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1.发明申请COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE 审中-公开炎症性皮肤疾病治疗和诊断的组合物和方法公开(公告)号：US20090142778A1
公开(公告)日：2009-06-04
申请号：US12036588
申请日：2008-02-25
申请人： Robert M. Hershberg , Nancy Ann Hosken , Michael J. Lodes , Raodoh Mohamath , Stephan R. Targan
发明人： Robert M. Hershberg , Nancy Ann Hosken , Michael J. Lodes , Raodoh Mohamath , Stephan R. Targan
IPC分类号： G01N33/53
CPC分类号： C07K16/1232 , A61K38/00 , A61K39/00 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/523 , A61K2039/53 , C07K14/001 , C07K14/195 , C07K14/205 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/00 , G01N33/505 , G01N33/6893 , G01N2800/065
摘要： Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
摘要翻译： 公开了用于治疗和诊断炎症性肠病（IBD）的组合物和方法，包括克罗恩病和溃疡性结肠炎。 说明性组合物包含一种或多种细菌多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如IBD的诊断，预防和/或治疗。
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公开(公告)号：US09290543B2
公开(公告)日：2016-03-22
申请号：US12036588
申请日：2008-02-25
发明人： Robert M. Hershberg , Nancy Ann Hosken , Michael J. Lodes , Raodoh Mohamath , Stephan R. Targan
IPC分类号： G01N33/50 , C07K14/195 , C07K14/205 , A61K38/00 , A61K39/00 , C07K14/00 , G01N33/68
CPC分类号： C07K16/1232 , A61K38/00 , A61K39/00 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/523 , A61K2039/53 , C07K14/001 , C07K14/195 , C07K14/205 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/00 , G01N33/505 , G01N33/6893 , G01N2800/065
摘要： Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
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3.发明申请COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE 有权炎症性皮肤疾病治疗和诊断的组合物和方法公开(公告)号：US20120039924A1
公开(公告)日：2012-02-16
申请号：US13092888
申请日：2011-04-22
IPC分类号： A61K39/02 , C07K17/00 , C07K19/00 , A61P31/04 , G01N33/566 , C12Q1/68 , A61P37/04 , A61P1/00 , C07K14/195 , C07H21/04
CPC分类号： C07K16/1232 , A61K38/00 , A61K39/00 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/523 , A61K2039/53 , C07K14/001 , C07K14/195 , C07K14/205 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/00 , G01N33/505 , G01N33/6893 , G01N2800/065
摘要： Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
摘要翻译： 公开了用于治疗和诊断炎症性肠病（IBD）的组合物和方法，包括克罗恩病和溃疡性结肠炎。 说明性组合物包含一种或多种细菌多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如IBD的诊断，预防和/或治疗。
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4.发明授权Compositions and methods for the therapy and diagnosis of inflammatory bowel disease 有权用于治疗和诊断炎症性肠病的组合物和方法公开(公告)号：US07361733B2
公开(公告)日：2008-04-22
申请号：US10449857
申请日：2003-05-30
IPC分类号： C07K14/195 , A61K38/16
CPC分类号： C07K16/1232 , A61K38/00 , A61K39/00 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/523 , A61K2039/53 , C07K14/001 , C07K14/195 , C07K14/205 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/00 , G01N33/505 , G01N33/6893 , G01N2800/065
摘要： Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
摘要翻译： 公开了用于治疗和诊断炎症性肠病（IBD）的组合物和方法，包括克罗恩病和溃疡性结肠炎。 说明性组合物包含一种或多种细菌多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如IBD的诊断，预防和/或治疗。
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5.发明授权Compositions and methods for the therapy and diagnosis of inflammatory bowel disease 有权用于治疗和诊断炎症性肠病的组合物和方法公开(公告)号：US08318901B2
公开(公告)日：2012-11-27
申请号：US13092888
申请日：2011-04-22
CPC分类号： C07K16/1232 , A61K38/00 , A61K39/00 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/523 , A61K2039/53 , C07K14/001 , C07K14/195 , C07K14/205 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/00 , G01N33/505 , G01N33/6893 , G01N2800/065
摘要： Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
摘要翻译： 公开了用于治疗和诊断炎症性肠病（IBD）的组合物和方法，包括克罗恩病和溃疡性结肠炎。 说明性组合物包含一种或多种细菌多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如IBD的诊断，预防和/或治疗。
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6.发明授权公开(公告)号：US06413518B1
公开(公告)日：2002-07-02
申请号：US09672595
申请日：2000-09-28
申请人： David M. Koelle , Hongbo Chen , Lawrence Corey , Nancy Ann Hosken , Patrick McGowan , Steven P. Fling , Christine M. Posavad
发明人： David M. Koelle , Hongbo Chen , Lawrence Corey , Nancy Ann Hosken , Patrick McGowan , Steven P. Fling , Christine M. Posavad
IPC分类号： A16K39245
CPC分类号： C07K14/005 , A61K35/12 , A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/5154 , A61K2039/53 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
摘要： The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
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7.发明授权Immunologically significant herpes simplex virus antigens and methods for identifying and using same 失效免疫学上显着的单纯疱疹病毒抗原及其鉴定和使用方法公开(公告)号：US06962709B2
公开(公告)日：2005-11-08
申请号：US10117476
申请日：2002-04-05
申请人： David M. Koelle , Hongbo Chen , Lawrence Corey , Nancy Ann Hosken , Patrick McGowan , Steven P. Fling , Christine M. Posavad
发明人： David M. Koelle , Hongbo Chen , Lawrence Corey , Nancy Ann Hosken , Patrick McGowan , Steven P. Fling , Christine M. Posavad
IPC分类号： G01N33/50 , A61K35/12 , A61K39/00 , A61K39/245 , A61K39/25 , A61K39/39 , A61P31/22 , C07K14/035 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/38 , C12P21/02 , G01N33/15 , G01N33/569 , C12P21/00 , C12P15/33 , C12P15/34 , C12P15/36
CPC分类号： C07K14/005 , A61K35/12 , A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/5154 , A61K2039/53 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
摘要： The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
摘要翻译： 本发明提供可用于预防和治疗HSV感染的HSV抗原。 本文公开了证实由来自疱疹病变的T细胞识别的表位。 对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。 鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。 含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。
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