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    Spill resistant pharmaceutical compositions in semi-solid form
    5.
    发明授权
    Spill resistant pharmaceutical compositions in semi-solid form 有权
    半固体形式的防溢剂药物组合物

    公开(公告)号：US06399079B1

    公开(公告)日：2002-06-04

    申请号：US09549148

    申请日：2000-04-13

    申请人： Rakesh Mehta ,  Dan Moros

    发明人： Rakesh Mehta ,  Dan Moros

    IPC分类号： A61K900

    CPC分类号： A61J7/0023 ,  A61J7/0015 ,  A61J7/0053 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/06 ,  A61K31/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/22 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

    摘要： A spill-resistant pharmaceutical formulation for oral administration from a squeezable container comprises a pharmaceutical agent in a suitable vehicle comprising a liquid base and a thickening agent, the formulation consisting of mutually compatible components and having the following properties: a viscosity within the range of about 7500 to about 12,500 cps using a Brookfield Viscometer with a ‘C’ spindle with Helipath movement at a spindle speed of 10 rpm and 20-25° C., a viscometric yield value of a semi-solid, a spill-resistant consistency permitting the composition to be squeezed by light manual pressure through a channel, to spread in a spoon bowl sufficiently quickly for accurate measurement, and to remain in the spoon bowl without spilling on spoon inversion, tilting at 90 degrees, and vibration, homogeneity such that the components do not separate under conditions of use, and a storage stability such that the foregoing properties are retained for at least two years shelf life. A method for producing a formulation for a spill-resistant pharmaceutical composition comprises combining a per-unit dose effective amount of a pharmaceutical agent with suitable vehicle components comprising a liquid base and a thickening agent, and testing the formulation for acceptance criteria.

    摘要翻译： 用于从可挤压容器口服给药的防溢剂药物制剂包括在合适的载体中的药剂，其包含液体碱和增稠剂，所述制剂由相互相容的组分组成并具有以下性质：粘度在约 7500至约12,500cps，使用布鲁克菲尔德粘度计，具有“C”主轴，带有Helipath运动，主轴转速为10rpm和20-25℃，半固体的粘度屈服值，防溢出的一致性允许 组合物通过通道通过轻的手动压力挤压，以足够快的速度在勺子碗中扩散以进行精确的测量，并且保持在勺子中而不会溢出勺子反转，倾斜90度，并且振动均匀，使得组分 不要在使用条件下分离，并且保存稳定性，使得上述性质保持至少两年的保质期 e。 用于制备用于防溢药物组合物的制剂的方法包括将每单位剂量有效量的药剂与包含液体碱和增稠剂的合适的载体组分组合，并测试该制剂的验收标准。

    Method for formulating spill resistant pharmaceutical compositions in semi-solid form
    6.
    发明授权
    Method for formulating spill resistant pharmaceutical compositions in semi-solid form 有权
    用于配制半固体形式的防溢药物组合物的方法

    公开(公告)号：US06355258B1

    公开(公告)日：2002-03-12

    申请号：US09548927

    申请日：2000-04-13

    申请人： Rakesh Mehta ,  Dan Moros

    发明人： Rakesh Mehta ,  Dan Moros

    IPC分类号： A61K900

    CPC分类号： A61J7/0023 ,  A61J7/0015 ,  A61J7/0053 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/06 ,  A61K31/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/22 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

    摘要： A spill-resistant pharmaceutical formulation for oral administration from a squeezable container comprises a pharmaceutical agent in a suitable vehicle comprising a liquid base and a thickening agent, the formulation consisting of mutually compatible components and having the following proper ties: a viscosity within the range of about 7500 to about 12,500 cps using a Brookfield Viscometer with a ‘C’ spindle with Helipath movement at a spindle speed of 20 rpm and 20-25° C., a viscometric yield value of a semi-solid, a spill-resistant consistency permitting the composition to be squeezed by light manual pressure through a channel, to spread in a spoon bowl sufficiently quickly for accurate measurement, and to remain in the spoon bowl without spilling on spoon inversion, tilting at 90 degrees, and vibration, homogeneity such that the components do not separate under conditions of use, and a storage stability such that the foregoing properties are retained for at least two years shelf life. A method for producing a formulation for a spill-resistant pharmaceutical composition comprises combining a per-unit dose effective amount of a pharmaceutical agent with suitable vehicle components comprising a liquid base and a thickening agent and testing the formulation for acceptance criteria.

    摘要翻译： 用于从可压榨容器口服的防溢剂药物制剂包括在合适的载体中的药剂，其包含液体碱和增稠剂，所述制剂由相互相容的组分组成并具有以下适当关系：粘度在 约7500至约12,500厘泊，使用布鲁克菲尔德粘度计，具有“C”主轴，带有Helipath运动，主轴转速为20rpm和20-25℃，半固体的粘度屈服值，防溢出稠度允许 组合物通过通道通过轻的手动压力挤压，以足够快的速度在勺子碗中扩散以进行精确的测量，并且保持在勺子中而不会溢出勺子反转，倾斜90度，并且振动，均匀，使得 组分在使用条件下不分离，并且存储稳定性使得上述性质保留至少两年 fe。 用于制备用于防溢药物组合物的制剂的方法包括将每单位剂量有效量的药剂与包含液体碱和增稠剂的合适的载体组分组合，并测试该制剂的验收标准。

    Magnetically responsive carbon nano-structures for transporting biologically active substances, and methods relating thereto
    9.
    发明申请
    Magnetically responsive carbon nano-structures for transporting biologically active substances, and methods relating thereto 审中-公开
    用于运输生物活性物质的磁响应性碳纳米结构及其相关方法

    公开(公告)号：US20060024378A1

    公开(公告)日：2006-02-02

    申请号：US11040426

    申请日：2005-01-21

    申请人： Rakesh Mehta

    发明人： Rakesh Mehta

    IPC分类号： H01F1/00 ,  A61K9/14

    CPC分类号： A61K9/5115 ,  A61K9/0092 ,  B82Y25/00 ,  H01F1/0045 ,  H01F1/33 ,  H01F1/44

    摘要： This invention is directed to a composition for medicinal transportation in a biological fluid. The carrier composition is a single or multi-walled nanostructure, open or closed at either end, having a non-metallic ferromagnetic component (A), a metallic ferromagnetic component (B), and a carbon component (C), where the atomic ratio of A:B:C is: 0.1-200: 0.05-75: 100. The cross-sectional size of the nanostructures of the present invention is less than 30 nanometers in at least one direction.

    摘要翻译： 本发明涉及用于生物流体中药物输送的组合物。 载体组合物是在任一端开放或封闭的单壁或多壁纳米结构体，其具有非金属铁磁组分（A），金属铁磁组分（B）和碳组分（C），其中原子比 的A：B：C为：0.1-200：0.05-75：100。本发明的纳米结构的横截面尺寸在至少一个方向上小于30纳米。

    Spill resistant pharmaceutical system
    10.
    发明授权
    Spill resistant pharmaceutical system 失效
    防溢药剂系统

    公开(公告)号：US06656482B2

    公开(公告)日：2003-12-02

    申请号：US10052462

    申请日：2002-01-23

    申请人： Rakesh Mehta ,  Dan Moros

    发明人： Rakesh Mehta ,  Dan Moros

    IPC分类号： A61K600

    CPC分类号： A61J7/0023 ,  A61J7/0015 ,  A61J7/0053 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/06 ,  A61K31/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/22 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

    摘要： A spill-resistant pharmaceutical formulation for oral administration from a squeezable container comprises a pharmaceutical agent in a suitable vehicle comprising a liquid base and a thickening agent, the formulation consisting of mutually compatible components and having the following properties: a viscosity within the range of about 7500 to about 12,500 cps using a Brookfield Viscometer with a ‘C’ spindle with Helipath movement at a spindle speed of 10 rpm and 20-25° C., a viscometric yield value of a semi-solid, a spill-resistant consistency permitting the composition to be squeezed by light manual pressure through a channel, to spread in a spoon bowl sufficiently quickly for accurate measurement, and to remain in the spoon bowl without spilling on spoon inversion, tilting at 90 degrees, and vibration, homogeneity such that the components do not separate under conditions of use, and a storage stability such that the foregoing properties are retained for at least two years shelf life. A method for producing a formulation for a spill-resistant pharmaceutical composition comprises combining a per-unit dose effective amount of a pharmaceutical agent with suitable vehicle components comprising a liquid base and a thickening agent, and testing the formulation for acceptance criteria.

    摘要翻译： 用于从可挤压容器口服给药的防溢剂药物制剂包括在合适的载体中的药剂，其包含液体碱和增稠剂，所述制剂由相互相容的组分组成并具有以下性质：粘度在约 7500至约12,500厘泊，使用布鲁克菲尔德粘度计，带有“C”主轴，带有Helipath运动，主轴转速为10rpm和20-25℃，半固体的粘度屈服值，防溢出的一致性允许 组合物通过通道通过轻的手动压力挤压，以足够快的速度在勺子碗中扩散以进行精确的测量，并且保持在勺子中而不会溢出勺子反转，倾斜90度，并且振动均匀，使得组分 不要在使用条件下分离，并且保存稳定性，使得上述性质保持至少两年的保质期 e。 用于制备用于防溢药物组合物的制剂的方法包括将每单位剂量有效量的药剂与包含液体碱和增稠剂的合适的载体组分组合，并测试该制剂的验收标准。