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公开(公告)号：US07118048B2
公开(公告)日：2006-10-10
申请号：US11231579
申请日：2005-09-21
IPC分类号： B05B1/28
CPC分类号： B41J2/14008
摘要： An apparatus and method for droplet steering is disclosed herein. A throated structure having a nozzle defines a converging throat with an inlet and an outlet and a vectored fluid stream directed therethrough. The fluid stream is driven through the system via a vacuum pump. As the fluid approaches the outlet, its velocity increases and is drawn away from the nozzle through a connecting channel. As a droplet is ejected from a liquid therebelow, it will have a first trajectory until it is introduced to the high velocity fluid stream at the perimeter of the interior walls of the nozzle. The fluid accordingly steers the momentum of the droplet such that it obtains a second or corrected trajectory. Alternative variations include an electrically chargeable member, e.g., a pin, positionable to be in apposition to the outlet and capillary tubes for controlling the ejection surface of the pool of source fluid.
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2.发明申请公开(公告)号：US20100249995A1
公开(公告)日：2010-09-30
申请号：US12416079
申请日：2009-03-31
申请人： Roger O. Williams , Ronald D. Jones , Charles A. Reichel , Gregory B. Stephens , Michael J. Forbush
发明人： Roger O. Williams , Ronald D. Jones , Charles A. Reichel , Gregory B. Stephens , Michael J. Forbush
CPC分类号： G06Q30/0603 , G06Q30/0601
摘要： A method and apparatus for ordering a preloaded chemical assay plate. The method comprises the steps accessing an Internet based order entry site; viewing a list of target chemical compounds; creating an order on the order entry site that lists the desired target compounds for the assay; specifying one or more well plate parameters, such as the number of wells in a well plate that will be used to hold the target compounds; specifying one or more assay parameters in the order, such as specifying the final test volume and concentration of the target compounds in the wells; and placing the order from the order entry site. The apparatus comprises a server for accepting the customer order transmitted over the Internet; a storage means for electronically storing the list of target compounds; process control means for generating a work order that contains instructions for retrieving one or more working plates that contain the chemical compounds specified in the customer order; and assay printing means for acoustically dispensing the chemical compounds onto the assay substrate.
摘要翻译： 一种用于订购预加载的化学测定板的方法和装置。 该方法包括访问基于因特网的订单输入站点的步骤; 查看目标化合物列表; 在订单输入站点上创建列出所需测试化合物的订单; 指定一个或多个孔板参数，例如将用于保持目标化合物的孔板中的孔的数量; 指定一个或多个测定参数，例如指定孔中的目标化合物的最终测试体积和浓度; 并从订单输入站点下订单。 该装置包括用于接受通过因特网传送的客户订单的服务器; 用于电子存储目标化合物列表的存储装置; 用于生成包含用于检索包含客户订单中指定的化学化合物的一个或多个工作板的指令的工作订单的过程控制装置; 以及用于将化学化合物声学分配到测定基底上的测定印刷装置。
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公开(公告)号：US08137640B2
公开(公告)日：2012-03-20
申请号：US11964628
申请日：2007-12-26
申请人： Roger O. Williams , Tarlochan S. Jutty , N. Nicolas Mansour , Lawrence Lee, Jr. , Michael J. Forbush
发明人： Roger O. Williams , Tarlochan S. Jutty , N. Nicolas Mansour , Lawrence Lee, Jr. , Michael J. Forbush
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00725 , B01L2300/0819 , B01L2400/0433 , B01L2400/0436 , B05B17/0615 , C40B30/04 , C40B40/02 , C40B40/04 , C40B40/08 , C40B40/10 , C40B50/00 , C40B60/14 , F04F7/00 , G01N21/11 , Y10T137/206 , Y10T137/2196 , Y10T436/2575
摘要： Invention methods employ the use of acoustic waves to transfer small amounts of fluid in a non-contact manner. In invention methods, acoustic waves are propagated through a separated pool of a source fluid in such a manner that causes the ejection of a single micro-droplet from the surface of the pool. The droplet is ejected towards a target with sufficient force to provide for contact of the droplet with the target. Because the fluid is not contacted by any fluid transfer device such as a pipette, the opportunities for contamination are minimized. Invention methods may be employed to transfer fluids from an array of source sites to an array of target sites, thereby enabling the precision automation of a wide variety of procedures including screening, and synthesis procedures commonly used in biotechnology.
摘要翻译： 本发明的方法采用声波以非接触方式传送少量流体。 在本发明的方法中，声波以这样的方式传播通过源流体的分离池，使得从池的表面喷出单个微滴。 液滴以足够的力朝向目标喷射以提供液滴与靶的接触。 由于流体不被诸如移液管之类的任何流体转移装置接触，污染的机会被最小化。 可以采用本发明的方法将流体从源位置阵列转移到目标位点阵列，从而能够精确自动化多种程序，包括生物技术中通常使用的筛选和合成方法。
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公开(公告)号：US06596239B2
公开(公告)日：2003-07-22
申请号：US09735709
申请日：2000-12-12
申请人： Roger O. Williams , Tarlochan Singh , N. Nicolas Mansour , Lawrence Lee, Jr. , Michael J. Forbush
发明人： Roger O. Williams , Tarlochan Singh , N. Nicolas Mansour , Lawrence Lee, Jr. , Michael J. Forbush
IPC分类号： B01L302
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00725 , B01L2300/0819 , B01L2400/0433 , B01L2400/0436 , B05B17/0615 , C40B30/04 , C40B40/02 , C40B40/04 , C40B40/08 , C40B40/10 , C40B50/00 , C40B60/14 , F04F7/00 , G01N21/11 , Y10T137/206 , Y10T137/2196 , Y10T436/2575
摘要： Acoustic waves are used to transfer small amounts of fluid in a non-contact manner. Acoustic waves are propagated through a pool of a source fluid in such a manner that causes the ejection of a single micro-droplet from the surface of the pool. The droplet is ejected towards a target with sufficient force to provide contact of the droplet with the target. Because the fluid is not contacted by any fluid transfer device such as a pipette, the opportunities for contamination are minimized. Methods may be employed to transfer fluids from an array of source sites to an array of target sites, thereby enabling the precise automation of a wide variety of procedures including screening and synthesis procedures commonly used in biotechnology.
摘要翻译： 声波用于以非接触方式转移少量流体。 声波以这样的方式传播通过源流体池，使得从池的表面喷射单个微滴。 液滴以足够的力朝向目标喷射以提供液滴与靶的接触。 由于流体不被诸如移液管之类的任何流体转移装置接触，污染的机会被最小化。 可以采用方法将流体从源位置阵列转移到靶位点阵列，从而能够精确自动化各种程序，包括通常用于生物技术的筛选和合成过程。
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5.发明授权Acoustic method for determining the viscosity and/or surface tension of a liquid 有权用于确定液体的粘度和/或表面张力的声学方法公开(公告)号：US07281413B2
公开(公告)日：2007-10-16
申请号：US11088436
申请日：2005-03-24
IPC分类号： G01N11/00
CPC分类号： G01N13/02 , B41J2/14008 , G01N11/16
摘要： The present invention comprises a noncontact method for measuring viscosity and/or surface tension information of a liquid in a liquid containment structure. The steps of the method include exciting a surface of the liquid with an excitation burst of acoustic energy that causes the surface to oscillate; generating a positional data set comprised of a plurality of positional measurements related to the detected position of the surface at a plurality of times after the surface is excited; generating a frequency domain data set from the positional data set, the amplitude spectrum of the frequency domain data set comprising information about the oscillation frequency of at least one vibrational mode of the of the surface as it oscillates; and processing the frequency domain data set and/or the positional data set to yield information about the surface tension and/or viscosity of the liquid. A Fast Fourier Transform technique may be used in generating the frequency domain data set.
摘要翻译： 本发明包括用于测量液体容纳结构中的液体的粘度和/或表面张力信息的非接触方法。 该方法的步骤包括以引起表面振荡的声能的激发脉冲激发液体的表面; 在所述表面被激发之后，多次生成与所述表面的检测位置有关的多个位置测量值的位置数据集; 从所述位置数据集合生成频域数据集，所述频域数据集的振幅谱包括当所述表面振荡时至少一个振动模式的振荡频率的信息; 并且处理频域数据集和/或位置数据集以产生关于液体的表面张力和/或粘度的信息。 快速傅立叶变换技术可用于产生频域数据集。
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公开(公告)号：US5759918A
公开(公告)日：1998-06-02
申请号：US689741
申请日：1996-08-13
申请人： Jon A. Hoshizaki , Roger O. Williams , James D. Buhler , Charles A. Reichel , William K. Hollywood , Richard de Geus , Lawrence L. Lee
发明人： Jon A. Hoshizaki , Roger O. Williams , James D. Buhler , Charles A. Reichel , William K. Hollywood , Richard de Geus , Lawrence L. Lee
IPC分类号： B24B7/24 , B24B37/04 , B24B37/10 , B24B37/30 , B24B37/32 , G05B19/18 , H01L21/304 , B24B1/00
CPC分类号： B24B37/105 , B24B37/042 , B24B37/30 , B24B37/32 , B24B7/241 , G05B19/182 , G05B2219/43142 , G05B2219/45058 , G05B2219/45232
摘要： A method and apparatus is disclosed for polishing the face of a semiconductor wafer. The wafer is held in position by a tooling head and is contacted by an abrasive pad. A table is provided on to which the abrasive pad is fixedly attached, both of which move in directions parallel to the face of the wafer being polished. A controller controls the motion of the table according to a predetermined polishing pattern and is capable of maintaining a constant velocity between the wafer and the abrasive pad. The tooling head includes a circular platen and a retention ring peripherally oriented about the outer edge of the platen which resists lateral forces on the wafer caused by engagement of the face of the wafer with the polishing surface. An adjustable coupling is mounted to the platen and the ring, and serves to adjustably position during polishing the height of the ring relative to the face of the wafer as well as to rigidly support during polishing the position of the retaining ring. A flexible disk is fixedly mounted between a support post and the platen and oriented substantially parallel to the face of the platen. The flexible disk is adapted to prevent rotation of the platen about the axis of the support post and to transmit forces between the platen and the post in directions parallel to the face of the platen.
摘要翻译： 公开了一种用于抛光半导体晶片的表面的方法和装置。 晶片通过工具头保持在适当位置并且被研磨垫接触。 提供了一个桌子，研磨垫固定在该工作台上，两者都沿平行于待抛光晶片的表面的方向移动。 控制器根据预定的抛光图案控制工作台的运动，并且能够在晶片和研磨垫之间保持恒定的速度。 工具头包括圆形压板和围绕压板的外边缘周向定向的保持环，其抵抗由晶片的表面与抛光表面的接合引起的晶片上的横向力。 可调联接件安装到压板和环上，并且用于在抛光环相对于晶片表面的高度期间可调节地定位，并且在抛光保持环的位置期间刚性地支撑。 柔性盘固定地安装在支撑柱和压板之间并且基本上平行于压板的表面定向。 柔性盘适于防止压板围绕支柱的轴线旋转并且在平行于压板的表面的方向上在压板和柱之间传递力。
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公开(公告)号：US5333084A
公开(公告)日：1994-07-26
申请号：US611962
申请日：1990-07-13
CPC分类号： G11B5/02 , G11B20/1816 , G11B27/36 , G11B5/035 , G11B5/5534 , G11B5/56
摘要： A disk drive in which the radial alignment, track zero alignment, index to data timing, write current, asymmetry and threshold dropout can be electronically adjusted. A plurality of programs stored in random access memory run a plurality of adjustment procedures used to control the electronic adjustment functions of the disk drive. An alignment disk read by the disk drive provides alignment data for the radial, track zero and index to data alignment procedures. A microstepper circuit in the disk drive allows the read/write heads to be moved in discrete steps of approximately 1/126 of the track pitch for electronically adjusting the radial and track zero parameters. The index to data alignment is set by generating and storing an artifical index offset value. The write current and asymmetry adjustment procedures utilize digital to analog convertors (DACS) to vary the voltage supplied to the read/write heads. The threshold dropout procedure utilizes a DAC to control the output of a pulse detector.
摘要翻译： 其中可以电子地调整径向对准，轨迹零对准，数据定时索引，写入电流，不对称和阈值丢失的磁盘驱动器。 存储在随机存取存储器中的多个程序运行用于控制磁盘驱动器的电子调整功能的多个调整程序。 由磁盘驱动器读取的对准磁盘提供径向，磁道零和索引到数据对齐过程的对齐数据。 磁盘驱动器中的微步进电路允许以大约1/126的磁道间距的离散步长移动读/写磁头，用于电子调节径向和磁道零参数。 通过生成和存储人为索引偏移值来设置数据对齐索引。 写入电流和不对称调整程序利用数模转换器（DACS）来改变提供给读/写头的电压。 阈值压差过程利用DAC来控制脉冲检测器的输出。
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公开(公告)号：US5220476A
公开(公告)日：1993-06-15
申请号：US608338
申请日：1990-11-02
摘要： A method for inscribing data onto a magnetic medium (12) wherein portions of an oxide coating (16) of the medium are removed from the medium (12) to create voids (88) while the oxide coating (16) is left undisturbed on areas adjacent to the voids (88). The adjacent areas are then uniformly magnetized. When the medium is moved past a read head (78), changes in magnetic field present at transition points (82) and (84) between the voids (88) and the uniformly magnetized oxide coating (16) of adjacent areas cause a current to be induced in a coil (80) of the read (78) head which current is interpreted by conventional read circuitry as being a data bit. The data inscribed by this method is not erasable by conventional means. The inventive method may be practiced upon selected portions of a medium (12) such that non-erasable data areas and conventional magnetically erasable data areas can coexist on the same medium (12).
摘要翻译： 一种用于将数据写入磁介质（12）的方法，其中介质的氧化物涂层（16）的部分从介质（12）中移除以产生空隙（88），同时氧化物涂层（16）不受干扰地区 邻近空隙（88）。 然后相邻区域被均匀地磁化。 当介质移动通过读取头（78）时，存在于空隙（88）和相邻区域的均匀磁化的氧化物涂层（16）之间的过渡点（82）和（84）处的磁场的变化导致电流 在读取（78）磁头的线圈（80）中被感应，该电流由常规读取电路解释为数据位。 通过这种方法刻录的数据不能通过常规方法进行擦除。 可以在介质（12）的选定部分上实施本发明的方法，使得不可擦除的数据区域和常规的磁性可擦除数据区域可以在同一介质（12）上共存。
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公开(公告)号：US06976639B2
公开(公告)日：2005-12-20
申请号：US10006489
申请日：2001-12-06
CPC分类号： B41J2/14008
摘要： An apparatus and method for droplet steering is disclosed herein. A throated structure having a nozzle defines a converging throat with an inlet and an outlet and a vectored fluid stream directed therethrough. The fluid stream is driven through the system via a vacuum pump. As the fluid approaches the outlet, its velocity increases and is drawn away from the nozzle through a connecting channel. As a droplet is ejected from a liquid therebelow, it will have a first trajectory until it is introduced to the high velocity fluid stream at the perimeter of the interior walls of the nozzle. The fluid accordingly steers the momentum of the droplet such that it obtains a second or corrected trajectory. Alternative variations include an electrically chargeable member, e.g., a pin, positionable to be in apposition to the outlet and capillary tubes for controlling the ejection surface of the pool of source fluid.
摘要翻译： 本文公开了一种用于液滴转向的装置和方法。 具有喷嘴的带喉的结构限定了具有入口和出口的会聚喉部以及从其中引导的向量流体流。 流体流经真空泵驱动通过系统。 当流体接近出口时，其速度增加，并通过连接通道从喷嘴中拉出。 当液滴从其下方的液体喷射时，它将具有第一轨迹，直到其被引入喷嘴内壁周边处的高速流体流。 流体相应地引导液滴的动量，使得其获得第二或校正的轨迹。 替代的变型包括可定位成与出口相配合的可引起电荷的构件，用于控制源流体池的喷射表面的毛细管。
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10.发明授权
公开(公告)号：US5515212A
公开(公告)日：1996-05-07
申请号：US111778
申请日：1993-08-25
申请人： James Chiao , Jimmy D. Godwin , Alton B. Otis, Jr. , Andrew M. Rose , Roger O. Williams , Stephen P. Williams , Mark E. Strysko
发明人： James Chiao , Jimmy D. Godwin , Alton B. Otis, Jr. , Andrew M. Rose , Roger O. Williams , Stephen P. Williams , Mark E. Strysko
CPC分类号： G11B20/1866 , G11B20/1252 , G11B27/3027 , G11B27/329 , G11B5/59677 , G11B2020/1087 , G11B2220/2512
摘要： A diskette comprising a jacket, a liner material disposed within said jacket, a flat circular media having a magnetic coating on both sides disposed within said liner material, a hub attached at the center of said media, a plurality of servo grooves on at least one of said sides of said media that have stitched patterns that will alternate on-and-off at twenty kilohertz in the presence of a constant, unmodulated light source. The diskette is magnetically formatted with reference and data tracks recorded in such a way that extremely accurate position determinations can be made by looking at the analog amplitude of the detected tracks and comparing them at different head positions. The innermost tracks contain redundant copies of a disk mapping table that comprises data for a media type code, a sector size code, a sector interleave code, a total track count, a reassignment area starting address, a data area starting address, a total sector count, an update count, and a reassignment table having at least room for 250 entries of three bytes each.
摘要翻译： 一种软盘，包括夹套，设置在所述护套中的衬垫材料，平坦的圆形介质，其两侧上设置有磁性涂层，设置在所述衬垫材料内;安装在所述介质中心的毂;至少一个 所述介质的所述侧面，在存在恒定的未调制的光源的情况下，其缝合图案将在二十千赫兹交替地开启和关闭。 磁盘被磁格式化，其参考和数据轨迹以这样的方式记录，即通过观察检测到的轨迹的模拟幅度并在不同的头部位置进行比较，可以进行非常精确的位置确定。 最内侧的轨道包含盘映射表的冗余副本，该盘映射表包括用于媒体类型码，扇区大小码，扇区交织码，总轨迹数，数据区起始地址，数据区起始地址，总扇区 计数，更新计数和重新分配表，其具有至少有250个条目的空间，每个条目为三个字节。
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