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83 条记录 (耗时 0.046 秒)

    Systems and Methods for Evaluating Enzyme Competency
    6.
    发明申请
    Systems and Methods for Evaluating Enzyme Competency 审中-公开
    评价酶能力的系统和方法

    公开(公告)号：US20090005270A1

    公开(公告)日：2009-01-01

    申请号：US11578323

    申请日：2005-09-20

    申请人： Richard J. Melker ,  Timothy E. Morey ,  Laszlo Prokai ,  Donn M. Dennis

    发明人： Richard J. Melker ,  Timothy E. Morey ,  Laszlo Prokai ,  Donn M. Dennis

    IPC分类号： C40B60/12 ,  C12Q1/00 ,  C12M1/00

    CPC分类号： C12Q1/00 ,  C12Q1/26

    摘要： The present invention provides systems and methods for determining enzymatic competency, which is important in determining whether a patient may suffer an adverse drug reaction, has a disease associated with defects in specific enzymatic function, and/or has an enzyme defect that is likely to cause pathophysiology. As contemplated herein, a parent molecular entity is administered to a patient in whom enzymatic competency is to be determined. A sample of the patient's bodily fluid is exposed to a sensor of the invention to distinguish, detect, and quantify a detectable entity in the bodily fluid. Sensor-acquired data regarding the detectable entity is used to determine enzymatic competency. Preferably, a sample of a patient's exhaled breath is collected and exposed to the sensor of the invention. Types of sensor systems of the invention include, but are not limited to, surface resonance arrays; microelectromechanical sensors (such as microcantilever-based technology); molecularly imprinted polymer sensors; amplifying fluorescent sensor technology; aptamer-based sensor technology; SAW sensors; infrared sensors; fuel cells; chemical reactors; and pH sensitive sensors.

    摘要翻译： 本发明提供了确定酶活性的系统和方法，其在确定患者是否可能遭受不良药物反应，具有与特定酶功能缺陷相关的疾病和/或具有可能导致的酶缺陷 病理生理学。 如本文所考虑的，将母体分子实体施用于要测定酶能力的患者。 将患者体液的样品暴露于本发明的传感器以区分，检测和定量体液中的可检测实体。 关于可检测实体的传感器获取的数据用于确定酶的能力。 优选地，将患者呼出的呼吸的样品收集并暴露于本发明的传感器。 本发明的传感器系统的类型包括但不限于表面共振阵列; 微机电传感器（如基于微型悬臂梁的技术）; 分子印迹聚合物传感器; 放大荧光传感器技术; 基于适体的传感器技术; SAW传感器; 红外传感器; 燃料电池; 化学反应堆 和pH敏感传感器。

    Hand washing compliance detection system
    7.
    发明授权
    Hand washing compliance detection system 有权
    手洗一致性检测系统

    公开(公告)号：US07978083B2

    公开(公告)日：2011-07-12

    申请号：US12772583

    申请日：2010-05-03

    申请人： Richard J. Melker ,  Nikolaus Gravenstein ,  Donn M. Dennis ,  Christopher D. Batich

    发明人： Richard J. Melker ,  Nikolaus Gravenstein ,  Donn M. Dennis ,  Christopher D. Batich

    IPC分类号： G08B23/00

    CPC分类号： G08B21/245

    摘要： Systems and methods are provided for monitoring use of hand washing agents to determine compliance with hand hygiene guidelines. A hand washing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's hand washing technique. After the hand washing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the hand washing agent and hand hygiene compliance.

    摘要翻译： 提供了系统和方法，用于监控洗手剂的使用，以确定是否符合手部卫生指南。 手洗剂具有可检测的挥发性化合物，例如气味，然后使用受试者的洗手技术将其摩擦到受试者的手上。 洗手后，将受试者的手暴露在检测器（例如徽章）中，该检测器包括能够检测挥发性化合物的传感器，以及传达挥发性化合物检测的指示剂，指示使用洗手液 代理和手卫生合规。

    Hand Washing Compliance Detection System
    8.
    发明申请
    Hand Washing Compliance Detection System 有权
    手洗一致性检测系统

    公开(公告)号：US20100231385A1

    公开(公告)日：2010-09-16

    申请号：US12772583

    申请日：2010-05-03

    申请人： Richard J. Melker ,  Nikolaus Gravenstein ,  Donn M. Dennis ,  Christopher D. Batich

    发明人： Richard J. Melker ,  Nikolaus Gravenstein ,  Donn M. Dennis ,  Christopher D. Batich

    IPC分类号： G08B21/00

    CPC分类号： G08B21/245

    摘要： Systems and methods are provided for monitoring use of hand washing agents to determine compliance with hand hygiene guidelines. A hand washing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's hand washing technique. After the hand washing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the hand washing agent and hand hygiene compliance.

    摘要翻译： 提供了系统和方法，用于监控洗手剂的使用，以确定是否符合手部卫生指南。 手洗剂具有可检测的挥发性化合物，例如气味，然后使用受试者的洗手技术将其摩擦到受试者的手上。 洗手后，将受试者的手暴露在检测器（例如徽章）中，该检测器包括能够检测挥发性化合物的传感器，以及传达挥发性化合物检测的指示剂，指示使用洗手液 代理和手卫生合规。

    Hand washing compliance detection system
    9.
    发明授权
    Hand washing compliance detection system 有权
    手洗一致性检测系统

    公开(公告)号：US07755494B2

    公开(公告)日：2010-07-13

    申请号：US11760100

    申请日：2007-06-08

    申请人： Richard J. Melker ,  Nikolaus Gravenstein ,  Donn M. Dennis ,  Christopher D. Batich

    发明人： Richard J. Melker ,  Nikolaus Gravenstein ,  Donn M. Dennis ,  Christopher D. Batich

    IPC分类号： G08B23/00

    CPC分类号： G08B21/245

    摘要： Systems and methods are provided for monitoring use of hand washing agents to determine compliance with hand hygiene guidelines. A hand washing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's hand washing technique. After the hand washing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the hand washing agent and hand hygiene compliance.

    摘要翻译： 提供了系统和方法，用于监控洗手剂的使用，以确定是否符合手部卫生指南。 手洗剂具有可检测的挥发性化合物，例如气味，然后使用受试者的洗手技术将其摩擦到受试者的手上。 洗手后，将受试者的手暴露在检测器（例如徽章）中，该检测器包括能够检测挥发性化合物的传感器，以及传达挥发性化合物检测的指示剂，指示使用洗手液 代理和手卫生合规。