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    Tubular articles
    2.
    发明授权
    Tubular articles 失效
    管状文章

    公开(公告)号：US5091442A

    公开(公告)日：1992-02-25

    申请号：US613581

    申请日：1990-11-28

    申请人： Richard Milner

    发明人： Richard Milner

    IPC分类号： A61M25/00 ,  A61B19/04 ,  A61F6/04 ,  A61L29/16 ,  A61L31/16 ,  A61L33/00

    CPC分类号： A61L29/16 ,  A61B42/00 ,  A61F6/04 ,  A61L31/16 ,  A61L2300/202 ,  A61L2300/404

    摘要： Tubular articles such as condoms or catheters are rendered antimicrobially effective by incorporating therein an effective amount of a non-ionic sparingly water soluble antimicrobial agent. Preferably the antimicrobial is triclosan and the tubular article is a condom made from natural rubber latex. A method of manufacturing the tubular articles is described in which the anti-microbial agent is incorporated into the material forming the article before the article is formed.

    摘要翻译： PCT No.PCT / GB89 / 01048 Sec。 371日期1990年11月28日 102（e）日期1990年11月28日PCT 1989年9月6日PCT公布。 第WO90 / 02573号公报 1990年3月22日。通过在其中加入有效量的非离子微水溶性抗微生物剂，诸如避孕套或导管之类的管状物品具有抗微生物效果。 优选地，抗微生物剂是三氯生，并且管状制品是由天然橡胶胶乳制成的避孕套。 描述了制造管状制品的方法，其中在形成制品之前将抗微生物剂并入形成制品的材料中。

    SURFACE BOUND ACTIVES
    3.
    发明申请
    SURFACE BOUND ACTIVES 审中-公开
    表面活性剂

    公开(公告)号：US20100098738A1

    公开(公告)日：2010-04-22

    申请号：US12526457

    申请日：2008-02-11

    申请人： Richard Milner

    发明人： Richard Milner

    IPC分类号： A61F2/00 ,  A61K38/16

    CPC分类号： A61L27/54 ,  A61L27/04 ,  A61L27/34 ,  A61L2300/216 ,  A61L2300/406 ,  A61L2300/606

    摘要： An implantable metal device having an active biosurface, the device comprising a non-peptide polymer spacer having a plurality of target sites, at least one or more of the target sites binding a biologically active agent, wherein the target sites are derived from a plurality of carbonyl, epoxy, hydroxyl or thiol target reactive groups or a combination thereof or wherein the biologically active agent is any agent which is capable of modifying the behaviour of cells; a process for generating an active biosurface at the surface of the implantable metal device, comprising contacting a non-peptide polymer spacer having a plurality of target reactive groups with a biologically active agent having one or more reactive functional groups and reaction thereof, thereby binding the biologically active agent to the polymer wherein the, polymer is anchored to the surface of the implantable metal device or subsequently anchoring the polymer to the surface of the implantable metal device by means of unreacted target reactive groups; the implantable metal device having a surface which is receptive for tethering the biologically active agent; a chemical intermediate comprising the polymer spacer anchored to the chemical anchor; processes for the preparation thereof; a method of treating an animal comprising inserting the implantable metal device into a site in need thereof on said animal; and uses thereof as an implantable or subcutaneous metal device, or non-surgical device or a coating thereof, preferably any orthopaedic, cardiovascular, circulatory system or dental implant, tissue engineering device, fixation device, reconstructive device or joint member or trauma-related devices or research tools or particles for shaping into such form.

    摘要翻译： 一种具有活性生物表面的可植入金属装置，该装置包括具有多个靶位点的非肽聚合物间隔基，至少一个或多个目标位点结合生物活性剂，其中靶位点衍生自多个 羰基，环氧基，羟基或硫醇靶反应性基团或其组合，或其中生物活性剂是能够改变细胞行为的任何试剂; 在可植入金属器件的表面产生活性生物表面的方法，包括使具有多个靶反应性基团的非肽聚合物间隔物与具有一个或多个反应性官能团的生物活性剂及其反应物接触，从而将 聚合物的生物活性剂，其中聚合物锚定到可植入金属装置的表面，或随后通过未反应的目标反应性基团将聚合物锚定到可植入金属装置的表面; 所述可植入金属装置具有可接受所述生物活性剂的束缚的表面; 化学中间体，其包含锚定在化学锚上的聚合物间隔物; 制备方法; 一种处理动物的方法，包括将所述可植入金属装置插入所述动物的有需要的部位; 及其用作可植入或皮下金属装置，或非手术装置或其涂层，优选任何矫形，心血管，循环系统或牙科植入物，组织工程装置，固定装置，重建装置或关节构件或创伤相关装置 或用于形成这种形式的研究工具或颗粒。

    Gloves, their manufacture and use
    4.
    发明授权
    Gloves, their manufacture and use 失效

    公开(公告)号：US5261421A

    公开(公告)日：1993-11-16

    申请号：US686171

    申请日：1991-04-16

    申请人： Richard Milner

    发明人： Richard Milner

    IPC分类号： A41D19/00 ,  A61B19/04 ,  A61L31/16 ,  A61B19/00

    CPC分类号： A61L31/16 ,  A61B42/00 ,  A41D19/0055 ,  A41D2400/34 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/404 ,  Y10S128/917

    摘要： Antimicrobial gloves such as those made of natural rubber latex may be manufactured by incorporating an antimicrobially effective amount of a non-ionic, sparingly water soluble antimicrobial agent, such as 2,4,4'-tricloro-2'-hydroxyphenyl ether, into the glove material prior to forming the glove. The antimicrobial agent may be present in amounts ranging from 0.1 to 10% by weight of the antimicrobial agent. The wearer contacting surface of the glove may also be dusted with a powder containing an antimicrobial effective amount of an antimicrobial agent such as chlorhexidine digluconate. The powder may comprise a complex of chlorhexidine digluconate and cyclodextrin.

    Gloves, their manufacture and use
    5.
    发明授权
    Gloves, their manufacture and use 失效
    手套，其制造和使用

    公开(公告)号：US5180605A

    公开(公告)日：1993-01-19

    申请号：US686177

    申请日：1991-04-16

    申请人： Richard Milner

    发明人： Richard Milner

    IPC分类号： A41D19/00 ,  A61B19/04 ,  A61L31/16

    CPC分类号： A61B42/00 ,  A41D19/0055 ,  A41D2400/34

    摘要： Antimicrobial gloves such as those made of natural rubber latex may be manufactured by incorporating an antimicrobially effective amount of a non-ionic, sparingly water soluble antimicrobial agent, such as 2,4,4'-tricloro-2'-hydroxyphenyl ether, into the glove material prior to forming the glove. The antimicrobial agent may be present in amounts ranging from 0.1 to 10% by weight of the antimicrobial agent. The wearer contacting surface of the glove may also be dusted with a powder containing an antimicrobial effective amount of an antimicrobial agent such as chlorhexidine digluconate. The powder may comprise a complex of chlorhexidine digluconate and cyclodextrin.

    摘要翻译： 可以通过将抗微生物有效量的非离子型微水溶性抗微生物剂如2,4,4'-三氯-2'-羟基苯基醚加入到抗微生物手套中，例如由天然橡胶胶乳制成的抗微生物手套 手套材料在形成手套之前。 抗微生物剂的存在量可以为抗微生物剂的0.1-10％（重量）。 手套的佩戴者接触表面也可以用含有抗微生物有效量的抗微生物剂（例如氯己定二葡萄糖酸盐）的粉末撒粉。 粉末可以包含氯己定二葡萄糖酸盐和环糊精的复合物。

    Gloves, their manufacture and use
    6.
    发明授权
    Gloves, their manufacture and use 失效
    手套，其制造和使用

    公开(公告)号：US5031245A

    公开(公告)日：1991-07-16

    申请号：US341946

    申请日：1989-04-20

    申请人： Richard Milner

    发明人： Richard Milner

    IPC分类号： A41D19/00 ,  A61B19/04 ,  A61L31/16

    CPC分类号： A61L31/16 ,  C08J5/02 ,  A41D19/0055 ,  A41D2400/34 ,  A61B42/00 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/404 ,  C08J2307/02

    摘要： Antimicrobial gloves such as those made of natural rubber latex may be manufactured by incorporating an antimicrobially effective amount of a non-ionic, sparingly water soluble antimicrobial agent, such as 2,4,4'-tricloro-2'-hydroxyphenyl ether, into the glove material prior to forming the glove. The antimicrobial agent may be present in amounts ranging from 0.1 to 10% by weight of the antimicrobial agent. The wearer contacting surface of the glove may also be dusted with a powder containing an antimicrobial effective amount of an antimicrobial agent such as chlorhexidine digluconate. The powder may comprise a complex of chlorhexidine digluconate and cyclodextrin.

    摘要翻译： 可以通过将抗微生物有效量的非离子型微水溶性抗微生物剂如2,4,4'-三氯-2'-羟基苯基醚加入到抗微生物手套中，例如由天然橡胶胶乳制成的抗微生物手套 手套材料在形成手套之前。 抗微生物剂的存在量可以为抗微生物剂的0.1-10％（重量）。 手套的佩戴者接触表面也可以用含有抗微生物有效量的抗微生物剂（例如氯己定二葡糖酸盐）的粉末撒粉。 粉末可以包含氯己定二葡萄糖酸盐和环糊精的复合物。

    Orthopaedic splinting material
    7.
    发明授权
    Orthopaedic splinting material 失效
    骨科夹板材料

    公开(公告)号：US4960116A

    公开(公告)日：1990-10-02

    申请号：US204084

    申请日：1988-06-08

    申请人： Richard Milner

    发明人： Richard Milner

    IPC分类号： A61L15/07 ,  A61F13/04 ,  A61L15/12 ,  C08G18/10 ,  C08G18/28 ,  C08G18/71 ,  C08G65/32 ,  C08G65/333 ,  C08K5/205

    CPC分类号： C08G18/10 ,  A61L15/12 ,  C08G18/283 ,  C08G18/71 ,  C08G65/33358 ,  C08K5/205

    摘要： A low tack orthopedic splinting material which includes a substrate coated with a low tack water curable composition that has an isocyanate resin which has dissolved therein from 1 to 10% of a compound of the formula (VII): R.sup.1 --X--(OCH.sub.2 CH.sub.2).sub.n --O--CO--(NH).sub.m --R.sup.2 wherein R.sup.1 is alkyl of 1 to 14 carbon atoms, phenyl, phenyl substituted by alkyl of 1 to 12 carbon atoms or alkyl of 1 to 4 carbon atoms substituted by phenyl, R.sup.2 is alkyl of 1 to 14 carbon atoms, phenyl, phenyl substituted by alkyl of 1 to 12 carbon atoms or alkyl of 1 to 4 carbon atoms substituted by phenyl, n is 6 to 100, m is 0 or 1 and x is a bond or --(NH).sub.m --CO--.