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    Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy
    1.
    发明授权
    Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy 失效
    使用时间分辨荧光光谱法确定组织是否恶性的方法与非恶性肿瘤相反

    公开(公告)号：US5348018A

    公开(公告)日：1994-09-20

    申请号：US797723

    申请日：1991-11-25

    申请人： Robert R. Alfano ,  Asima Pradhan ,  Guichen C. Tang ,  Leming Wang ,  Yury Budansky ,  Bidyut Baran Das

    发明人： Robert R. Alfano ,  Asima Pradhan ,  Guichen C. Tang ,  Leming Wang ,  Yury Budansky ,  Bidyut Baran Das

    IPC分类号： A61B5/00 ,  B23K26/06 ,  G01N21/64 ,  A61B6/00

    CPC分类号： G01N21/6486 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/4312 ,  B23K26/0624 ,  G01N21/6408 ,  A61B5/0075 ,  A61B5/0086 ,  G01N2021/6417

    摘要： A method for determining if tissue is malignant as opposed to non-malignant (i.e., benign tumor tissue, benign tissue, or normal tissue), In one embodiment, the method comprises irradiating a human breast tissue sample with light at a wavelength of about 310 nm and measuring the time-resolved fluorescence emitted therefrom at about 340 nm. The time-resolved fluorescence profile is then compared to similar profiles obtained from known malignant and non-malignant human breast tissues. By fitting the profiles to the formula I(t)=A.sub.1 e(-t/.tau..sub.1)+A.sub.2 e(-t/.tau..sub.2) one can quantify the differences between tissues of various conditions. For example, non-malignant human breast tissues exhibit a slow component (.tau..sub.2) which is less than 1.6 ns whereas malignant human breast tissues exhibit a slow component (.tau..sub.2) which is greater than 1.6 ns. In addition, non-malignant human breast tissues exhibit a ratio of fast to slow amplitudes (A.sub.1 /A.sub.2) which is greater than 0.85 whereas malignant human breast tissues exhibit a ratio of fast to slow amplitudes (A.sub.1 /A.sub.2) which is less than 0.6. This technique can be used with different excitation and/or emission wavelengths, and can be applied to the detection of malignancies (or other abnormal states) in tissues other than human breast tissue.

    摘要翻译： 与非恶性（即，良性肿瘤组织，良性组织或正常组织）相反，用于确定组织是否为恶性的方法。在一个实施方案中，该方法包括用约310的波长的光照射人乳房组织样品 并测量在约340nm处从其发射的时间分辨荧光。 然后将时间分辨的荧光图谱与从已知的恶性和非恶性人乳腺组织获得的相似特征进行比较。 通过拟合公式I（t）= A1e（-t / tau1）+ A2e（-t / tau2），可以量化各种条件的组织之间的差异。 例如，非恶性人乳腺组织表现出小于1.6ns的缓慢成分（tau 2），而恶性人乳腺组织表现出大于1.6ns的缓慢成分（tau 2）。 此外，非恶性人乳腺组织表现出快于慢振幅（A1 / A2）的比值大于0.85，而恶性人乳腺组织表现出快于慢振幅（A1 / A2）的比值小于0.6 。 该技术可以用于不同的激发和/或发射波长，并且可以应用于除人乳腺组织以外的组织中的恶性肿瘤（或其他异常状态）的检测。

    Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy
    2.
    发明授权
    Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy 失效
    使用时间分辨荧光光谱法确定组织是否恶性的方法与非恶性肿瘤相反

    公开(公告)号：US5467767A

    公开(公告)日：1995-11-21

    申请号：US112291

    申请日：1993-08-27

    申请人： Robert R. Alfano ,  Asima Pradhan ,  Guichen C. Tang ,  Leming Wang ,  Yury Budansky ,  Bidyut B. Das

    发明人： Robert R. Alfano ,  Asima Pradhan ,  Guichen C. Tang ,  Leming Wang ,  Yury Budansky ,  Bidyut B. Das

    IPC分类号： A61B5/00 ,  B23K26/06 ,  G01N21/64 ,  A61B6/00

    CPC分类号： G01N21/6408 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/4312 ,  B23K26/0624 ,  G01N21/6486 ,  A61B5/0075 ,  A61B5/0086 ,  G01N2021/6417

    摘要： A method for determining if tissue is malignant as opposed to non-malignant (i.e., benign tumor tissue, benign tissue, or normal tissue). In one embodiment, the method comprises irradiating a human breast tissue sample with light at a wavelength of about 310 nm and measuring the time-resolved fluorescence emitted therefrom at about 340 nm. The time-resolved fluorescence profile is then compared to similar profiles obtained from known malignant and non-malignant human breast tissues. By fitting the profiles to the formula I(t)=A.sub.1 e.sup.(-t/.tau. 1.sup.) +A.sub.2 e.sup.(-t/.tau. 2.sup.), one can quantify the differences between tissues of various conditions. For example, non-malignant human breast tissues exhibit a slow component (.tau..sub.2) which is less than 1.6 ns whereas malignant human breast tissues exhibit a slow component (.tau..sub.2) which is greater than 1.6 ns. In addition, non-malignant human breast tissues exhibit a ratio of fast to slow amplitudes (A.sub.1 /A.sub.2) which is greater than 0.85 whereas malignant human breast tissues exhibit a ratio of fast to slow amplitudes (A.sub.1 /A.sub.2) which is less than 0.6. This technique can be used with different excitation and/or emission wavelengths, and can be applied to the detection of malignancies (or other abnormal states) in tissues other than human breast tissue.

    摘要翻译： 与非恶性（即良性肿瘤组织，良性组织或正常组织）相反，确定组织是否为恶性的方法。 在一个实施方案中，该方法包括用约310nm波长的光照射人乳房组织样品，并测量在约340nm发射的时间分辨荧光。 然后将时间分辨的荧光图谱与从已知的恶性和非恶性人乳腺组织获得的相似特征进行比较。 通过拟合公式I（t）= A1e（-t / tau1）+ A2e（-t / tau2），可以量化各种条件的组织之间的差异。 例如，非恶性人乳腺组织表现出小于1.6ns的缓慢成分（tau 2），而恶性人乳腺组织表现出大于1.6ns的缓慢成分（tau 2）。 此外，非恶性人乳腺组织表现出快于慢振幅（A1 / A2）的比值大于0.85，而恶性人乳腺组织表现出快于慢振幅（A1 / A2）的比值小于0.6 。 该技术可以用于不同的激发和/或发射波长，并且可以应用于除人乳腺组织以外的组织中的恶性肿瘤（或其他异常状态）的检测。

    Optical imaging of breast tissues to enable the detection therein of calcification regions suggestive of cancer
    3.
    发明授权
    Optical imaging of breast tissues to enable the detection therein of calcification regions suggestive of cancer 失效
    乳腺组织的光学成像可以在其中检测钙化区域，提示癌症

    公开(公告)号：US5799656A

    公开(公告)日：1998-09-01

    申请号：US733558

    申请日：1996-10-21

    申请人： Robert R. Alfano ,  Ping-Pei Ho ,  Leming Wang ,  Xiangchun Liang ,  Pierre A. Galland

    发明人： Robert R. Alfano ,  Ping-Pei Ho ,  Leming Wang ,  Xiangchun Liang ,  Pierre A. Galland

    IPC分类号： A61B5/00 ,  A61B6/00

    CPC分类号： A61B5/0091 ,  A61B5/4312

    摘要： A method for detecting the presence of one or more calcifications within a portion of a turbid medium, such as a breast tissue. According to one aspect, the method involves illuminating at least a portion of the turbid medium with light, whereby light emerges from the turbid medium consisting of a ballistic component, a snake-like component and a diffuse component, temporally and/or spatially gating the emergent light to preferentially pass the ballistic and/or snake-like components, using the temporally and/or spatially gated light to form an image of the illuminated portion of the turbid medium, and examining the image for the presence of one or more calcifications. Wavelength difference images may also be used to highlight tumors and calcification regions. The foregoing method may be used to form optical images of breast tissues, with the presence in such images of calcifications suggestive of cancer being used to identify the corresponding breast tissues as good candidates for biopsy and screening for tumors.

    摘要翻译： 一种用于检测在混浊介质（例如乳房组织）的一部分内存在一种或多种钙化的方法。 根据一个方面，该方法包括用光照射混浊介质的至少一部分，由此光从由弹道组件，蛇形部件和扩散部件组成的混浊介质中暂时和/或空间门控 使用时间和/或空间门控的光来优先地通过弹道和/或蛇状部件以形成混浊介质的被照射部分的图像，并检查图像中是否存在一种或多种钙化。 波长差图像也可用于突出肿瘤和钙化区域。 上述方法可以用于形成乳腺组织的光学图像，存在这样的钙化图像，暗示癌症用于鉴定相应的乳腺组织作为肿瘤活检和筛选的良好候选物。

    Ultrafast optical imaging of objects in a scattering medium
    4.
    发明授权
    Ultrafast optical imaging of objects in a scattering medium 失效
    物体在散射介质中的超快光学成像

    公开(公告)号：US5371368A

    公开(公告)日：1994-12-06

    申请号：US920193

    申请日：1992-07-23

    申请人： Robert R. Alfano ,  Ping-Pei Ho ,  Leming Wang

    发明人： Robert R. Alfano ,  Ping-Pei Ho ,  Leming Wang

    IPC分类号： A61B5/00 ,  G01N21/47 ,  G01N21/49

    CPC分类号： A61B5/0091 ,  A61B5/4312 ,  G01N21/4795 ,  A61B5/7257 ,  G01N2021/4797

    摘要： A system for imaging an object in or behind a highly scattering medium includes a laser for illuminating the highly scattering medium with a beam of light. The light emerging from the highly scattering medium consists of a ballistic component, a snake-like component and a diffuse component. A 4F Fourier imaging system with a Kerr gate located at 2F is used to form a time-space gated image of the emerging light, the time-space gated image consisting primarily of the ballistic component and the snake-like component.

    摘要翻译： 用于在高度散射介质中或其后成像物体的系统包括用于以光束照射高散射介质的激光器。 从高度散射介质出射的光由弹道组件，蛇形部件和漫射部件组成。 使用位于2F的克尔门的4F傅立叶成像系统来形成主要由弹道组件和蛇形部件组成的时空门控图像。

    INTERNALLY COOLED, THERMALLY CLOSED MODULAR LASER PACKAGE SYSTEM
    8.
    发明申请
    INTERNALLY COOLED, THERMALLY CLOSED MODULAR LASER PACKAGE SYSTEM 审中-公开
    内部冷却，热封闭模块化激光包装系统

    公开(公告)号：US20130051413A1

    公开(公告)日：2013-02-28

    申请号：US13218341

    申请日：2011-08-25

    申请人： Pei Chuang Chen ,  Leming Wang ,  Xin Simon Luo

    发明人： Pei Chuang Chen ,  Leming Wang ,  Xin Simon Luo

    IPC分类号： H01S3/04

    CPC分类号： H01S5/02415 ,  H01S5/02 ,  H01S5/02212 ,  H01S5/02284

    摘要： An internal laser module may be capable of providing a similar high performance as that provided by traditional internally cooled laser modules, but with improved cost efficiency and manufacturability. In the internally cooled laser module, a laser subassembly, such as a coaxial semiconductor laser, may be mounted on a thermoelectric cooler cooler-base with several other components enclosed in a properly designed case.

    摘要翻译： 内部激光模块可以提供与传统的内部冷却的激光模块相同的高性能，但具有提高的成本效率和可制造性。 在内部冷却的激光器模块中，诸如同轴半导体激光器的激光子组件可以安装在热电冷却器冷却器基座上，其中几个其它部件封装在适当设计的壳体中。