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    PLACENTAL STEM CELLS DERIVE FROM POST-PARTUM MANMALIAN PLACENTA, AND USES AND METHODS OF TREATMENT USING SAID CELLS
    5.
    发明申请
    PLACENTAL STEM CELLS DERIVE FROM POST-PARTUM MANMALIAN PLACENTA, AND USES AND METHODS OF TREATMENT USING SAID CELLS 审中-公开
    来自马氏体后代的普通干细胞，以及使用细胞的治疗方法和治疗方法

    公开(公告)号：US20120034195A1

    公开(公告)日：2012-02-09

    申请号：US13275246

    申请日：2011-10-17

    申请人： Robert J. HARIRI

    发明人： Robert J. HARIRI

    IPC分类号： A61K35/12 ,  A61P25/28

    CPC分类号： A61K35/28 ,  A61K35/50 ,  A61K35/51 ,  A61K35/545 ,  A61K48/00 ,  A61M1/02 ,  A61M2202/0462 ,  A61M2210/1458 ,  A61M2210/1466 ,  C12N5/0068 ,  C12N5/0605 ,  C12N5/0607 ,  C12N2500/90 ,  C12N2509/00 ,  C12N2533/90

    摘要： The present invention provides compositions and methods of using placental stem cells that originate from a post-partum placenta with conventional cord blood compositions or other stem or progenitor cells. The placental stem cells can be used alone or in a mixture with other stem cell populations. In accordance with the present invention, the placental stem cells may be mixed with other stem cell populations, including but not limited to, umbilical cord blood, fetal and neonatal hematopoietic stem cells and progenitor cells, human stem cells and progenitor cells derived from bone marrow. The placental stem cells and the mixed populations of placental stem cells and stem cells have a multitude of uses and applications, including but not limited to, therapeutic uses for transplantation and treatment and prevention of disease, and diagnostic and research uses.

    摘要翻译： 本发明提供了使用源自产后胎盘的胎盘干细胞与常规脐带血组合物或其它干细胞或祖细胞的组合物和方法。 胎盘干细胞可以单独使用或与其他干细胞群混合使用。 根据本发明，胎盘干细胞可以与其它干细胞群体混合，包括但不限于脐带血，胎儿和新生儿造血干细胞和祖细胞，源自骨髓的人干细胞和祖细胞 。 胎盘干细胞和胎盘干细胞和干细胞的混合种群具有多种用途和应用，包括但不限于用于移植和治疗和预防疾病的治疗用途以及诊断和研究用途。

    TREATMENT OF BRAIN OR SPINAL CORD INJURY USING PLACENTAL STEM CELLS
    6.
    发明申请
    TREATMENT OF BRAIN OR SPINAL CORD INJURY USING PLACENTAL STEM CELLS 审中-公开
    使用平面干细胞治疗脑或脊髓损伤

    公开(公告)号：US20110223141A1

    公开(公告)日：2011-09-15

    申请号：US13108891

    申请日：2011-05-16

    申请人： Robert J. HARIRI

    发明人： Robert J. HARIRI

    IPC分类号： A61K35/12 ,  A61P25/00

    CPC分类号： C12N5/0605 ,  A01N1/021 ,  A61K35/12 ,  A61K35/50 ,  A61K48/00 ,  A61K2035/124 ,  A61M1/02 ,  A61M2202/0462 ,  A61M2210/1458 ,  A61M2210/1466 ,  C12M29/10 ,  C12M47/04 ,  C12N5/0603 ,  C12N5/0647 ,  C12N5/0668 ,  C12N2509/00 ,  C12N2510/02 ,  C12N2533/90

    摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.

    摘要翻译： 本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。 通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。 收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。 本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。 本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。

    POST-PARTUM MAMMALIAN PLACENTA, ITS USE AND PLACENTAL STEM CELLS THEREFROM
    7.
    发明申请
    POST-PARTUM MAMMALIAN PLACENTA, ITS USE AND PLACENTAL STEM CELLS THEREFROM 有权
    后处理药物，其使用和普通干细胞

    公开(公告)号：US20090053805A1

    公开(公告)日：2009-02-26

    申请号：US12259259

    申请日：2008-10-27

    申请人： Robert J. HARIRI

    发明人： Robert J. HARIRI

    IPC分类号： C12N5/06

    CPC分类号： C12N5/0605 ,  A01N1/021 ,  A61K35/12 ,  A61K35/50 ,  A61K48/00 ,  A61K2035/124 ,  A61M1/02 ,  A61M2202/0462 ,  A61M2210/1458 ,  A61M2210/1466 ,  C12M29/10 ,  C12M47/04 ,  C12N5/0603 ,  C12N5/0647 ,  C12N5/0668 ,  C12N2509/00 ,  C12N2510/02 ,  C12N2533/90

    摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.

    摘要翻译： 本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。 通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。 收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。 本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。 本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。

    TREATMENT OF ORGAN INJURIES AND BURNS USING PLACENTAL STEM CELLS
    9.
    发明申请
    TREATMENT OF ORGAN INJURIES AND BURNS USING PLACENTAL STEM CELLS 有权
    使用PLACENTAL STEM细胞治疗有机伤害和死亡

    公开(公告)号：US20120058089A1

    公开(公告)日：2012-03-08

    申请号：US13251059

    申请日：2011-09-30

    申请人： Robert J. HARIRI

    发明人： Robert J. HARIRI

    IPC分类号： A61K35/50 ,  A61P17/00 ,  A61P17/02

    CPC分类号： C12N5/0605 ,  A01N1/021 ,  A61K35/12 ,  A61K35/50 ,  A61K48/00 ,  A61K2035/124 ,  A61M1/02 ,  A61M2202/0462 ,  A61M2210/1458 ,  A61M2210/1466 ,  C12M29/10 ,  C12M47/04 ,  C12N5/0603 ,  C12N5/0647 ,  C12N5/0668 ,  C12N2509/00 ,  C12N2510/02 ,  C12N2533/90

    摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.

    摘要翻译： 本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。 通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。 收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。 本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。 本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。

    TREATMENT OF DISEASES OR DISORDERS USING PLACENTAL STEM CELLS
    10.
    发明申请
    TREATMENT OF DISEASES OR DISORDERS USING PLACENTAL STEM CELLS 有权
    使用普通干细胞治疗疾病或疾病

    公开(公告)号：US20110217271A1

    公开(公告)日：2011-09-08

    申请号：US13108871

    申请日：2011-05-16

    申请人： Robert J. HARIRI

    发明人： Robert J. HARIRI

    IPC分类号： A61K35/12 ,  A61P25/28 ,  A61P9/10 ,  A61P25/16 ,  A61P13/00 ,  A61P13/02 ,  A61P13/12 ,  A61P3/00 ,  A61P11/00 ,  A61P17/02

    CPC分类号： C12N5/0605 ,  A01N1/021 ,  A61K35/12 ,  A61K35/50 ,  A61K48/00 ,  A61K2035/124 ,  A61M1/02 ,  A61M2202/0462 ,  A61M2210/1458 ,  A61M2210/1466 ,  C12M29/10 ,  C12M47/04 ,  C12N5/0603 ,  C12N5/0647 ,  C12N5/0668 ,  C12N2509/00 ,  C12N2510/02 ,  C12N2533/90

    摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.

    摘要翻译： 本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。 通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。 收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。 本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。 本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。