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    Use of creatine or creatine compounds for skin preservation
    5.
    发明授权
    Use of creatine or creatine compounds for skin preservation 失效
    使用肌酸或肌酸化合物进行皮肤保养

    公开(公告)号：US07186754B2

    公开(公告)日：2007-03-06

    申请号：US11088519

    申请日：2005-03-23

    申请人： Rima Kaddurah-Daouk

    发明人： Rima Kaddurah-Daouk

    IPC分类号： A61K31/195 ,  A61K31/19 ,  A61K6/00 ,  A61K8/02

    CPC分类号： A61Q19/08 ,  A61K8/44 ,  A61K8/55 ,  A61K31/155 ,  A61K31/195 ,  A61K31/198 ,  A61K2800/92 ,  A61Q19/02 ,  Y10S514/859 ,  Y10S514/861 ,  Y10S514/864

    摘要： The present invention relates to the use of creatine compounds such as, for example, creatine, creatine phosphate or analogs of creatine, such as creatine-pyruvate, creatine-ascorbate, cyclocreatine, 3 guanidinopropionic acid, guanidinoacetate, homocyclocreatine, guanidino benzoates as energy generating systems and antioxidants for preservation of skin against adverse aging effects and damage secondary to insults such as harmful sun radiations, stress and fatigue. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) molecules that mimic the biological activity of creatine (3) molecules that modulate the creatine kinase system.

    摘要翻译： 本发明涉及肌酸化合物例如肌酸，肌酸磷酸酯或肌酸类似物如肌酸 - 丙酮酸，肌酸 - 抗坏血酸酯，环磷酸，胍胍丙酸，胍基乙酸酯，高碘环酸，苯胍酸胍等作为能量的产生 系统和抗氧化剂，用于保护皮肤免受不利的老化作用和继发于诸如有害的太阳辐射，压力和疲劳等侮辱之类的损伤。 可用于本方法的肌酸化合物包括（1）肌酸，磷酸肌酸和这些化合物的类似物，其可以作为肌酸激酶的底物或底物类似物; （2）模仿肌酸（3）分子调节肌酸激酶系统的生物活性的分子。

    Inhibition of cell death responses induced by oxidative stress
    6.
    发明申请
    Inhibition of cell death responses induced by oxidative stress 审中-公开
    抑制氧化应激引起的细胞死亡反应

    公开(公告)号：US20060128720A1

    公开(公告)日：2006-06-15

    申请号：US10518665

    申请日：2003-03-20

    申请人： Donald Kufe ,  Rima Kaddurah-Daouk

    发明人： Donald Kufe ,  Rima Kaddurah-Daouk

    IPC分类号： A61K31/506

    CPC分类号： A61K31/513 ,  A61K31/505 ,  A61K31/506

    摘要： The invention provides methods of reducing or preventing oxidative stress-induced cell death by contacting a cell with a compound that inhibits the kinase activity and/or the mitochondrial translocation of c-Abl. The methods of the invention can be used to treat individuals individual diagnosed as having or being at risk of contracting a disorder characterized by excessive oxidative stress-induced cell death.

    摘要翻译： 本发明提供了通过使细胞与抑制c-Abl的激酶活性和/或线粒体易位的化合物接触来减少或预防氧化应激诱导的细胞死亡的方法。 本发明的方法可用于治疗个体被诊断为具有或处于以过度氧化应激诱导的细胞死亡为特征的疾病的风险中的个体。