C321/28 , C07C323/22 , C07C323/62 , C07D333/22
摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式I化合物。 本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。
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公开(公告)号：US06812346B2
公开(公告)日：2004-11-02
申请号：US10395788
申请日：2003-03-24
申请人： Daniel Dube , Rejean Fortin , Richard Friesen
发明人： Daniel Dube , Rejean Fortin , Richard Friesen
IPC分类号： C07D21322
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用。本发明还包括 用于治疗包含式I化合物的COX-2介导的疾病的某些药物组合物。
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公开(公告)号：US6001843A
公开(公告)日：1999-12-14
申请号：US181887
申请日：1998-10-29
IPC分类号： A61K31/44 , A61K31/444 , A61K31/655 , C07D213/04 , C07D213/22 , C07D213/26 , C07D213/34 , C07D213/36 , C07D213/44 , C07D213/54 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89 , A61K31/535 , C07D211/70 , C07D211/72 , C07D211/78
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
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公开(公告)号：US07060715B2
公开(公告)日：2006-06-13
申请号：US10916097
申请日：2004-08-11
IPC分类号： C07D213/22 , C07D211/72 , A61K31/435 , A61K31/44
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
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公开(公告)号：US06596736B2
公开(公告)日：2003-07-22
申请号：US10021187
申请日：2001-10-30
IPC分类号： A61K3144
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用。本发明还包括 用于治疗包含式I化合物的COX-2介导的疾病的某些药物组合物。
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公开(公告)号：US6071936A
公开(公告)日：2000-06-06
申请号：US312790
申请日：1999-05-17
IPC分类号： A61K31/44 , A61K31/444 , A61K31/655 , C07D213/04 , C07D213/22 , C07D213/26 , C07D213/34 , C07D213/36 , C07D213/44 , C07D213/54 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
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公开(公告)号：US5861419A
公开(公告)日：1999-01-19
申请号：US893395
申请日：1997-07-11
IPC分类号： A61K31/44 , A61K31/444 , A61K31/655 , C07D213/04 , C07D213/22 , C07D213/26 , C07D213/34 , C07D213/36 , C07D213/44 , C07D213/54 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新型化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无效治疗有效量的式I化合物的患者给药。图像I 本发明还包括用于治疗包含式I化合物的COX-2介导的疾病的某些药物组合物。
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公开(公告)号：US6004950A
公开(公告)日：1999-12-21
申请号：US151633
申请日：1998-09-11
申请人： Richard Friesen , Daniel Dube , Denis Deschenes
发明人： Richard Friesen , Daniel Dube , Denis Deschenes
IPC分类号： C07D213/73 , C07D401/04 , C07D213/74 , A61K31/44 , A61K31/55
CPC分类号： C07D213/73 , C07D401/04
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新化合物以及治疗环加氧酶-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用本发明还包括 用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。
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