公开(公告)号：US20080308505A1

公开(公告)日：2008-12-18

申请号：US12047673

申请日：2008-03-13

申请人： Robert Jansen ,  Sebastien Camborieux ,  Genevieve Kenny ,  Richard Tanner ,  Loren Luppes ,  Anthony Baiada ,  John Kerr ,  Timothy Windebank

发明人： Robert Jansen ,  Sebastien Camborieux ,  Genevieve Kenny ,  Richard Tanner ,  Loren Luppes ,  Anthony Baiada ,  John Kerr ,  Timothy Windebank

IPC分类号： B01J20/04

CPC分类号： C02F1/5254 ,  B01D9/004 ,  B01D9/005 ,  C02F2101/105 ,  C02F2101/16 ,  C02F2103/06 ,  C02F2103/32

摘要： We disclose a process for the removal of phosphorous and ammonia from an aqueous stream by contacting the aqueous stream with magnesium and base in a first zone having a first pH, to form an (n−1)th mixed stream and a first portion of struvite; separating the (n−1)th mixed stream from the first portion of struvite; removing at least some struvite from the first portion of struvite; contacting the (n−1)th mixed stream with base in an nth zone, wherein n is an integer incrementing from 2 to nmax, wherein nmax is an integer from 2 to about 5, and wherein the nth zone has an nth pH higher than the (n−1)th pH, to form an nth mixed stream and an nth portion of struvite, except no base is added and the nth pH need not be higher than the (n−1)th pH when n=nmax; separating the nth mixed stream from the nth portion of struvite; returning the nth portion of struvite to the (n−1)th zone; and, if n

摘要翻译： 我们公开了通过在具有第一pH的第一区域中使含水物流与镁和碱接触以形成第（n-1）混合物流和第一部分的鸟粪石来从水流中除去磷和氨的方法 ; 将第（n-1）混合物流与第一部分的鸟粪分离; 从鸟粪的第一部分去除至少一些鸟粪石; 使第（n-1）混合物流与第n区的碱接触，其中n为从2增加至nm 3的整数，其中nmax为2至约5的整数，并且其中第n个区的第n个pH高于 （n-1）pH，形成第n混合物流和第n部分的鸟粪石，除了没有碱，并且当n = nmax时，第n个pH不需要高于第（n-1）个pH; 将第n个混合物流从鸟粪的第n部分分离出来; 将第n部分的鸟粪返回到第（n-1）区; 并且如果n

公开(公告)号：US20090264633A1

公开(公告)日：2009-10-22

申请号：US12345998

申请日：2008-12-30

申请人： John Kerr ,  Robert Jansen ,  Duane A. Leinhos ,  James Edwin Wiley, JR. ,  Sebastien Camborieux ,  Anthony Baiada ,  Gordon Walker ,  Carlo Maffezzoni

发明人： John Kerr ,  Robert Jansen ,  Duane A. Leinhos ,  James Edwin Wiley, JR. ,  Sebastien Camborieux ,  Anthony Baiada ,  Gordon Walker ,  Carlo Maffezzoni

IPC分类号： C07H15/00

CPC分类号： C07H1/06 ,  C07H5/02

摘要： The present invention provides a method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle. The feed stream includes a sucralose-6-acylate, the reaction vehicle, water, and salts. The salts include one or more selected from the group consisting of alkali metal chlorides, alkaline earth metal chlorides and ammonium chloride. The method includes: (i) deacylation of the sucralose-6-acylate by treatment with a base to afford a product stream comprising sucralose; (ii) partial removal of water and, optionally, reaction vehicle from the product stream of (i) in order to cause precipitation of the salts from the product stream; (iii) removal of the precipitated salts from the product stream of (ii); and (iv) isolation of sucralose from the product stream of (iii).

摘要翻译： 本发明提供了由反应载体中蔗糖-6-酰化物的氯化得到的进料流中生产三氯蔗糖的方法。 进料流包括三氯蔗糖-6-酰化物，反应载体，水和盐。 所述盐包括选自碱金属氯化物，碱土金属氯化物和氯化铵中的一种或多种。 该方法包括：（i）用碱处理三氯半乳蔗糖-6-酰化物脱酰基，得到包含三氯蔗糖的产物流; （ii）从（i）的产物流中部分除去水和任选的反应载体，以便使产物流中的盐沉淀; （iii）从（ii）的产物流中除去沉淀的盐; 和（iv）从（iii）的产物流中分离三氯半乳蔗糖。

公开(公告)号：US08436156B2

公开(公告)日：2013-05-07

申请号：US12345998

申请日：2008-12-30

申请人： John Kerr ,  Robert Jansen ,  Duane A. Leinhos ,  James Edwin Wiley, Jr. ,  Sebastien Camborieux ,  Anthony Baiada ,  Gordon Walker ,  Carlo Maffezzoni

发明人： John Kerr ,  Robert Jansen ,  Duane A. Leinhos ,  James Edwin Wiley, Jr. ,  Sebastien Camborieux ,  Anthony Baiada ,  Gordon Walker ,  Carlo Maffezzoni

IPC分类号： C07H15/00

CPC分类号： C07H1/06 ,  C07H5/02

摘要： The present invention provides a method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle. The feed stream includes a sucralose-6-acylate, the reaction vehicle, water, and salts. The salts include one or more selected from the group consisting of alkali metal chlorides, alkaline earth metal chlorides and ammonium chloride. The method includes: (i) deacylation of the sucralose-6-acylate by treatment with a base to afford a product stream comprising sucralose; (ii) partial removal of water and, optionally, reaction vehicle from the product stream of (i) in order to cause precipitation of the salts from the product stream; (iii) removal of the precipitated salts from the product stream of (ii); and (iv) isolation of sucralose from the product stream of (iii).

摘要翻译： 本发明提供了由反应载体中蔗糖-6-酰化物的氯化得到的进料流中生产三氯蔗糖的方法。 进料流包括三氯蔗糖-6-酰化物，反应载体，水和盐。 所述盐包括选自碱金属氯化物，碱土金属氯化物和氯化铵中的一种或多种。 该方法包括：（i）用碱处理三氯半乳蔗糖-6-酰化物脱酰基，得到包含三氯蔗糖的产物流; （ii）从（i）的产物流中部分除去水和任选的反应载体，以便使产物流中的盐沉淀; （iii）从（ii）的产物流中除去沉淀的盐; 和（iv）从（iii）的产物流中分离三氯半乳蔗糖。

公开(公告)号：US20090095286A1

公开(公告)日：2009-04-16

申请号：US12173257

申请日：2008-07-15

申请人： John Kerr ,  Robert Jansen ,  Loren Luppes ,  Peter Lloyd-Jones ,  Richard Tanner

发明人： John Kerr ,  Robert Jansen ,  Loren Luppes ,  Peter Lloyd-Jones ,  Richard Tanner

IPC分类号： C08B30/00

CPC分类号： C12M43/04 ,  A23J1/12 ,  A23L7/152 ,  A23L7/197 ,  C12M21/04 ,  C12M21/12 ,  C12P5/023 ,  C12P7/06 ,  F23G2900/50208 ,  Y02E50/17 ,  Y02E50/343

摘要： A process including steeping cereal kernels in an aqueous liquid, producing softened cereal; milling the softened cereal, producing a milled cereal comprising germ, protein, starch, and fiber; separating at least some of at least one material selected from the group consisting of germ, starch, and protein from the milled cereal, producing at least one of germ, starch, and a first protein portion, and also producing a first fiber portion that comprises fiber and starch, and a light steep water that comprises protein; separating at least some protein from the light steep water, producing a second protein portion and a process water that comprises protein; converting at least some of the starch in the first fiber portion to saccharides; separating at least some of the saccharides from the first fiber portion, producing saccharides and a second fiber portion that comprises fiber; and burning at least some of the fiber from the second fiber portion, producing a flue gas and a first quantity of energy; wherein the process further comprises at least one step selected from the group consisting of least partially powering at least one previous step with the first quantity of energy; and drying at least one separated material selected from the group consisting of the germ, the starch, the first protein portion, the second protein portion, and the saccharides with the flue gas, producing a dried separated material and a dryer exhaust. In one further embodiment, the process further includes digesting anaerobically the biologically available organic residues from the process water, producing a biogas and a final waste water. In a still further embodiment, the process further includes burning the biogas to produce a second quantity of energy and at least partially powering at least one previous step with the second quantity of energy.

摘要翻译： 一种包括在水性液体中浸泡谷粒的方法，产生软化谷物; 研磨软化谷物，生产包含胚芽，蛋白质，淀粉和纤维的碾磨谷物; 从磨碎的谷物中分离至少一种选自细菌，淀粉和蛋白质的至少一种材料，产生胚芽，淀粉和第一蛋白质部分中的至少一种，并且还产生第一纤维部分，其包含 纤维和淀粉，以及包含蛋白质的轻陡的水; 从轻水中分离出至少一些蛋白质，产生第二蛋白质部分和包含蛋白质的工艺水; 将第一纤维部分中的至少一些淀粉转化为糖; 从第一纤维部分分离出至少一些糖类，生成糖类和包含纤维的第二纤维部分; 并且从第二纤维部分燃烧至少一些纤维，产生烟道气和第一量的能量; 其中所述方法还包括至少一个步骤，所述步骤选自由对所述第一能量的至少一个先前步骤进行的至少部分供电; 并用烟道气干燥选自由胚芽，淀粉，第一蛋白质部分，第二蛋白质部分和糖类组成的组中的至少一种分离的材料，产生干燥的分离的材料和干燥器排气。 在一个另外的实施方案中，该方法还包括厌氧地从工艺水中消化生物可获得的有机残余物，产生沼气和最终的废水。 在又一个实施例中，该方法还包括燃烧沼气以产生第二数量的能量，并且至少部分地为第二数量的能量提供至少一个先前步骤。

公开(公告)号：US20060251762A1

公开(公告)日：2006-11-09

申请号：US11121295

申请日：2005-05-03

申请人： Robert Jansen ,  John Kerr ,  Edward Farley ,  Gordon Walker ,  Sebastien Camborieux

发明人： Robert Jansen ,  John Kerr ,  Edward Farley ,  Gordon Walker ,  Sebastien Camborieux

IPC分类号： A23L1/10

CPC分类号： C12P7/06 ,  Y02E50/16 ,  Y02E50/17

摘要： Whole grain, such as wheat, barley, rye, and/or rice, can be processed by (a) steeping the grain in an aqueous liquid to produce softened grain, (b) milling the softened grain to produce milled grain, (c) liquefying the milled grain by contacting it with amylase and heating it to a temperature of at least about 50° C., producing a liquefied material, (d) at least partially saccharifying the liquefied material by contacting it with amyloglucosidase at a temperature of at least about 50° C., producing a first saccharified material, and (e) separating fiber and germ from the first saccharified material, producing a screened material that is substantially free of fiber and germ. The process also includes the steps of (f) further saccharifying and fermenting the screened material with a microorganism that produces ethanol, thereby producing a broth that comprises ethanol, soluble protein, and insoluble protein, and (g) separating ethanol from the broth. A protein-rich product can be recovered from the broth that comprises both gluten from the grain and microorganism from the fermenting step.

摘要翻译： （a）在水溶液中浸渍谷物以产生软化谷粒，（b）研磨软化谷物以产生碾磨的谷物，（c）可以加工全谷物如小麦，大麦，黑麦和/或米，（c） 通过使其与淀粉酶接触并将其加热到至少约50℃的温度来液化碾磨的颗粒，产生液化材料，（d）至少部分地使液化物料与淀粉葡糖苷酶接触至少部分糖化， 约50℃，产生第一糖化物质，和（e）从第一糖化物质分离纤维和胚芽，产生基本上不含纤维和细菌的筛选材料。 该方法还包括以下步骤：（f）用生产乙醇的微生物进一步对筛选的材料进行糖化和发酵，从而产生包含乙醇，可溶性蛋白质和不溶性蛋白质的肉汤，和（g）从肉汤中分离乙醇。 富含蛋白质的产物可以从含有谷物的谷蛋白和发酵步骤的微生物的肉汤中回收。

公开(公告)号：US20060251761A1

公开(公告)日：2006-11-09

申请号：US11121170

申请日：2005-05-03

申请人： Robert Jansen ,  John Kerr ,  Edward Farley ,  Gordon Walker ,  Sebastien Camborieux

发明人： Robert Jansen ,  John Kerr ,  Edward Farley ,  Gordon Walker ,  Sebastien Camborieux

IPC分类号： A23L1/10

CPC分类号： C12Y302/00 ,  A23J1/125 ,  A23J3/18 ,  A23K10/30 ,  A23K20/179 ,  A23K50/80 ,  A23L7/104 ,  A23L29/35 ,  C13B20/142 ,  C13K1/08 ,  Y02A40/818

摘要： Whole grain, such as wheat, barley, rye, and/or rice, can be processed by (a) steeping the grain or at least partially dehulled grain in an aqueous liquid to produce softened grain, (b) milling the softened grain to produce milled grain, (c) liquefying the milled grain by contacting it with amylase and heating it to a temperature of at least about 50° C., producing a liquefied material, (d) at least partially saccharifying the liquefied material by contacting it with amyloglucosidase at a temperature of at least about 50° C., producing a first saccharified material, and (e) separating fiber and germ from the first saccharified material, producing a screened material that is substantially free of fiber and wheat germ. The process also includes the steps of (f) further saccharifying the screened material by contacting it with amyloglucosidase at a temperature of at least about 50° C., producing a second saccharified material, (g) membrane filtering the second saccharified material, producing a permeate that comprises primarily dextrose and other soluble components and a retentate that comprises insoluble protein, and (h) purifying the permeate by chromatographic separation, producing a purified dextrose stream. The chromatographic separation can also produce a raffinate, and the process can further include the steps of (i) combining the retentate from the membrane filtration and the raffinate from the chromatographic separation to form a fermentation medium, (j) fermenting the fermentation medium aerobically with a microorganism, (k) separating a protein product that comprises insoluble protein and microorganism from the medium, and (l) drying the protein product.

摘要翻译： 可以通过（a）在水性液体中浸渍颗粒或至少部分去壳的颗粒以产生软化的颗粒，（b）研磨软化的颗粒以产生（例如，麦粒，大麦，黑麦和/或米） （c）通过使其与淀粉酶接触并将其加热到至少约50℃的温度来液化所研磨的颗粒，产生液化材料，（d）通过使液化物质与淀粉葡糖苷酶接触而至少部分地糖化 在至少约50℃的温度下，产生第一糖化材料，和（e）从第一糖化物质分离纤维和胚芽，产生基本上不含纤维和小麦胚芽的筛选材料。 该方法还包括以下步骤：（f）通过使筛选的材料与淀粉葡糖苷酶在至少约50℃的温度下接触进一步糖化，产生第二糖化物质，（g）膜过滤第二糖化物质，产生 主要包含葡萄糖和其他可溶性组分的渗透物和包含不溶性蛋白质的渗余物，和（h）通过色谱分离纯化渗透物，产生纯化的葡萄糖流。 色谱分离还可以产生萃余液，并且该方法还可以包括以下步骤：（i）将来自膜过滤的残留物和来自色谱分离的萃余液组合以形成发酵培养基，（j）有氧地发酵发酵培养基， 微生物，（k）从培养基中分离含有不溶性蛋白质和微生物的蛋白质产物，和（l）干燥蛋白质产物。

公开(公告)号：US08404109B2

公开(公告)日：2013-03-26

申请号：US13316278

申请日：2011-12-09

申请人： Robert Jansen ,  John Kerr ,  Anthony Baiada

发明人： Robert Jansen ,  John Kerr ,  Anthony Baiada

IPC分类号： B01D17/12 ,  C13K3/00 ,  B01J14/00

CPC分类号： C13K3/00 ,  C13B20/14

摘要： A method of inverting sucrose, including (i) determining an initial solids concentration of an aqueous sucrose solution, an initial bed volume of a sucrose inversion resin system, a minimum target inversion percentage, a maximum target inversion percentage, a target maximum hydroxymethylfuran (HMF) concentration, a minimum target pH, or a maximum target pH; (ii) contacting the sucrose inversion resin system with the aqueous sucrose solution under conditions of aqueous solution flow rate and aqueous solution temperature to produce an inverted sucrose solution having an inversion percentage, an HMF concentration, and a pH; (iii) observing an instantaneous inversion percentage, an instantaneous HMF concentration, or an instantaneous pH of the inverted sucrose solution; and, if appropriate; (iv) changing at least one of the aqueous solution flow rate or the aqueous solution temperature to yield a product having a desired inversion percentage, HMF concentration, and/or pH. An apparatus capable of performing the method.

摘要翻译： 一种反相蔗糖的方法，包括（i）测定蔗糖水溶液的初始固体浓度，蔗糖反转树脂体系的初始床体积，最小目标反转百分比，最大目标反转百分比，目标最大羟甲基呋喃（HMF ）浓度，最小目标pH或最大目标pH; （ii）在水溶液流动速率和水溶液温度条件下使蔗糖反转树脂体系与蔗糖溶液水溶液接触，以产生具有倒置百分比，HMF浓度和pH值的倒置蔗糖溶液; （iii）观察反转蔗糖溶液的瞬时反转百分比，瞬时HMF浓度或瞬时pH值; 并酌情; （iv）改变水溶液流速或水溶液温度中的至少一个，得到具有所需转化百分比，HMF浓度和/或pH值的产物。 一种能够执行该方法的装置。

公开(公告)号：US08092609B2

公开(公告)日：2012-01-10

申请号：US12025153

申请日：2008-02-04

申请人： Robert Jansen ,  John Kerr ,  Anthony Baiada

发明人： Robert Jansen ,  John Kerr ,  Anthony Baiada

IPC分类号： C13K1/08

CPC分类号： C13K3/00 ,  C13B20/14

摘要： We disclose a method of inverting sucrose, including (i) determining an initial solids concentration of an aqueous sucrose solution (solidsi), an initial bed volume (BVi) of a sucrose inversion resin system, a minimum target inversion percentage (invert %min), a maximum target inversion percentage (invert %max), a target maximum hydroxymethylfuran (HMF) concentration (HMFmax), a minimum target pH (pHmin), or a maximum target pH (pHmax); (ii) contacting the sucrose inversion resin system with the aqueous sucrose solution under conditions of aqueous solution flow rate in BVi/hr (ratep) and aqueous solution temperature in ° C. (temperaturep) to produce an inverted sucrose solution having an inversion percentage (invert %product), an HMF concentration (HMFproduct), and a pH (pHproduct); (iii) observing an instantaneous inversion percentage (invert %inst), an instantaneous HMF concentration (HMFinst), or an instantaneous pH (pHinst) of the inverted sucrose solution; and, if invert %inst invert %max, HMFinst>HMFmax, pHinst pHmax; (iv) changing at least one of the aqueous solution flow rate or the aqueous solution temperature such that invert %min≦invert %product≦invert %max, HMFproduct≦HMFmax, or pHmin≦pHproduct≦pHmax. We also disclose a computing apparatus capable of use in performing a method of inverting sucrose.

摘要翻译： 我们公开了一种蔗糖翻转方法，包括（i）测定蔗糖反应树脂体系的初始固体浓度，蔗糖反转树脂体系的初始床体积（BVi），最小目标反转百分比（反转百分比） ，最大目标反转百分比（反转百分比最大值），目标最大羟甲基呋喃（HMF）浓度（HMFmax），最小目标pH（pHmin）或最大目标pH（pHmax））; （ii）在水溶液流速（BVi / hr（速率））和水溶液温度（℃）（℃）下的条件下，将蔗糖反转树脂体系与蔗糖溶液的蔗糖溶液接触，得到反转百分比的倒转蔗糖溶液 转化％产物），HMF浓度（HMF产物）和pH（pH值产物）; （iii）观察反转蔗糖溶液的瞬时反转百分率（反转％inst），瞬时HMF浓度（HMFinst）或瞬时pH（pHinst）; 并且，如果反转％inst invert％max，HMFinst> HMFmax，pHinst pHmax; （iv）改变水溶液流速或水溶液温度中的至少一个，使得反相％min和nlE反相％max，HMFproduct＆NlE; HMFmax或pHmin＆amp; NlE; pH值＆amp; NlE; pHmax。 我们还公开了一种能够用于执行蔗糖翻转方法的计算装置。

公开(公告)号：US20090299054A1

公开(公告)日：2009-12-03

申请号：US12413955

申请日：2009-03-30

申请人： Robert Jansen ,  Gordon Walker ,  John Kerr ,  Anthony Baiada

发明人： Robert Jansen ,  Gordon Walker ,  John Kerr ,  Anthony Baiada

IPC分类号： C13K13/00

CPC分类号： C07H5/02

摘要： A process for the extraction of sucralose from an aqueous solution containing at least sucralose, other chlorinated saccharides, sodium chloride and dimethylammonium chloride into an organic solvent for sucralose by contacting said organic solvent with said solution to extract sucralose into the organic solvent. The ratio of sodium chloride to dimethylammonium chloride in the aqueous solution is increased prior to or during contact so as to increase the partition coefficient of sucralose into said organic solvent.

摘要翻译： 通过使所述有机溶剂与所述溶液接触将三氯半乳蔗糖，其它氯化糖，氯化钠和二甲基氯化铵的水溶液提取到三氯半乳蔗糖的有机溶剂中以将三氯蔗糖萃取到有机溶剂中的方法。 在接触之前或接触期间，水溶液中氯化钠与二甲基氯化铵的比例增加，从而增加三氯蔗糖分配成所述有机溶剂的分配系数。

公开(公告)号：US20120157676A1

公开(公告)日：2012-06-21

申请号：US13262147

申请日：2010-03-24

申请人： John Kerr ,  Robert Jansen ,  Anthony Baiada ,  Duane Leinhos ,  James Edwin Wiley

发明人： John Kerr ,  Robert Jansen ,  Anthony Baiada ,  Duane Leinhos ,  James Edwin Wiley

IPC分类号： C07C209/86 ,  C07H1/06

CPC分类号： C07H5/02

摘要： A process for removing dimethylamine (DMA) before and/or during and/or after deacylation in a reaction vessel of a feed stream comprising a sucralose-6-acylate resulting from the chlorination of a sucrose-6-acylate in the presence of dimethyl formamide (DMF), wherein the deacylation is conducted at a first set of conditions of temperature, pH and pressure, the process comprising: (a) providing a side stream loop from and to the reaction vessel; (b) adjusting the conditions of one or more of temperature, pH, and pressure in the loop, and setting the flow rate through the loop, to remove DMA while minimising carbohydrate degradation.

摘要翻译： 在二甲基甲酰胺存在下，在包含由蔗糖-6-酰化物氯化得到的三氯半氯蔗糖-6-酰化物的进料流的反应容器中脱酰基之前和/或之前和/或之后除去二甲胺（DMA）的方法 （DMF），其中所述脱酰基在温度，pH和压力的第一组条件下进行，所述方法包括：（a）从反应容器提供侧流回路; （b）调节循环中的一个或多个温度，pH和压力的条件，并设定流过循环的流速，以除去DMA同时使碳水化合物降解最小化。