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    Bifunctional fusion protein with thrombolytic and anticoagulant activities and uses thereof
    3.
    发明授权
    Bifunctional fusion protein with thrombolytic and anticoagulant activities and uses thereof 有权
    具有溶栓和抗凝活性的双功能融合蛋白及其用途

    公开(公告)号：US08212003B2

    公开(公告)日：2012-07-03

    申请号：US10526682

    申请日：2003-09-03

    申请人： Bingxing Shi ,  Zuze Wu ,  Aiping Yu ,  Chunna Dong

    发明人： Bingxing Shi ,  Zuze Wu ,  Aiping Yu ,  Chunna Dong

    IPC分类号： A61K38/48 ,  C07K14/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/31 ,  C07K14/815 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/50 ,  C12N9/6459 ,  C12N15/62 ,  C12Y304/21069

    摘要： This application relates to a fusion protein, which is composed of a thrombolytic protein, an anticoagulant protein, and a linker peptide. In particular, the fusion protein is composed of an anticoagulant protein and a protein molecule having plasminogen-activating activity, wherein said two proteins are linked together via a linker peptide, which can be recognized and cleaved by blood coagulation factors. The application also relates to the medical use of said fusion protein, and to the use of the linker peptide which can be recognized by blood coagulation factor in linking a thrombolytic protein and an anticoagulation protein.

    摘要翻译： 本申请涉及融合蛋白，其由溶血栓蛋白，抗凝血蛋白和接头肽组成。 特别地，融合蛋白由抗凝血蛋白和具有纤溶酶原激活活性的蛋​​白质分子组成，其中所述两种蛋白质通过接头肽连接在一起，可通过凝血因子识别和切割。 本申请还涉及所述融合蛋白的医学用途，以及使用凝血因子可以识别血液凝固蛋白和抗凝蛋白的接头肽。

    METHOD FOR PRODUCING FEW-LAYER GRAPHENE
    5.
    发明申请
    METHOD FOR PRODUCING FEW-LAYER GRAPHENE 审中-公开
    生产薄层石墨的方法

    公开(公告)号：US20150376013A1

    公开(公告)日：2015-12-31

    申请号：US14654215

    申请日：2013-12-20

    申请人： Aiping YU ,  Victor CHABOT ,  Zhongwei CHEN

    发明人： Aiping Yu ,  Victor Chabot ,  Zhongwei Chen

    IPC分类号： C01B31/04

    CPC分类号： C01B31/0469 ,  C01B32/19 ,  C01B2204/02 ,  C01B2204/04

    摘要： A method of producing single or few-layer graphene comprises exfoliating graphite with a polymer to form a graphene-polymer composite and subsequently treating the composite to disassociate graphene. The exfoliation process is conducted using sonication. The graphene is disassociated from the polymer by a treatment step such as acid hydrolysis. The method results in highly pure graphene.

    摘要翻译： 生产单层或几层石墨烯的方法包括用聚合物去除石墨以形成石墨烯 - 聚合物复合材料，随后处理复合材料以分离石墨烯。 剥离过程使用超声处理进行。 石墨烯通过诸如酸水解的处理步骤与聚合物分离。 该方法产生高纯度石墨烯。

    Fused protein with the function of both hemolysis and anticoagulation and use of it
    10.
    发明申请
    Fused protein with the function of both hemolysis and anticoagulation and use of it 有权
    融合蛋白具有溶血和抗凝作用的功能

    公开(公告)号：US20060127389A1

    公开(公告)日：2006-06-15

    申请号：US10526682

    申请日：2003-09-03

    申请人： Bingxing Shi ,  Zuze Wu ,  Aiping Yu ,  Chunna Dong

    发明人： Bingxing Shi ,  Zuze Wu ,  Aiping Yu ,  Chunna Dong

    IPC分类号： A61K38/48 ,  C07H21/04 ,  C12P21/04 ,  C12N9/70 ,  C12N9/68

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/31 ,  C07K14/815 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/50 ,  C12N9/6459 ,  C12N15/62 ,  C12Y304/21069

    摘要： This application relates to a fusion protein, which is composed of a thrombolytic protein, an anticoagulant protein, and a linker peptide. In particular, the fusion protein is composed of an anticoagulant protein and a protein molecule having plasminogen-activating activity, wherein said two proteins are linked together via a linker peptide, which can be recognized and cleaved by blood coagulation factors. The application also relates to the medical use of said fusion protein, and to the use of the linker peptide which can be recognized by blood coagulation factor in linking a thrombolytic protein and an anticoagulation protein.

    摘要翻译： 本申请涉及融合蛋白，其由溶血栓蛋白，抗凝血蛋白和接头肽组成。 特别地，融合蛋白由抗凝血蛋白和具有纤溶酶原激活活性的蛋​​白质分子组成，其中所述两种蛋白质通过接头肽连接在一起，可通过凝血因子识别和切割。 本申请还涉及所述融合蛋白的医学用途，以及使用凝血因子可以识别血液凝固蛋白和抗凝蛋白的接头肽。