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1.发明授权3-substituted-8-oxo-7-substituted-thioxomethylamino-5 -thia-1-azabicyclo-(4.2.0)oct-2-ene-2-carboxylic acid, diphenylmethyl esters 失效3-取代-8-氧代-7-取代 - 硫代甲基氨基-5-硫杂-1-氮杂双环 - （4.2.0）辛-2-烯-2-羧酸二苯基甲酯
公开(公告)号：US4866169A
公开(公告)日：1989-09-12
申请号：US920398
申请日：1986-10-20
申请人： Robert Babine , William V. Curran , Ving J. Lee
发明人： Robert Babine , William V. Curran , Ving J. Lee
IPC分类号： C07D499/00 , C07D501/34 , C07D501/36
CPC分类号： C07D499/00
摘要： Diphenylmethyl esters of cephalosporins, and processes for synthesizing such, are described and disclosed.
摘要翻译： 头孢菌素的二苯基甲酯及其合成方法的描述和公开。
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2.发明授权
公开(公告)号：US4927922A
公开(公告)日：1990-05-22
申请号：US222463
申请日：1988-07-21
申请人： Ving J. Lee , William V. Curran
发明人： Ving J. Lee , William V. Curran
IPC分类号： A61K31/545 , C07D501/16 , C07D501/18 , C07D501/36 , C07D501/57
CPC分类号： C07D501/36 , C07D501/18 , C07D501/57
摘要： 7.beta.-(Substituted)amino-3-substituted cephalosporanic acids, esters and salts, useful as anti-bacterial agents are described.
摘要翻译： 描述了可用作抗菌剂的7β-（取代的）氨基-3-取代的头孢菌酸，酯和盐。
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公开(公告)号：US4803280A
公开(公告)日：1989-02-07
申请号：US883189
申请日：1986-07-08
申请人： Ving J. Lee , William V. Curran
发明人： Ving J. Lee , William V. Curran
IPC分类号： C07C67/00 , C07C325/00 , C07C327/56 , C07D285/06 , C07D309/04 , C07D333/24 , C07D417/04 , C07D501/20
CPC分类号： C07D417/04 , C07D285/06 , C07D309/04 , C07D333/24
摘要： Intermediates useful for synthesis of cephalosporins are disclosed, which intermediates are concerned with 1,2,3-thiadiazole-4-thiolates and the preparation of such thiolates.
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公开(公告)号：US4958020A
公开(公告)日：1990-09-18
申请号：US350966
申请日：1989-05-12
申请人： Raghavan Krishnan , Jesse Gamble , David Blum , William V. Curran , Ving J. Lee , Ransom B. Conrow
发明人： Raghavan Krishnan , Jesse Gamble , David Blum , William V. Curran , Ving J. Lee , Ransom B. Conrow
IPC分类号： C07D499/87 , A61K31/43 , A61P31/04 , C07D499/00 , C07D499/86 , C07D499/897
CPC分类号： C07D499/00
摘要： A process for producing the compound [2S-(2.alpha.,3.beta.,5.alpha.)]-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-yl-methyl)-4-thia-1-azabicyclo[3 2 0]-heptane-2-carboxylic acid, (4-nitrophenyl)methyl ester, 4,4-dioxide, which comprises reacting a solution of azidopenamsulfone, 4-methoxyphenol and vinylpropionate with a solution of bis(trimethylsilyl)acetamide and 4-methoxyphenol is toluene at 80.degree.-100.degree. C. for 18-30 hours followed by filtering the resulting solution and cooling the filtrate to 0.degree.-10.degree. C.
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公开(公告)号：US4916237A
公开(公告)日：1990-04-10
申请号：US237301
申请日：1988-08-26
申请人： Ving J. Lee , William V. Curran
发明人： Ving J. Lee , William V. Curran
IPC分类号： C07D285/06 , C07D309/04 , C07D333/24 , C07D417/04
CPC分类号： C07D417/04 , C07D285/06 , C07D309/04 , C07D333/24
摘要： Intermediates useful for synthesis of cephalosporins are disclosed, which intermediates are concerned with 1,2,3-thiadiazole-4-thiolates and the preparation of such thiolates.
摘要翻译： 公开了用于合成头孢菌素的中间体，其中间体涉及1,2,3-噻二唑-4-硫醇盐和这种硫醇盐的制备。
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公开(公告)号：US08889826B2
公开(公告)日：2014-11-18
申请号：US11630847
申请日：2005-07-01
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/06086 , C07K7/62 , C07K7/64 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are novel peptides and protected peptides. These compounds can be derived from naturally occurring peptides, such as those selected from colistin, circulin A, polymyxin A, polymyxin B, polymyxin D, octapeptin B, octapeptin C, and [Ile7]polymyxin B1. Also disclosed are pharmaceutical compositions containing the new peptides, as well as methods for preparing the novel peptides and protected peptides.
摘要翻译： 本文公开了新型肽和保护肽。 这些化合物可以衍生自天然存在的肽，例如选自粘菌素，环状蛋白A，多粘菌素A，多粘菌素B，多粘菌素D，八肽蛋白B，八肽蛋白C和[Ile7]多粘菌素B1的肽。 还公开了含有新肽的药物组合物，以及制备新肽和保护肽的方法。
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公开(公告)号：US08415307B1
公开(公告)日：2013-04-09
申请号：US13167495
申请日：2011-06-23
申请人： William V. Curran , Christopher M. Liu , Amy C. D. Bombardier , Richard A. Leese , You Seok Hwang , Blaise S. Lippa , Yanzhi Zhang
发明人： William V. Curran , Christopher M. Liu , Amy C. D. Bombardier , Richard A. Leese , You Seok Hwang , Blaise S. Lippa , Yanzhi Zhang
IPC分类号： A61K38/08
CPC分类号： C07K7/62 , A01N43/713 , A61K38/12 , Y02A50/473 , Y10S930/19
摘要： Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.
摘要翻译： 本文提供了可衍生自多粘菌素（例如多粘菌素A）的新型化合物和新的受保护化合物。该新化合物对多种革兰氏阴性细菌具有抗菌性能，与多粘菌素如多粘菌素A相比具有降低的毒性。还提供 是含有新化合物和新型受保护化合物的抗菌药物组合物，以及制备抗菌化合物和受保护化合物的方法。
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8.发明授权Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them 失效新型2-取代的烷基-3-羧基碳青霉烯作为抗生素及其制备方法
公开(公告)号：US5068232A
公开(公告)日：1991-11-26
申请号：US507271
申请日：1990-04-10
IPC分类号： A61K31/40 , A61K31/397 , A61P31/04 , C07D205/08 , C07D477/00 , C07D477/14 , C07D477/18
CPC分类号： C07D477/14 , C07D205/08
摘要： The invention relates to new 2-substituted alkyl-3-carboxy carbapenems having the formula: ##STR1## with R.sup.1, R.sup.2, R.sup.3, X and Y defined hereafter as antibiotics and beta lactamase inhibitors produced by a novel Michael addition-elimination reaction of a substituted allyl azetidinone in the reaction shown: ##STR2## with R.sup.1, R.sup.2, Q, X and Y defined hereafter.
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9.发明授权4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them 失效4-取代的氮杂环丁酮作为2-取代-3-羧基碳青霉烯类抗生素的前体及其制备方法
公开(公告)号：US5700930A
公开(公告)日：1997-12-23
申请号：US420955
申请日：1995-04-12
IPC分类号： C07D205/08 , C07D477/04 , C07F7/18 , C07F9/568 , C07D477/00 , C07D409/06 , C07D463/00
CPC分类号： C07D205/08 , C07D477/04 , C07F7/1856 , C07F7/186 , C07F9/568
摘要： New 4-substituted azetidinones having the formulae I and II: ##STR1## wherein X is oxygen, sulfur or a moiety of the formula NR.sup.6 where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined hereafter, which are intermediates for the preparation of carbapenem and carbacephem antibacterials and processes for producing such antibacterials through the utilization of an acid mediated ring closure reaction.
摘要翻译： 具有式I和II的新的4-取代的氮杂环丁酮：其中X是氧，硫或式NR6的部分，其中R 1，R 2，R 3，R 4，R 5和R 6在下文中定义，其中 是用于制备碳青霉烯类和碳青霉烯类抗生素的中间体以及通过利用酸介导的闭环反应产生这种抗菌剂的方法。
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10.发明授权4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them 失效4-取代的亚硫酸酯作为2-取代三碳卡巴因抗生素的前体及其生产方法
公开(公告)号：US5189158A
公开(公告)日：1993-02-23
申请号：US672496
申请日：1991-03-20
IPC分类号： C07D205/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/06 , C07D413/12 , C07D463/04 , C07D471/04 , C07D477/00 , C07D477/04 , C07D487/04 , C07F7/18 , C07F9/568 , C07F9/6561
CPC分类号： C07D477/04 , C07D205/08 , C07F7/1856 , C07F7/186 , C07F9/568
摘要： New 4-substituted azetidinones having the formulea I and II: ##STR1## with R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and X defined hereafter, which are intermediates for the preparation of carbapenem and carbacephem antibacterials and processes for producing such antibacterials through the utilization of an acid mediated ring closure reaction.
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