公开(公告)号：US20130185852A1

公开(公告)日：2013-07-25

申请号：US13877937

申请日：2011-10-06

申请人： Richard Vince ,  Andrew Woodhead

发明人： Richard Vince ,  Andrew Woodhead

IPC分类号： A41D13/00

CPC分类号： A63B69/20 ,  A41D13/0015 ,  A63B69/004 ,  A63B69/26 ,  A63B69/34 ,  A63B71/081 ,  A63B71/12 ,  A63B71/1225 ,  A63B2071/1208 ,  A63B2071/1241 ,  A63B2071/1258 ,  A63B2225/62 ,  F16M13/02

摘要： Protective apparel for use in martial arts or fitness training exercises involving contact between two participants, such as pad work or spar training, comprises a strike surface (11) carried on an inflatable bladder (12), and securing means (21-23) to enable the apparel (10, 40) to be worn by a user (30) during spar training. During use, the inflatable bladder (12) is inflated to a sufficient pressure to withstand strikes from a sparring partner. The protective apparel may take the form of a torso protector (10) or thigh protector (40), or other variants. These may be worn by the user (30) either alone or in combination to increase the area of the strike surface (11), and thus also increase the area of the user's body (30) which is protected.

摘要翻译： 用于武术或健身训练的保护性服装涉及两个参与者之间的接触，例如衬垫工作或翼梁训练，包括承载在可充气囊（12）上的撞击表面（11）和固定装置（21-23）， 使得服装（10,40）能够在训练期间由用户（30）佩戴。 在使用期间，可充气囊（12）被充气到足够的压力以经受来自搭档的撞击。 保护性服装可以采取躯干保护器（10）或大腿保护器（40）或其他变体的形式。 这些可以由用户（30）单独地或组合地佩戴以增加撞击表面（11）的面积，并且因此也增加了被保护的使用者的身体（30）的面积。

公开(公告)号：US09227127B2

公开(公告)日：2016-01-05

申请号：US13877950

申请日：2011-09-14

申请人： Richard Vince ,  Andrew Woodhead

发明人： Richard Vince ,  Andrew Woodhead

IPC分类号： A63B69/20 ,  A63B69/00 ,  A63B69/26 ,  A63B69/34 ,  A63B71/08 ,  A63B71/12 ,  A41D13/00 ,  F16M13/02

CPC分类号： A63B69/20 ,  A41D13/0015 ,  A63B69/004 ,  A63B69/26 ,  A63B69/34 ,  A63B71/081 ,  A63B71/12 ,  A63B71/1225 ,  A63B2071/1208 ,  A63B2071/1241 ,  A63B2071/1258 ,  A63B2225/62 ,  F16M13/02

摘要： Apparatus (10) for use in martial arts or fitness training, comprises a strike surface adapted to be kicked or punched by a user during training, and mounting means (12) adapted for removably securing the strike surface (11) to a structural element, such as a door frame. The mounting means (12) are shaped and dimensioned so as to receive the structural element, and comprise at least one inflatable bladder (16) adapted upon inflation to cause the mounting means (12) to grip the structural element.

摘要翻译： 用于武术或健身训练的装置（10）包括适于在训练期间由使用者踢或打孔的撞击表面以及适于将冲击表面（11）可移除地固定到结构元件上的安装装置（12） 例如门框。 安装装置（12）的形状和尺寸被设计成接收结构件，并且包括至少一个适于膨胀的可膨胀气囊（16），以使安装装置（12）夹紧结构件。

公开(公告)号：US20130203564A1

公开(公告)日：2013-08-08

申请号：US13877950

申请日：2011-09-14

申请人： Richard Vince ,  Andrew Woodhead

发明人： Richard Vince ,  Andrew Woodhead

IPC分类号： A63B69/20 ,  F16M13/02

CPC分类号： A63B69/20 ,  A41D13/0015 ,  A63B69/004 ,  A63B69/26 ,  A63B69/34 ,  A63B71/081 ,  A63B71/12 ,  A63B71/1225 ,  A63B2071/1208 ,  A63B2071/1241 ,  A63B2071/1258 ,  A63B2225/62 ,  F16M13/02

摘要： Apparatus (10) for use in martial arts or fitness training, comprises a strike surface adapted to be kicked or punched by a user during training, and mounting means (12) adapted for removably securing the strike surface (11) to a structural element, such as a door frame. The mounting means (12) are shaped and dimensioned so as to receive the structural element, and comprise at least one inflatable bladder (16) adapted upon inflation to cause the mounting means (12) to grip the structural element.

摘要翻译： 用于武术或健身训练的装置（10）包括适于在训练期间由使用者踢或打孔的撞击表面以及适于将冲击表面（11）可移除地固定到结构元件上的安装装置（12） 例如门框。 安装装置（12）的形状和尺寸被设计成接收结构件，并且包括至少一个适于膨胀的可膨胀气囊（16），以使安装装置（12）夹紧结构件。

公开(公告)号：US20060063782A1

公开(公告)日：2006-03-23

申请号：US10519922

申请日：2003-07-03

申请人： Christopher Murray ,  Michael Hartshorn ,  Martyn Frederickson ,  Miles Congreve ,  Alessandro Padova ,  Steven Woodhead ,  Adrian Gill ,  Andrew Woodhead

发明人： Christopher Murray ,  Michael Hartshorn ,  Martyn Frederickson ,  Miles Congreve ,  Alessandro Padova ,  Steven Woodhead ,  Adrian Gill ,  Andrew Woodhead

IPC分类号： A61K31/4965 ,  C07D213/63 ,  A61K31/44

CPC分类号： C07D213/73 ,  C07D213/65 ,  C07D213/74 ,  C07D213/81 ,  C07D241/18 ,  C07D241/20 ,  C07D241/24 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

摘要： Compounds of the formula (I), wherein: —X═Y— is selected from —CR =CR — and —CR ═N—; R is selected from H, halo, NRR′, NHC(═O)R, NHC(═O)NRR′, NH2SO2R, and C(═O)NRR′; R and R (where present) are independently selected from H, optionally substituted C1-7 alkyl, optionally substituted C5-20 aryl, optionally substituted C3-20 heterocyclyl, halo, amino, amido, hydroxy, ether, thio, thioether, acylamido, ureido and sulfonamino; R is an optionally substituted C5-20 aryl or C5-20 heteroaryl group; and R is selected from R , halo, NHR , C(═O)NHR , OR , SR , NHC(═O)R , NHC(═O)NHR , NHS(═O)R , wherein R is H or C1-3 alkyl (optionally substituted by halo, NH2, OH, SH) are disclosed for use in therapy and for treating diseases ameliorated by inhibiting p38 MAP kinase.

摘要翻译： 式（I）的化合物，其中：-X-Y-选自-CR 2 = CR 3 - 和-CR 2 -N-; R 1选自H，卤素，NRR'，NHC（-O）R，NHC（-O）NRR'，NH 2 SO 2 R和C（-O）NRR'; R 2和R 3（如果存在）独立地选自H，任选取代的C 1-7烷基，任选取代的C 5-20芳基，任选取代的C 3-20杂环基，卤素，氨基，酰胺基，羟基，醚， 硫代，硫醚，酰氨基，脲基和磺氨基; R 4是任选取代的C 5-20芳基或C 5-20杂芳基; R 5选自R 5，卤素，NHR 5，C（O）NHR 5，OR 5，SR 5，NHC（-O） R 5，NHC（-O）NHR 5，NHS（-O）R 5，其中R 5'是H或C 1-3烷基（任选地被卤素，NH 2，OH ，SH）被公开用于治疗和治疗通过抑制p38 MAP激酶而改善的疾病。

公开(公告)号：US20070105900A1

公开(公告)日：2007-05-10

申请号：US10563350

申请日：2004-07-04

申请人： Valerio Berdini ,  Andrew Woodhead ,  Paul Wyatt ,  Michael O'Brien ,  Eva Navarro

发明人： Valerio Berdini ,  Andrew Woodhead ,  Paul Wyatt ,  Michael O'Brien ,  Eva Navarro

IPC分类号： A61K31/4709 ,  A61K31/4745 ,  A61K31/422 ,  A61K31/42 ,  A61K31/4439 ,  A61K31/4178 ,  A61K31/416 ,  C07D403/14 ,  C07D471/02

CPC分类号： C07D401/14 ,  A61K31/00 ,  A61K31/4184 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

摘要： The invention provides compounds of the formula (I): The compounds have activity against cyclin dependent kinases, glycogen synthase kinase and Auroa kinases and are therefore useful to treat cancer and viral diseases.

摘要翻译： 本发明提供式（I）化合物：该化合物具有抗细胞周期蛋白依赖性激酶，糖原合成酶激酶和Auroa激酶的活性，因此可用于治疗癌症和病毒性疾病。

公开(公告)号：US20070259886A1

公开(公告)日：2007-11-08

申请号：US11680818

申请日：2007-03-01

申请人： Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead

发明人： Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead

IPC分类号： A61K31/497 ,  A61P35/00 ,  C07D403/00

CPC分类号： C07D209/44 ,  C07D401/04 ,  C07D401/12

摘要： Compounds having the formula (I): and in particular, those of subgenus VIIa are disclosed as inhibits or modulators of the activity of the heat shock protein Hsp90. As such they are useful for treating cancer, particularly hematopoietic tumors of lymphoid or myeloid lineage, prostate cancer, lung cancer, gastrointestinal stromal tumor, breast cancer and melanoma.

摘要翻译： 公开了具有式（I）：特别是亚属VIIa的化合物作为热休克蛋白Hsp90的活性的抑制剂或调节剂。 因此，它们可用于治疗癌症，特别是淋巴或骨髓谱系的造血肿瘤，前列腺癌，肺癌，胃肠道间质瘤，乳腺癌和黑素瘤。

公开(公告)号：US09179895B2

公开(公告)日：2015-11-10

申请号：US13256884

申请日：2010-03-16

申请人： Gordon Jowett ,  Andrew Woodhead

发明人： Gordon Jowett ,  Andrew Woodhead

IPC分类号： A61B10/00

CPC分类号： A61B10/0051 ,  Y10T29/49826

摘要： According to a first aspect of the present invention there is provided an oral fluid collection device. The oral fluid collection device comprises a handle, a swab holder, and a swab. The swab is in the form of a hollow tube of absorbent material coaxially located about the swab holder, such that the swab is supported by the swab holder along the entire length of the swab.

摘要翻译： 根据本发明的第一方面，提供一种口腔液体收集装置。 口腔液体收集装置包括手柄，拭子保持器和拭子。 拭子是吸收材料的中空管的形式，其同轴地位于拭子保持器周围，使得拭子沿着拭子的整个长度被拭子保持器支撑。

公开(公告)号：US20070259871A1

公开(公告)日：2007-11-08

申请号：US11680830

申请日：2007-03-01

申请人： Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead ,  Alison Woolford

发明人： Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead ,  Alison Woolford

IPC分类号： A61K31/4035 ,  A61K31/47 ,  A61K31/496 ,  A61K31/5377 ,  A61P35/00 ,  C07D209/04 ,  C07D215/00 ,  C07D217/00 ,  C07D227/00 ,  C07D241/00 ,  C07D265/30 ,  C07D401/02 ,  C07D471/00

CPC分类号： C07D401/12 ,  C07C65/21 ,  C07D209/08 ,  C07D209/44 ,  C07D215/08 ,  C07D217/06 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10 ,  C07D491/08 ,  C07D491/10

摘要： The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.

摘要翻译： 本发明提供式（I）的化合物：或其盐，互变异构体，溶剂合物和N-氧化物; 其中R 1是羟基或氢; R 2是羟基; 甲氧基或氢; 条件是R 1和R 2中的至少一个是羟基; R 3选自氢; 卤素; 氰基; 任选取代的C 1-5烃基和任选取代的C 1-5 - 烃氧基; R 4选自氢; 其中n为0或1且R 7为任选取代的无环C 1 - （O）N - ， - -5个烃基或具有3〜7个环成员的单环碳环或杂环基; 卤素; 氰基; 羟基; 氨基; 和任选取代的单或二-C 1-5烃基 - 氨基; 或R 3和R 4一起形成5至7个环成员的单环碳环或杂环; 并且NR 5 R 6形成具有8至12个环成员的任选取代的双环杂环基，其中多达5个环成员是选自氧，氮和硫的杂原子。 该化合物具有作为Hsp90抑制剂的活性。

公开(公告)号：US20060194843A1

公开(公告)日：2006-08-31

申请号：US11336599

申请日：2006-01-20

申请人： Valerio Berdini ,  Michael O'Brien ,  Maria Carr ,  Theresa Early ,  Adrian Gill ,  Gary Trewartha ,  Alison Woolford ,  Andrew Woodhead ,  Paul Wyatt

发明人： Valerio Berdini ,  Michael O'Brien ,  Maria Carr ,  Theresa Early ,  Adrian Gill ,  Gary Trewartha ,  Alison Woolford ,  Andrew Woodhead ,  Paul Wyatt

IPC分类号： A61K31/454 ,  A61K31/416 ,  A61K31/4152 ,  C07D403/02

CPC分类号： C07D231/38 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C04B35/632 ,  C07D231/14 ,  C07D231/40 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D453/02 ,  C07D471/04

摘要： The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3. In formula (0): X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C═O, NRg(C═O) or O(C═O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g. methoxy); or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy); R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).

公开(公告)号：US20120071789A1

公开(公告)日：2012-03-22

申请号：US13256884

申请日：2010-03-16

申请人： Gordon Jowett ,  Andrew Woodhead

发明人： Gordon Jowett ,  Andrew Woodhead

IPC分类号： A61B10/02 ,  B23P11/00

CPC分类号： A61B10/0051 ,  Y10T29/49826

摘要： According to a first aspect of the present invention there is provided an oral fluid collection device 1. The oral fluid collection device 1 comprises a handle 2, a swab holder 4, and a swab 3. The swab 3 is in the form of a hollow tube of absorbent material coaxially located about the swab holder 4, such that the swab 3 is supported by the swab holder 4 along the entire length of the swab 3.

摘要翻译： 根据本发明的第一方面，提供了口腔液体收集装置1.口腔液体收集装置1包括手柄2，拭子保持器4和拭子3.拭子3是中空的形式 吸管材料管同轴地位于拭子保持器4周围，使得拭子3沿拭子3的整个长度被拭子保持件4支撑。