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公开(公告)号：US07235243B2
公开(公告)日：2007-06-26
申请号：US11173364
申请日：2005-07-01
申请人： Robert S. Becker , Robert C. Huebner , Maryann Gray , Karen S. Biscardi , Lorne F. Erdile , Bruno Guy
发明人： Robert S. Becker , Robert C. Huebner , Maryann Gray , Karen S. Biscardi , Lorne F. Erdile , Bruno Guy
IPC分类号： A61K39/00
CPC分类号： A61K39/0225 , A61K39/092 , A61K39/105 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5252 , A61K2039/542 , A61K2039/543 , A61K2039/55505 , A61K2039/55516 , A61K2039/55544 , A61K2039/6018 , A61K2039/70 , C07K14/20 , C07K14/285 , C07K14/3156 , C12N2760/16134 , Y02A50/401 , Y10S424/828 , A61K39/102 , A61K39/09 , A61K2300/00
摘要： Immununological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immunogenic. The antigen can be influenza HA and the lipoprotein a recombinantly expressed product having an OspA leader for lipidation and PspA for the protein portion. The antigen can be OspC and the lipoprotein OspA. The components of the composition are co-administered. A potentiated immunological response is obtained by the compositions and methods.
摘要翻译： 免疫学组成和制备和使用它们的方法。 组合物含有至少一种抗原和至少一种脂蛋白和任选的佐剂。 脂蛋白本身可以是抗原性的或免疫原性的。 抗原可以是流感HA，脂蛋白是具有用于脂质化的OspA前导物和蛋白质部分的PspA的重组表达产物。 抗原可以是OspC和脂蛋白OspA。 组合物的组分共同施用。 通过组合物和方法获得增强的免疫应答。
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公开(公告)号：US06984385B2
公开(公告)日：2006-01-10
申请号：US10096687
申请日：2002-03-12
申请人： Robert S. Becker , Robert C. Huebner , Maryann Gray , Karen S. Biscardi , Lorne F. Erdile , Bruno Guy
发明人： Robert S. Becker , Robert C. Huebner , Maryann Gray , Karen S. Biscardi , Lorne F. Erdile , Bruno Guy
IPC分类号： A61K39/00
CPC分类号： A61K39/0225 , A61K39/092 , A61K39/105 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5252 , A61K2039/542 , A61K2039/543 , A61K2039/55505 , A61K2039/55516 , A61K2039/55544 , A61K2039/6018 , A61K2039/70 , C07K14/20 , C07K14/285 , C07K14/3156 , C12N2760/16134 , Y02A50/401 , Y10S424/828 , A61K39/102 , A61K39/09 , A61K2300/00
摘要： Immunological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immunogenic. The antigen can be influenza HA and the lipoprotein a recombinantly expressed product having an OspA leader for lipidation and PspA for the protein portion. The antigen can be OspC and the lipoprotein OspA. The components of the composition are co-administered. A potentiated immunological response is obtained by the compositions and methods.
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公开(公告)号：US06379675B1
公开(公告)日：2002-04-30
申请号：US08588621
申请日：1996-01-19
申请人： Robert S. Becker , Robert C. Huebner , Maryann Gray , Karen S. Biscardi , Lorne F. Erdile , Bruno Guy
发明人： Robert S. Becker , Robert C. Huebner , Maryann Gray , Karen S. Biscardi , Lorne F. Erdile , Bruno Guy
IPC分类号： A61K3902
CPC分类号： A61K39/0225 , A61K39/092 , A61K39/105 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5252 , A61K2039/542 , A61K2039/543 , A61K2039/55505 , A61K2039/55516 , A61K2039/55544 , A61K2039/6018 , A61K2039/70 , C07K14/20 , C07K14/285 , C07K14/3156 , C12N2760/16134 , Y02A50/401 , Y10S424/828 , A61K39/102 , A61K39/09 , A61K2300/00
摘要： Immunological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immunogenic. The antigen can be influenza HA and the lipoprotein a recombinantly expressed product having an OspA leader for lipidation and PspA for the protein portion. The antigen can be OspC and the lipoprotein OspA. The components of the composition are co-administered. A potentiated immunological response is obtained by the compositions and methods.
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公开(公告)号：US20080089911A1
公开(公告)日：2008-04-17
申请号：US11804446
申请日：2007-05-18
申请人： Robert Becker , Robert Huebner , Maryann Gray , Karen Biscardi , Lorne Erdile , Bruno Guy
发明人： Robert Becker , Robert Huebner , Maryann Gray , Karen Biscardi , Lorne Erdile , Bruno Guy
CPC分类号： A61K39/0225 , A61K39/092 , A61K39/105 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5252 , A61K2039/542 , A61K2039/543 , A61K2039/55505 , A61K2039/55516 , A61K2039/55544 , A61K2039/6018 , A61K2039/70 , C07K14/20 , C07K14/285 , C07K14/3156 , C12N2760/16134 , Y02A50/401 , Y10S424/828 , A61K39/102 , A61K39/09 , A61K2300/00
摘要： Immununological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immunogenic. The antigen can be influenza HA and the lipoprotein a recombinantly expressed product having an OspA leader for lipidation and PspA for the protein portion. The antigen can be OspC and the lipoprotein OspA. The components of the composition are co-administered. A potentiated immunological response is obtained by the compositions and methods.
摘要翻译： 免疫学组成和制备和使用它们的方法。 组合物含有至少一种抗原和至少一种脂蛋白和任选的佐剂。 脂蛋白本身可以是抗原性的或免疫原性的。 抗原可以是流感HA，脂蛋白是具有用于脂质化的OspA前导物和蛋白质部分的PspA的重组表达产物。 抗原可以是OspC和脂蛋白OspA。 组合物的组分共同施用。 通过组合物和方法获得增强的免疫应答。
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公开(公告)号：US20060110408A1
公开(公告)日：2006-05-25
申请号：US11173364
申请日：2005-07-01
申请人： Robert Becker , Robert Huebner , Maryann Gray , Karen Biscardi , Lorne Erdile , Bruno Guy
发明人： Robert Becker , Robert Huebner , Maryann Gray , Karen Biscardi , Lorne Erdile , Bruno Guy
CPC分类号： A61K39/0225 , A61K39/092 , A61K39/105 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5252 , A61K2039/542 , A61K2039/543 , A61K2039/55505 , A61K2039/55516 , A61K2039/55544 , A61K2039/6018 , A61K2039/70 , C07K14/20 , C07K14/285 , C07K14/3156 , C12N2760/16134 , Y02A50/401 , Y10S424/828 , A61K39/102 , A61K39/09 , A61K2300/00
摘要： Immununological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immunogenic. The antigen can be influenza HA and the lipoprotein a recombinantly expressed product having an OspA leader for lipidation and PspA for the protein portion. The antigen can be OspC and the lipoprotein OspA. The components of the composition are co-administered. A potentiated immunological response is obtained by the compositions and methods.
摘要翻译： 免疫学组成和制备和使用它们的方法。 组合物含有至少一种抗原和至少一种脂蛋白和任选的佐剂。 脂蛋白本身可以是抗原性的或免疫原性的。 抗原可以是流感HA，脂蛋白是具有用于脂质化的OspA前导物和蛋白质部分的PspA的重组表达产物。 抗原可以是OspC和脂蛋白OspA。 组合物的组分共同施用。 通过组合物和方法获得增强的免疫应答。
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公开(公告)号：US20050171343A1
公开(公告)日：2005-08-04
申请号：US10359435
申请日：2003-02-06
申请人： Robert Huebner , Lorne Erdile , Donald Warakomski , Robert Becker , Maryann Gray , Derek Pyle
发明人： Robert Huebner , Lorne Erdile , Donald Warakomski , Robert Becker , Maryann Gray , Derek Pyle
IPC分类号： A61K38/00 , C07K14/195 , C07K14/205 , C07K14/315 , C12N15/62 , C12P21/02 , C12Q1/68 , C07H21/04 , C12N15/09 , A61K39/02 , C12N1/21
CPC分类号： C07K14/315 , A61K38/00 , C07K14/195 , C07K14/205 , C07K2319/02 , C07K2319/40 , C12N15/625 , C12P21/02 , Y02A50/401
摘要： Heterologous lipidated proteins formed recombinantly are disclosed and claimed. The expression system can be E. coli. The heterologous lipidated protein has a leader sequence which does not naturally occur with the protein portion of the lipidated protein. The lipidated protein can have the Borrelia OspA leader sequence. The protein portion can be OspC, PspA, UreA, Ure B, or a fragment thereof. Methods and compositions for forming and employing the proteins are also disclosed and claimed.
摘要翻译： 公开并要求重组形成的异源脂质化蛋白。 表达系统可以是大肠杆菌。 异源脂质化蛋白质具有不与脂质化蛋白质的蛋白质部分天然存在的前导序列。 脂质化蛋白可以具有疏螺旋体OspA前导序列。 蛋白质部分可以是OspC，PspA，UreA，Ure B或其片段。 用于形成和应用蛋白质的方法和组合物也被公开和要求保护。
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