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    Apparatus for stem cell collection and methods thereof
    5.
    发明授权
    Apparatus for stem cell collection and methods thereof 有权
    干细胞收集装置及其方法

    公开(公告)号：US08157774B1

    公开(公告)日：2012-04-17

    申请号：US11687149

    申请日：2007-03-16

    申请人： David E. Altobelli

    发明人： David E. Altobelli

    IPC分类号： A61M1/00

    CPC分类号： A61M1/0023 ,  A61B5/150038 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150366 ,  A61B5/150755 ,  A61B5/150977 ,  A61M1/0021 ,  A61M1/005 ,  A61M1/0281 ,  A61M5/445 ,  A61M2202/0437 ,  A61M2202/0462 ,  A61M2205/366 ,  A61M2210/1458 ,  A61M2210/1466

    摘要： Apparatus and methods for collecting stem cells from an umbilical cord utilize a plurality of needles that are inserted into the umbilical cord. The needles may be fenestrated, and may have a common output to a line via which the stem cells are collected. A negative pressure source, such as a vacuum, may be used to draw the cells through the needles and the line. Apparatus for holding the umbilical cord, compressing the umbilical cord, positioning the plurality of needles in relation to the umbilical cord, guiding insertion of the needles toward and into the umbilical cord, withdrawing blood from the umbilical cord, and/or collecting blood withdrawn from the umbilical cord may be provided. One or more one-way check valves may be used to control fluid flow. Additionally or alternatively, a shunt may be used during blood collection to prevent backflow through the needles.

    摘要翻译： 用于从脐带收集干细胞的装置和方法利用插入脐带的多个针。 针可以被开窗，并且可以具有通过其收集干细胞的线的共同输出。 可以使用负压源（例如真空）来通过针和线吸引细胞。 用于保持脐带的装置，压缩脐带，将多个针相对于脐带定位，引导针朝向和插入脐带，从脐带取出血液，和/或收集从 可以提供脐带。 可以使用一个或多个单向止回阀来控制流体流动。 另外或替代地，在采血期间可以使用分流器以防止通过针的回流。

    PLACENTAL STEM CELLS
    6.
    发明申请
    PLACENTAL STEM CELLS 有权
    普通干细胞

    公开(公告)号：US20090142831A1

    公开(公告)日：2009-06-04

    申请号：US12341961

    申请日：2008-12-22

    申请人： ROBERT J. HARIRI

    发明人： ROBERT J. HARIRI

    IPC分类号： C12N5/08

    CPC分类号： C12N5/0605 ,  A01N1/021 ,  A61K35/12 ,  A61K35/50 ,  A61K48/00 ,  A61K2035/124 ,  A61M1/02 ,  A61M2202/0462 ,  A61M2210/1458 ,  A61M2210/1466 ,  C12M29/10 ,  C12M47/04 ,  C12N5/0603 ,  C12N5/0647 ,  C12N5/0668 ,  C12N2509/00 ,  C12N2510/02 ,  C12N2533/90

    摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.

    摘要翻译： 本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。 通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。 收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。 本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。 本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。

    Method and device for extracting and/or collecting blood from placenta and/or umbilical cord
    7.
    发明申请
    Method and device for extracting and/or collecting blood from placenta and/or umbilical cord 失效
    从胎盘和/或脐带提取和/或收集血液的方法和装置

    公开(公告)号：US20090035845A1

    公开(公告)日：2009-02-05

    申请号：US11792114

    申请日：2005-12-01

    申请人： Kok Kiong Tan ,  Sunan Huang ,  Kok Zuea Tang ,  Chye Ng Soon

    发明人： Kok Kiong Tan ,  Sunan Huang ,  Kok Zuea Tang ,  Chye Ng Soon

    IPC分类号： C12M1/34

    CPC分类号： A61B5/150045 ,  A61B5/150038 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150267 ,  A61B17/42 ,  A61M1/02 ,  A61M1/025 ,  A61M2202/0413 ,  A61M2210/1458 ,  A61M2210/1466 ,  A61M2202/0014

    摘要： A device for extracting and collecting blood from a delivered placenta comprising a compartment to contain and support a delivered placenta and umbilical cord. The compartment includes a flexible membrane which can be displaced (preferably under the influence of a fluid (preferably gas) pressure differential between the compartment side and non compartment side of the membrane) to impart onto the placenta a pressure to encourage the displacement of fluid carried by the placenta towards the umbilical cord. The compartment includes at least one outlet opening via which the umbilical cord can extend (preferably in a sealed manner) to allow the flexible membrane pressure induced flow of fluid carried by the placenta to displace from the compartment for external to the compartment collection of the fluid.

    摘要翻译： 一种用于从递送的胎盘中提取和收集血液的装置，包括隔室以容纳和支持递送的胎盘和脐带。 隔室包括柔性膜，其可以被移位（优选地在膜的隔室侧和非隔室侧之间的流体（优选气体）压差的影响下）以赋予胎盘压力，以促进携带的流体的移位 由胎盘朝向脐带。 隔室包括至少一个出口开口，脐带可以通过该出口开口延伸（优选以密封方式），以允许柔性膜压力引起由胎盘承载的流体的流动从腔室移位到外部到腔室收集流体 。

    Placental stem cells
    8.
    发明授权
    Placental stem cells 有权
    胎盘干细胞

    公开(公告)号：US07468276B2

    公开(公告)日：2008-12-23

    申请号：US10874828

    申请日：2004-06-22

    申请人： Robert J. Hariri

    发明人： Robert J. Hariri

    IPC分类号： C12N5/02 ,  A01N65/00

    CPC分类号： C12N5/0605 ,  A61K35/12 ,  A61K48/00 ,  A61M1/02 ,  A61M2202/0462 ,  A61M2210/1458 ,  A61M2210/1466 ,  C12N5/0068 ,  C12N2500/90 ,  C12N2509/00 ,  C12N2533/90

    摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.

    摘要翻译： 本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。 通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。 收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。 本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。 本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。

    Treatment of diseases or disorders using placental stem cells
    10.
    发明授权
    Treatment of diseases or disorders using placental stem cells 有权
    使用胎盘干细胞治疗疾病或病症

    公开(公告)号：US09149569B2

    公开(公告)日：2015-10-06

    申请号：US13108871

    申请日：2011-05-16

    申请人： Robert J. Hariri

    发明人： Robert J. Hariri

    IPC分类号： C12N5/071 ,  A61M1/02 ,  C12N5/073 ,  C12N5/0775 ,  A61K35/12 ,  A61K48/00

    CPC分类号： C12N5/0605 ,  A01N1/021 ,  A61K35/12 ,  A61K35/50 ,  A61K48/00 ,  A61K2035/124 ,  A61M1/02 ,  A61M2202/0462 ,  A61M2210/1458 ,  A61M2210/1466 ,  C12M29/10 ,  C12M47/04 ,  C12N5/0603 ,  C12N5/0647 ,  C12N5/0668 ,  C12N2509/00 ,  C12N2510/02 ,  C12N2533/90

    摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.

    摘要翻译： 本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。 通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。 收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。 本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。 本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。