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公开(公告)号：US08987437B2
公开(公告)日：2015-03-24
申请号：US13475569
申请日：2012-05-18
申请人： Richard Hung Chiu Yu , Brandon Heath Brown , Richard P. Polniaszek , Benjamin R. Graetz , Keiko Sujino , Duong Duc-Phi Tran , Alan Scott Triman , Kenneth M. Kent , Steven Pfeiffer
发明人： Richard Hung Chiu Yu , Brandon Heath Brown , Richard P. Polniaszek , Benjamin R. Graetz , Keiko Sujino , Duong Duc-Phi Tran , Alan Scott Triman , Kenneth M. Kent , Steven Pfeiffer
IPC分类号： C07H19/00 , C07F9/6561 , C07D473/34 , C07F9/40 , C07F9/44 , C07H19/20 , C07H19/16 , C07H23/00
CPC分类号： C07H19/20 , C07D473/34 , C07F9/4075 , C07F9/4449 , C07F9/65616 , C07H19/02 , C07H19/04 , C07H19/16 , C07H19/173 , C07H23/00
摘要： The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
摘要翻译： 本发明提供可用于制备具有有效抗HIV特性的化合物的合成方法和合成中间体。
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公开(公告)号：US20120296076A1
公开(公告)日：2012-11-22
申请号：US13475569
申请日：2012-05-18
申请人： Richard Hung Chiu Yu , Brandon Heath Brown , Richard P. Polniaszek , Benjamin R. Graetz , Keiko Sujino , Duong Duc-Phi Tran , Alan Scott Triman , Kenneth M. Kent , Steven Pfeiffer
发明人： Richard Hung Chiu Yu , Brandon Heath Brown , Richard P. Polniaszek , Benjamin R. Graetz , Keiko Sujino , Duong Duc-Phi Tran , Alan Scott Triman , Kenneth M. Kent , Steven Pfeiffer
CPC分类号： C07H19/20 , C07D473/34 , C07F9/4075 , C07F9/4449 , C07F9/65616 , C07H19/02 , C07H19/04 , C07H19/16 , C07H19/173 , C07H23/00
摘要： The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
摘要翻译： 本发明提供可用于制备具有有效抗HIV特性的化合物的合成方法和合成中间体。
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公开(公告)号：US20120108601A1
公开(公告)日：2012-05-03
申请号：US13336512
申请日：2011-12-23
申请人： Eric D. Dowdy , Kenneth M. Kent , Norma J. Tom , Vahid Zia
发明人： Eric D. Dowdy , Kenneth M. Kent , Norma J. Tom , Vahid Zia
IPC分类号： A61K31/501 , A61P31/14
CPC分类号： C07D471/04
摘要： A crystalline compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating crystalline compound (1) are provided.
摘要翻译： 提供式（1）的结晶化合物及其盐和溶剂合物用于治疗或预防丙型肝炎病毒感染提供制备和配制结晶化合物（1）的方法。
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公开(公告)号：US5886213A
公开(公告)日：1999-03-23
申请号：US917640
申请日：1997-08-22
申请人： Kenneth M. Kent , Choung U. Kim , Lawrence R. McGee , John D. Munger , Ernest J. Prisbe , Michael J. Postich , John C. Rohloff , Daphne E. Kelly , Matthew A. Williams , Lijun Zhang
发明人： Kenneth M. Kent , Choung U. Kim , Lawrence R. McGee , John D. Munger , Ernest J. Prisbe , Michael J. Postich , John C. Rohloff , Daphne E. Kelly , Matthew A. Williams , Lijun Zhang
IPC分类号： C07C233/52 , C07C247/14 , C07C205/04 , C07C229/08
CPC分类号： C07C247/14 , C07C233/52 , C07B2200/07 , C07C2101/16
摘要： The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.
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公开(公告)号：US20090036460A1
公开(公告)日：2009-02-05
申请号：US12217347
申请日：2008-07-03
申请人： Eric D. Dowdy , Kenneth M. Kent , Norma J. Tom , Vahid Zia
发明人： Eric D. Dowdy , Kenneth M. Kent , Norma J. Tom , Vahid Zia
IPC分类号： A61K31/501 , C07D403/14 , A61P31/12
CPC分类号： C07D471/04
摘要： A crystalline compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating crystalline compound (1) are provided.
摘要翻译： 提供式（1）的结晶化合物及其盐和溶剂合物用于治疗或预防丙型肝炎病毒感染提供制备和配制结晶化合物（1）的方法。
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公开(公告)号：US06518438B2
公开(公告)日：2003-02-11
申请号：US09967368
申请日：2001-09-27
申请人： Kenneth M. Kent , Choung U. Kim , Lawrence R. McGee , John D. Munger , Ernest J. Prisbe , Michael J. Postich , John C. Rohloff , Daphne E. Kelly , Matthew A. Williams , Lijun Zhang
发明人： Kenneth M. Kent , Choung U. Kim , Lawrence R. McGee , John D. Munger , Ernest J. Prisbe , Michael J. Postich , John C. Rohloff , Daphne E. Kelly , Matthew A. Williams , Lijun Zhang
IPC分类号： C07D20326
CPC分类号： C07D317/46 , C07C227/08 , C07C2601/16 , C07D203/26 , C07D303/40
摘要： The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.
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7.发明授权
公开(公告)号：US5204455A
公开(公告)日：1993-04-20
申请号：US833242
申请日：1992-02-10
申请人： Brian C. Froehler , Kenneth M. Kent , Sylvia Wu
发明人： Brian C. Froehler , Kenneth M. Kent , Sylvia Wu
CPC分类号： C07H21/00 , B01J19/0046 , C07H19/04 , C07H19/10 , C07H19/20 , B01J2219/00286 , B01J2219/00497 , B01J2219/0059 , B01J2219/00596 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： The present invention describes methods for the production of oligonucleotides under conditions which exploit the desirable characteristics, such as the property of sustaining high degrees of substitution, of functionalized organic polymeric supports while avoiding the sluggish kinetics and low rates of conversion which normally plague syntheses involving such solid supports. By employing the methods and materials disclosed, functionalized support, substituted to a degree of about 250 .mu.mol/g, can be utilized at greater than 98% conversion levels for each sequential nucleotide coupling cycle, to provide unprecedented amounts of isolated oligonucleotide per gram of solid support.
摘要翻译： 本发明描述了在消除官能化有机聚合物载体的所需特性（如维持高取代度的性质）的条件下生产寡核苷酸的方法，同时避免了通常的瘟疫合成涉及这样的动力学和低转化率 固体支持。 通过使用所公开的方法和材料，可以以每个顺序核苷酸偶联循环的大于98％的转化水平使用取代约250μmol/ g的功能化载体，以提供前所未有量的分离的寡核苷酸/克 坚实的支持。
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公开(公告)号：US06204398B1
公开(公告)日：2001-03-20
申请号：US09242119
申请日：1999-04-28
申请人： Kenneth M. Kent , Choung U. Kim , Lawrence R. McGee , John D. Munger , Ernest J. Prisbe , Michael J. Postich , John C. Rohloff , Daphne E. Kelly , Matthew A. Williams , Lijun Zhang
发明人： Kenneth M. Kent , Choung U. Kim , Lawrence R. McGee , John D. Munger , Ernest J. Prisbe , Michael J. Postich , John C. Rohloff , Daphne E. Kelly , Matthew A. Williams , Lijun Zhang
IPC分类号： C07D31744
CPC分类号： C07D303/40 , B05B7/1209 , C07C227/08 , C07C2601/16 , C07D203/26 , C07D317/46 , Y02P20/55
摘要： The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.
摘要翻译： 本发明提供了新的合成方法和组合物。 特别地，提供了可用于合成神经氨酸酶抑制剂的中间体如具有式（I） - （IV）的中间体的新方法和可用作中间体的组合物，其本身可用于合成神经氨酸酶抑制剂。
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公开(公告)号：US6057459A
公开(公告)日：2000-05-02
申请号：US175744
申请日：1998-10-20
申请人： Kenneth M. Kent , Choung U. Kim , Lawrence R. McGee , John D. Munger, Jr. , Ernest J. Prisbe , Michael J. Postich , John C. Rohloff , Daphne E. St. John , Matthew A. Williams , Lijun Zhang
发明人： Kenneth M. Kent , Choung U. Kim , Lawrence R. McGee , John D. Munger, Jr. , Ernest J. Prisbe , Michael J. Postich , John C. Rohloff , Daphne E. St. John , Matthew A. Williams , Lijun Zhang
IPC分类号： B05B7/12 , C07C227/08 , C07D203/26 , C07D303/40 , C07D317/46 , C07D317/68
CPC分类号： C07D303/40 , B05B7/1209 , C07C227/08 , C07D203/26 , C07D317/46 , C07C2101/16 , Y02P20/55
摘要： The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.
摘要翻译： 本发明提供了新的合成方法和组合物。 特别地，提供了可用于合成神经氨酸酶抑制剂的中间体的新方法和可用作中间体的组合物，其本身可用于神经氨酸酶抑制剂的合成。
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公开(公告)号：US5859284A
公开(公告)日：1999-01-12
申请号：US701942
申请日：1996-08-23
申请人： Kenneth M. Kent , Choung U. Kim , Lawrence R. McGee , John D. Munger, Jr. , Ernest J. Prisbe , Michael J. Postich , John C. Rohloff , Daphne E. St. John , Matthew A. Williams , Lijun Zhang
发明人： Kenneth M. Kent , Choung U. Kim , Lawrence R. McGee , John D. Munger, Jr. , Ernest J. Prisbe , Michael J. Postich , John C. Rohloff , Daphne E. St. John , Matthew A. Williams , Lijun Zhang
IPC分类号： B05B7/12 , C07C227/08 , C07D203/26 , C07D303/40 , C07D317/46 , C07C69/757 , C07D307/00
CPC分类号： C07D303/40 , B05B7/1209 , C07C227/08 , C07D203/26 , C07D317/46 , C07C2101/16 , Y02P20/55
摘要： The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.
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